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Search results 1201 to 1300 out of 5471 for Tyr

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0.048s

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Soat1/Soat1
Background: AKR/O
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ap2b1/Ap2b1
Background: FVB/NJ-Ap2b1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fkrp/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Publication
15281913 | J:94064
First Author: Takagaki K
Year: 2004
Journal: Biochem J
Title: Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38.
Volume: 383
Issue: Pt. 3
Pages: 447-55
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Publication
9467911 | -
 
First Author: Toyama H
Year: 1998
Journal: Microbiology
Title: pqqA is not required for biosynthesis of pyrroloquinoline quinone in Methylobacterium extorquens AM1.
Volume: 144 ( Pt 1)
Pages: 183-91
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Publication
17118402 | -
First Author: Romir J
Year: 2007
Journal: J Mol Biol
Title: Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs.
Volume: 365
Issue: 5
Pages: 1417-28
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Publication
17998336 | -
First Author: Li M
Year: 2008
Journal: Mol Cell Biol
Title: The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1.
Volume: 28
Issue: 2
Pages: 630-41
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Publication
16257509 | -
First Author: Fukushima A
Year: 2006
Journal: Cell Signal
Title: Lck couples Shc to TCR signaling.
Volume: 18
Issue: 8
Pages: 1182-9
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Publication
21983898 | -
First Author: Patrussi L
Year: 2012
Journal: Apoptosis
Title: p66Shc-dependent apoptosis requires Lck and CamKII activity.
Volume: 17
Issue: 2
Pages: 174-86
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Publication
15489916 | -
First Author: Palacios EH
Year: 2004
Journal: Oncogene
Title: Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Volume: 23
Issue: 48
Pages: 7990-8000
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Publication
28033507 | -
 
First Author: Zahratka JA
Year: 2017
Journal: Neurobiol Aging
Title: Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease.
Volume: 51
Pages: 43-53
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Publication
26157004 | J:225820
First Author: Panicker N
Year: 2015
Journal: J Neurosci
Title: Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.
Volume: 35
Issue: 27
Pages: 10058-77
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Publication
10716632 | -
First Author: Martins-Green M
Year: 2000
Journal: Int J Biochem Cell Biol
Title: Tissue specific expression of Yrk kinase: implications for differentiation and inflammation.
Volume: 32
Issue: 3
Pages: 351-64
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Protein Domain
IPR026067 | Dual_phosphatase_23
Type: Family
Description: Dual specificity protein phosphatases mediate dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. Dual specificity phosphatase 23 can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. It is able to enhance activation of JNK and p38 (MAPK14) [].
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Protein Domain
IPR046490 | DUF6583
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, mainly in Firmicutes. Proteins in this family are typically between 454 and 596 amino acids in length. There are two highly conserved residues, a Tyr and an Asp.
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Protein Domain
IPR046664 | DUF6773
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 151 and 172 amino acids in length. This family has a conserved sequence motif DER and two conserved residues, a Tyr and a Gly.
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Protein Domain
IPR046698 | DUF6568
Type: Family
Description: This family of proteins is functionally uncharacterised. This family of proteins is mainly found in firmicutes. Proteins in this family are approximately 170 amino acids in length. There are two conserved motifs, CxxF and YxN, and two conserved residues, Tyr at the N-terminal and a Gly at the C-terminal. Many members of this family are thought to belong to the Thioredoxin superfamily.
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Protein Domain
IPR035579 | TXK_SH3
Type: Domain
Description: TXK is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal cysteine-rich region. TXK forms a complex with EF-1alpha and PARP1 that regulates interferon-gamma gene transcription in Th1 cells []. This entry represents the SH3 domain of TXK.
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Protein Domain
IPR035749 | Lck_SH3
Type: Domain
Description: Lck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cellsand natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling [, ]. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events []. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling []. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
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Protein Domain
IPR035750 | Fyn/Yrk_SH3
Type: Domain
Description: Fyn and Yrk (Yes-related kinase) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells []. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's []and Parkinson's diseases []. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury [].Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The SH3 domain of Src kinases contributes to substrate recruitment by binding adaptor proteins/substrates, and regulation of kinase activity through an intramolecular interaction [, ].
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Protein Domain
IPR011725 | PQQ_synth_PqqA
Type: Family
Description: This entry describes a very small protein, coenzyme PQQ biosynthesis protein A, which is smaller than 25 amino acids in many species. It is proposed to serve as a peptide precursor of coenzyme pyrrolo-quinoline-quinone (PQQ), with Glu and Tyr of a conserved motif Glu-Xxx-Xxx-Xxx-Tyr becoming part of the product [].
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Publication
14210786 | J:220223
 
