| Type |
Details |
Score |
| Allele |
| Name: |
transgene insertion, Christian Wolfrum |
| Allele Type: |
Transgenic |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao XY |
| Year: |
2014 |
| Journal: |
Mol Cell |
| Title: |
A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation. |
| Volume: |
55 |
| Issue: |
3 |
| Pages: |
372-82 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
247
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu Q |
| Year: |
2024 |
| Journal: |
Nat Metab |
| Title: |
PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels. |
| Volume: |
6 |
| Issue: |
7 |
| Pages: |
1347-1366 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 13, National Applied Research Laboratories |
| Allele Type: |
Transgenic |
| Attribute String: |
Inducible, Recombinase, Reporter |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yu S |
| Year: |
2004 |
| Journal: |
Biochimie |
| Title: |
Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. |
| Volume: |
86 |
| Issue: |
11 |
| Pages: |
743-61 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Paqr3/Paqr3<+> |
| Background: |
involves: 129 * C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Paqr7/Paqr7<+> |
| Background: |
C57BL/6N-Paqr7/J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
330
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
343
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
345
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
375
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Flock GB |
| Year: |
2013 |
| Journal: |
Diabetes |
| Title: |
Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice. |
| Volume: |
62 |
| Issue: |
1 |
| Pages: |
283-90 |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang YT |
| Year: |
2005 |
| Journal: |
J Mol Evol |
| Title: |
PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. |
| Volume: |
61 |
| Issue: |
3 |
| Pages: |
372-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao L |
| Year: |
2022 |
| Journal: |
Sex Dev |
| Title: |
Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice. |
| Volume: |
16 |
| Issue: |
4 |
| Pages: |
270-282 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
354
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sassmann A |
| Year: |
2010 |
| Journal: |
Genesis |
| Title: |
Tamoxifen-inducible Cre-mediated recombination in adipocytes. |
| Volume: |
48 |
| Issue: |
10 |
| Pages: |
618-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rorick NK |
| Year: |
2011 |
| Journal: |
Am J Med Genet A |
| Title: |
Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome. |
| Volume: |
155A |
| Issue: |
6 |
| Pages: |
1314-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pavlovic G |
| Year: |
2013 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Data submissions from the Mouse Clinical Institute (ICS) |
|
|
|
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lindhorst A |
| Year: |
2020 |
| Journal: |
Adipocyte |
| Title: |
Unspecific DNA recombination in AdipoqCre-ERT2 - mediated knockout approaches in transgenic mice is sex-, age- and genotype-dependent. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
1-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mitschke MM |
| Year: |
2013 |
| Journal: |
FASEB J |
| Title: |
Increased cGMP promotes healthy expansion and browning of white adipose tissue. |
| Volume: |
27 |
| Issue: |
4 |
| Pages: |
1621-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li S |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis. |
| Volume: |
114 |
| Issue: |
34 |
| Pages: |
E7111-E7120 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Trivedi CM |
| Year: |
2010 |
| Journal: |
Dev Cell |
| Title: |
Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. |
| Volume: |
19 |
| Issue: |
3 |
| Pages: |
450-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin Y |
| Year: |
2021 |
| Journal: |
Immunology |
| Title: |
PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis. |
| Volume: |
163 |
| Issue: |
1 |
| Pages: |
60-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dalle H |
| Year: |
2019 |
| Journal: |
Diabetes |
| Title: |
Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure. |
| Volume: |
68 |
| Issue: |
2 |
| Pages: |
305-317 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin L |
| Year: |
2023 |
| Journal: |
Cell Metab |
| Title: |
Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood. |
| Volume: |
35 |
| Issue: |
7 |
| Pages: |
1227-1241.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Haque N |
| Year: |
2023 |
| Journal: |
Cells |
| Title: |
Deficiency of Adipose Aryl Hydrocarbon Receptor Protects against Diet-Induced Metabolic Dysfunction through Sexually Dimorphic Mechanisms. |
| Volume: |
12 |
| Issue: |
