Type |
Details |
Score |
Publication |
First Author: |
Derewenda U |
Year: |
2007 |
Journal: |
Structure |
Title: |
The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly. |
Volume: |
15 |
Issue: |
11 |
Pages: |
1467-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
El-Husseini AE |
Year: |
2001 |
Journal: |
Genomics |
Title: |
Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5. |
Volume: |
71 |
Issue: |
3 |
Pages: |
363-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wade RH |
Year: |
2000 |
Journal: |
Nat Struct Biol |
Title: |
Structural links to kinesin directionality and movement. |
Volume: |
7 |
Issue: |
6 |
Pages: |
456-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Soilleux EJ |
Year: |
2000 |
Journal: |
J Immunol |
Title: |
DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. |
Volume: |
165 |
Issue: |
6 |
Pages: |
2937-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu P |
Year: |
1993 |
Journal: |
Science |
Title: |
Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. |
Volume: |
261 |
Issue: |
5124 |
Pages: |
1041-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Campbell IG |
Year: |
1994 |
Journal: |
Hum Mol Genet |
Title: |
A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. |
Volume: |
3 |
Issue: |
4 |
Pages: |
589-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nielsen BB |
Year: |
1997 |
Journal: |
FEBS Lett |
Title: |
Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil. |
Volume: |
412 |
Issue: |
2 |
Pages: |
388-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jin DY |
Year: |
1999 |
Journal: |
J Biomed Sci |
Title: |
Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28. |
Volume: |
6 |
Issue: |
2 |
Pages: |
115-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen HC |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
Live cell imaging reveals continuous STAT6 nuclear trafficking. |
Volume: |
185 |
Issue: |
1 |
Pages: |
64-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koirala S |
Year: |
2010 |
Journal: |
J Cell Biol |
Title: |
Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes. |
Volume: |
191 |
Issue: |
6 |
Pages: |
1127-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Van Heurck R |
Year: |
2023 |
Journal: |
Neuron |
Title: |
CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors. |
Volume: |
111 |
Issue: |
1 |
Pages: |
65-80.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ji YM |
Year: |
1995 |
Journal: |
Mol Cells |
Title: |
Expression and purification of mouse sulfated glycoprotein- 2. |
Volume: |
5 |
Issue: |
5 |
Pages: |
413-418 |
|
•
•
•
•
•
|
Allele |
Name: |
NAD(P) dependent steroid dehydrogenase-like; striated 1 Harwell |
Allele Type: |
Radiation induced |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Eda/? Tnfrsf19/Tnfrsf19 |
Background: |
involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Eda/Eda Tnfrsf19/Tnfrsf19 |
Background: |
involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Wnt10a/Wnt10a |
Background: |
involves: 129X1/SvJ * BALB/cJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Alahari SK |
Year: |
2004 |
Journal: |
EMBO J |
Title: |
The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK. |
Volume: |
23 |
Issue: |
14 |
Pages: |
2777-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang SJ |
Year: |
2005 |
Journal: |
Proteins |
Title: |
Solution structure of HP1242 from Helicobacter pylori. |
Volume: |
61 |
Issue: |
4 |
Pages: |
1111-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lim KP |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region. |
Volume: |
279 |
Issue: |
52 |
Pages: |
54770-82 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Nischarin, also known as Imidazoline Receptor Antisera-Selected (IRAS), contains an N-terminal PX domain, leucine rich repeats, and a predicted coiled coil domain. The PX domain of IRAS binds to phosphatidylinositol-3-phosphate in membranes. Together with the coiled coil domain, it is essential for the localization of IRAS to endosomes []. IRAS has been shown to interact with integrin and inhibit cell migration []. Its interaction with alpha5 integrin causes a redistribution of the receptor from the cell surface to endosomal structures, suggesting that IRAS may function as a sorting nexin (SNX) which regulates the endosomal trafficking of integrin [].This entry represents the PX domain of nischarin/IRAS. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The Yersinia adhesin A (YadA) is a trimeric autotransporter adhesin of enteric yersiniae. It consists of three major domains: a head mediating adherence to host cells, a stalk involved in serum resistance, and an anchor that forms a membrane pore and is responsible for the autotransport function [].This entry represents the head domain of YadA. This domain is composed almost solely of β-sheets making a novel nine coiled left-handed parallel β-roll (LPBR), surrounded by a partly disordered (N)-terminal random coil and a C-terminal neck region, which consists of a random coil and a short helix at the start of the stalk domain []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyata H |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. |
Volume: |
113 |
Issue: |
28 |
Pages: |
7704-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sang L |
Year: |
2011 |
Journal: |
Cell |
Title: |
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. |
Volume: |
145 |
Issue: |
4 |
Pages: |
513-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Joshi S |
Year: |
2007 |
Journal: |
BMC Dev Biol |
Title: |
Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. |
Volume: |
7 |
|
Pages: |
67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Agbu SO |
Year: |
2018 |
Journal: |
J Cell Biol |
Title: |
The small GTPase RSG1 controls a final step in primary cilia initiation. |
