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Search results 1201 to 1300 out of 1341 for Yap1

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Hits by Pathway

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Hits by Strain

Type Details Score
Allele
Yap1<M1Btlr> | MGI:6268758
Name: yes-associated protein 1; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6268759 | C57BL/6J-Yap1<M1Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Allele
Gt(ROSA)26Sor<tm3(CAG-YAP1*,-lacZ)Jmao> | MGI:6763056
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Junhao Mao
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Epitope tag, Inserted expressed sequence, Reporter
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Allele
Tg(CAG-YAP1*)1Jfm | MGI:7782579
Name: transgene insertion 1, James F. Martin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Yap1/Yap1
Background: C57BL/6J-Yap1
Zygosity: hm
Has Mutant Allele: true
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Publication
18579750 | -
First Author: Zhao B
Year: 2008
Journal: Genes Dev
Title: TEAD mediates YAP-dependent gene induction and growth control.
Volume: 22
Issue: 14
Pages: 1962-71
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Publication
19324877 | -
First Author: Zhang H
Year: 2009
Journal: J Biol Chem
Title: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.
Volume: 284
Issue: 20
Pages: 13355-62
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Publication
9671946 | J:48579
First Author: Jacquemin P
Year: 1998
Journal: Dev Dyn
Title: Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro.
Volume: 212
Issue: 3
Pages: 423-36
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Publication
9869635 | -
First Author: Simmonds AJ
Year: 1998
Journal: Genes Dev
Title: Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila.
Volume: 12
Issue: 24
Pages: 3815-20
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Publication
18313299 | -
First Author: Goulev Y
Year: 2008
Journal: Curr Biol
Title: SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila.
Volume: 18
Issue: 6
Pages: 435-41
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Publication
8626521 | -
First Author: Farrance IK
Year: 1996
Journal: J Biol Chem
Title: The role of transcription enhancer factor-1 (TEF-1) related proteins in the formation of M-CAT binding complexes in muscle and non-muscle tissues.
Volume: 271
Issue: 14
Pages: 8266-74
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Publication
17652751 | -
First Author: Appukuttan B
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina.
Volume: 48
Issue: 8
Pages: 3775-82
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Publication
15073166 | -
First Author: Shie JL
Year: 2004
Journal: J Biol Chem
Title: RTEF-1, a novel transcriptional stimulator of vascular endothelial growth factor in hypoxic endothelial cells.
Volume: 279
Issue: 24
Pages: 25010-6
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Protein Domain
IPR016361 | TEF_metazoa
Type: Family
Description: Proteins in the transcriptional enhancer factor family (also known as TEAD family, includes TEAD 1 to 4) play a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. TEAD transcription factors act by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction [, ]. This entry includes protein Scalloped from Drosophila melanogasterwhich in combination with protein Vestigial promotes wing formation [], and in combination with Yorkie which promotes transcriptional activity and movement of Yorkie to the nucleus [].
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Protein Domain
IPR027253 | TEF-5
Type: Family
Description: The TEAD family (also known as TEF family) transcription factors play a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. TEAD transcription factors act by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction [, ].Four TEAD genes exist in mammals (TEAD 1 to 4). TEAD3 (transcriptional enhancer factor TEF-5) has a role in placental development [].
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Protein Domain
IPR027255 | TEF-3
Type: Family
Description: The TEAD family (also known as the TEF family) transcription factors play a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. TEAD transcription factors act by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction [, ].Four TEAD genes exist in mammals (TEAD 1 to 4). TEAD4 protein (also known as TEF-3) was reported to regulate muscle-specific genes in cardiac and smooth muscle cells []. Alternatively spliced transcripts for TEAD4 have been identified in human retinal vascular endothelial cells []. TEAD4 protein has been shown to enhance VEGF gene expression in bovine aortic endothelial cells [].
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Protein Domain
IPR028741 | LATS1
Type: Family
Description: There are two mammalian homologue of Drosophila tumor suppressor Lats (large tumor suppressor, also known as Warts): LATS1 and LATS2. Lats/Warts is a serine/threonine-protein kinase that negatively regulates YAP1 (Drosophila Yorkie (Yki) homologue) in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis [, ]. This entry represents LATS1 from mammals. During cell division, LATS1 interacts with MOB1A and serves as a mitotic exit network kinase [].
