Type |
Details |
Score |
Publication |
First Author: |
Schneider A |
Year: |
1999 |
Journal: |
Nat Med |
Title: |
NF-kappaB is activated and promotes cell death in focal cerebral ischemia. |
Volume: |
5 |
Issue: |
5 |
Pages: |
554-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helbig C |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells. |
Volume: |
10 |
Issue: |
1 |
Pages: |
8152 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tachibana M |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. |
Volume: |
276 |
Issue: |
27 |
Pages: |
25309-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ueda J |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. |
Volume: |
281 |
Issue: |
29 |
Pages: |
20120-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Collins RE |
Year: |
2008 |
Journal: |
Nat Struct Mol Biol |
Title: |
The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. |
Volume: |
15 |
Issue: |
3 |
Pages: |
245-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang J |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
G9a and Glp methylate lysine 373 in the tumor suppressor p53. |
Volume: |
285 |
Issue: |
13 |
Pages: |
9636-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amberg N |
Year: |
2024 |
Journal: |
STAR Protoc |
Title: |
Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry. |
Volume: |
5 |
Issue: |
1 |
Pages: |
102771 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu J |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. |
Volume: |
285 |
Issue: |
20 |
Pages: |
15126-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pfeuffer T |
Year: |
2000 |
Journal: |
Cell Microbiol |
Title: |
LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system, co-localizes with intracellular Listeria monocytogenes. |
Volume: |
2 |
Issue: |
2 |
Pages: |
101-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kwon HJ |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL. |
Volume: |
24 |
Issue: |
21 |
Pages: |
9317-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu Y |
Year: |
2012 |
Journal: |
Mol Cell |
Title: |
Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA. |
Volume: |
46 |
Issue: |
1 |
Pages: |
7-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho YY |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation. |
Volume: |
67 |
Issue: |
17 |
Pages: |
8104-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rathert P |
Year: |
2008 |
Journal: |
Nat Chem Biol |
Title: |
Protein lysine methyltransferase G9a acts on non-histone targets. |
Volume: |
4 |
Issue: |
6 |
Pages: |
344-6 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Histone-lysine N-methyltransferase EHMT2 () mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin []. H3K9me is a specific tag for repression of epigenetic transcription, recruiting HP1 proteins to methylated histones. EHMT2 also monomethylates 'Lys-56' of histone H3 (H3K56me1) during the G1 phase of the cell cycle [], and methylates 'Lys-27' of histone H3 (H3K27me) []. EHMT2 also dimethylates other proteins [], including 'Lys-373' of p53 []. EHMT2 forms a heterdimer with EHMT1 [], and is a component of the E2F6.com-1 complex in G0 phase []. EHMT2 contains seven ankyrin repeats which bind the monomethylated RELA subunit of NF-kappa-B, a SET domain which interacts with WIZ [], and a pre-SET domain that binds three zinc ions via cysteine residues []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents ribosomal protein S6 kinase II []. This enzyme acts as a serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). It plays an essential role in the control of RELA transcriptional activity in response to TNF. It directly represses transcription via phosphorylation of Ser-1 of histone H2A. It phosphorylates Ser-10 of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. It mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). It requires magnesium ions as a cofactor. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents a family of proteins from bacteria, archaea and animals, including Interleukin-1 receptor-associated kinase 1-binding protein 1 from mouse, which has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL is a component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. It functions by enhancing RelA transcriptional activity [, ]. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerisation. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics []. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane. |
|
•
•
•
•
•
|
Publication |
First Author: |
Hertweck A |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex. |
Volume: |
15 |
Issue: |
12 |
Pages: |
2756-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2010 |
Journal: |
Neuron |
Title: |
Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling. |
Volume: |
68 |
Issue: |
1 |
Pages: |
45-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maedera S |
Year: |
2019 |
Journal: |
FEBS Lett |
Title: |
GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages. |
Volume: |
593 |
Issue: |
2 |
Pages: |
195-208 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mise-Omata S |
Year: |
2014 |
Journal: |
Biochem Biophys Res Commun |
