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Search results 1301 to 1384 out of 1384 for Id2

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Type Details Score
Interaction Experiment
Liu J (2000)
Description: A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function.
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Interaction Experiment
Ferrer-Vicens I (2014)
Description: In vivo genome-wide binding of Id2 to E2F4 target genes as part of a reversible program in mice liver.
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Allele
Id2<em2Smoc> | MGI:7264559
Name: inhibitor of DNA binding 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Id2<em1(cre/ERT2)Smoc> | MGI:6724579
Name: inhibitor of DNA binding 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Strain
MGI:6475529 | C57BL/6JSmoc-Id2<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
10891368 | -
First Author: Liu J
Year: 2000
Journal: Biochem Biophys Res Commun
Title: A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function.
Volume: 273
Issue: 3
Pages: 1042-7
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Strain
MGI:6428881 | C57BL/6JSmoc-Id2<em1(cre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Gt(ROSA)26Sor<em1(CAG-Id2,-EGFP)Rbrc> | MGI:6780027
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, RIKEN BioResource Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, Inserted expressed sequence, No functional change, Reporter
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Publication
24573694 | -
First Author: Ferrer-Vicens I
Year: 2014
Journal: Cell Mol Life Sci
Title: In vivo genome-wide binding of Id2 to E2F4 target genes as part of a reversible program in mice liver.
Volume: 71
Issue: 18
Pages: 3583-97
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HT Experiment
GSE64779 | A genetic circuitry linking Id-proteins (Id2 and Id3) and the AKT-FOXO-mTORC1 axis to suppress innate-variant TFH cell development, maintain T cell quiescence and prevent lymphomagenesis.
Series Id: E-GEOD-64779
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Id2<em1Smoc> | MGI:7290304
Name: inhibitor of DNA binding 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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HT Experiment
E-GEOD-59360 | Whole gene expression data from Gfi-1-/- and Gfi-1-/-;Id2+/- mouse bone marrow cells
Series Id: GSE59360
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Id2<tm1.1(cre/ERT2)Blh> | MGI:4398923
Name: inhibitor of DNA binding 2; targeted mutation 1.1, Brigid L Hogan
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Allele
Id2<tm2.1Blh> | MGI:4398924
Name: inhibitor of DNA binding 2; targeted mutation 2.1, Brigid L Hogan
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Tg(Id2-EGFP)NW236Gsat | MGI:4940630
Name: transgene insertion NW236, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:4949513 | B6.129S(Cg)-Id2<tm1.1(cre/ERT2)Blh>/ZhuJ
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:4949514 | B6.129S(Cg)-Id2<tm2.1Blh>/ZhuJ
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:5004307 | STOCK Tg(Id2-EGFP)NW236Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Id2/Id2<+>
Background: involves: 129S/SvEv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Id2/Id2<+>
Background: involves: 129S/SvEv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Id2/Id2<+>
Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
23812095 | J:205723
First Author: Nechanitzky R
Year: 2013
Journal: Nat Immunol
Title: Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells.
Volume: 14
Issue: 8
Pages: 867-75
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Publication
25964371 | J:224616
First Author: Yu Y
Year: 2015
Journal: J Exp Med
Title: The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.
Volume: 212
Issue: 6
Pages: 865-74
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Publication
35138904 | J:326041
First Author: Jiao A
Year: 2022
Journal: Sci Adv
Title: DExD/H-box helicase 9 intrinsically controls CD8+ T cell-mediated antiviral response through noncanonical mechanisms.
Volume: 8
Issue: 6
Pages: eabk2691
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Publication
28930659 | J:258967
First Author: Mowel WK
Year: 2017
Journal: Immunity
Title: Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.
Volume: 47
Issue: 3
Pages: 435-449.e8
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Publication
31396572 | J:278091
 
First Author: Yamamoto M
Year: 2019
Journal: Commun Biol
Title: TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion.
Volume: 2
Pages: 292
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Publication
27612641 | J:259932
First Author: Ettersperger J
Year: 2016
Journal: Immunity
Title: Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease.
Volume: 45
Issue: 3
Pages: 610-625
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Publication
29103804 | J:256130
First Author: Petersen MA
Year: 2017
Journal: Neuron
Title: Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.
Volume: 96
Issue: 5
Pages: 1003-1012.e7
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Publication
8001126 | J:21936
First Author: Sun XH
Year: 1994
Journal: Cell
Title: Constitutive expression of the Id1 gene impairs mouse B cell development.