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Publication
25117705 | J:214599
First Author: Svalina MN
Year: 2014
Journal: Cancer Cell
Title: YAPping about differentiation therapy in muscle cancer.
Volume: 26
Issue: 2
Pages: 154-5
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Protein
Q3UTZ3
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
E9Q6X8
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: false
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Protein
A0A0G2JDC3
Organism: Mus musculus/domesticus
Length: 311  
Fragment?: false
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Protein
F6VAB1
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: true
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Publication
30715179 | -
First Author: Perez Y
Year: 2019
Journal: Brain
Title: Mutations in the microtubule-associated protein MAP11 (C7orf43) cause microcephaly in humans and zebrafish.
Volume: 142
Issue: 3
Pages: 574-585
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Publication
30447097 | -
First Author: Amisaki M
Year: 2019
Journal: Cancer Sci
Title: Identification of genes involved in the regulation of TERT in hepatocellular carcinoma.
Volume: 110
Issue: 2
Pages: 550-560
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Publication
31467083 | -
First Author: Cuenca A
Year: 2019
Journal: J Biol Chem
Title: The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.
Volume: 294
Issue: 42
Pages: 15418-15434
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Protein Domain
IPR031626 | TRAPPC14
Type: Family
Description: TRAPPC14 (also known as MAP11) is a microtubule associated protein that regulates preciliary trafficking of Rabin8 (a guanine nucleotide exchange factor for Rab8) and ciliogenesis []. It is a specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether [, , ]. TRAPPC14 is dispensable for TRAPPII complex integrity but mediates Rabin8 association with the TRAPPII complex []. It also modulates YAP1 activity as transcriptional regulator []. Mutations in the MAP11 gene cause microcephaly in humans and zebrafish [].
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Protein Coding Gene
MGI:2442631 | Mob1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
18158288 | -
First Author: Hao Y
Year: 2008
Journal: J Biol Chem
Title: Tumor suppressor LATS1 is a negative regulator of oncogene YAP.
Volume: 283
Issue: 9
Pages: 5496-509
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Publication
16096061 | -
First Author: Huang J
Year: 2005
Journal: Cell
Title: The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.
Volume: 122
Issue: 3
Pages: 421-34
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Publication
15343267 | J:93191
First Author: McPherson JP
Year: 2004
Journal: EMBO J
Title: Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.
Volume: 23
Issue: 18
Pages: 3677-88
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Protein
P70210
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
Q62296
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: false
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Protein
Q9Z0P8
Organism: Mus musculus/domesticus
Length: 460  
Fragment?: false
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Protein
F6TTJ9
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
A0A3F2YNR7
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
A0A0R4IZY5
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: false
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Protein
Q8VCA7
Organism: Mus musculus/domesticus
Length: 469  
Fragment?: true
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Protein
F8VPU0
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
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Protein Domain
IPR028742 | LATS2
Type: Family
Description: There are two mammalian homologue of Drosophila tumor suppressor Lats (large tumor suppressor, also known as Warts): LATS1 and LATS2. Lats/Warts is a serine/threonine-protein kinase that negatively regulates YAP1 (Drosophila Yorkie (Yki) homologue) in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis [, ]. This entry represents LATS2, which plays an important part in centrosome duplication, maintenance of mitotic fidelity and genomic stability []. This entry also includes Warts from Drosophila melanogaster which is a negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signalling pathway that plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis [].
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Protein Coding Gene
MGI:1915723 | Mob1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
37736049 | J:340737
First Author: Sharifkhodaei Z
Year: 2023
Journal: iScience
Title: Colitis-induced upregulation of tumor necrosis factor receptor-2 (TNFR2) terminates epithelial regenerative signaling to restore homeostasis.
Volume: 26
Issue: 10
Pages: 107829
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Publication
30205046 | J:265468
First Author: Kitajima S
Year: 2018
Journal: Cancer Cell
Title: Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS.
Volume: 34
Issue: 3
Pages: 439-452.e6
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Publication
30333301 | J:286967
 
