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Search results 1201 to 1300 out of 1334 for Yy1

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Type Details Score
Genotype
Genotype
Symbol: Yy1/Yy1 Tg(Ucp1-cre)1Evdr/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Gfap-cre)73.12Mvs/? Yy1/Yy1
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
14557078 | J:86245
 
First Author: Kaneko T
Year: 2003
Journal: Gene
Title: The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos.
Volume: 315
Pages: 183-92
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Publication
25603536 | J:251056
First Author: Park SY
Year: 2015
Journal: Biochim Biophys Acta
Title: YAF2 promotes TP53-mediated genotoxic stress response via stabilization of PDCD5.
Volume: 1853
Issue: 5
Pages: 1060-72
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Publication
32203418 | J:291681
First Author: Zhao J
Year: 2020
Journal: Nat Cell Biol
Title: RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division.
Volume: 22
Issue: 4
Pages: 439-452
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Publication
17070805 | J:117714
First Author: Arrigoni R
Year: 2006
Journal: FEBS Lett
Title: The Polycomb-associated protein Rybp is a ubiquitin binding protein.
Volume: 580
Issue: 26
Pages: 6233-41
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Publication
10919273 | J:65481
First Author: Ebling FJ
Year: 2000
Journal: Endocrinology
Title: Estrogenic induction of spermatogenesis in the hypogonadal mouse.
Volume: 141
Issue: 8
Pages: 2861-9
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Publication
30560907 | J:268338
First Author: Chagraoui H
Year: 2018
Journal: Nat Commun
Title: SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.
Volume: 9
Issue: 1
Pages: 5375
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Publication
10369680 | J:65786
First Author: GarcĂ­a E
Year: 1999
Journal: EMBO J
Title: RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1.
Volume: 18
Issue: 12
Pages: 3404-18
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Genotype
Genotype
Symbol: Rybp/Rybp<+>
Background: involves: 129S1/Sv * 129X1/SvJ * ICR
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rybp/Rybp<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yy1/Yy1 Shh/Shh<+>
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yy1/Yy1 Tg(Dct-lacZ)A12Jkn/? Tg(Tyr-cre)1Lru/?
Background: involves: 129S4/SvJae * C57BL/6 * CBA * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rybp/Rybp<+>
Background: C57BL/6N-Rybp/Bay
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Shh/Shh<+> Yy1/Yy1
Background: involves: 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Publication
21326896 | -
First Author: Deng Z
Year: 2010
Journal: Transcription
Title: Yin Yang 1: a multifaceted protein beyond a transcription factor.
Volume: 1
Issue: 2
Pages: 81-4
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Protein Domain
IPR017114 | YY1-like
Type: Family
Description: This entry represents a group of C2H2-type Zinc finger proteins, including a transcription factor yin and yang 1 (YY1). YY1 has been shown to regulate cell proliferation and differentiation, and its deficiency in mice results in peri-implantation lethality during embryonic development. It has also been linked to cancers [].Proteins in this entry also include YY2. It may antagonize YY1 and function in development and differentiation [].
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Publication
27081692 | J:233752
First Author: Eid A
Year: 2016
Journal: Epigenetics
Title: Characterization of non-canonical Polycomb Repressive Complex 1 subunits during early mouse embryogenesis.
Volume: 11
Issue: 6
Pages: 389-97
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HT Experiment
GSE207014 | Astrocytic yin yang 1 (YY1) is critical for murine brain development and protection against apoptosis, oxidative stress and inflammation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
20471950 | J:162930
First Author: Eskeland R
Year: 2010
Journal: Mol Cell
Title: Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.
Volume: 38
Issue: 3
Pages: 452-64
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Publication
23395003 | J:197096
First Author: Wu X
Year: 2013
Journal: Mol Cell
Title: Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation.
Volume: 49
Issue: 6
Pages: 1134-46
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Genotype
Genotype
Symbol: Tg(Zp3-cre)93Knw/? Yy1/Yy1
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: H2az2/H2az2<+> Yy1/Yy1
Background: involves: 129S4/SvJae * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Emx1/Emx1<+> Yy1/Yy1
Background: involves: 129S2/SvPas * 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pax7/Pax7<+> Yy1/Yy1
Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cnp/Cnp<+> Yy1/Yy1
Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cnp/Cnp<+> Yy1/Yy1<+>
Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
34994686 | J:317827
   
First Author: Sawai A
Year: 2022
Journal: Elife
Title: PRC1 sustains the integrity of neural fate in the absence of PRC2 function.
