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Search results 1201 to 1300 out of 1369 for Vip

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Type Details Score
Protein Domain
IPR003334 | GPCR_2_latrophilin_rcpt_C
Type: Domain
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The secretin-like GPCRs include secretin [], calcitonin [], parathyroid hormone/parathyroid hormone-related peptides []and vasoactive intestinal peptide [], all of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. These receptors contain seven transmembrane regions, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins (however there is no significant sequence identity between these families, the secretin-like receptors thus bear their own unique '7TM' signature). Their N-terminal is probably located on the extracellular side of the membrane and potentially glycosylated. This N-terminal region contains a long conserved region which allows the binding of large peptidic ligand such as glucagon, secretin, VIP and PACAP; this region contains five conserved cysteines residues which could be involved in disulphide bond. The C-terminal region of these receptor is probably cytoplasmic. Every receptor gene in this family is encoded on multiple exons, and several of these genes are alternatively spliced to yield functionally distinct products. Latrophilins are a family of secretin-like GPCRs that can be subdividedinto 3 subtypes: LPH1, LPH2 and LPH3. LPH1 is a brain-specific calciumindependent receptor of alpha-latrotoxin (LTX), a neurotoxin. It is the affinity of this form of the receptor for LTX that gives the family its name. LPH2 and LPH3, whilst sharing extensive sequence similarity to LPH1, do not bind LTX. LPH2 is distributed throughout most tissues, whereas LPH3 is also brain-specific []. The endogenous ligand(s) for these receptors are at present unknown. Binding of LTX to LPH1 stimulates exocytosis and the subsequent release of large amounts of neurotransmitters from neuronal and endocrine cells. The latrophilins possess up to 7 sites of alternative splicing; the resulting number of possible splice variants leads to a highly variable family of proteins.Structurally, these proteins have a seven-transmembrane region and a large extracellular N-terminal region which consists of several domains: a rhamnose binding lectin (RBL) domain, an olfactomedin-like (OLF) domain followed by a Serine/Threonine rich domain that is O-linked glycosylated, a hormone binding (HR) domain; and a GPCR Autoproteolysis INducing (GAIN) domain [].This entry represents the C-terminal region of latrophilin.
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Protein
Q8BM96
Organism: Mus musculus/domesticus
Length: 785  
Fragment?: false
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Publication
26235031 | J:225579
First Author: Ranaivoson FM
Year: 2015
Journal: Structure
Title: Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development.
Volume: 23
Issue: 9
Pages: 1665-77
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Protein
Q8C206
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
E9Q4J9
Organism: Mus musculus/domesticus
Length: 644  
Fragment?: false
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Protein
F7BHW1
Organism: Mus musculus/domesticus
Length: 900  
Fragment?: true
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Protein
Q3U4E0
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: true
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Protein
Q3V2C4
Organism: Mus musculus/domesticus
Length: 764  
Fragment?: true
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Protein
Q148S2
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Publication
8222502 | -
First Author: Njuki F
Year: 1993
Journal: Clin Sci (Lond)
Title: A new calcitonin-receptor-like sequence in rat pulmonary blood vessels.
Volume: 85
Issue: 4
Pages: 385-8
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Publication
8626685 | -
First Author: Aiyar N
Year: 1996
Journal: J Biol Chem
Title: A cDNA encoding the calcitonin gene-related peptide type 1 receptor.
Volume: 271
Issue: 19
Pages: 11325-9
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Publication
7818539 | -
First Author: Flühmann B
Year: 1995
Journal: Biochem Biophys Res Commun
Title: A human orphan calcitonin receptor-like structure.
