|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1301 to 1400 out of 1845 for Igf1

<< First    < Previous  |  Next >    Last >>
0.024s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Allele
Igfdq1<C57BL/6J> | MGI:6111742
 
Name: Igf1 levels in DDD, QTL 1; C57BL/6J
Allele Type: QTL
•
•
•
•
•
Allele
Igfdq2<C57BL/6J> | MGI:6111743
 
Name: Igf1 levels in DDD, QTL 2; C57BL/6J
Allele Type: QTL
•
•
•
•
•
Allele
Igfdq3<C57BL/6J> | MGI:6111744
 
Name: Igf1 levels in DDD, QTL 3; C57BL/6J
Allele Type: QTL
•
•
•
•
•
Allele
Igfdq1<DDD/SgnRbrc> | MGI:6111748
 
Name: Igf1 levels in DDD, QTL 1; DDD/SgnRbrc
Allele Type: QTL
•
•
•
•
•
Allele
Igfdq2<DDD/SgnRbrc> | MGI:6111749
 
Name: Igf1 levels in DDD, QTL 2; DDD/SgnRbrc
Allele Type: QTL
•
•
•
•
•
Allele
Igfdq3<DDD/SgnRbrc> | MGI:6111750
 
Name: Igf1 levels in DDD, QTL 3; DDD/SgnRbrc
Allele Type: QTL
•
•
•
•
•
Publication
25676570 | J:221499
 
First Author: Skarra DV
Year: 2015
Journal: Mol Cell Endocrinol
Title: FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes.
Volume: 405
Pages: 14-24
•
•
•
•
•
HT Experiment
E-GEOD-17157 | Expression data from E18.5 Igf1 -/- (homozygous mutant) and Igf1+/+ (normal wild type control) mouse lungs
Series Id: GSE17157
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Publication
28330997 | J:243129
First Author: Wang YA
Year: 2017
Journal: Mol Cancer Res
Title: IGFBP3 Modulates Lung Tumorigenesis and Cell Growth through IGF1 Signaling.
Volume: 15
Issue: 7
Pages: 896-904
•
•
•
•
•
Publication
32078587 | J:301919
 
First Author: Miyagawa K
Year: 2020
Journal: JCI Insight
Title: Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo.
Volume: 5
Issue: 6
•
•
•
•
•
MP Term
MP:0008831 | abnormal insulin-like growth factor I level
•
•
•
•
•
Publication
28817801 | J:253232
First Author: Liu Y
Year: 2017
Journal: Neuron
Title: A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions.
Volume: 95
Issue: 4
Pages: 817-833.e4
•
•
•
•
•
HT Experiment
E-GEOD-11844 | Transcription profiling of mouse Igf1 null mutant
Series Id: GSE11844
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Publication
26010009 | J:224776
First Author: Hu L
Year: 2015
Journal: Stem Cells
Title: IGF1 Promotes Adipogenesis by a Lineage Bias of Endogenous Adipose Stem/Progenitor Cells.
Volume: 33
Issue: 8
Pages: 2483-95
•
•
•
•
•
Publication
34039634 | J:308177
First Author: Matsushita M
Year: 2021
Journal: Cancer Res
Title: Gut Microbiota-Derived Short-Chain Fatty Acids Promote Prostate Cancer Growth via IGF1 Signaling.
Volume: 81
Issue: 15
Pages: 4014-4026
•
•
•
•
•
Publication
35626664 | J:354837
 
First Author: Sarfstein R
Year: 2022
Journal: Cells
Title: Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action.
Volume: 11
Issue: 10
•
•
•
•
•
Publication
39448593 | J:361540
First Author: Escribano-Núñez A
Year: 2024
Journal: Nat Commun
Title: IGF1 drives Wnt-induced joint damage and is a potential therapeutic target for osteoarthritis.
Volume: 15
Issue: 1
Pages: 9170
•
•
•
•
•
Publication
24958891 | J:212165
First Author: Castro J
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome.
Volume: 111
Issue: 27
Pages: 9941-6
•
•
•
•
•
Publication
29401624 | J:273822
First Author: Neirijnck Y
Year: 2018
Journal: FASEB J
Title: Insulin and IGF1 receptors are essential for the development and steroidogenic function of adult Leydig cells.
Volume: 32
Issue: 6
Pages: 3321-3335
•
•
•
•
•
Publication
29339473 | J:257760
First Author: Nagaraj K
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action.
Volume: 115
Issue: 5
Pages: 1045-1050
•
•
•
•
•
Publication
32857104 | J:310253
First Author: Sidhom S
Year: 2021
Journal: J Gerontol A Biol Sci Med Sci
Title: 17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner.
Volume: 76
Issue: 5
Pages: 778-785
•
•
•
•
•
MP Term
MP:0004700 | abnormal circulating insulin-like growth factor I level
•
•
•
•
•
Publication
24548465 | J:219044
 