Volume: 11
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HT Experiment
GSE85602 | A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
14744866 | -
First Author: Wang CY
Year: 2004
Journal: J Biol Chem
Title: YY1AP, a novel co-activator of YY1.
Volume: 279
Issue: 17
Pages: 17750-5
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Publication
17541814 | -
First Author: Li L
Year: 2007
Journal: Mol Cell Biochem
Title: Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2.
Volume: 304
Issue: 1-2
Pages: 297-304
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Publication
25597408 | -
First Author: Zhao X
Year: 2015
Journal: Oncogene
Title: Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM(+) AFP(+) hepatocellular carcinoma.
Volume: 34
Issue: 39
Pages: 5095-104
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Publication
27939641 | -
First Author: Guo DC
Year: 2017
Journal: Am J Hum Genet
Title: Loss-of-Function Mutations in YY1AP1 Lead to Grange Syndrome and a Fibromuscular Dysplasia-Like Vascular Disease.
Volume: 100
Issue: 1
Pages: 21-30
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Protein Domain
IPR033274 | YY1AP1
Type: Family
Description: YY1-associated protein 1 enhances transcription activation by the multifunctional zinc finger transcription factor YY1 []. It is also known as HCCA2 (hepatocellular carcinoma-associated gene 2). It is an oncogenic driver in hepatocellular carcinoma []and may play a role in cell cycle regulation []. It is component of the INO80 chromatin remodeling complex which is responsible for transcriptional regulation, DNA repair, and replication [].
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Publication
28111200 | J:251488
First Author: Li H
Year: 2017
Journal: Cell Stem Cell
Title: RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions.
Volume: 20
Issue: 4
Pages: 462-477.e6
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Publication
23180829 | J:192806
First Author: Solca C
Year: 2013
Journal: J Lipid Res
Title: Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice.
Volume: 54
Issue: 2
Pages: 397-409
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Genotype
Genotype
Symbol: Yy1/Yy1 Edil3/Edil3<+>
Background: involves: 129S4/SvJae * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Emx1/Emx1<+> Trp53/Trp53 Yy1/Yy1<+>
Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Emx1/Emx1<+> Trp53/Trp53 Yy1/Yy1
Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Yy1/Yy1 Edil3/Edil3<+>
Background: involves: 129S4/SvJae * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: H2az2/H2az2<+> Yy1/Yy1<+>
Background: involves: 129S4/SvJae * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Publication
22325148 | J:186106
First Author: Tavares L
Year: 2012
Journal: Cell
Title: RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3.
Volume: 148
Issue: 4
Pages: 664-78
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Publication
21530438 | J:193806
First Author: Garcia-Tuñon I
Year: 2011
Journal: Stem Cell Res
Title: Association of Rex-1 to target genes supports its interaction with Polycomb function.
Volume: 7
Issue: 1
Pages: 1-16
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Publication
27705745 | J:238637
   
First Author: Rose NR
Year: 2016
Journal: Elife
Title: RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.
Volume: 5
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Genotype
Genotype
Symbol: Dicer1/Dicer1<+> Yy1/Yy1<+> Shh/Shh<+>
Background: involves: 129 * 129S4/SvJae * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE40984 | Non-coding transcription within the Igh distal VH region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells
Series Id: E-GEOD-40984
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
23486062 | J:194892
First Author: Yokobayashi S
Year: 2013
Journal: Nature
Title: PRC1 coordinates timing of sexual differentiation of female primordial germ cells.
Volume: 495
Issue: 7440
Pages: 236-40
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HT Experiment
GSE221077 | SIRT6 is a key regulator of mitochondrial function in the brain
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
22770845 | J:227373
First Author: Qin J
Year: 2012
Journal: Cell Stem Cell
Title: The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.