First Author: ROWE FP
Year: 1964
Journal: J Hyg (Lond)
Title: THE TOXICITY OF 0-025 PER CENT WARFARIN TO WILD HOUSE-MICE (MUS MUSCULUS L.).
Volume: 62
Pages: 389-93
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Publication
- | J:220221
 
First Author: Wallace ME
Year: 1972
Journal: Mouse News Lett
Title: PBI wild strain, warfarin resistance linked to Tyrc-e
Volume: 47
Pages: 24
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Publication
- | J:220220
 
First Author: Wallace ME
Year: 1971
Journal: Mouse News Lett
Title: PBI wild strain, warfarin resistant
Volume: 45
Pages: 19
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Publication
5226973 | J:220225
First Author: Rowe FP
Year: 1967
Journal: J Hyg (Lond)
Title: The effect of sex and age on the response to warfarin in a non-inbred strain of mice.
Volume: 65
Issue: 1
Pages: 55-60
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Publication
1060612 | J:24607
First Author: Lush IE
Year: 1975
Journal: Heredity (Edinb)
Title: High coumarin 7-hydroxylase activity does not protect mice against Warfarin.
Volume: 35
Issue: 2
Pages: 279-81
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Publication
5212842 | J:220224
First Author: Rowe FP
Year: 1965
Journal: J Hyg (Lond)
Title: Toxicity tests on suspected warfarin resistant house mice (Mus musculus L.).
Volume: 63
Issue: 3
Pages: 417-25
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Publication
15654330 | J:102099
First Author: Belyantseva IA
Year: 2005
Journal: Nat Cell Biol
Title: Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia.
Volume: 7
Issue: 2
Pages: 148-56
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Publication
16829577 | J:111803
First Author: Mburu P
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Whirlin complexes with p55 at the stereocilia tip during hair cell development.
Volume: 103
Issue: 29
Pages: 10973-8
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Publication
15590699 | J:95916
First Author: Kikkawa Y
Year: 2005
Journal: Hum Mol Genet
Title: Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium.
Volume: 14
Issue: 3
Pages: 391-400
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Publication
13170359 | J:225
First Author: CARTER TC
Year: 1953
Journal: Z Indukt Abstamm Vererbungsl
Title: The sex distribution of waved-2, shaker-2 and Rex in the house mouse.
Volume: 85
Issue: 4
Pages: 564-78
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Publication
- | J:265
First Author: Heston WE
Year: 1941
Journal: J Natl Cancer Inst
Title: Relationship between susceptibility to induced pulmonary tumors and certain known genes in mice
Volume: 2
Issue: 2
Pages: 127-32
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Publication
34903829 | J:332716
First Author: Pacentine IV
Year: 2021
Journal: Sci Rep
Title: Cy3-ATP labeling of unfixed, permeabilized mouse hair cells.
Volume: 11
Issue: 1
Pages: 23855
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Publication
26302205 | J:226820
   
First Author: Fang Q
Year: 2015
Journal: Elife
Title: The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing.
Volume: 4
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Strain
MGI:3584175 | C57BL/6-Ins2<Akita>
Attribute String: coisogenic, spontaneous mutation
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Strain
MGI:6145226 | A.AKITA-Ins2<Akita>/Rbrc
Attribute String: mutant strain, congenic, spontaneous mutation
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Strain
MGI:2164426 | C3H/He-Ins2<Akita>
Attribute String: mutant strain, spontaneous mutation
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Strain
MGI:3721801 | D2.B6-Ins2<Akita>/MatbJ
Attribute String: congenic, mutant strain, spontaneous mutation
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Strain
MGI:3713268 | FVB.B6-Ins2<Akita>/MlnJ
Attribute String: congenic, mutant strain, spontaneous mutation
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Strain
MGI:3664419 | C57BL/6-Ins2<Akita>/Slc
Attribute String: coisogenic, mutant strain, spontaneous mutation
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Strain
MGI:5287487 | B6.Cg-Ins2<Akita> Ldlr<tm1Her>
Attribute String: targeted mutation, mutant strain, congenic, spontaneous mutation
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Strain
MGI:2164793 | C57BL/6-Ins2<Akita>/J
Attribute String: mutant strain, spontaneous mutation
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Strain
MGI:5512650 | C.B6N-Ins2<Akita>
Attribute String: congenic, spontaneous mutation, mutant strain
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Strain
MGI:4431364 | 129S6.B6-Ins2<Akita>/CofJ
Attribute String: spontaneous mutation, mutant strain, congenic
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Publication
7534338 | J:23782
First Author: Ha JH
Year: 1995
Journal: J Neurochem
Title: Striatal met-enkephalin and substance P levels are decreased in mice infected with the LP-BM5 murine leukemia virus.
Volume: 64
Issue: 4
Pages: 1896-8
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Publication
38446901 | J:347026
First Author: Clotet-Freixas S
Year: 2024
Journal: Sci Transl Med
Title: Sex differences in kidney metabolism may reflect sex-dependent outcomes in human diabetic kidney disease.
Volume: 16
Issue: 737
Pages: eabm2090
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Publication
38142581 | J:344317
 