Title: |
p100, a precursor of NF-κB2, inhibits c-Rel and reduces the expression of IL-23 in dendritic cells. |
Volume: |
453 |
Issue: |
3 |
Pages: |
332-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dubois SP |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Survival adjustment of mature dendritic cells by IL-15. |
Volume: |
102 |
Issue: |
24 |
Pages: |
8662-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Balasubramani A |
Year: |
2010 |
Journal: |
Immunity |
Title: |
Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. |
Volume: |
33 |
Issue: |
1 |
Pages: |
35-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ozawa T |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB. |
Volume: |
23 |
Issue: |
13 |
Pages: |
3787-3797 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun H |
Year: |
2016 |
Journal: |
PLoS Pathog |
Title: |
A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis. |
Volume: |
12 |
Issue: |
3 |
Pages: |
e1005484 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee H |
Year: |
2009 |
Journal: |
Cancer Cell |
Title: |
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. |
Volume: |
15 |
Issue: |
4 |
Pages: |
283-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin J |
Year: |
2014 |
Journal: |
Immunity |
Title: |
Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity. |
Volume: |
40 |
Issue: |
3 |
Pages: |
342-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ferch U |
Year: |
2007 |
Journal: |
Nat Immunol |
Title: |
MALT1 directs B cell receptor-induced canonical nuclear factor-kappaB signaling selectively to the c-Rel subunit. |
Volume: |
8 |
Issue: |
9 |
Pages: |
984-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Z |
Year: |
2021 |
Journal: |
iScience |
Title: |
Zfp521 is essential for the quiescence and maintenance of adult hematopoietic stem cells under stress. |
Volume: |
24 |
Issue: |
2 |
Pages: |
102039 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fu J |
Year: |
2011 |
Journal: |
Blood |
Title: |
The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis. |
Volume: |
117 |
Issue: |
5 |
Pages: |
1652-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tucker E |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor". |
Volume: |
179 |
Issue: |
11 |
Pages: |
7514-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis. |
Volume: |
10 |
Issue: |
1 |
Pages: |
2795 |
|
•
•
•
•
•
|
Publication |
First Author: |
Poulsen LC |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers. |
Volume: |
38 |
Issue: |
4 |
Pages: |
854-869 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reynaert NL |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. |
Volume: |
103 |
Issue: |
35 |
Pages: |
13086-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahad A |
Year: |
2019 |
Journal: |
iScience |
Title: |
NCoR1: Putting the Brakes on the Dendritic Cell Immune Tolerance. |
Volume: |
19 |
|
Pages: |
996-1011 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jaitin DA |
Year: |
2016 |
Journal: |
Cell |
Title: |
Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq. |
Volume: |
167 |
Issue: |
7 |
Pages: |
1883-1896.e15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qin C |
Year: |
2022 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis. |
Volume: |
119 |
Issue: |
26 |
Pages: |
e2122897119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Himes SR |
Year: |
1996 |
Journal: |
Immunity |
Title: |
High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters. |
Volume: |
5 |
Issue: |
5 |
Pages: |
479-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
van de Sluis B |
Year: |
2007 |
Journal: |
Cell Cycle |
Title: |
COMMD1: a novel protein involved in the proteolysis of proteins. |
Volume: |
6 |
Issue: |
17 |
Pages: |
2091-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jüttler E |
Year: |
2007 |
Journal: |
J Neuroimmunol |
Title: |
Neuronal NF-kappaB influences thermoregulation and survival in a sepsis model. |
Volume: |
189 |
Issue: |
1-2 |
Pages: |
41-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim M |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Loss of HDAC-Mediated Repression and Gain of NF-κB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer. |
Volume: |
17 |
Issue: |
1 |
Pages: |
275-288 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rapicavoli NA |
Year: |
2013 |
Journal: |
Elife |
Title: |
A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. |
Volume: |
2 |
|
Pages: |
e00762 |
|
•
•
•
•
•
|
Publication |
First Author: |
Whitley SK |
Year: |
2018 |
Journal: |
J Biol Chem |
Title: |
IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription. |
Volume: |
293 |
Issue: |
41 |
Pages: |
15790-15800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumari S |
Year: |
2021 |
Journal: |
Life Sci Alliance |
Title: |
NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation. |
Volume: |
4 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Vig E |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. |
Volume: |
276 |
Issue: |
11 |
Pages: |
7859-66 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
259
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
237