Volume: 79
Issue: 5
Pages: 893-900
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Publication
27114303 | J:235395
First Author: Nakatani M
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Scaffold protein enigma homolog 1 overcomes the repression of myogenesis activation by inhibitor of DNA binding 2.
Volume: 474
Issue: 2
Pages: 413-420
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Publication
30926235 | J:279184
First Author: Xu W
Year: 2019
Journal: Immunity
Title: An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Volume: 50
Issue: 4
Pages: 1054-1068.e3
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Publication
33761313 | J:305909
First Author: He Y
Year: 2021
Journal: Cell Metab
Title: Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity.
Volume: 33
Issue: 5
Pages: 988-1000.e7
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Publication
9726234 | J:49410
First Author: Vicent D
Year: 1998
Journal: Diabetes
Title: Alterations in skeletal muscle gene expression of ob/ob mice by mRNA differential display.
Volume: 47
Issue: 9
Pages: 1451-8
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Publication
30814306 | J:274339
First Author: Millan AJ
Year: 2019
Journal: J Immunol
Title: Sostdc1 Regulates NK Cell Maturation and Cytotoxicity.
Volume: 202
Issue: 8
Pages: 2296-2306
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Publication
18988671 | J:158091
First Author: Aupperlee MD
Year: 2009
Journal: Endocrinology
Title: Strain-specific differences in the mechanisms of progesterone regulation of murine mammary gland development.
Volume: 150
Issue: 3
Pages: 1485-94
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Publication
27069114 | J:233317
First Author: Zook EC
Year: 2016
Journal: J Exp Med
Title: The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2.
Volume: 213
Issue: 5
Pages: 687-96
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Publication
11818069 | J:73917
First Author: Tsai KY
Year: 2002
Journal: Curr Biol
Title: ARF is not required for apoptosis in Rb mutant mouse embryos.
Volume: 12
Issue: 2
Pages: 159-63
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Publication
24509713 | J:205609
First Author: Constantinides MG
Year: 2014
Journal: Nature
Title: A committed precursor to innate lymphoid cells.
Volume: 508
Issue: 7496
Pages: 397-401
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Publication
10391928 | J:56303
First Author: Hollnagel A
Year: 1999
Journal: J Biol Chem
Title: Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells.
Volume: 274
Issue: 28
Pages: 19838-45
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Publication
27492138 | J:250147
 
First Author: Araki M
Year: 2016
Journal: Sci Rep
Title: Conditional Deletion of Smad1 Ameliorates Glomerular Injury in Progressive Glomerulonephritis.
Volume: 6
Pages: 31216
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Publication
17311813 | J:121663
First Author: Nair M
Year: 2007
Journal: Nucleic Acids Res
Title: Ovol1 represses its own transcription by competing with transcription activator c-Myb and by recruiting histone deacetylase activity.
Volume: 35
Issue: 5
Pages: 1687-97
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Publication
27485735 | J:250162
 
First Author: Lee J
Year: 2016
Journal: Sci Rep
Title: STAT5 is a key transcription factor for IL-3-mediated inhibition of RANKL-induced osteoclastogenesis.
Volume: 6
Pages: 30977
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Publication
24591644 | J:207383
First Author: Ippolito GC
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Dendritic cell fate is determined by BCL11A.
Volume: 111
Issue: 11
Pages: E998-1006
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Publication
18384878 | J:136143
First Author: Wikström I
Year: 2008
Journal: Mol Immunol
Title: A role for E2-2 at the DN3 stage of early thymopoiesis.
Volume: 45
Issue: 11
Pages: 3302-11
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Publication
21189289 | J:169181
First Author: Braunstein M
Year: 2011
Journal: Mol Cell Biol
Title: HEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation.
Volume: 31
Issue: 5
Pages: 971-82
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Publication
18641300 | J:137876
First Author: Zhang XK
Year: 2008
Journal: J Immunol
Title: The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice.
Volume: 181
Issue: 3
Pages: 1644-54
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Publication
22065991 | J:178066
First Author: Edelson BT
Year: 2011
Journal: PLoS One
Title: Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.
Volume: 6
Issue: 10
Pages: e25660
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Publication
23691170 | J:202169
First Author: Khandelwal P
Year: 2013
Journal: PLoS One
Title: Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses.
Volume: 8
Issue: 5
Pages: e64193
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Publication
24866916 | J:215340
First Author: Kibschull M
Year: 2014
Journal: Stem Cells Dev
Title: Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development.