Volume: |
217 |
Issue: |
1 |
Pages: |
413-427 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang C |
Year: |
2018 |
Journal: |
Development |
Title: |
Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse. |
Volume: |
145 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
van der Zwaag B |
Year: |
2005 |
Journal: |
Genomics |
Title: |
Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. |
Volume: |
86 |
Issue: |
1 |
Pages: |
55-67 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
386
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
345
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
90
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
63
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
80
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
169
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
102
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Hales KG |
Year: |
1997 |
Journal: |
Cell |
Title: |
Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. |
Volume: |
90 |
Issue: |
1 |
Pages: |
121-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pu YG |
Year: |
2011 |
Journal: |
J Struct Biol |
Title: |
Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33. |
Volume: |
175 |
Issue: |
3 |
Pages: |
469-74 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Repeat |
Description: |
The tertiary structures of pectate lyases andrhamnogalacturonase A show a stack of parallel betastrands that are coiled into a large helix. Each coil of the helix representsa structural repeat that, insome homologues, can be recognised from sequence information alone.Conservation ofasparagines might be connected with asparagine-ladders that contribute to thestability of the fold.Proteins containing these repeats most often are enzymes with polysaccharidesubstrates []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents a coiled-coil domain found in cytochrome c oxidase assembly factor 3 and homologues.Cytochrome c oxidase assembly factor 3, previously known as coiled coil domain-containing protein 56 (CCDC56), plays a critical role in the biogenesis and activity of cytochrome c oxidase (COX) []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the conserved region of NUDE proteins. Proteins containing this domain are homologues of the nuclear distribution protein RO11 of Neurospora crassa. NUDE interacts with the NUDF via an N-terminal coiled coil domain; this is the only domain which is absolutely required for NUDE function. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Matrix (M) protein is an important structural component of rhabdovirus virions, and also plays a number of roles during the replication cycle of the virus []. It is involved in condensing and targeting the ribonucleoprotein (RNP) coil to the plasma membrane. M interacts specifically with the transmembrane spike protein (G) and it is important for the incorporation of G protein into budding virions []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the heptad repeat domain which is conserved at the C terminus of Fzo/mitofusion family of GTPases. Fzo is a mediator of mitochondrial fusion during spermatogenesis []. This conserved region is also found in the human mitofusin protein [].This domain forms a dimeric antiparallel coiled coil structure, which has been proposed to act as a mitochodrial tether before vesicle fusion []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
The Gp7 protein contains a DNA-binding function and may have a role in mediating the structural transition from prohead to mature virus and also scaffold release []. Gp7 is arranged within the capsid as a series of concentric shells [].The structure of Gp7 forms a dimer that resemble arrows, with a four-helix bundle composing the arrowhead and a coiled coil forming the tail []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
Family members are found in small bacterial proteins, and also in the heavy chains of fungal proteins that contain the domain kinesin, in which this region is located C-terminal of the motor domain. Members of this family may form coiled coil structures []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
Matrix (M) protein is an important structural component of rhabdovirus virions, and also plays a number of roles during the replication cycle of the virus []. It is involved in condensing and targeting the ribonucleoprotein (RNP) coil to the plasma membrane. M interacts specifically with the transmembrane spike protein (G) and it is important for the incorporation of G protein into budding virions []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
This entry represents a short domain found the matrilin (cartilage matrix) proteins. It forms a coiled coil structure and contains a single cysteine residue at its start which is likely to form a di-sulphide bridge with a corresponding cysteine in an upstream EGF domain, thereby spanning the VWA domain of the protein ().This domain is likely to be responsible for protein trimerisation [, ]. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
The osmosensory transporter coiled coil is a C-terminal domain found in various bacterial osmoprotective transporters, such as ProP, Proline/betaine transporter, Proline permease 2 and the citrate proton symporters. It adopts an antiparallel coiled-coil structure, and is essential for osmosensory and osmoprotectant transporter function []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