Volume: 11
Issue: 3
Pages: 319-32
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Publication
12952889 | J:85280
First Author: Fellner T
Year: 2003
Journal: Genes Dev
Title: A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo.
Volume: 17
Issue: 17
Pages: 2138-50
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Protein
P58389
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
B7ZDE0
Organism: Mus musculus/domesticus
Length: 61  
Fragment?: false
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Protein
F6Z6I0
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
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Protein
Q8C0E1
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
A2AWF0
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
A2AWE9
Organism: Mus musculus/domesticus
Length: 281  
Fragment?: false
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Protein
Q543N6
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Publication
16916641 | -
First Author: Chao Y
Year: 2006
Journal: Mol Cell
Title: Structure and mechanism of the phosphotyrosyl phosphatase activator.
Volume: 23
Issue: 4
Pages: 535-46
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Publication
16885030 | -
First Author: Leulliot N
Year: 2006
Journal: Mol Cell
Title: Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.
Volume: 23
Issue: 3
Pages: 413-24
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Publication
16782712 | -
First Author: Magnusdottir A
Year: 2006
Journal: J Biol Chem
Title: The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.
Volume: 281
Issue: 32
Pages: 22434-8
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Publication
16380387 | -
First Author: Jordens J
Year: 2006
Journal: J Biol Chem
Title: The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis/trans-isomerase.
Volume: 281
Issue: 10
Pages: 6349-57
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Publication
15447631 | -
First Author: Van Hoof C
Year: 2005
Journal: Biochem J
Title: Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2.
Volume: 386
Issue: Pt 1
Pages: 93-102
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HT Experiment
E-GEOD-35322 | Expression data from tail skin in young (5 months) and old (30 months) CB6F1 mice
Series Id: GSE35322
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Protein Domain
IPR004327 | Phstyr_phstse_ac
Type: Family
Description: Phosphotyrosyl phosphatase activator (PTPA, also known as protein phosphatase 2A activator) proteins stimulate the phosphotyrosyl phosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognised phosphoserine/ threonine protein phosphorylase activity. It also reactivates the serine/threonine phosphatase activity of an inactive form of PP2A. The specific biological role of PTPA is unknown. PTPA has been suggested to play a role in the insertion of metals to the PP2A catalytic subunit (PP2Ac) active site, to act as a chaperone, and more recently, to have peptidyl prolyl cis/trans isomerase activity that specifically targets human PP2Ac [, , , , , ]. Together, PTPA and PP2A constitute an ATPase and it has been suggested that PTPA alters the relative specificity of PP2A from phosphoserine/phosphothreonine substrates to phosphotyrosine substrates in an ATP-hydrolysis-dependent manner. Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumour suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1 [].
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Protein Domain
IPR037218 | PTPA_sf
Type: Homologous_superfamily
Description: Phosphotyrosyl phosphatase activator (PTPA, also known as protein phosphatase 2A activator) proteins stimulate the phosphotyrosyl phosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognised phosphoserine/ threonine protein phosphorylase activity. It also reactivates the serine/threonine phosphatase activity of an inactive form of PP2A. The specific biological role of PTPA is unknown. PTPA has been suggested to play a role in the insertion of metals to the PP2A catalytic subunit (PP2Ac) active site, to act as a chaperone, and more recently, to have peptidyl prolyl cis/trans isomerase activity that specifically targets human PP2Ac [, , , , , ]. Together, PTPA and PP2A constitute an ATPase and it has been suggested that PTPA alters the relative specificity of PP2A from phosphoserine/phosphothreonine substrates to phosphotyrosine substrates in an ATP-hydrolysis-dependent manner. Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumour suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1 [].PTPA as a multihelical structure fold.