Volume: 206
Issue: 1
Pages: 341-7
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Protein
Q80TR1
Organism: Mus musculus/domesticus
Length: 1466  
Fragment?: false
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Protein
Q80TS3
Organism: Mus musculus/domesticus
Length: 1537  
Fragment?: false
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Protein
Q60755
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
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Protein
Q8JZZ7
Organism: Mus musculus/domesticus
Length: 1487  
Fragment?: false
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Protein
P35347
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q60748
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
Q924D7
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
D3Z6J2
Organism: Mus musculus/domesticus
Length: 1240  
Fragment?: false
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Protein
E9QNK5
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
A0A0G2JDK6
Organism: Mus musculus/domesticus
Length: 1478  
Fragment?: false
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Protein
D3YTW7
Organism: Mus musculus/domesticus
Length: 1534  
Fragment?: false
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Protein
A0A0G2JFF5
Organism: Mus musculus/domesticus
Length: 1467  
Fragment?: false
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Protein
D3YWR3
Organism: Mus musculus/domesticus
Length: 1268  
Fragment?: false
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Protein
A0A0G2JFV3
Organism: Mus musculus/domesticus
Length: 1341  
Fragment?: false
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Protein
A0A0G2JDE3
Organism: Mus musculus/domesticus
Length: 1403  
Fragment?: false
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Protein
H7BX15
Organism: Mus musculus/domesticus
Length: 1471  
Fragment?: false
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Protein
D3Z5M6
Organism: Mus musculus/domesticus
Length: 1580  
Fragment?: false
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Protein
E9Q9Q9
Organism: Mus musculus/domesticus
Length: 1511  
Fragment?: false
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Protein
E9PXI8
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein
D3Z3X6
Organism: Mus musculus/domesticus
Length: 1308  
Fragment?: false
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Protein
D3YVT9
Organism: Mus musculus/domesticus
Length: 1550  
Fragment?: false
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Protein
A0A0G2JEQ8
Organism: Mus musculus/domesticus
Length: 1123  
Fragment?: false
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Protein
K3W4M8
Organism: Mus musculus/domesticus
Length: 1543  
Fragment?: false
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Protein
D3Z593
Organism: Mus musculus/domesticus
Length: 1503  
Fragment?: false
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Protein
D3Z6H7
Organism: Mus musculus/domesticus
Length: 1351  
Fragment?: false
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Protein
A0A1D5RLK7
Organism: Mus musculus/domesticus
Length: 431  
Fragment?: false
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Protein
D3Z4S7
Organism: Mus musculus/domesticus
Length: 1571  
Fragment?: false
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Protein
A0A0G2JG66
Organism: Mus musculus/domesticus
Length: 1435  
Fragment?: false
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Protein
D3YWB1
Organism: Mus musculus/domesticus
Length: 1283  
Fragment?: false
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Protein
D3Z634
Organism: Mus musculus/domesticus
Length: 1460  
Fragment?: false
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Protein
D3Z3G4
Organism: Mus musculus/domesticus
Length: 1512  
Fragment?: false
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Protein
A0A0G2JGM8
Organism: Mus musculus/domesticus
Length: 1487  
Fragment?: false
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Protein
Q924D6
Organism: Mus musculus/domesticus
Length: 495  
Fragment?: false
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Protein
D3Z4V0
Organism: Mus musculus/domesticus
Length: 1274  
Fragment?: false
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Protein
D3Z6H9
Organism: Mus musculus/domesticus
Length: 1299  
Fragment?: false
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Protein
E9Q3V9
Organism: Mus musculus/domesticus
Length: 1516  
Fragment?: false
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Protein
Q924D5
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
A0A0G2JH16
Organism: Mus musculus/domesticus
Length: 1177  
Fragment?: false
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Protein
C0K3M3
Organism: Mus musculus/domesticus
Length: 420  
Fragment?: false
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Protein
Q790U4
Organism: Mus musculus/domesticus
Length: 515  
Fragment?: false
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Protein
D3YU23
Organism: Mus musculus/domesticus
Length: 1231  
Fragment?: false
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Protein
A0A0G2JDF4
Organism: Mus musculus/domesticus
Length: 1452  
Fragment?: false
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Protein
Q3ZAT0
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q3UQP0
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
Q80ZF8
Organism: Mus musculus/domesticus
Length: 1522  
Fragment?: false