Volume: 23
Issue: 21
Pages: 2649-60
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Publication
23752615 | J:204823
First Author: Zhang P
Year: 2013
Journal: J Immunol
Title: Notch-regulated periphery B cell differentiation involves suppression of E protein function.
Volume: 191
Issue: 2
Pages: 726-36
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Publication
31024568 | J:281803
 
First Author: Zhang X
Year: 2019
Journal: Front Immunol
Title: Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector Function.
Volume: 10
Pages: 744
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Publication
19961844 | J:156721
First Author: Alfieri CM
Year: 2010
Journal: Dev Biol
Title: Wnt signaling in heart valve development and osteogenic gene induction.
Volume: 338
Issue: 2
Pages: 127-35
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Publication
24603907 | J:219130
First Author: Hao J
Year: 2014
Journal: PLoS One
Title: DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer.
Volume: 9
Issue: 6
Pages: e90748
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Publication
7769987 | J:23288
First Author: Chiaramello A
Year: 1995
Journal: Brain Res Mol Brain Res
Title: Differential expression and distinct DNA-binding specificity of ME1a and ME2 suggest a unique role during differentiation and neuronal plasticity.
Volume: 29
Issue: 1
Pages: 107-18
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Publication
15530557 | J:94095
 
First Author: de Candia P
Year: 2004
Journal: Adv Cancer Res
Title: A role for Id proteins in mammary gland physiology and tumorigenesis.
Volume: 92
Pages: 81-94
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Publication
16820005 | J:112162
First Author: Hisaoka T
Year: 2006
Journal: Eur J Neurosci
Title: Characterization of TROY-expressing cells in the developing and postnatal CNS: the possible role in neuronal and glial cell development.
Volume: 23
Issue: 12
Pages: 3149-60
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Publication
17615296 | J:128302
First Author: Shirakihara T
Year: 2007
Journal: Mol Biol Cell
Title: Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta.
Volume: 18
Issue: 9
Pages: 3533-44
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Publication
25969143 | J:222937
First Author: Matsumoto T
Year: 2015
Journal: Carcinogenesis
Title: Hepatic inflammation facilitates transcription-associated mutagenesis via AID activity and enhances liver tumorigenesis.
Volume: 36
Issue: 8
Pages: 904-13
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Publication
26951930 | J:231774
First Author: Rahme GJ
Year: 2016
Journal: Cancer Res
Title: PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-Mediated Survival of Proneural Glioma Cells.
Volume: 76
Issue: 10
Pages: 2964-76
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Publication
33432227 | J:305262
First Author: Ferreira ACF
Year: 2021
Journal: Nat Immunol
Title: RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus.
Volume: 22
Issue: 2
Pages: 166-178
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Publication
34968772 | J:319778
 
First Author: Chauhan KS
Year: 2022
Journal: Cell Immunol
Title: IRF8 and BATF3 interaction enhances the cDC1 specific Pfkfb3 gene expression.
Volume: 371
Pages: 104468
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Publication
39838296 | J:361575
First Author: He Z
Year: 2025
Journal: BMC Genomics
Title: Transcriptomic dynamics and cell-to-cell communication during the transition of prospermatogonia to spermatogonia revealed at single-cell resolution.
Volume: 26
Issue: 1
Pages: 58
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Publication
11751402 | J:73360
First Author: Wilson JW
Year: 2001
Journal: Cancer Res
Title: Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index.
Volume: 61
Issue: 24
Pages: 8803-10
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Publication
21454537 | J:172682
First Author: Hao F
Year: 2011
Journal: J Biol Chem
Title: Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium.
Volume: 286
Issue: 20
Pages: 18104-17
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Publication
34502541 | J:313818
 
First Author: Duffield GE
Year: 2021
Journal: Int J Mol Sci
Title: Targeted Disruption of the Inhibitor of DNA Binding 4 (Id4) Gene Alters Photic Entrainment of the Circadian Clock.
Volume: 22
Issue: 17
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Publication
24586788 | J:213825
First Author: Townley-Tilson WH
Year: 2014
Journal: PLoS One
Title: The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2.
Volume: 9
Issue: 2
Pages: e89451
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Publication
19104664 | J:144354
First Author: Bordon A
Year: 2008
Journal: PLoS One
Title: Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development.
Volume: 3
Issue: 12
Pages: e4007
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Publication
30995255 | J:274632
First Author: Nguyen TM
Year: 2019
Journal: PLoS One
Title: The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs.
Volume: 14
Issue: 4
Pages: e0214793
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Publication
12590144 | -
First Author: Wissmann R
Year: 2003
Journal: J Biol Chem
Title: Solution structure and function of the "tandem inactivation domain" of the neuronal A-type potassium channel Kv1.4.