13 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shi L |
| Year: |
2023 |
| Journal: |
Redox Biol |
| Title: |
FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgfβ1 signaling pathway. |
| Volume: |
63 |
|
| Pages: |
102727 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou H |
| Year: |
2015 |
| Journal: |
J Lipid Res |
| Title: |
Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals. |
| Volume: |
56 |
| Issue: |
10 |
| Pages: |
1912-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oppong AK |
| Year: |
2020 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Reducing 14-3-3ζ expression influences adipocyte maturity and impairs function. |
| Volume: |
319 |
| Issue: |
1 |
| Pages: |
E117-E132 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sundararaman SS |
| Year: |
2021 |
| Journal: |
Sci Rep |
| Title: |
Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe-/- mice. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
10409 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Adipoq-cre/ERT2)#Wfrm/? |
| Background: |
involves: C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kennaway DJ |
| Year: |
2012 |
| Journal: |
Obesity (Silver Spring) |
| Title: |
Adipokines and adipocyte function in Clock mutant mice that retain melatonin rhythmicity. |
| Volume: |
20 |
| Issue: |
2 |
| Pages: |
295-305 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Song A |
| Year: |
2020 |
| Journal: |
J Clin Invest |
| Title: |
Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue. |
| Volume: |
130 |
| Issue: |
1 |
| Pages: |
247-257 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiong X |
| Year: |
2017 |
| Journal: |
J Endocrinol |
| Title: |
Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice. |
| Volume: |
233 |
| Issue: |
3 |
| Pages: |
307-314 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yi SA |
| Year: |
2022 |
| Journal: |
Exp Mol Med |
| Title: |
S6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2. |
| Volume: |
54 |
| Issue: |
3 |
| Pages: |
324-333 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang M |
| Year: |
2021 |
| Journal: |
Mol Metab |
| Title: |
Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D. |
| Volume: |
47 |
|
| Pages: |
101182 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moreno-Navarrete JM |
| Year: |
2015 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Deleted in breast cancer 1 plays a functional role in adipocyte differentiation. |
| Volume: |
308 |
| Issue: |
7 |
| Pages: |
E554-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zha D |
| Year: |
2017 |
| Journal: |
Endocrinology |
| Title: |
Adiponectin and Its Receptors in Diabetic Kidney Disease: Molecular Mechanisms and Clinical Potential. |
| Volume: |
158 |
| Issue: |
7 |
| Pages: |
2022-2034 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma X |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity. |
| Volume: |
12 |
| Issue: |
6 |
| Pages: |
e0179889 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saha PK |
| Year: |
2020 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
miR-30a targets gene networks that promote browning of human and mouse adipocytes. |
| Volume: |
319 |
| Issue: |
4 |
| Pages: |
E667-E677 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang X |
| Year: |
2022 |
| Journal: |
Cell Death Differ |
| Title: |
Targeting adipocytic discoidin domain receptor 2 impedes fat gain while increasing bone mass. |
| Volume: |
29 |
| Issue: |
4 |
| Pages: |
737-749 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Illison J |
| Year: |
2016 |
| Journal: |
Diabetes |
| Title: |
Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels. |
| Volume: |
65 |
| Issue: |
12 |
| Pages: |
3621-3635 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Straub LG |
| Year: |
2019 |
| Journal: |
Diabetologia |
| Title: |
Antioxidants protect against diabetes by improving glucose homeostasis in mouse models of inducible insulin resistance and obesity. |
| Volume: |
62 |
| Issue: |
11 |
| Pages: |
2094-2105 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ruiz de Azua I |
| Year: |
2017 |
| Journal: |
J Clin Invest |
| Title: |
Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. |
| Volume: |
127 |
| Issue: |
11 |
| Pages: |
4148-4162 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang T |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
3489 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Frei IC |
| Year: |
2023 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Hepatic mTORC2 compensates for loss of adipose mTORC2 in mediating energy storage and glucose homeostasis. |
| Volume: |
324 |
| Issue: |
6 |
| Pages: |
E589-E598 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pagano Zottola AC |
| Year: |
2022 |
| Journal: |
Cells |
| Title: |
