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Search results 1201 to 1300 out of 1503 for Star

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Hits by Strain

Type Details Score
DO Term
Strain
Attribute String: mutant strain, targeted mutation
Strain
Attribute String: mutant strain, targeted mutation
Strain
Attribute String: mutant strain, targeted mutation, coisogenic
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Genotype
Symbol: Stard13/Stard13 Tg(Pdx1-cre)89.1Dam/?
Background: involves: C57BL/6 * CBA * SJL
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Lim JM
Year: 2018
Journal: J Biol Chem
Title: Myristoylated methionine sulfoxide reductase A is a late endosomal protein.
Volume: 293
Issue: 19
Pages: 7355-7366
Publication
First Author: Petzold KM
Year: 2013
Journal: Development
Title: Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas.
Volume: 140
Issue: 1
Pages: 126-35
Publication
First Author: Ponnusamy S
Year: 2017
Journal: Hum Mol Genet
Title: Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy.
Volume: 26
Issue: 13
Pages: 2526-2540
Publication
First Author: Leelahavanichkul A
Year: 2012
Journal: J Immunol
Title: Class B scavenger receptor types I and II and CD36 targeting improves sepsis survival and acute outcomes in mice.
Volume: 188
Issue: 6
Pages: 2749-58
Publication
First Author: Shvedova AA
Year: 2012
Journal: PLoS One
Title: Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice.
Volume: 7
Issue: 3
Pages: e30923
Publication
First Author: Puentes F
Year: 2017
Journal: Immunology
Title: Neurofilament light as an immune target for pathogenic antibodies.
Volume: 152
Issue: 4
Pages: 580-588
Genotype
Symbol: Stard7/Stard7<+>
Background: involves: C57BL/6N
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Stard7/Stard7<+>
Background: C57BL/6N-Stard7/Wtsi
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Stard10/Stard10<+>
Background: C57BL/6N-Stard10/H
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Lin S
Year: 2015
Journal: J Biol Chem
Title: Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically Interacts with Phospholipid Transfer Protein StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type II Cells.
Volume: 290
Issue: 30
Pages: 18559-74
Publication
First Author: Riss J
Year: 2006
Journal: Cancer Res
Title: Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma.
Volume: 66
Issue: 14
Pages: 7216-24
Publication
First Author: Wang M
Year: 2005
Journal: Exp Lung Res
Title: Analysis of the Par2 modifier of pulmonary adenoma formation in mice.
Volume: 31
Issue: 2
Pages: 193-204
HT Experiment
Series Id: GSE47480
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
Publication
First Author: Lee MH
Year: 2001
Journal: Genes Dev
Title: Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development.
Volume: 15
Issue: 18
Pages: 2408-20
Publication
First Author: Zaffran S
Year: 1997
Journal: Development
Title: The held out wings (how) Drosophila gene encodes a putative RNA-binding protein involved in the control of muscular and cardiac activity.
Volume: 124
Issue: 10
Pages: 2087-98
Publication
First Author: Lo PC
Year: 1997
Journal: Dev Biol
Title: A novel KH-domain protein mediates cell adhesion processes in Drosophila.
Volume: 190
Issue: 2
Pages: 241-56
Protein Domain
Type: Family
Description: GLD-1 from Caenorhabditis nematodes belongs to the Signal Transduction and Activation of RNA (STAR)-domain family of RNA-binding proteins [, ], conserved throughout eukaryotes. All STAR proteins contain maxi K-homology (KH)-RNA binding domain. STAR proteins control a wide range of developmental events by regulating alternative splicing and translational repression of specific mRNA targets. GLD-1 functions in Caenorhabditis elegans as a germline-specific translational repressor [].This entry also includes protein held out wings (also known as how) from Drosophila melanogaster. How is a RNA-binding protein involved in the control of muscular and cardiac activity []. It also mediates cell adhesion processes [].
Protein Domain
Type: Family
Description: This family consists of cyclin-related protein FAM58A (also known as cyclin-Q or cyclin-M). Cyclin M is an orphan cyclin, whose mutations cause a human developmental anomaly known as STAR syndrome. It may be involved in regulation of ETS2, which plays key roles in cancer and development [].
Publication
First Author: Wines ME
Year: 2001
Journal: Genomics
Title: Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis.
Volume: 72
Issue: 1
Pages: 88-98
Publication
First Author: Ha SD
Year: 2012
Journal: Mol Cell Biol
Title: Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages.