First Author: Aldoghachi AF
Year: 2024
Journal: Biochem Biophys Res Commun
Title: Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes.
Volume: 694
Pages: 149392
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Publication
37628852 | J:339659
 
First Author: Zerbini G
Year: 2023
Journal: Int J Mol Sci
Title: Progressive Thinning of Retinal Nerve Fiber Layer/Ganglion Cell Layer (RNFL/GCL) as Biomarker and Pharmacological Target of Diabetic Retinopathy.
Volume: 24
Issue: 16
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Publication
33069809 | J:299817
 
First Author: Otomo H
Year: 2020
Journal: Metabolism
Title: Sodium-glucose cotransporter 2 inhibition attenuates protein overload in renal proximal tubule via suppression of megalin O-GlcNacylation in progressive diabetic nephropathy.
Volume: 113
Pages: 154405
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Publication
29972779 | J:270881
First Author: Xu B
Year: 2018
Journal: Cell Rep
Title: Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes.
Volume: 24
Issue: 1
Pages: 181-196
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Publication
22653270 | J:186435
First Author: Liu GC
Year: 2012
Journal: Diabetologia
Title: Deletion of p47phox attenuates the progression of diabetic nephropathy and reduces the severity of diabetes in the Akita mouse.
Volume: 55
Issue: 9
Pages: 2522-32
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Publication
30019207 | J:269355
First Author: Hombrebueno JR
Year: 2018
Journal: Diabetologia
Title: Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.
Volume: 61
Issue: 11
Pages: 2433-2446
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Publication
24163078 | J:207722
First Author: Rajab M
Year: 2013
Journal: Am J Physiol Heart Circ Physiol
Title: Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin.
Volume: 305
Issue: 12
Pages: H1807-16
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Publication
18558660 | J:145654
First Author: Kim ST
Year: 2008
Journal: Reproduction
Title: Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression.
Volume: 136
Issue: 3
Pages: 313-22
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Publication
20520806 | J:160899
First Author: de Preux Charles AS
Year: 2010
Journal: PLoS One
Title: Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice.
Volume: 5
Issue: 5
Pages: e10832
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Publication
28214591 | J:248726
 
First Author: Maresch CC
Year: 2017
Journal: Mol Cell Endocrinol
Title: Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2Akita+/- mouse model of type 1 diabetes.
Volume: 446
Pages: 91-101
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Publication
36809274 | J:335186
 
