| Type |
Details |
Score |
| Genotype |
| Symbol: |
Cd44/Cd44 |
| Background: |
D1.129P2-Cd44 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 |
| Background: |
B6.Cg-Cd44 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 |
| Background: |
B6.Cg-Cd44 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Larry S Sherman |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1859561 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2022-06-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689622 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:7287753 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Co-localization with Cd44 expression in central domain of chiasmatic neurons, extending to chiasmatic midline. Predominate localization in lateral region of chiasmatic neurons apposing optic tract. |
| Specimen Label: |
4D |
| Detected: |
true |
| Specimen Num: |
24 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1859561 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2022-06-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689622 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:7287753 |
| Age: |
embryonic day 14.5 |
|
| Note: |
At rostral level of chiasm, co-localization with Cd44 in chiasmatic neurons in central domain extending process into fiber layer at midline. |
| Specimen Label: |
4F |
| Detected: |
true |
| Specimen Num: |
26 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:17747 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
1999-09-10 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1620115 |
| Pattern: |
Regionally restricted |
| Stage: |
TS15 |
| Assay Id: |
MGI:1343765 |
| Age: |
embryonic day 9.5 |
|
| Note: |
The distribution of tek in arterial walls was similar to that of CD44 mRNA. Single dispersed cells expressing tek mRNA were not detected. |
| Specimen Label: |
Not shown |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:17747 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
1999-09-10 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1620117 |
| Pattern: |
Regionally restricted |
| Stage: |
TS17 |
| Assay Id: |
MGI:1343765 |
| Age: |
embryonic day 10.5 |
|
| Note: |
The distribution of tek in arterial walls was similar to that of CD44 mRNA. Single dispersed cells expressing tek mRNA were not detected. |
| Specimen Label: |
Not shown |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Banerji S |
| Year: |
1999 |
| Journal: |
J Cell Biol |
| Title: |
LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. |
| Volume: |
144 |
| Issue: |
4 |
| Pages: |
789-801 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brissett NC |
| Year: |
1996 |
| Journal: |
FEBS Lett |
| Title: |
The protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily. |
| Volume: |
388 |
| Issue: |
2-3 |
| Pages: |
211-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Banerji S |
| Year: |
2007 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction. |
| Volume: |
14 |
| Issue: |
3 |
| Pages: |
234-9 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, spontaneous mutation, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, spontaneous mutation, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, chemically induced mutation, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, transgenic, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 Il10/Il10 |
| Background: |
involves: 129/Sv * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 Sell/Sell |
| Background: |
involves: 129S2/SvPas * BALB/c * DBA/1 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 Tg(TNF)197Gkl/? |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44<+> |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 Tg(MMTV-PyVT)634Mul/? |
| Background: |
B6.Cg-Cd44 Tg(MMTV-PyVT)634Mul |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 Tg(MMTV-PyVT)634Mul/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * FVB/N |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Apoe/Apoe Cd44/Cd44 |
| Background: |
B6.129P2-Cd44 Apoe |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 Itgal/Itgal |
| Background: |
B6.129P2-Cd44 Itgal |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 Met/Met<+> |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 Tnf/Tnf<+> |
| Background: |
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Naujokas MF |
| Year: |
1993 |
| Journal: |
Cell |
| Title: |
The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44. |
| Volume: |
74 |
| Issue: |
2 |
| Pages: |
257-68 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
E-GEOD-53150 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
GEO |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 Trp53/Trp53<+> |
| Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Apoe/Apoe Cd44/Cd44<+> |
| Background: |
B6.129P2-Cd44 Apoe |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Apc/Apc<+> Cd44/Cd44 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 Hgf/Hgf<+> |
| Background: |
involves: 129S4/SvJae * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Apc/Apc<+> Cd44/Cd44 |
| Background: |
involves: C57BL/6J * C57BL/6JIco |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Apc/Apc<+> Cd44/Cd44 |
| Background: |
involves: C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Apc/Apc<+> Cd44/Cd44 |
| Background: |
involves: C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44<+> Tnf/Tnf<+> |
| Background: |
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Felemban M |
| Year: |
2018 |
| Journal: |
Acta Biomater |
| Title: |
Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix. |
| Volume: |
74 |
|
| Pages: |
207-221 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bourguignon LY |