Volume: 32
Issue: 23
Pages: 4846-60
Publication
First Author: Thomas JW
Year: 2003
Journal: Mamm Genome
Title: Comparative sequence analysis of a single-gene conserved segment in mouse and human.
Volume: 14
Issue: 10
Pages: 673-8
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Youlten SE
Year: 2021
Journal: Nat Commun
Title: Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.
Volume: 12
Issue: 1
Pages: 2444
Protein Domain
Type: Family
Description: This entry represents the guanylin family. Its members include guanylate cyclase activator 2A and 2B. They are endogenous activators of intestinal guanylate cyclases. Guanylin, a 15-amino-acid peptide, is an endogenous ligand of the intestinal receptor guanylate cyclase-C, known as STaR [, ]. Upon receptor binding, guanylin increases the intracellular concentration of cGMP, it induces chloride secretion and decreases intestinal fluid absorption, ultimately causing diarrhoea []. The peptide stimulates the enzyme through the same receptor binding region as the heat-stable enterotoxins [].
Protein Domain
Type: Family
Description: This entry includes EDR2 and EDR2L from Arabidopsis. They contain a pleckstrin homology and a StAR transfer (START) domain as well as a plant-specific domain of unknown function, DUF1336. EDR2 is a negative regulator of the salicylic acid- (SA-) mediated resistance to pathogens, including the biotrophic powdery mildew pathogens Golovinomyces cichoracearum and Blumeria graminis, and the downy mildew pathogen Hyaloperonospora parasitica, probably by limiting the initiation of cell death and the establishment of the hypersensitive response (HR) [, ].
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Winter H
Year: 1994
Journal: Exp Cell Res
Title: Sequence and expression of murine type I hair keratins mHa2 and mHa3.
Volume: 212
Issue: 2
Pages: 190-200
Publication
First Author: Golas A
Year: 2008
Journal: Int J Dev Biol
Title: Gene mapping of sperm quality parameters in recombinant inbred strains of mice.
Volume: 52
Issue: 2-3
Pages: 287-93
Publication
First Author: Aksu S
Year: 2007
Journal: J Appl Genet
Title: Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines.
Volume: 48
Issue: 2
Pages: 133-43
HT Experiment
Series Id: E-GEOD-31328
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Lukong KE
Year: 2003
Journal: Biochim Biophys Acta
Title: Sam68, the KH domain-containing superSTAR.
Volume: 1653
Issue: 2
Pages: 73-86
Protein Domain
Type: Homologous_superfamily
Description: This entry represents the guanylin superfamily. Its members include guanylate cyclase activator 2A and 2B. They are endogenous activators of intestinal guanylate cyclases. Guanylin, a 15-amino-acid peptide, is an endogenous ligand of the intestinal receptor guanylate cyclase-C, known as STaR [, ]. Upon receptor binding, guanylin increases the intracellular concentration of cGMP, it induces chloride secretion and decreases intestinal fluid absorption, ultimately causing diarrhoea []. The peptide stimulates the enzyme through the same receptor binding region as the heat-stable enterotoxins [].Guanylin structure has a beta(2)-alpha(3)-beta fold and two layers (alpha/beta) with an antiparallel sheet topology.
Protein
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: false
Publication
First Author: de Sauvage FJ
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Precursor structure, expression, and tissue distribution of human guanylin.
Volume: 89
Issue: 19
Pages: 9089-93
Publication
First Author: Sciaky D
Year: 1994
Journal: Genomics
Title: Genomic sequence of the murine guanylin gene.
Volume: 24
Issue: 3
Pages: 583-7
Protein
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: false
Publication
First Author: Currie MG
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Guanylin: an endogenous activator of intestinal guanylate cyclase.
Volume: 89
Issue: 3
Pages: 947-51
Publication
First Author: Adissu HA
Year: 2014
Journal: Dis Model Mech
Title: Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.
Volume: 7
Issue: 5
Pages: 515-24
Publication
First Author: Tuck E
Year: 2015
Journal: Dis Model Mech
Title: A gene expression resource generated by genome-wide lacZ profiling in the mouse.
Volume: 8
Issue: 11
Pages: 1467-78
Publication
First Author: Hedlund E
Year: 2004
Journal: J Neurosci Res
Title: Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development.
Volume: 75
Issue: 3
Pages: 307-19
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Mouzat K
Year: 2009
Journal: Endocrinology
Title: Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.