First Author: Van Mater D
Year: 2018
Journal: JCI Insight
Title: Injury promotes sarcoma development in a genetically and temporally restricted manner.
Volume: 3
Issue: 20
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Publication
28000790 | J:243447
 
First Author: Jeric I
Year: 2016
Journal: Nat Commun
Title: A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Volume: 7
Pages: 13781
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Publication
34348664 | J:310973
First Author: Dimitrakopoulos C
Year: 2021
Journal: BMC Genomics
Title: Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma.
Volume: 22
Issue: 1
Pages: 592
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Publication
30840887 | J:287712
First Author: He C
Year: 2019
Journal: Cell Rep
Title: A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis.
Volume: 26
Issue: 10
Pages: 2636-2650.e5
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Publication
29091764 | J:254873
First Author: Li L
Year: 2017
Journal: Cell Rep
Title: A CREB-MPP7-AMOT Regulatory Axis Controls Muscle Stem Cell Expansion and Self-Renewal Competence.
Volume: 21
Issue: 5
Pages: 1253-1266
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Publication
27013234 | J:232490
First Author: Li P
Year: 2016
Journal: Genes Dev
Title: αE-catenin inhibits a Src-YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway.
Volume: 30
Issue: 7
Pages: 798-811
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Publication
28698296 | J:243895
First Author: Sarkar S
Year: 2017
Journal: Genes Dev
Title: PRKCI promotes immune suppression in ovarian cancer.
Volume: 31
Issue: 11
Pages: 1109-1121
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Publication
29985391 | J:266397
First Author: Martin D
Year: 2018
Journal: Nat Commun
Title: Assembly and activation of the Hippo signalome by FAT1 tumor suppressor.
Volume: 9
Issue: 1
Pages: 2372
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Publication
30625312 | J:299600
First Author: Yang G
Year: 2019
Journal: Cell Rep
Title: Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development.
Volume: 26
Issue: 2
Pages: 302-312.e4
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Publication
32483624 | J:304367
First Author: Althoff MJ
Year: 2020
Journal: Blood
Title: Yap1-Scribble polarization is required for hematopoietic stem cell division and fate.
Volume: 136
Issue: 16
Pages: 1824-1836
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Publication
31883835 | J:340381
First Author: Tang J
Year: 2020
Journal: Cell Stem Cell
Title: Arterial Sca1(+) Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration.
Volume: 26
Issue: 1
Pages: 81-96.e4
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Publication
26050962 | J:307274
First Author: Mohamed AD
Year: 2015
Journal: Biochim Biophys Acta
Title: The Hippo signal transduction pathway in soft tissue sarcomas.
Volume: 1856
Issue: 1
Pages: 121-9
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Publication
36220823 | J:329956
First Author: Wan S
Year: 2022
Journal: Cell Death Dis
Title: mTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation.
Volume: 13
Issue: 10
Pages: 862
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Protein
P30051
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: false
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Protein
P48301
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Protein
E9PVS2
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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Protein
Q80UL2
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
Q3UPV9
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Protein
Q6PAQ8
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
Q3UMJ5
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Protein
E9QAK6
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: false
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Protein
F6QIG2
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
Q80W05
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: true
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Protein
E9Q387
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: false
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Protein
F6ZIM6
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
E9PZ73
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q3V262
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Protein
F7B3M8
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: false
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Protein
F6TBI7
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
Q3UFP5
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
A0A0R4J1U4
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
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Protein
Q3USK5
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: false
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Protein Coding Gene
MGI:1261872 | Wwc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16061636 | -
First Author: Bothos J
Year: 2005
Journal: Cancer Res
Title: Human LATS1 is a mitotic exit network kinase.
Volume: 65
Issue: 15
Pages: 6568-75
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Publication
38510108 | J:358519
First Author: Li RG
Year: 2024
Journal: Nat Cardiovasc Res
Title: YAP induces a neonatal-like pro-renewal niche in the adult heart.
Volume: 3
Issue: 3
Pages: 283-300
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Protein Coding Gene
MGI:109241 | Tead3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922973 | Amotl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30304034 | J:266498
First Author: Vita GL
Year: 2018
Journal: PLoS One
Title: Hippo signaling pathway is altered in Duchenne muscular dystrophy.
Volume: 13
Issue: 10
Pages: e0205514
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Publication
26040669 | J:224465
First Author: Sun T
Year: 2015
Journal: Biol Reprod
Title: Lats1 Deletion Causes Increased Germ Cell Apoptosis and Follicular Cysts in Mouse Ovaries.
Volume: 93
Issue: 1
Pages: 22
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Publication
33328637 | J:303984
First Author: Pastushenko I
Year: 2021
Journal: Nature
Title: Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis.
Volume: 589
Issue: 7842
Pages: 448-455
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Publication
29364867 | J:257934
First Author: Mueller S
Year: 2018
Journal: Nature
Title: Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes.
Volume: 554
Issue: 7690
Pages: 62-68
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Publication
26701088 | J:232811
First Author: Wang G
Year: 2016
Journal: Cancer Discov
Title: Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression.
Volume: 6
Issue: 1
Pages: 80-95
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Publication
34303764 | J:309428
 