This mitochondrial matrix protein superfamily contains members of the MAM33 superfamily which bind to the globular 'heads' of C1Q.b. It is thought to be involved in mitochondrial oxidative phosphorylation and in nucleus-mitochondrion interactions [, , ]. Its structure consists of an beta(7)-alpha(2) fold with N- and C-terminal extensions forming a coiled coil subdomain. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Family members are found in small bacterial proteins, and also in the heavy chains of fungal proteins that contain the domain kinesin, in which this region is located C-terminal of the motor domain. Members of this family may form coiled coil structures []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents a short domain found the matrilin (cartilage matrix) proteins. It forms a coiled coil structure and contains a single cysteine residue at its start which is likely to form a di-sulphide bridge with a corresponding cysteine in an upstream EGF domain, thereby spanning the VWA domain of the protein ().This domain is likely to be responsible for protein trimerisation [, ]. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
The E2F transcription factors associated with the corresponding domain of the DP transcription factor forming an heterodimer fold with the N-terminal long helices of both chains forming a parallel coiled coil and their C-terminal folded β-hairpins interlocking together in a β-sandwich. This complex binds the C terminus of retinoblastoma protein []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
The plant-specific protein, TSP9 is phosphorylated and released in response to changing light conditions from the photosynthetic membrane. The protein resembles the characteristics of transcription/translation regulatory factors. The structure of the protein is predicted to consist of a random coil []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The plant-specific protein, TSP9 is phosphorylated and released in response to changing light conditions from the photosynthetic membrane. The protein resembles the characteristics of transcription/translation regulatory factors. The structure of the protein is predicted to consist of a random coil []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Teh CE |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency. |
Volume: |
107 |
Issue: |
33 |
Pages: |
14709-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu DY |
Year: |
2017 |
Journal: |
Cell Death Differ |
Title: |
IL-2 prevents deletion of developing T-regulatory cells in the thymus. |
Volume: |
24 |
Issue: |
6 |
Pages: |
1007-1016 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nekanti U |
Year: |
2024 |
Journal: |
NPJ Regen Med |
Title: |
Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI. |
Volume: |
9 |
Issue: |
1 |
Pages: |
12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kwan KY |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons. |
Volume: |
105 |
Issue: |
41 |
Pages: |
16021-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Azim E |
Year: |
2009 |
Journal: |
Nat Neurosci |
Title: |
SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. |
Volume: |
12 |
Issue: |
10 |
Pages: |
1238-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jimeno D |
Year: |
2006 |
Journal: |
Exp Eye Res |
Title: |
Kinesin-2 and photoreceptor cell death: requirement of motor subunits. |
Volume: |
82 |
Issue: |
2 |
Pages: |
351-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Altin JA |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation. |
Volume: |
188 |
Issue: |
11 |
Pages: |
5478-88 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Still IH |
Year: |
1999 |
Journal: |
Genomics |
Title: |
The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. |
Volume: |
58 |
Issue: |
2 |
Pages: |
165-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baens M |
Year: |
1997 |
Journal: |
Genomics |
Title: |
A human homologue (BICD1) of the Drosophila bicaudal-D gene. |
Volume: |
45 |
Issue: |
3 |
Pages: |
601-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim L |
Year: |
1995 |
Journal: |
Mol Cell Biol |
Title: |
The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors. |
Volume: |
15 |
Issue: |
8 |
Pages: |
4553-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Brien KP |
Year: |
2000 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Characterization of five novel human genes in the 11q13-q22 region. |
Volume: |
273 |
Issue: |
1 |
Pages: |
90-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Furukawa K |
Year: |
1994 |
Journal: |
Exp Cell Res |
Title: |
Identification and cloning of an mRNA coding for a germ cell-specific A-type lamin in mice. |
Volume: |
212 |
Issue: |
2 |
Pages: |
426-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng J |
Year: |
2019 |
Journal: |
J Mol Cell Biol |
Title: |
Microtubule-bundling protein Spef1 enables mammalian ciliary central apparatus formation. |
Volume: |
11 |
Issue: |
1 |
Pages: |
67-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leung CL |
Year: |
2001 |
Journal: |
J Cell Biol |
Title: |
The BPAG1 locus: Alternative splicing produces multiple isoforms with distinct cytoskeletal linker domains, including predominant isoforms in neurons and muscles. |
Volume: |
154 |
Issue: |
4 |
Pages: |
691-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lan Z |
Year: |
2005 |
Journal: |
Biochemistry |
Title: |
Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. |
Volume: |
44 |
Issue: |
7 |
Pages: |
2385-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hong DH |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Retinitis pigmentosa GTPase regulator (RPGRr)-interacting protein is stably associated with the photoreceptor ciliary axoneme and anchors RPGR to the connecting cilium. |
Volume: |
276 |
Issue: |
15 |
Pages: |
12091-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hjeij R |
Year: |
2014 |
Journal: |
Am J Hum Genet |
Title: |
CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation. |
Volume: |
95 |
Issue: |
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