Volume: 150
Issue: 7
Pages: 3369-75
Publication
First Author: Salinas L
Year: 2024
Journal: Commun Biol
Title: Sexual dimorphism in a mouse model of Friedreich's ataxia with severe cardiomyopathy.
Volume: 7
Issue: 1
Pages: 1250
Publication
First Author: Jee D
Year: 2018
Journal: Mol Cell
Title: Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals.
Volume: 69
Issue: 2
Pages: 265-278.e6
Publication
First Author: Richard S
Year: 2008
Journal: Oncogene
Title: Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis.
Volume: 27
Issue: 4
Pages: 548-56
Publication  
First Author: Iijima Y
Year: 2019
Journal: iScience
Title: SAM68-Specific Splicing Is Required for Proper Selection of Alternative 3' UTR Isoforms in the Nervous System.
Volume: 22
Pages: 318-335
Publication
First Author: Bassi G
Year: 2022
Journal: iScience
Title: Prohibitin-1 plays a regulatory role in Leydig cell steroidogenesis.
Volume: 25
Issue: 4
Pages: 104165
Publication
First Author: Hartung S
Year: 1995
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and in vivo expression of the bovine steroidogenic acute regulatory protein.
Volume: 215
Issue: 2
Pages: 646-53
Publication
First Author: Lukong KE
Year: 2007
Journal: Future Oncol
Title: Targeting the RNA-binding protein Sam68 as a treatment for cancer?
Volume: 3
Issue: 5
Pages: 539-44
Publication  
First Author: Mori Sequeiros Garcia M
Year: 2015
Journal: Mol Cell Endocrinol
Title: cAMP-activated Nr4a1 expression requires ERK activity and is modulated by MAPK phosphatase-1 in MA-10 Leydig cells.
Volume: 408
Pages: 45-52
Publication
First Author: Gerhold KA
Year: 2013
Journal: PLoS One
Title: The star-nosed mole reveals clues to the molecular basis of mammalian touch.
Volume: 8
Issue: 1
Pages: e55001
Publication
First Author: Tang D
Year: 2005
Journal: Plant J
Title: Regulation of plant defense responses in Arabidopsis by EDR2, a PH and START domain-containing protein.
Volume: 44
Issue: 2
Pages: 245-57
Publication  
First Author: Vorwerk S
Year: 2007
Journal: BMC Plant Biol
Title: EDR2 negatively regulates salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thaliana.
Volume: 7
Pages: 35
Protein Domain
Type: Family
Description: Proteins in this family contain the START domain. Their function is not clear.START (StAR-related lipid-transfer) is a lipid-binding domain in StAR, HD-ZIP and signalling proteins []. StAR (Steroidogenic Acute Regulatory protein) is a mitochondrial protein that is synthesised in response to luteinising hormone stimulation [].Expression of the protein in the absence of hormone stimulation is sufficient to inducesteroid production, suggesting that this protein is required in the acute regulation ofsteroidogenesis. Representatives of the START domain family havebeen shown to bind different ligands such as sterols (StAR protein) andphosphatidylcholine (PC-TP). Ligand binding by the START domain can alsoregulate the activities of other domains that co-occur with the START domainin multidomain proteins such as Rho-gap, the homeodomain,and the thioesterase domain [, ].
HT Experiment
Series Id: GSE41637
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Vernet C
Year: 1997
Journal: Trends Genet
Title: STAR, a gene family involved in signal transduction and activation of RNA.
Volume: 13
Issue: 12
Pages: 479-84
Publication
First Author: Nakagawa T
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.
Volume: 94
Issue: 18
Pages: 9654-9
Publication
First Author: Patra D
Year: 2014
Journal: PLoS One
Title: Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.
Volume: 9
Issue: 8
Pages: e105674
Publication
First Author: Van Dyck F
Year: 2007
Journal: Cell Metab
Title: Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.
Volume: 6
Issue: 5
Pages: 406-13
Publication
First Author: Nahaboo W
Year: 2022
Journal: EMBO J
Title: Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo.
Volume: 41
Issue: 7
Pages: e108747
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment
Series Id: GSE38365
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: E-GEOD-65753
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Tsujishita Y
Year: 2000
Journal: Nat Struct Biol
Title: Structure and lipid transport mechanism of a StAR-related domain.
Volume: 7
Issue: 5
Pages: 408-14
Protein
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 785  
Fragment?: true