| Type |
Details |
Score |
| Publication |
| First Author: |
Panagopoulos D |
| Year: |
2004 |
| Journal: |
J Virol |
| Title: |
Comparative analysis of signal transduction by CD40 and the Epstein-Barr virus oncoprotein LMP1 in vivo. |
| Volume: |
78 |
| Issue: |
23 |
| Pages: |
13253-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Debnath I |
| Year: |
2007 |
| Journal: |
J Immunol |
| Title: |
Defining in vivo transcription factor complexes of the murine CD21 and CD23 genes. |
| Volume: |
178 |
| Issue: |
11 |
| Pages: |
7139-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee JC |
| Year: |
2011 |
| Journal: |
Cancer Res |
| Title: |
In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy. |
| Volume: |
71 |
| Issue: |
8 |
| Pages: |
2871-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Le Huu D |
| Year: |
2013 |
| Journal: |
Blood |
| Title: |
Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease. |
| Volume: |
121 |
| Issue: |
16 |
| Pages: |
3274-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang Y |
| Year: |
2016 |
| Journal: |
Mol Immunol |
| Title: |
BIP induces mice CD19(hi) regulatory B cells producing IL-10 and highly expressing PD-L1, FasL. |
| Volume: |
69 |
|
| Pages: |
44-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Duque-Afonso J |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice. |
| Volume: |
10 |
| Issue: |
11 |
| Pages: |
e0143216 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ross SL |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
Bispecific T cell engager (BiTE®) antibody constructs can mediate bystander tumor cell killing. |
| Volume: |
12 |
| Issue: |
8 |
| Pages: |
e0183390 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen L |
| Year: |
2016 |
| Journal: |
Immunol Lett |
| Title: |
A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells. |
| Volume: |
172 |
|
| Pages: |
67-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Uehre GM |
| Year: |
2023 |
| Journal: |
Int J Mol Sci |
| Title: |
B Cells Induce Early-Onset Maternal Inflammation to Protect against LPS-Induced Fetal Rejection. |
| Volume: |
24 |
| Issue: |
22 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mortales CL |
| Year: |
2020 |
| Journal: |
J Immunol |
| Title: |
N-Glycan Branching Is Required for Development of Mature B Cells. |
| Volume: |
205 |
| Issue: |
3 |
| Pages: |
630-636 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nolte MA |
| Year: |
2004 |
| Journal: |
J Immunol |
| Title: |
B cells are crucial for both development and maintenance of the splenic marginal zone. |
| Volume: |
172 |
| Issue: |
6 |
| Pages: |
3620-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Keller AM |
| Year: |
2008 |
| Journal: |
Immunity |
| Title: |
Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity. |
| Volume: |
29 |
| Issue: |
6 |
| Pages: |
934-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wensveen FM |
| Year: |
2010 |
| Journal: |
Immunity |
| Title: |
Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones. |
| Volume: |
32 |
| Issue: |
6 |
| Pages: |
754-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Luo J |
| Year: |
2013 |
| Journal: |
Mol Immunol |
| Title: |
Up-regulation of transcription factor Blimp1 in systemic lupus erythematosus. |
| Volume: |
56 |
| Issue: |
4 |
| Pages: |
574-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen J |
| Year: |
2019 |
| Journal: |
Nature |
| Title: |
NR4A transcription factors limit CAR T cell function in solid tumours. |
| Volume: |
567 |
| Issue: |
7749 |
| Pages: |
530-534 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nutt SL |
| Year: |
1998 |
| Journal: |
EMBO J |
| Title: |
Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments. |
| Volume: |
17 |
| Issue: |
8 |
| Pages: |
2319-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gannot G |
| Year: |
2004 |
| Journal: |
Oral Oncol |
| Title: |
Interaction between the immune system and tongue squamous cell carcinoma induced by 4-nitroquinoline N-oxide in mice. |
| Volume: |
40 |
| Issue: |
3 |
| Pages: |
287-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chonwerawong M |
| Year: |
2020 |
| Journal: |
Gastroenterology |
| Title: |
Innate Immune Molecule NLRC5 Protects Mice From Helicobacter-induced Formation of Gastric Lymphoid Tissue. |
| Volume: |
159 |
| Issue: |
1 |
| Pages: |
169-182.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rip J |
| Year: |
2019 |
| Journal: |
Front Immunol |
| Title: |
Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease. |
| Volume: |
10 |
|
| Pages: |
95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pocock CF |
| Year: |
1995 |
| Journal: |
Br J Haematol |
| Title: |
BCL-2 expression by leukaemic blasts in a SCID mouse model of biphenotypic leukaemia associated with the t(4;11)(q21;q23) translocation. |
| Volume: |
90 |
| Issue: |
4 |
| Pages: |
855-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ouk C |
| Year: |
2021 |
| Journal: |
Front Immunol |
| Title: |
Continuous MYD88 Activation Is Associated With Expansion and Then Transformation of IgM Differentiating Plasma Cells. |
| Volume: |
12 |
|
| Pages: |
641692 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Englebert K |
| Year: |
2024 |
| Journal: |
Cell Rep |
| Title: |
The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis. |
| Volume: |
43 |
| Issue: |
3 |
| Pages: |
113824 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Waisman A |
| Year: |
2007 |
| Journal: |
J Exp Med |
| Title: |
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. |
| Volume: |
204 |
| Issue: |
4 |
| Pages: |
747-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peperzak V |
| Year: |
2013 |
| Journal: |
J Immunol |
| Title: |
CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool. |
| Volume: |
191 |
| Issue: |
6 |
| Pages: |
3025-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ingley E |
| Year: |
2008 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Src family kinases: regulation of their activities, levels and identification of new pathways. |
| Volume: |
1784 |
| Issue: |
1 |
| Pages: |
56-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Engen JR |
| Year: |
2008 |
| Journal: |
Cell Mol Life Sci |
| Title: |
Structure and dynamic regulation of Src-family kinases. |
| Volume: |
65 |
| Issue: |
19 |
| Pages: |
3058-73 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
The paired domain is an approximately 126 amino acid DNA-binding domain, which is found in eukaryotic transcription regulatory proteins involved in embryogenesis. The domain was originally described as the 'paired box' in the Drosophila protein paired (prd) [, ]. The paired domain is generally located in the N-terminal part. An octapeptide []and/or a homeodomain can occur C-terminal to the paired domain, as well as a Pro-Ser-Thr-rich C terminus.Paired domain proteins can function as transcription repressors or activators. The paired domain contains three subdomains, which show functional differences in DNA-binding. The crystal structures of prd and Pax proteins show that the DNA-bound paired domain is bipartite, consisting of an N-terminal subdomain (PAI or NTD) and a C-terminal subdomain (RED or CTD), connected by a linker. PAI and RED each form a three-helical fold, with the most C-terminal helices comprising a helix-turn-helix (HTH) motif that binds the DNA major groove. In addition, the PAI subdomain encompasses an N-terminal β-turn andβ-hairpin, also named 'wing', participating in DNA-binding. The linker canbind into the DNA minor groove. Different Pax proteins and their alternativelyspliced isoforms