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Protein Domain
IPR043170 | PTPA_C_lid
Type: Homologous_superfamily
Description: Phosphotyrosyl phosphatase activator (PTPA, also known as protein phosphatase 2A activator) proteins stimulate the phosphotyrosyl phosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognised phosphoserine/ threonine protein phosphorylase activity. It also reactivates the serine/threonine phosphatase activity of an inactive form of PP2A. The specific biological role of PTPA is unknown. PTPA has been suggested to play a role in the insertion of metals to the PP2A catalytic subunit (PP2Ac) active site, to act as a chaperone, and more recently, to have peptidyl prolyl cis/trans isomerase activity that specifically targets human PP2Ac [, , , , , ]. Together, PTPA and PP2A constitute an ATPase and it has been suggested that PTPA alters the relative specificity of PP2A from phosphoserine/phosphothreonine substrates to phosphotyrosine substrates in an ATP-hydrolysis-dependent manner. Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumour suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1 [].PTPA is an α-helical protein which consists of three distinct domains: the core, the linker and the lid. This superfamily consists of the lid domain of PTPA, located usually at the C-terminal.
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Publication
25703348 | J:225041
First Author: Hasegawa K
Year: 2015
Journal: Dev Cell
Title: SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination.
Volume: 32
Issue: 5
Pages: 574-88
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Publication
17952071 | J:130305
First Author: Xu N
Year: 2007
Journal: Nat Genet
Title: Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein.
Volume: 39
Issue: 11
Pages: 1390-6
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Publication
10576891 | J:57758
First Author: Hurd YL
Year: 1999
Journal: Mol Cell Neurosci
Title: A novel neuron-specific DNA end-binding factor in the murine brain.
Volume: 14
Issue: 3
Pages: 213-24
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Publication
36791105 | J:340955
First Author: Misra N
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: The circadian demethylation of a unique intronic deoxymethylCpG-rich island boosts the transcription of its cognate circadian clock output gene.
Volume: 120
Issue: 8
Pages: e2214062120
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Publication
25803486 | J:220830
   
First Author: Laurette P
Year: 2015
Journal: Elife
Title: Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells.
Volume: 4
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Publication
29576529 | J:262040
First Author: Qiu X
Year: 2018
Journal: Mol Cell
Title: Sequential Enhancer Sequestration Dysregulates Recombination Center Formation at the IgH Locus.
Volume: 70
Issue: 1
Pages: 21-33.e6
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Publication
35330681 | J:327766
First Author: Fu W
Year: 2022
Journal: iScience
Title: Long noncoding RNA LINC01435 impedes diabetic wound healing by facilitating YY1-mediated HDAC8 expression.
Volume: 25
Issue: 4
Pages: 104006
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Publication
8120001 | J:37094
First Author: Inouye CJ
Year: 1994
Journal: J Biol Chem
Title: Relief of YY1-induced transcriptional repression by protein-protein interaction with the nucleolar phosphoprotein B23.
Volume: 269
Issue: 9
Pages: 6506-10
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Publication
9685495 | J:49223
First Author: Yao YL
Year: 1998
Journal: Nucleic Acids Res
Title: Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1.
Volume: 26
Issue: 16
Pages: 3776-83
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Publication
20887952 | J:165658
First Author: Palacios D
Year: 2010
Journal: Cell Stem Cell
Title: TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.
Volume: 7
Issue: 4
Pages: 455-69
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Publication
25559185 | J:223964
First Author: Harr JC
Year: 2015
Journal: J Cell Biol
Title: Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins.
Volume: 208
Issue: 1
Pages: 33-52
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Publication
28892470 | J:260319
First Author: Kwon HK
Year: 2017
Journal: Nat Immunol
Title: Different molecular complexes that mediate transcriptional induction and repression by FoxP3.
Volume: 18
Issue: 11
Pages: 1238-1248
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Publication
29567711 | J:260758
First Author: Bedrosian TA
Year: 2018
Journal: Science
Title: Early life experience drives structural variation of neural genomes in mice.
Volume: 359
Issue: 6382
Pages: 1395-1399
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Publication
11171037 | -
First Author: Janssens V
Year: 2001
Journal: Biochem J
Title: Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling.
Volume: 353
Issue: Pt 3
Pages: 417-39
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Publication
17287250 | J:118937
First Author: Kaji K
Year: 2007
Journal: Development
Title: Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.
Volume: 134
Issue: 6
Pages: 1123-32
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Publication
15520282 | J:93445
First Author: Caretti G
Year: 2004
Journal: Genes Dev
Title: The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.
Volume: 18
Issue: 21
Pages: 2627-38
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Publication
11322887 | J:69357
First Author: Cook M
Year: 2001
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