| Year: |
2007 |
| Journal: |
J Neurochem |
| Title: |
Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes. |
| Volume: |
101 |
| Issue: |
4 |
| Pages: |
1002-17 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
E-GEOD-51892 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
Baseline |
| Source: |
GEO |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd44/Cd44 Gab1/Gab1<+> |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Apc/Apc<+> Cd44/Cd44 |
| Background: |
involves: C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Adam10/Adam10<+> Cd44/Cd44 Hr /Hr
|
| Background: |
involves: 129S1/Sv * 129X1/SvJ * HRA/SkhKcl |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ponta H |
| Year: |
2003 |
| Journal: |
Nat Rev Mol Cell Biol |
| Title: |
CD44: from adhesion molecules to signalling regulators. |
| Volume: |
4 |
| Issue: |
1 |
| Pages: |
33-45 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
ESRP2 has been identified as an epithelial cell type-specific regulator of fibroblast growth factor receptor 2 (FGFR2) splicing []. It is required for expression of epithelial FGFR2-IIIb and the regulation of CD44, CTNND1 (also termed p120-Catenin) and ENAH (also termed hMena) splicing. It enhances epithelial-specific exons of CD44 and ENAH, silences mesenchymal exons of CTNND1, or both within FGFR2 []. ESRP2 contains three RNA recognition motifs (RRMs). |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Nuclear speckles are subnuclear storage sites containing pre-mRNA splicing machinery. Nuclear speckle splicing regulatory protein 1 (Nsrp1), also known as NSRP70, is a nuclear speckle-related protein that mediates alternative splice site selection, targeting several pre-mRNAs []. It contains an N-terminal coiled-coil domain that is critical not only for self-oligomerization but also for splicing activity. It interacts physically with two SR (serine/arginine) proteins, SRSF1 and SRSF2, and reverses their splicing activity in terms of CD44 exon v5 as exon exclusion []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Do JS |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism. |
| Volume: |
184 |
| Issue: |
4 |
| Pages: |
1675-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsumoto M |
| Year: |
2016 |
| Journal: |
Cell Immunol |
| Title: |
Moesin regulates neutrophil rolling velocity in vivo. |
| Volume: |
304-305 |
|
| Pages: |
59-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mamalaki C |
| Year: |
1996 |
| Journal: |
Dev Immunol |
| Title: |
Tolerance in TCR/cognate antigen double-transgenic mice mediated by incomplete thymic deletion and peripheral receptor downregulation. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
299-315 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zöller M |
| Year: |
2011 |
| Journal: |
Nat Rev Cancer |
| Title: |
CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? |
| Volume: |
11 |
| Issue: |
4 |
| Pages: |
254-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dardenne E |
| Year: |
2012 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. |
| Volume: |
19 |
| Issue: |
11 |
| Pages: |
1139-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Phang JM |
| Year: |
2016 |
| Journal: |
Biochem J |
| Title: |
Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin. |
| Volume: |
473 |
| Issue: |
18 |
| Pages: |
2763-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dardenne E |
| Year: |
2014 |
| Journal: |
Cell Rep |
| Title: |
RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. |
| Volume: |
7 |
| Issue: |
6 |
| Pages: |
1900-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ngo TD |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis. |
| Volume: |
29 |
| Issue: |
12 |
| Pages: |
4024-4035.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hilbert M |
| Year: |
2009 |
| Journal: |
Biol Chem |
| Title: |
The mechanism of ATP-dependent RNA unwinding by DEAD box proteins. |
| Volume: |
390 |
| Issue: |
12 |
| Pages: |
1237-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ali MAM |
| Year: |
2021 |
| Journal: |
Int J Clin Oncol |
| Title: |
The DEAD-box protein family of RNA helicases: sentinels for a myriad of cellular functions with emerging roles in tumorigenesis. |
| Volume: |
26 |
| Issue: |
5 |
| Pages: |
795-825 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Erazo A |
| Year: |
2015 |
| Journal: |
Retrovirology |
| Title: |
Nuclear matrix protein Matrin 3 is a regulator of ZAP-mediated retroviral restriction. |
| Volume: |
12 |
|
| Pages: |
57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hönig A |
| Year: |
2002 |
| Journal: |
Mol Cell Biol |
| Title: |
Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72. |
| Volume: |
22 |
| Issue: |
16 |
| Pages: |
5698-707 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sithole N |
| Year: |
2015 |
| Journal: |
Lancet |
| Title: |
The roles of DEAD box helicases in the life cycle of HIV-1. |
| Volume: |
385 Suppl 1 |
|
| Pages: |
S89 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the ATP-binding domain of DEAD box protein 17 (DDX17, also known as p72) found in chordates. This protein is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation [, , , ]. DDX17 has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner [, , , , , ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Warzecha CC |
| Year: |
2009 |
| Journal: |
Mol Cell |
| Title: |
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. |
| Volume: |
33 |
| Issue: |
5 |
| Pages: |
591-601 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
131
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
188
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li Q |