Volume: 278
Issue: 18
Pages: 16142-50
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Protein Domain
IPR012897 | K_chnl_volt-dep_Kv1.4_TID
Type: Domain
Description: Potassium channels are the most diverse group of the ion channel family [, ]. They are important in shaping the action potential, and in neuronal excitability and plasticity []. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups []: the practically non-inactivating 'delayed' group and the rapidly inactivating 'transient' group.These are all highly similar proteins, with only small amino acid changes causing the diversity of the voltage-dependent gating mechanism, channel conductance and toxin binding properties. Each type of K+channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter, together with intracellular kinases; while others are regulated by GTP-binding proteins or other second messengers []. In eukaryotic cells, K+channels are involved in neural signalling and generation of the cardiac rhythm, act as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes []. In prokaryotic cells, they play a role in the maintenance of ionic homeostasis [].All K+channels discovered so far possess a core of alpha subunits, each comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG), which has been termed the K+selectivity sequence. In families that contain one P-domain, four subunits assemble to form a selective pathway for K+across the membrane. However, it remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+channels; and three types of calcium (Ca)-activated K+channels (BK, IK and SK) []. The 2TM domain family comprises inward-rectifying K+channels. In addition, there are K+channel alpha-subunits that possess two P-domains. These are usually highly regulated K+selective leak channels.The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic TM domains with a P-domain between the fifth and sixth, which partially resides in the membrane. The fourth TM domain has positively charged residues at every third residue and acts as a voltage sensor, which triggers the conformational change that opens the channel pore in response to a displacement in membrane potential []. More recently, 4 new electrically-silent alpha subunits have been cloned: Kv5 (KCNF), Kv6 (KCNG), Kv8 and Kv9 (KCNS). These subunits do not themselves possess any functional activity, but appear to form heteromeric channels with Kv2 subunits, and thus modulate Shab channel activity []. When highly expressed, they inhibit channel activity, but at lower levels show more specific modulatory actions.The first Kv1 sequence (also known as Shaker) was found in Drosophila melanogaster (Fruit fly). Several vertebrate potassium channels with similar amino acid sequences were subsequently found and, together with the D. melanogaster Shaker channel, now constitute the Kv1 family. The family consists of at least 6 genes (Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5 and Kv1.6) which each play distinct physiological roles. A conserved motif found towards the C terminus of these channels is required for efficient processing and surface expression []. Variations in this motif account for the differences in cell surface expression and localisation between family members. These channels are mostly expressed in the brain, but can also be found in non-excitable cells, such as lymphocytes []. This entry features the tandem inactivation domain found at the N terminus of the Kv1.4 potassium channel. It is composed of two subdomains. Inactivation domain 1 (ID1, residues 1-38) consists of a flexible N terminus anchored at a 5-turn helix, and is thought to work by occluding the ion pathway, as is the case with a classical ball domain. Inactivation domain 2 (ID2, residues 40-50) is a 2.5 turn helix with a high proportion of hydrophobic residues that probably serves to attach ID1 to the cytoplasmic face of the channel. In this way, it can promote rapid access of ID1 to the receptor site in the open channel. ID1 and ID2 function together to bring about fast inactivation of the Kv1.4 channel, which is important for the role of the channel in short-term plasticity [].
