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Search results 1301 to 1400 out of 3891 for Gli2

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Type Details Score
Publication
20871598 | J:165573
First Author: Depianto D
Year: 2010
Journal: Nat Genet
Title: Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin.
Volume: 42
Issue: 10
Pages: 910-4
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Genotype
Genotype
Symbol: Gli2/Gli2
Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli1/Gli1 Gli2/Gli2
Background: involves: 129S6/SvEvTac * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gli2/Gli2 Gli3/Gli3
Background: involves: 101/H * C3H/HeH * C57BL * CBA/H * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Protein
A5A9W4
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
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Protein
A5A9W3
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: true
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Protein
Q8BKI7
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: true
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Protein Domain
IPR043359 | GLI-like
Type: Family
Description: This entry includes a group of zinc finger transcription regulators, including GLI1-3 and GLIS1/3 from humans.GLI1-3 are central effectors of the Hedgehog (Hh) pathway in vertebrates [, ]. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions []. The full-length GLI3 form, after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while its C-terminally truncated form acts as a repressor (GLI3R). GLI3 participates in the patterning and growth of many organs, including the central nervous system (CNS) and limbs [, , , , ].GLIS1/3 play key roles in the regulation of a number of physiological processes and have been implicated in several pathologies. Glis1-3 share a highly homologous zinc finger domain (ZFD) containing five Cys2-His2-type zinc finger (ZF) motifs with members of the Gli and Zic family [].
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HT Experiment
GSE251669 | CPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling.
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
38261656 | J:345410
First Author: Wang Y
Year: 2024
Journal: Sci Signal
Title: TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.
Volume: 17
Issue: 820
Pages: eabo0465
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Publication
24276242 | J:216560
First Author: Rajurkar M
Year: 2014
Journal: Oncogene
Title: Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis.
Volume: 33
Issue: 46
Pages: 5370-8
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Publication
38968120 | J:360708
First Author: Yoshida S
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase.
Volume: 121
Issue: 28
Pages: e2320070121
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Publication
17114586 | J:116111
First Author: Pasca di Magliano M
Year: 2006
Journal: Genes Dev
Title: Hedgehog/Ras interactions regulate early stages of pancreatic cancer.
Volume: 20
Issue: 22
Pages: 3161-73
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Publication
26168014 | J:231848
First Author: Hobbs RP
Year: 2015
Journal: Nat Genet
Title: Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.
Volume: 47
Issue: 8
Pages: 933-8
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Genotype
Genotype
Symbol: Gli3/Gli3 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ihh/Ihh Tg(Col2a1-cre)3Amc/?
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ
Zygosity: cn
Has Mutant Allele: true
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Publication
16854408 | J:119301
First Author: Kadison SR
Year: 2006
Journal: Dev Biol
Title: The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord.
Volume: 296
Issue: 2
Pages: 499-513
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Publication
16518394 | J:112555
First Author: El Andaloussi A
Year: 2006
Journal: Nat Immunol
Title: Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus.
Volume: 7
Issue: 4
Pages: 418-26
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Publication
23291299 | J:194353
First Author: Kim J
Year: 2013
Journal: Cancer Cell
Title: Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists.
Volume: 23
Issue: 1
Pages: 23-34
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Publication
32155439 | J:286590
First Author: Rao-Bhatia A
Year: 2020
Journal: Dev Cell
Title: Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development.
Volume: 52
Issue: 5
Pages: 647-658.e6
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Publication
17227833 | J:145323
First Author: Rowbotham NJ
Year: 2007
Journal: Blood
Title: Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation.
Volume: 109
Issue: 9
Pages: 3757-66
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Publication
25490446 | J:217685
First Author: Tiberi L
Year: 2014
Journal: Cancer Cell
Title: A BCL6/BCOR/SIRT1 complex triggers neurogenesis and suppresses medulloblastoma by repressing Sonic Hedgehog signaling.
Volume: 26
Issue: 6
Pages: 797-812
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Publication
27633013 | J:235647
First Author: Liu X
Year: 2016
Journal: Genes Dev
Title: Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.
Volume: 30
Issue: 17
Pages: 1943-55
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Publication
23871669 | J:202107
First Author: Kakanj P
Year: 2013
Journal: Cell Rep
Title: Indian hedgehog controls proliferation and differentiation in skin tumorigenesis and protects against malignant progression.
Volume: 4
Issue: 2
Pages: 340-51
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Publication
27039827 | J:236822
 