First Author: Lin S
Year: 2021
Journal: Cancer Lett
Title: Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression.
Volume: 518
Pages: 230-242
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Publication
32434991 | J:306794
 
First Author: Hidalgo-Sastre A
Year: 2020
Journal: JCI Insight
Title: Loss of Wasl improves pancreatic cancer outcome.
Volume: 5
Issue: 10
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Publication
26731476 | J:231162
First Author: Kim TD
Year: 2016
Journal: J Clin Invest
Title: Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.
Volume: 126
Issue: 2
Pages: 706-20
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Publication
33228790 | J:313916
First Author: Takadera M
Year: 2020
Journal: Acta Neuropathol Commun
Title: Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes.
Volume: 8
Issue: 1
Pages: 203
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Publication
35930670 | J:333660
First Author: Zhou X
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Microenvironmental sensing by fibroblasts controls macrophage population size.
Volume: 119
Issue: 32
Pages: e2205360119
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Publication
30640535 | J:289144
First Author: Nishio M
Year: 2019
Journal: FASEB J
Title: Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency.
Volume: 33
Issue: 4
Pages: 5548-5560
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Publication
34293352 | J:314693
     
First Author: Yuan Y
Year: 2021
Journal: J Invest Dermatol
Title: Oncogenic Hedgehog-Smoothened Signaling Depends on YAP1‒TAZ/TEAD Transcription to Restrain Differentiation in Basal Cell Carcinoma.
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Publication
23143302 | J:193981
First Author: Nishio M
Year: 2012
Journal: J Clin Invest
Title: Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.
Volume: 122
Issue: 12
Pages: 4505-18
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Publication
23921128 | J:201624
First Author: Chen CL
Year: 2013
Journal: J Clin Invest
Title: Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells.
Volume: 123
Issue: 7
Pages: 2832-49
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Publication
38569926 | J:354510
 
First Author: Srivastava T
Year: 2024
Journal: J Neurosci
Title: TSG-6-Mediated Extracellular Matrix Modifications Regulate Hypoxic-Ischemic Brain Injury.
Volume: 44
Issue: 21
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Publication
30093562 | J:265555
First Author: Oristian KM
Year: 2018
Journal: Cancer Res
Title: Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis.
Volume: 78
Issue: 19
Pages: 5513-5520
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Publication
22710434 | J:191036
First Author: van der Weyden L
Year: 2012
Journal: Cancer Res
Title: Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.
Volume: 72
Issue: 15
Pages: 3817-3827
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Publication
38012141 | J:343458
First Author: Yan MQ
Year: 2023
Journal: Cell Death Dis
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