use different (sub)domains for DNA-binding to mediate thespecificity of sequence recognition [, ].Some proteins known to contain a paired domain:Drosophila paired (prd), a segmentation pair-rule class protein.Drosophila gooseberry proximal (gsb-p) and gooseberry distal (gsb-d),segmentation polarity class proteins.Drosophila Pox-meso and Pox-neuro proteins.The Pax proteins:Mammalian protein Pax1, which may play a role in the formation of segmented structures in the embryo. In mouse, mutations in Pax1 produce the undulated phenotype, characterised by vertebral malformations along the entire rostro-caudal axis.Mammalian protein Pax2, a probable transcription factor that may have arole in kidney cell differentiation.Mammalian protein Pax3. Pax3 is expressed during early neurogenesis. In humans, defects in Pax3 are the cause of Waardenburg's syndrome (WS), anautosomal dominant combination of deafness and pigmentary disturbance.Mammalian protein Pax4 pays an important role in the differentiation and development of pancreatic islet beta cells. It binds to a common element in the glucagon, insulin and somatostatin promoters. In humans, it has been related to the rare, familial, clinically and genetically heterogeneous form of diabetes MODY (maturity-onset diabetes of the young).Mammalian protein Pax5, also known as B-cell specific transcription factor(BSAP). Pax5 is involved in the regulation of the CD19 gene. It plays animportant role in B-cell differentiation as well as neural development andspermatogenesis.Mammalian protein Pax6 (oculorhombin). Pax6 is a transcription factor withimportant functions in eye and nasal development. In Man, defects in Pax6are the cause of aniridia type II (AN2), an autosomal dominant disordercharacterised by complete or partial absence of the iris.Mammalian protein Pax7 is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.Mammalian protein Pax8, required in thyroid development.Mammalian protein Pax9, required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. In man, defects in Pax9 cause oligodontia.Zebrafish protein Paired box protein Pax-2a, involved in the development of the midbrain/hindbrain boundary organizer and specification of neuronal cell fates.Xenopus laevis protein Paired box protein Pax-3-A, which promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
783
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
811
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eberhard D |
| Year: |
2000 |
| Journal: |
EMBO J |
| Title: |
Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family. |
| Volume: |
19 |
| Issue: |
10 |
| Pages: |
2292-303 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
132
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
132
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
49
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
783
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
157
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
139
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
273
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
146
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
102
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
336
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
118
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
64
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bopp D |
| Year: |
1986 |
| Journal: |
Cell |
| Title: |
Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila. |
| Volume: |
47 |
| Issue: |
6 |
| Pages: |
1033-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baumgartner S |
| Year: |
1987 |
| Journal: |
Genes Dev |
| Title: |
Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis. |
| Volume: |
1 |
| Issue: |
10 |
| Pages: |
1247-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Underhill DA |
| Year: |
2000 |
| Journal: |
Biochem Cell Biol |
| Title: |
Genetic and biochemical diversity in the Pax gene family. |
| Volume: |
78 |
| Issue: |
5 |
| Pages: |
629-38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Apuzzo S |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
Cross-talk between the paired domain and the homeodomain of Pax3: DNA binding by each domain causes a structural change in the other domain, supporting interdependence for DNA Binding. |
| Volume: |
279 |
| Issue: |
32 |
| Pages: |
33601-12 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
446
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
391
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
414
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
457
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
342
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
307
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
361
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
212
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
169
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
342
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
416
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
291
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
88
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
404
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
348
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
322
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
251
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
362
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
108
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
319
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
384
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
355
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
412
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
69
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
303
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
288
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
361
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
248
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
357
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
326
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
200
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
328
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
292
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
394
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
342
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
503
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
349
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
479
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
422
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
309
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
488
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
479
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
352
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
505
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
307
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
349
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
335
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
484
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
484
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
512
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
491
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
491
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
512
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peters J |
| Year: |
1992 |
| Journal: |
Mouse Genome |
| Title: |
New gene symbols |
| Volume: |
90 |
|
| Pages: |
99-104 |
|
•
•
•
•
•
|