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Protein Domain
IPR037065 | K_chnl_volt-dep_Kv1.4_TID_sf
Type: Homologous_superfamily
Description: Potassium channels are the most diverse group of the ion channel family [, ]. They are important in shaping the action potential, and in neuronal excitability and plasticity []. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups []: the practically non-inactivating 'delayed' group and the rapidly inactivating 'transient' group.These are all highly similar proteins, with only small amino acid changes causing the diversity of the voltage-dependent gating mechanism, channel conductance and toxin binding properties. Each type of K+channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter, together with intracellular kinases; while others are regulated by GTP-binding proteins or other second messengers []. In eukaryotic cells, K+channels are involved in neural signalling and generation of the cardiac rhythm, act as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes []. In prokaryotic cells, they play a role in the maintenance of ionic homeostasis [].All K+channels discovered so far possess a core of alpha subunits, each comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG), which has been termed the K+selectivity sequence. In families that contain one P-domain, four subunits assemble to form a selective pathway for K+across the membrane. However, it remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+channels; and three types of calcium (Ca)-activated K+channels (BK, IK and SK) []. The 2TM domain family comprises inward-rectifying K+channels. In addition, there are K+channel alpha-subunits that possess two P-domains. These are usually highly regulated K+selective leak channels.The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic TM domains with a P-domain between the fifth and sixth, which partially resides in the membrane. The fourth TM domain has positively charged residues at every third residue and acts as a voltage sensor, which triggers the conformational change that opens the channel pore in response to a displacement in membrane potential []. More recently, 4 new electrically-silent alpha subunits have been cloned: Kv5 (KCNF), Kv6 (KCNG), Kv8 and Kv9 (KCNS). These subunits do not themselves possess any functional activity, but appear to form heteromeric channels with Kv2 subunits, and thus modulate Shab channel activity []. When highly expressed, they inhibit channel activity, but at lower levels show more specific modulatory actions.The first Kv1 sequence (also known as Shaker) was found in Drosophila melanogaster (Fruit fly). Several vertebrate potassium channels with similar amino acid sequences were subsequently found and, together with the D. melanogaster Shaker channel, now constitute the Kv1 family. The family consists of at least 6 genes (Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5 and Kv1.6) which each play distinct physiological roles. A conserved motif found towards the C terminus of these channels is required for efficient processing and surface expression []. Variations in this motif account for the differences in cell surface expression and localisation between family members. These channels are mostly expressed in the brain, but can also be found in non-excitable cells, such as lymphocytes []. This entry features the tandem inactivation domain superfamily found at the N terminus of the Kv1.4 potassium channel. It is composed of two subdomains. Inactivation domain 1 (ID1, residues 1-38) consists of a flexible N terminus anchored at a 5-turn helix, and is thought to work by occluding the ion pathway, as is the case with a classical ball domain. Inactivation domain 2 (ID2, residues 40-50) is a 2.5 turn helix with a high proportion of hydrophobic residues that probably serves to attach ID1 to the cytoplasmic face of the channel. In this way, it can promote rapid access of ID1 to the receptor site in the open channel. ID1 and ID2 function together to bring about fast inactivation of the Kv1.4 channel, which is important for the role of the channel in short-term plasticity [].
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Protein
Q61423
Organism: Mus musculus/domesticus
Length: 654  
Fragment?: false
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Publication
11343973 | -
First Author: Levitan ES
Year: 2000
Journal: Trends Cardiovasc Med
Title: Surface expression of Kv1 voltage-gated K+ channels is governed by a C-terminal motif.
Volume: 10
Issue: 7
Pages: 317-20
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Publication
10798390 | -
First Author: Littleton JT
Year: 2000
Journal: Neuron
Title: Ion channels and synaptic organization: analysis of the Drosophila genome.
Volume: 26
Issue: 1
Pages: 35-43
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Publication
9305895 | J:43210
First Author: Salinas M
Year: 1997
Journal: J Biol Chem
Title: New modulatory alpha subunits for mammalian Shab K+ channels.
Volume: 272
Issue: 39
Pages: 24371-9
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Publication
10712896 | -
First Author: Sansom MS
Year: 2000
Journal: Curr Biol
Title: Potassium channels: watching a voltage-sensor tilt and twist.
Volume: 10
Issue: 5
Pages: R206-9
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Publication
2451788 | J:9129
First Author: Tempel BL
Year: 1988
Journal: Nature
Title: Cloning of a probable potassium channel gene from mouse brain.
Volume: 332
Issue: 6167
Pages: 837-9
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Publication
1772658 | -
First Author: Perney TM
Year: 1991
Journal: Curr Opin Cell Biol
Title: The molecular biology of K+ channels.
Volume: 3
Issue: 4
Pages: 663-70
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Publication
1879548 | -
First Author: Luneau C
Year: 1991
Journal: FEBS Lett
Title: Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.
Volume: 288
Issue: 1-2
Pages: 163-7
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Publication
1373731 | J:931
First Author: Attali B
Year: 1992
Journal: J Biol Chem
Title: Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.
Volume: 267
Issue: 12
Pages: 8650-7
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Publication
2448635 | -
First Author: Schwarz TL
Year: 1988
Journal: Nature
Title: Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.
Volume: 331
Issue: 6152
Pages: 137-42
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Publication
2555158 | -
First Author: Stühmer W
Year: 1989
Journal: EMBO J
Title: Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.
Volume: 8
Issue: 11
Pages: 3235-44
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Publication
11178249 | -
First Author: Miller C
Year: 2000
Journal: Genome Biol
Title: An overview of the potassium channel family.
Volume: 1
Issue: 4
Pages: REVIEWS0004
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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