First Author: Yan B
Year: 2016
Journal: Nat Commun
Title: mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation.
Volume: 7
Pages: 11151
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Publication
31953387 | J:284576
First Author: Kim JE
Year: 2020
Journal: Nat Commun
Title: Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches.
Volume: 11
Issue: 1
Pages: 334
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Publication
17054904 | J:115277
First Author: Kise Y
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels.
Volume: 351
Issue: 1
Pages: 78-84
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Publication
23149744 | J:225072
 
First Author: Jimenez-Sanchez M
Year: 2012
Journal: Nat Commun
Title: The Hedgehog signalling pathway regulates autophagy.
Volume: 3
Pages: 1200
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Publication
27477274 | J:238983
First Author: Jin X
Year: 2016
Journal: Cell Rep
Title: The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells.
Volume: 16
Issue: 6
Pages: 1629-1641
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Publication
29996106 | J:271145
First Author: Akgül S
Year: 2018
Journal: Cell Rep
Title: Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.
Volume: 24
Issue: 2
Pages: 463-478.e5
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Publication
31134896 | J:277228
   
First Author: Adams CR
Year: 2019
Journal: Elife
Title: Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer.
Volume: 8
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Publication
32094404 | J:297796
First Author: Zhuo M
Year: 2020
Journal: Oncogene
Title: Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling.
Volume: 39
Issue: 16
Pages: 3336-3353
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Publication
34518642 | J:325936
First Author: Petsouki E
Year: 2021
Journal: Commun Biol
Title: FBW7 couples structural integrity with functional output of primary cilia.
Volume: 4
Issue: 1
Pages: 1066
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Publication
34644112 | J:312379
First Author: Lai FP
Year: 2021
Journal: Sci Adv
Title: Ciliary protein Kif7 regulates Gli and Ezh2 for initiating the neuronal differentiation of enteric neural crest cells during development.
Volume: 7
Issue: 42
Pages: eabf7472
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Publication
31488567 | J:331901
 
First Author: Muthu V
Year: 2019
Journal: Development
Title: Genomic architecture of Shh-dependent cochlear morphogenesis.
Volume: 146
Issue: 18
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Protein
E0CX93
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: true
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Publication
26542012 | J:228881
First Author: Gazea M
Year: 2016
Journal: Dev Biol
Title: Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain.
Volume: 409
Issue: 1
Pages: 55-71
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Protein
P47806
Organism: Mus musculus/domesticus
Length: 1111  
Fragment?: false
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Protein
A2RRI7
Organism: Mus musculus/domesticus
Length: 980  
Fragment?: false
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Protein Coding Gene
MGI:95727 | Gli1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0015893 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017819 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017794 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017757 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017758 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017582 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_95727 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0017142 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017551 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017657 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017652 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017731 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017680 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018253 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017203 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031192 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016719 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9524201 | J:46858
First Author: Liu CZ
Year: 1998
Journal: Gene
Title: Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway.
Volume: 209
Issue: 1-2
Pages: 1-11
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Publication
12438220 | J:80299
First Author: Weiner HL
Year: 2002
Journal: Cancer Res
Title: Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1.
Volume: 62
Issue: 22
Pages: 6385-9
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Publication
25313900 | J:223558
First Author: Kitaura Y
Year: 2014
Journal: PLoS One
Title: Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice.
Volume: 9
Issue: 10
Pages: e109597
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Publication
18842815 | J:143414
First Author: Thomas NA
Year: 2008
Journal: Development
Title: Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential.
Volume: 135
Issue: 22
Pages: 3789-99
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Publication
34399854 | J:310473
First Author: Gao FJ
Year: 2021
Journal: Acta Neuropathol Commun
Title: Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates.
Volume: 9
Issue: 1
Pages: 137
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Publication
30061668 | J:266236
First Author: Ransom RC
Year: 2018
Journal: Nat Commun
Title: Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes.
Volume: 9
Issue: 1
Pages: 2971
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Publication
37991018 | J:349254
 
First Author: Dubner AM
Year: 2023
Journal: JCI Insight
Title: Smooth muscle-derived adventitial progenitor cells direct atherosclerotic plaque composition complexity in a Klf4-dependent manner.
Volume: 8
Issue: 22
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Publication
37287453 | J:346333
 
First Author: Altrieth AL
Year: 2023
Journal: Front Cell Dev Biol
Title: Identifying fibrogenic cells following salivary gland obstructive injury.
Volume: 11
Pages: 1190386
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Publication
35330911 | J:322293
 
First Author: Chen S
Year: 2022
Journal: Front Cell Dev Biol
Title: Gli1+ Osteogenic Progenitors Contribute to Condylar Development and Fracture Repair.
Volume: 10
Pages: 819689
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Publication
36107746 | J:350256
First Author: Zheng CX
Year: 2022
Journal: STAR Protoc
Title: Optimized immunofluorescence staining protocol for identifying resident mesenchymal stem cells in bone using LacZ transgenic mice.
Volume: 3
Issue: 4
Pages: 101674
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Publication
32668219 | J:353694
First Author: Chen J
Year: 2020
Journal: Stem Cell Reports
Title: Gli1(+) Cells Couple with Type H Vessels and Are Required for Type H Vessel Formation.
Volume: 15
Issue: 1
Pages: 110-124
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Publication
29337143 | J:261139
 
First Author: Bobarnac Dogaru GL
Year: 2018
Journal: Exp Neurol
Title: The role of Hedgehog-responsive fibroblasts in facial nerve regeneration.
Volume: 303
Pages: 72-79
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Publication
20107231 | J:159192
First Author: Merchant A
Year: 2010
Journal: Blood
Title: Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors.
Volume: 115
Issue: 12
Pages: 2391-6
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Publication
19071955 | J:207593
First Author: Lees CW
Year: 2008
Journal: PLoS Med
Title: Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways.
Volume: 5
Issue: 12
Pages: e239
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Publication
25465115 | J:223860
First Author: Kramann R
Year: 2015
Journal: Cell Stem Cell
Title: Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis.
Volume: 16
Issue: 1
Pages: 51-66
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Publication
33188955 | J:301302
 
First Author: Moore ER
Year: 2021
Journal: Bone
Title: Prx1-expressing cells contributing to fracture repair require primary cilia for complete healing in mice.
Volume: 143
Pages: 115738
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Publication
26912062 | J:319635
 
First Author: Gurdziel K
Year: 2016
Journal: BMC Dev Biol
Title: Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathway.
Volume: 16
Pages: 4
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Publication
37164217 | J:338330
 
First Author: Fujii S
Year: 2023
Journal: Bone
Title: Bone formation ability of Gli1(+) cells in the periodontal ligament after tooth extraction.
Volume: 173
Pages: 116786
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Publication
37117787 | J:339225
First Author: Wu Y
Year: 2023
Journal: Nat Aging
Title: Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus.
Volume: 3
Issue: 4
Pages: 380-390
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Publication
28734986 | J:257902
 
First Author: Liu X
Year: 2017
Journal: Bone
Title: Exogenous hedgehog antagonist delays but does not prevent fracture healing in young mice.
Volume: 103
Pages: 241-251
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Publication
32496193 | J:358579
   
First Author: Licht T
Year: 2020
Journal: Elife
Title: Hippocampal neural stem cells facilitate access from circulation via apical cytoplasmic processes.
Volume: 9
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Publication
38673956 | J:352380
 
First Author: Yang P
Year: 2024
Journal: Int J Mol Sci
Title: Gli1(+) Progenitors Mediate Glucocorticoid-Induced Osteoporosis In Vivo.
Volume: 25
Issue: 8
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Publication
36459968 | J:350347
First Author: Fang F
Year: 2022
Journal: Cell Stem Cell
Title: A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential.
Volume: 29
Issue: 12
Pages: 1669-1684.e6
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Publication
33301706 | J:350603
First Author: Leimkühler NB
Year: 2021
Journal: Cell Stem Cell
Title: Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.
Volume: 28
Issue: 4
Pages: 637-652.e8
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Publication
23699504 | J:198419
First Author: Hester MS
Year: 2013
Journal: J Neurosci
Title: Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity.
Volume: 33
Issue: 21
Pages: 8926-36
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Publication
30303712 | J:313202
First Author: Ó hAinmhire E
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: A conditionally immortalized Gli1-positive kidney mesenchymal cell line models myofibroblast transition.
Volume: 316
Issue: 1
Pages: F63-F75
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Publication
28457748 | J:253988
First Author: Schneider RK
Year: 2017
Journal: Cell Stem Cell
Title: Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Volume: 20
Issue: 6
Pages: 785-800.e8
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Publication
26756038 | J:239973
 
First Author: Singh SP
Year: 2015
Journal: eNeuro
Title: Clonal Analysis of Newborn Hippocampal Dentate Granule Cell Proliferation and Development in Temporal Lobe Epilepsy.
Volume: 2
Issue: 6
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Publication
34085927 | J:312424
   
First Author: Wei Y
Year: 2021
Journal: Elife
Title: The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair.
Volume: 10
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Publication
25448080 | J:223861
First Author: Li C
Year: 2015
Journal: Stem Cells
Title: Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm.
Volume: 33
Issue: 3
Pages: 999-1012
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Publication
38000021 | J:343311
First Author: Kaesler N
Year: 2023
Journal: Sci Adv
Title: Mapping cardiac remodeling in chronic kidney disease.
Volume: 9
Issue: 47
Pages: eadj4846
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Publication
11717126 | J:72866
First Author: Kroft TL
Year: 2001
Journal: Biol Reprod
Title: GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene.
Volume: 65
Issue: 6
Pages: 1663-71
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Publication
2832761 | J:9101
First Author: Kinzler KW
Year: 1988
Journal: Nature
Title: The GLI gene is a member of the Kruppel family of zinc finger proteins.
Volume: 332
Issue: 6162
Pages: 371-4
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Publication
2850480 | J:14708
First Author: Ruppert JM
Year: 1988
Journal: Mol Cell Biol
Title: The GLI-Kruppel family of human genes.
Volume: 8
Issue: 8
Pages: 3104-13
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Publication
16421275 | J:105048
First Author: Huntzicker EG
Year: 2006
Journal: Genes Dev
Title: Dual degradation signals control Gli protein stability and tumor formation.
Volume: 20
Issue: 3
Pages: 276-81
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Publication
16943197 | J:117396
First Author: Hochman E
Year: 2006
Journal: J Biol Chem
Title: Molecular pathways regulating pro-migratory effects of Hedgehog signaling.
Volume: 281
Issue: 45
Pages: 33860-70
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Publication
17928300 | J:129005
First Author: Fiaschi M
Year: 2007
Journal: J Biol Chem
Title: Targeted expression of GLI1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure.
Volume: 282
Issue: 49
Pages: 36090-101
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Publication
19458072 | J:149439
First Author: Fiaschi M
Year: 2009
Journal: Cancer Res
Title: Development of mammary tumors by conditional expression of GLI1.
Volume: 69
Issue: 11
Pages: 4810-7
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Publication
21933656 | J:177358
First Author: Fiaschi M
Year: 2011
Journal: Am J Pathol
Title: Targeted expression of GLI1 in the salivary glands results in an altered differentiation program and hyperplasia.
Volume: 179
Issue: 5
Pages: 2569-79
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Publication
29875413 | J:264082
First Author: Degirmenci B
Year: 2018
Journal: Nature
Title: GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells.
Volume: 558
Issue: 7710
Pages: 449-453
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Publication
25104358 | J:310017
First Author: Mathew E
Year: 2014
Journal: J Biol Chem
Title: The transcription factor GLI1 modulates the inflammatory response during pancreatic tissue remodeling.
Volume: 289
Issue: 40
Pages: 27727-43
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GXD Expression
GXD Expression
   
Probe: MGI:1277646
Assay Type: Northern blot
Annotation Date: 1998-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:1278433
Age: embryonic day 9.5
Image: 5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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