| Year: |
2007 |
| Journal: |
J Mol Biol |
| Title: |
Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain. |
| Volume: |
365 |
| Issue: |
5 |
| Pages: |
1446-59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lagresle-Peyrou C |
| Year: |
2016 |
| Journal: |
J Allergy Clin Immunol |
| Title: |
X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene. |
| Volume: |
138 |
| Issue: |
6 |
| Pages: |
1681-1689.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen H |
| Year: |
2011 |
| Journal: |
Int J Biochem Cell Biol |
| Title: |
Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus. |
| Volume: |
43 |
| Issue: |
4 |
| Pages: |
545-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Warzecha CC |
| Year: |
2009 |
| Journal: |
RNA Biol |
| Title: |
The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events. |
| Volume: |
6 |
| Issue: |
5 |
| Pages: |
546-62 |
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| Protein Domain |
| Type: |
Family |
| Description: |
The ERM family consists of three closely-related proteins, ezrin, radixin and moesin []. Ezrin was first identified as a constituent of microvilli [], radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions [], and moesin as a heparin binding protein [], which is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance [, ]. Members of this family have been associated with axon-associated Schwann cell (SC) motility and the maintenance of the polarity of these cells []. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein) []. ERM molecules contain 3 domains, an N-terminal globular domain, an extended α-helical domain and a charged C-terminal domain []. Ezrin, radixin and merlin also contain a polyproline region between the helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain []. ERM proteins crosslink actin filaments with plasma membranes. They co-localise with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains []. The α-helical region is involved in intramolecular masking of protein-protein interaction sites which regulates the activity of this proteins []. |
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| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents ERM family of proteins.The ERM family consists of three closely-related proteins, ezrin, radixin and moesin []. Ezrin was first identified as a constituent of microvilli [], radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions [], and moesin as a heparin binding protein [], which is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance [, ]. Members of this family have been associated with axon-associated Schwann cell (SC) motility and the maintenance of the polarity of these cells []. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein) []. ERM molecules contain 3 domains, an N-terminal globular domain, an extended α-helical domain and a charged C-terminal domain []. Ezrin, radixin and merlin also contain a polyproline region between the helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain []. ERM proteins crosslink actin filaments with plasma membranes. They co-localise with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains []. The α-helical region is involved in intramolecular masking of protein-protein interaction sites which regulates the activity of this proteins []. |
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| Protein Domain |
| Type: |
Domain |
| Description: |
The ERM family consists of three closely-related proteins, ezrin, radixin and moesin [, ]. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin-binding protein []. ERM proteins crosslink actin filaments with plasma membranes. They co-localise with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains []. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein) []. ERM molecules contain 3 domains, an N-terminal globular domain, an extended α-helical domain and a charged C-terminal domain () []. Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. This entry represents the α-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, that regulate the activity of these proteins [, ]. |
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| Protein Domain |
| Type: |
Domain |
| Description: |
The ERM family consists of three closely-related proteins, ezrin, radixin and moesin []. Ezrin was first identified as a constituent of microvilli [], radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions [], and moesin as a heparin binding protein [], which is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance [, ]. Members of this family have been associated with axon-associated Schwann cell (SC) motility and the maintenance of the polarity of these cells []. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein) []. ERM molecules contain 3 domains, an N-terminal globular domain, an extended α-helical domain and a charged C-terminal domain []. Ezrin, radixin and merlin also contain a polyproline region between the helical and C-terminal domains. The N-terminal domain is highly conserved, and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain []. ERM proteins crosslink actin filaments with plasma membranes. They co-localise with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains []. The α-helical region is involved in intramolecular masking of protein-protein interaction sites which regulates the activity of this proteins [].This entry represents the C-terminal domain of ERM family of proteins which corresponds to the actin-binding tail domain [, ]. |
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| Year: |
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| Title: |
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