Expression of Functional Cannabinoid Type-1 (CB1) Receptor in Mitochondria of White Adipocytes. |
| Volume: |
11 |
| Issue: |
16 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Niitsu Y |
| Year: |
2023 |
| Journal: |
PLoS One |
| Title: |
Increased serum extracellular vesicle miR-144-3p and miR-486a-3p in a mouse model of adipose tissue regeneration promote hepatocyte proliferation by targeting Txnip. |
| Volume: |
18 |
| Issue: |
5 |
| Pages: |
e0284989 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sakaguchi M |
| Year: |
2017 |
| Journal: |
Cell Metab |
| Title: |
Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor. |
| Volume: |
25 |
| Issue: |
2 |
| Pages: |
448-462 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brasil BB |
| Year: |
2022 |
| Journal: |
Mol Metab |
| Title: |
Apolipoprotein C3 and circulating mediators of preadipocyte proliferation in states of lipodystrophy. |
| Volume: |
64 |
|
| Pages: |
101572 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee ES |
| Year: |
2023 |
| Journal: |
J Biol Chem |
| Title: |
Activin receptor ALK4 promotes adipose tissue hyperplasia by suppressing differentiation of adipocyte precursors. |
| Volume: |
299 |
| Issue: |
1 |
| Pages: |
102716 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Heikelä H |
| Year: |
2020 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Hydroxysteroid (17β) dehydrogenase 12 is essential for metabolic homeostasis in adult mice. |
| Volume: |
319 |
| Issue: |
3 |
| Pages: |
E494-E508 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Roth L |
| Year: |
2024 |
| Journal: |
Cell Rep |
| Title: |
Thyroid hormones are required for thermogenesis of beige adipocytes induced by Zfp423 inactivation. |
| Volume: |
43 |
| Issue: |
12 |
| Pages: |
114987 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moser C |
| Year: |
2021 |
| Journal: |
Cell Rep |
| Title: |
Quantification of adipocyte numbers following adipose tissue remodeling. |
| Volume: |
35 |
| Issue: |
4 |
| Pages: |
109023 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Balaz M |
| Year: |
2019 |
| Journal: |
Cell Metab |
| Title: |
Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation. |
| Volume: |
29 |
| Issue: |
4 |
| Pages: |
901-916.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mancini G |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight. |
| Volume: |
26 |
| Issue: |
11 |
| Pages: |
2849-2858.e4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Girousse A |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
The Release of Adipose Stromal Cells from Subcutaneous Adipose Tissue Regulates Ectopic Intramuscular Adipocyte Deposition. |
| Volume: |
27 |
| Issue: |
2 |
| Pages: |
323-333.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yan C |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
2622 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim K |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
1822 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kwon J |
| Year: |
2023 |
| Journal: |
iScience |
| Title: |
Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes. |
| Volume: |
26 |
| Issue: |
3 |
| Pages: |
106161 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Poursharifi P |
| Year: |
2020 |
| Journal: |
JCI Insight |
| Title: |
Adipose ABHD6 regulates tolerance to cold and thermogenic programs. |
| Volume: |
5 |
| Issue: |
24 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Granade ME |
| Year: |
2022 |
| Journal: |
Mol Metab |
| Title: |
Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation. |
| Volume: |
63 |
|
| Pages: |
101543 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Med19/Med19 Tg(Adipoq-icre/ERT2)1Soff/? |
| Background: |
involves: C57BL/6J * C57BL/6N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ashton KJ |
| Year: |
2017 |
| Journal: |
Purinergic Signal |
| Title: |
Transcriptomic effects of adenosine 2A receptor deletion in healthy and endotoxemic murine myocardium. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
27-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friesen M |
| Year: |
2016 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Adipocyte insulin receptor activity maintains adipose tissue mass and lifespan. |
| Volume: |
476 |
| Issue: |
4 |
| Pages: |
487-492 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lundbäck V |
| Year: |
2020 |
| Journal: |
Physiol Rep |
| Title: |
Adipose-specific inactivation of thyroid stimulating hormone receptors in mice modifies body weight, temperature and gene expression in adipocytes. |
| Volume: |
8 |
| Issue: |
16 |
| Pages: |
e14538 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Antonopoulos AS |
| Year: |
2016 |
| Journal: |
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