First Author: Kogot-Levin A
Year: 2023
Journal: JCI Insight
Title: Mapping the metabolic reprogramming induced by sodium-glucose cotransporter 2 inhibition.
Volume: 8
Issue: 7
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Publication
20042456 | J:157873
First Author: Gurley SB
Year: 2010
Journal: Am J Physiol Renal Physiol
Title: Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice.
Volume: 298
Issue: 3
Pages: F788-95
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Publication
22205225 | J:182441
First Author: Lo CS
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice.
Volume: 302
Issue: 7
Pages: F840-52
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Publication
21467180 | J:181425
First Author: Losiewicz MK
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Diabetes impairs the neuroprotective properties of retinal alpha-crystallins.
Volume: 52
Issue: 9
Pages: 5034-42
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Publication
17082643 | J:140617
First Author: Gyurko R
Year: 2006
Journal: J Immunol
Title: Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice.
Volume: 177
Issue: 10
Pages: 7250-6
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Publication
17334640 | J:125256
First Author: Asakawa A
Year: 2007
Journal: Int J Mol Med
Title: Ins2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system.
Volume: 19
Issue: 4
Pages: 649-52
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Publication
21872588 | J:178385
First Author: Schmidt RE
Year: 2011
Journal: Exp Neurol
Title: Effect of insulin and an erythropoietin-derived peptide (ARA290) on established neuritic dystrophy and neuronopathy in Akita (Ins2 Akita) diabetic mouse sympathetic ganglia.
Volume: 232
Issue: 2
Pages: 126-35
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Publication
17585110 | J:141650
First Author: Martens GW
Year: 2007
Journal: Am J Respir Cell Mol Biol
Title: Tuberculosis susceptibility of diabetic mice.
Volume: 37
Issue: 5
Pages: 518-24
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Publication
11854314 | J:78863
First Author: Ron D
Year: 2002
Journal: J Clin Invest
Title: Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
Volume: 109
Issue: 4
Pages: 443-5
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Publication
29304075 | J:257015
First Author: Choi J
Year: 2018
Journal: PLoS One
Title: β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice.
Volume: 13
Issue: 1
Pages: e0190863
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Publication
26597883 | J:228139
First Author: Venegas-Pino DE
Year: 2016
Journal: Am J Pathol
Title: Sex-Specific Differences in an ApoE(-/-):Ins2(+/Akita) Mouse Model of Accelerated Atherosclerosis.
Volume: 186
Issue: 1
Pages: 67-77
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Publication
25207540 | J:213912
First Author: Soto I
Year: 2014
Journal: PLoS One
Title: DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.
Volume: 9
Issue: 9
Pages: e107291
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Publication
23404117 | J:214916
First Author: Murray AR
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model.
Volume: 54
Issue: 3
Pages: 1689-97
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Publication
30480744 | J:267368
First Author: You ZP
Year: 2018
Journal: Invest Ophthalmol Vis Sci
Title: Bioinformatics Analysis of Weighted Genes in Diabetic Retinopathy.
Volume: 59
Issue: 13
Pages: 5558-5563
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Publication
28324005 | J:246874
First Author: Ghosh A
Year: 2017
Journal: Endocrinology
Title: Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice.
Volume: 158
Issue: 4
Pages: 903-919
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Publication
23825921 | J:200768
 
First Author: Howell SJ
Year: 2013
Journal: Mol Vis
Title: Degeneration of retinal ganglion cells in diabetic dogs and mice: relationship to glycemic control and retinal capillary degeneration.
Volume: 19
Pages: 1413-21
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Publication
24247978 | J:217958
First Author: Chen H
Year: 2014
Journal: J Physiol
Title: Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse.
Volume: 592
Issue: 3
Pages: 505-21
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Publication
12630555 | J:107880
First Author: Haseyama T
Year: 2002
Journal: Tohoku J Exp Med
Title: Complications of IgA nephropathy in a non-insulin-dependent diabetes model, the Akita mouse.
Volume: 198
Issue: 4
Pages: 233-44
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Publication
16954344 | J:118086
First Author: Nasrallah R
Year: 2007
Journal: Am J Physiol Renal Physiol
Title: Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice.
Volume: 292
Issue: 1
Pages: F278-84
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Publication
26203118 | J:290893
First Author: You YH
Year: 2016
Journal: J Am Soc Nephrol
Title: Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease.
Volume: 27
Issue: 2
Pages: 466-81
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Publication
18469181 | J:141696
First Author: Smith SB
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine.
Volume: 49
Issue: 9
Pages: 4154-61
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Publication
34680110 | J:312502
 
First Author: Juin SK
Year: 2021
Journal: Biomolecules
Title: GYY4137 Regulates Extracellular Matrix Turnover in the Diabetic Kidney by Modulating Retinoid X Receptor Signaling.
Volume: 11
Issue: 10
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Publication
28493939 | J:245597
First Author: Lin SH
Year: 2017
Journal: PLoS One
Title: Inhibition of nitric oxide production reverses diabetes-induced Kupffer cell activation and Klebsiella pneumonia liver translocation.
Volume: 12
Issue: 5
Pages: e0177269
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Publication
29231167 | J:254988
   
First Author: Nakano H
Year: 2017
Journal: Elife
Title: Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis.
Volume: 6
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Publication
24385342 | J:220054
First Author: Dokun AO
Year: 2014
Journal: Cardiovasc Res
Title: Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD.
Volume: 101
Issue: 3
Pages: 364-72
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Publication
38835661 | J:352318
 
First Author: Juin SK
Year: 2024
Journal: Front Pharmacol
Title: Nimbidiol protects from renal injury by alleviating redox imbalance in diabetic mice.
Volume: 15
Pages: 1369408
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Publication
21559376 | J:172346
First Author: Wang J
Year: 2011
Journal: PLoS One
Title: Control of precursor maturation and disposal is an early regulative mechanism in the normal insulin production of pancreatic β-cells.
Volume: 6
Issue: 4
Pages: e19446
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Publication
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