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Cunningham FX Jr |
Year: |
2000 |
Journal: |
J Bacteriol |
Title: |
Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis. |
Volume: |
182 |
Issue: |
20 |
Pages: |
5841-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rohdich F |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. |
Volume: |
99 |
Issue: |
3 |
Pages: |
1158-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Potter S |
Year: |
1998 |
Journal: |
J Bacteriol |
Title: |
Occurrence of homologs of the Escherichia coli lytB gene in gram-negative bacterial species. |
Volume: |
180 |
Issue: |
7 |
Pages: |
1959-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Röhrich RC |
Year: |
2005 |
Journal: |
FEBS Lett |
Title: |
Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum. |
Volume: |
579 |
Issue: |
28 |
Pages: |
6433-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hsieh MH |
Year: |
2005 |
Journal: |
Plant Physiol |
Title: |
The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. |
Volume: |
138 |
Issue: |
2 |
Pages: |
641-53 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Terpenes are among the largest groups of natural products and include compounds such as vitamins, cholesterol and carotenoids. The biosynthesis of all terpenoids begins with one or both of the two C5 precursors of the pathway: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). In animals, fungi, and certain bacteria, the synthesis of IPP and DMAPP occurs via the well-known mevalonate pathway, however, a second, nonmevalonate terpenoid pathway has been identified in many eubacteria, algae, malaria parasite and the chloroplasts of higher plants [, , ].LytB(IspH) is the last enzyme in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) in the 1-deoxy-d-xylulose-5-phosphate (DOXP, the nonmevalonate pathway, also known as MEP) pathway []. This enzyme contains a [4Fe-4S]cluster and forms a stable complex with ferredoxin, which suggests that ferredoxin/ferredoxin-NADP+ reductase redox system serves as the physiological electron donor for LytB []. Escherichia coli LytB protein had been found to regulate the activity of RelA (guanosine 3',5'-bispyrophosphate synthetase I), which in turn controls the level of a regulatory metabolite. It is involved in penicillin tolerance and the stringent response []. |
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•
•
•
•
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Publication |
First Author: |
Sounni NE |
Year: |
2010 |
Journal: |
Dis Model Mech |
Title: |
Stromal regulation of vessel stability by MMP14 and TGFbeta. |
Volume: |
3 |
Issue: |
5-6 |
Pages: |
317-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shinzawa M |
Year: |
2015 |
Journal: |
Sci Rep |
Title: |
Catalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression. |
Volume: |
5 |
|
Pages: |
10758 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bonnard M |
Year: |
2000 |
Journal: |
EMBO J |
Title: |
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. |
Volume: |
19 |
Issue: |
18 |
Pages: |
4976-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ito M |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease. |
Volume: |
13 |
Issue: |
1 |
Pages: |
9616 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuda S |
Year: |
2009 |
Journal: |
Blood |
Title: |
Critical role of class IA PI3K for c-Rel expression in B lymphocytes. |
Volume: |
113 |
Issue: |
5 |
Pages: |
1037-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yilmaz ZB |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. |
Volume: |
22 |
Issue: |
1 |
Pages: |
121-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seno T |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
15-Deoxy-Δ¹²,¹⁴ prostaglandin J₂ reduces the formation of atherosclerotic lesions in apolipoprotein E knockout mice. |
Volume: |
6 |
Issue: |
10 |
Pages: |
e25541 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quinton LJ |
Year: |
2009 |
Journal: |
Infect Immun |
Title: |
Mechanisms of the hepatic acute-phase response during bacterial pneumonia. |
Volume: |
77 |
Issue: |
6 |
Pages: |
2417-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ruiz PA |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
IL-10 gene-deficient mice lack TGF-beta/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis. |
Volume: |
174 |
Issue: |
5 |
Pages: |
2990-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoentjen F |
Year: |
2005 |
Journal: |
Blood |
Title: |
STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells. |
Volume: |
105 |
Issue: |
2 |
Pages: |
689-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mühlbauer M |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Impaired Bcl3 up-regulation leads to enhanced lipopolysaccharide-induced interleukin (IL)-23P19 gene expression in IL-10(-/-) mice. |
Volume: |
283 |
Issue: |
21 |
Pages: |
14182-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bhattacharyya S |
Year: |
2013 |
Journal: |
Mediators Inflamm |
Title: |
Carrageenan-induced colonic inflammation is reduced in Bcl10 null mice and increased in IL-10-deficient mice. |
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