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Protein
Q68FL1
Organism: Mus musculus/domesticus
Length: 1282  
Fragment?: true
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Protein
F6WMY5
Organism: Mus musculus/domesticus
Length: 873  
Fragment?: true
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Protein
Q499E3
Organism: Mus musculus/domesticus
Length: 1522  
Fragment?: false
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Protein
Q923X1
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Protein
Q9Z0M6
Organism: Mus musculus/domesticus
Length: 818  
Fragment?: false
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Protein
B7ZCC9
Organism: Mus musculus/domesticus
Length: 3073  
Fragment?: false
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Protein
Q80T32
Organism: Mus musculus/domesticus
Length: 903  
Fragment?: false
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Protein
B2RXV6
Organism: Mus musculus/domesticus
Length: 871  
Fragment?: false
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Protein
Q4FJS6
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
E9QJS7
Organism: Mus musculus/domesticus
Length: 818  
Fragment?: false
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Protein
E9QMJ5
Organism: Mus musculus/domesticus
Length: 773  
Fragment?: false
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Protein
Q5DU39
Organism: Mus musculus/domesticus
Length: 1484  
Fragment?: true
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Protein
A0A0D9SEG8
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein
Q9DC42
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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Protein
B7ZCD1
Organism: Mus musculus/domesticus
Length: 2736  
Fragment?: true
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Protein
Q6ZQ96
Organism: Mus musculus/domesticus
Length: 612  
Fragment?: true
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Publication
10025961 | -
First Author: Matsushita H
Year: 1999
Journal: FEBS Lett
Title: The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution.
Volume: 443
Issue: 3
Pages: 348-52
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Protein
Q91ZV8
Organism: Mus musculus/domesticus
Length: 1336  
Fragment?: false
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Protein
Q6F3F9
Organism: Mus musculus/domesticus
Length: 1165  
Fragment?: false
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Protein
Q3UHD1
Organism: Mus musculus/domesticus
Length: 1582  
Fragment?: false
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Protein
G5E8Q8
Organism: Mus musculus/domesticus
Length: 1348  
Fragment?: false
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Protein
Q8CGM1
Organism: Mus musculus/domesticus
Length: 1561  
Fragment?: false
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Protein
Q91ZI0
Organism: Mus musculus/domesticus
Length: 3301  
Fragment?: false
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Protein
Q61549
Organism: Mus musculus/domesticus
Length: 931  
Fragment?: false
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Protein
Q3U9R0
Organism: Mus musculus/domesticus
Length: 931  
Fragment?: false
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Protein
H7BX74
Organism: Mus musculus/domesticus
Length: 1544  
Fragment?: false
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Protein
A0A1L7NR37
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Protein
A0A076N9U7
Organism: Mus musculus/domesticus
Length: 3309  
Fragment?: false
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Protein
A0A1L1SUG9
Organism: Mus musculus/domesticus
Length: 3309  
Fragment?: false
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Protein
A0A087WQV8
Organism: Mus musculus/domesticus
Length: 1143  
Fragment?: false
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Protein
A0A140LIH4
Organism: Mus musculus/domesticus
Length: 1193  
Fragment?: false
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Protein
B1ASC0
Organism: Mus musculus/domesticus
Length: 1473  
Fragment?: false
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Protein
A0A286YDT5
Organism: Mus musculus/domesticus
Length: 1143  
Fragment?: true
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Protein
J3QMG7
Organism: Mus musculus/domesticus
Length: 1121  
Fragment?: false
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Protein
A0A571BEJ4
Organism: Mus musculus/domesticus
Length: 1220  
Fragment?: false
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Protein
Q3U1M9
Organism: Mus musculus/domesticus
Length: 915  
Fragment?: false
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Protein
Q69ZZ8
Organism: Mus musculus/domesticus
Length: 1143  
Fragment?: true
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Protein
H7BX92
Organism: Mus musculus/domesticus
Length: 1489  
Fragment?: false
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Protein
A0A0G2JDH6
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
H7BWZ2
Organism: Mus musculus/domesticus
Length: 1577  
Fragment?: false
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Protein
A0A0R4J1W0
Organism: Mus musculus/domesticus
Length: 623  
Fragment?: false
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Protein
D3Z080
Organism: Mus musculus/domesticus
Length: 707  
Fragment?: false
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Protein
B2RXQ9
Organism: Mus musculus/domesticus
Length: 652  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom