Type |
Details |
Score |
Allele |
Name: |
transgene insertion, Dimitrina D Pravtcheva |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
H19, imprinted maternally expressed transcript; targeted mutation 1, Jennifer V Schmidt |
Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, William T Pu |
Allele Type: |
Transgenic |
Attribute String: |
Inducible, Recombinase, Transactivator |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion YZ15, Justin Ainscough |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion YZ8, Justin Ainscough |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Keiji Tanimoto |
Allele Type: |
Transgenic |
|
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion del-5, Keiji Tanimoto |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion del-6, Keiji Tanimoto |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion del-2, Keiji Tanimoto |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion del-3, Keiji Tanimoto |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion del-4, Keiji Tanimoto |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion del-7, Keiji Tanimoto |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion del-8, Keiji Tanimoto |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion del-9, Keiji Tanimoto |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rr27/Rr27<+> |
Background: |
involves: 129S1/Sv |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ainscough JF |
Year: |
2000 |
Journal: |
Development |
Title: |
A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene. |
Volume: |
127 |
Issue: |
18 |
Pages: |
3923-30 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Cattanach BM |
Year: |
2000 |
Journal: |
Hum Mol Genet |
Title: |
Two imprinted gene mutations: three phenotypes. |
Volume: |
9 |
Issue: |
15 |
Pages: |
2263-73 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion YZ46, Justin Ainscough |
Allele Type: |
Transgenic |
Attribute String: |
Conditional ready, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion YZ20, Justin Ainscough |
Allele Type: |
Transgenic |
Attribute String: |
Conditional ready, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion YZ17, Justin Ainscough |
Allele Type: |
Transgenic |
Attribute String: |
Conditional ready, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Antonellis A |
Year: |
2006 |
Journal: |
Hum Mol Genet |
Title: |
Deletion of long-range sequences at Sox10 compromises developmental expression in a mouse model of Waardenburg-Shah (WS4) syndrome. |
Volume: |
15 |
Issue: |
2 |
Pages: |
259-71 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
H19/H19<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * SJL |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
H19/H19<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rr27/Rr27 Tg(CD2-cre)1Sriv/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ward A |
Year: |
1997 |
Journal: |
Genes Funct |
Title: |
Genomic regions regulating imprinting and insulin-like growth factor-II promoter 3 activity in transgenics: novel enhancer and silencer elements. |
Volume: |
1 |
Issue: |
1 |
Pages: |
25-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alders M |
Year: |
1997 |
Journal: |
Hum Mol Genet |
Title: |
The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts. |
Volume: |
6 |
Issue: |
6 |
Pages: |
859-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Benitez-Amaro A |
Year: |
2020 |
Journal: |
Metabolism |
Title: |
Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity. |
Volume: |
106 |
|
Pages: |
154191 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wise TL |
Year: |
2006 |
Journal: |
Cancer Res |
Title: |
Delayed onset of Igf2-induced mammary tumors in Igf2r transgenic mice. |
Volume: |
66 |
Issue: |
3 |
Pages: |
1327-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boogerd CJ |
Year: |
2018 |
Journal: |
Circ Res |
Title: |
Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. |
Volume: |
123 |
Issue: |
4 |
Pages: |
428-442 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rr27/Rr27<+> Tg(Tpbpa-cre,-EGFP)5Jcc/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rr27/Rr27 Tg(Ckmm-cre)5Khn/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * FVB |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Znhit1/Znhit1 Tg(Tnnt2-rtTA,tetO-cre)1Wtp/? |
Background: |
involves: C57BL/6 * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Smarcd3-cre/ERT2)#Bbr/? |
Background: |
involves: 129S4/SvJaeSor |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishihara K |
Year: |
2006 |
Journal: |
Mol Cell |
Title: |
CTCF-dependent chromatin insulator is linked to epigenetic remodeling. |
Volume: |
23 |
Issue: |
5 |
Pages: |
733-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang C |
Year: |
2020 |
Journal: |
Commun Biol |
Title: |
Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice. |
Volume: |
3 |
Issue: |
1 |
Pages: |
210 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li ZK |
Year: |
2018 |
Journal: |
Cell Stem Cell |
Title: |
Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. |
Volume: |
23 |
Issue: |
5 |
Pages: |
665-676.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kalscheuer VM |
Year: |
1993 |
Journal: |
Nat Genet |
Title: |
The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans. |
Volume: |
5 |
Issue: |
1 |
Pages: |
74-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Held WA |
Year: |
1994 |
Journal: |
Cancer Res |
Title: |
Genetic analysis of liver tumorigenesis in SV40 T antigen transgenic mice implies a role for imprinted genes. |
Volume: |
54 |
Issue: |
24 |
Pages: |
6489-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hatada I |
Year: |
1995 |
Journal: |
Nat Genet |
Title: |
Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor, in mouse. |
Volume: |
11 |
Issue: |
2 |
Pages: |
204-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyamoto T |
Year: |
1996 |
Journal: |
Cytogenet Cell Genet |
Title: |
Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2). |
Volume: |
73 |
Issue: |
4 |
Pages: |
312-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Spear BT |
Year: |
2006 |
Journal: |
Cell Mol Life Sci |
Title: |
Transcriptional control in the mammalian liver: liver development, perinatal repression, and zonal gene regulation. |
Volume: |
63 |
Issue: |
24 |
Pages: |
2922-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoon YS |
Year: |
2007 |
Journal: |
Mol Cell Biol |
Title: |
Analysis of the H19ICR insulator. |
Volume: |
27 |
Issue: |
9 |
Pages: |
3499-510 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gebert C |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
H19ICR mediated transcriptional silencing does not require target promoter methylation. |
Volume: |
476 |
Issue: |
3 |
Pages: |
121-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhong C |
Year: |
2015 |
Journal: |
Cell Stem Cell |
Title: |
CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA Library. |
Volume: |
17 |
Issue: |
2 |
Pages: |
221-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han Y |
Year: |
2024 |
Journal: |
Physiol Rep |
Title: |
Zbtb7b defines a compensatory mechanism in MASLD-related HCC progression by suppressing H19-mediated hepatic lipid deposition. |
Volume: |
12 |
Issue: |
24 |
Pages: |
e70160 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wise TL |
Year: |
2017 |
Journal: |
Genes Brain Behav |
Title: |
Changes in insulin-like growth factor signaling alter phenotypes in Fragile X Mice. |
Volume: |
16 |
Issue: |
2 |
Pages: |
241-249 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krup AL |
Year: |
2023 |
Journal: |
Development |
Title: |
A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors. |
Volume: |
150 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang W |
Year: |
2016 |
Journal: |
Circulation |
Title: |
Critical Roles of STAT3 in β-Adrenergic Functions in the Heart. |
Volume: |
133 |
Issue: |
1 |
Pages: |
48-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hubbi ME |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. |
Volume: |
111 |
Issue: |
32 |
Pages: |
E3325-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao K |
Year: |
2022 |
Journal: |
Development |
Title: |
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development. |
Volume: |
149 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Han P |
Year: |
2016 |
Journal: |
Biochim Biophys Acta |
Title: |
Epigenetic response to environmental stress: Assembly of BRG1-G9a/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts. |
Volume: |
1863 |
Issue: |
7 Pt B |
Pages: |
1772-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pravtcheva DD |
Year: |
2008 |
Journal: |
Mol Reprod Dev |
Title: |
Igf2r improves the survival and transmission ratio of Igf2 transgenic mice. |
Volume: |
75 |
Issue: |
11 |
Pages: |
1678-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han P |
Year: |
2014 |
Journal: |
Nature |
Title: |
A long noncoding RNA protects the heart from pathological hypertrophy. |
Volume: |
514 |
Issue: |
7520 |
Pages: |
102-106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu M |
Year: |
2021 |
Journal: |
Development |
Title: |
The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. |
Volume: |
148 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yu W |
Year: |
2016 |
Journal: |
Development |
Title: |
GATA4 regulates Fgf16 to promote heart repair after injury. |
Volume: |
143 |
Issue: |
6 |
Pages: |
936-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu H |
Year: |
2024 |
Journal: |
iScience |
Title: |
Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. |
Volume: |
27 |
Issue: |
1 |
Pages: |
108722 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang D |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
REST regulates the cell cycle for cardiac development and regeneration. |
Volume: |
8 |
Issue: |
1 |
Pages: |
1979 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Zfpm2/Zfpm2 Tg(Tnnt2-rtTA,tetO-cre)1Wtp/? |
Background: |
involves: 129S1/Sv * 129S7/SvEvBrd |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Smarcd3-cre/ERT2)#Bbr/? |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Igs2/Igs2<+> |
Background: |
involves: 129S4/SvJaeSor |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Igs2/Igs2<+> |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Igs2/Igs2<+> |
Background: |
involves: 129P2/OlaHsd |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
692
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gonsalvez GB |
Year: |
2007 |
Journal: |
J Cell Biol |
Title: |
Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. |
Volume: |
178 |
Issue: |
5 |
Pages: |
733-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Durcova-Hills G |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Influence of sex chromosome constitution on the genomic imprinting of germ cells. |
Volume: |
103 |
Issue: |
30 |
Pages: |
11184-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Constância M |
Year: |
2000 |
Journal: |
Nat Genet |
Title: |
Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19. |
Volume: |
26 |
Issue: |
2 |
Pages: |
203-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanimoto K |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Genomic imprinting recapitulated in the human beta-globin locus. |
Volume: |
102 |
Issue: |
29 |
Pages: |
10250-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tucker KL |
Year: |
1996 |
Journal: |
Genes Dev |
Title: |
Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. |
Volume: |
10 |
Issue: |
8 |
Pages: |
1008-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Linhart HG |
Year: |
2009 |
Journal: |
Gastroenterology |
Title: |
Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations. |
Volume: |
136 |
Issue: |
1 |
Pages: |
227-235.e3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohta K |
Year: |
2012 |
Journal: |
Biol Reprod |
Title: |
Male differentiation of germ cells induced by embryonic age-specific Sertoli cells in mice. |
Volume: |
86 |
Issue: |
4 |
Pages: |
112 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fertan E |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1-42 in Alzheimer's disease. |
Volume: |
13 |
Issue: |
1 |
Pages: |
2043 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song JY |
Year: |
2011 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Retrotransposon-specific DNA hypomethylation and two-step loss-of-imprinting during WW45 haploinsufficiency-induced hepatocarcinogenesis. |
Volume: |
404 |
Issue: |
2 |
Pages: |
728-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang D |
Year: |
2017 |
Journal: |
Cancer Res |
Title: |
Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade. |
Volume: |
77 |
Issue: |
18 |
Pages: |
4773-4784 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura T |
Year: |
2015 |
Journal: |
Stem Cells |
Title: |
Pluripotent stem cells derived from mouse primordial germ cells by small molecule compounds. |
Volume: |
33 |
Issue: |
1 |
Pages: |
45-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishihara K |
Year: |
2002 |
Journal: |
Hum Mol Genet |
Title: |
An evolutionarily conserved putative insulator element near the 3' boundary of the imprinted Igf2/H19 domain. |
Volume: |
11 |
Issue: |
14 |
Pages: |
1627-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hiura H |
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