First Author: Matz-Soja M
Year: 2014
Journal: Cell Commun Signal
Title: Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels.
Volume: 12
Pages: 11
•
•
•
•
•
HT Experiment
GSE164969 | Elucidating oncogenic effects of androgen signaling in prostate tumorigenesis through aberrant activation of IGF1 and WNT signaling pathways [scRNA-Seq 1]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
•
•
•
•
•
Publication
35722884 | J:334623
First Author: Thomas SS
Year: 2022
Journal: Circ Res
Title: SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.
Volume: 131
Issue: 3
Pages: 207-221
•
•
•
•
•
Publication
35902588 | J:327072
First Author: Kim WK
Year: 2022
Journal: Nat Commun
Title: Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes.
Volume: 13
Issue: 1
Pages: 4364
•
•
•
•
•
Publication
23454899 | J:200122
First Author: Molina-Arcas M
Year: 2013
Journal: Cancer Discov
Title: Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer.
Volume: 3
Issue: 5
Pages: 548-63
•
•
•
•
•
Publication
11923875 | J:76208
First Author: Kulkarni RN
Year: 2002
Journal: Nat Genet
Title: beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.
Volume: 31
Issue: 1
Pages: 111-5
•
•
•
•
•
Publication
29294332 | J:257476
 
First Author: Ji Y
Year: 2018
Journal: Neurosci Lett
Title: IGF1 affects macrophage invasion and activation and TNF-α production in the sciatic nerves of female SOD1G93A mice.
Volume: 668
Pages: 1-6
•
•
•
•
•
Publication
36450880 | J:331814
First Author: Xiao L
Year: 2022
Journal: Sci Rep
Title: Bone loss is ameliorated by fecal microbiota transplantation through SCFA/GPR41/ IGF1 pathway in sickle cell disease mice.
Volume: 12
Issue: 1
Pages: 20638
•
•
•
•
•
Publication
35557964 | J:327279
 
First Author: Hoffmann CJ
Year: 2022
Journal: Front Physiol
Title: Zfp580 Regulates Paracrine and Endocrine Igf1 and Igfbp3 Differently in the Brain and Blood After a Murine Stroke.
Volume: 13
Pages: 887180
•
•
•
•
•
Publication
31967391 | J:285888
First Author: Li Z
Year: 2020
Journal: Aging Cell
Title: A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice.
Volume: 19
Issue: 3
Pages: e13104
•
•
•
•
•
Publication
23518924 | J:283285
First Author: Pitetti JL
Year: 2013
Journal: Mol Endocrinol
Title: An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.
Volume: 27
Issue: 5
Pages: 814-27
•
•
•
•
•
Publication
25502173 | J:286123
First Author: Babey M
Year: 2015
Journal: J Bone Miner Res
Title: Gender-Specific Differences in the Skeletal Response to Continuous PTH in Mice Lacking the IGF1 Receptor in Mature Osteoblasts.
Volume: 30
Issue: 6
Pages: 1064-76
•
•
•
•
•
Publication
28249168 | J:256196
First Author: Rajbhandari N
Year: 2017
Journal: Cell Rep
Title: Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers.
Volume: 18
Issue: 9
Pages: 2243-2255
•
•
•
•
•
Publication
1371961 | J:1810
First Author: Surmacz E
Year: 1992
Journal: Exp Cell Res
Title: The role of the IGF1 receptor in the regulation of cdc2 mRNA levels in fibroblasts.
Volume: 199
Issue: 2
Pages: 275-8
•
•
•
•
•
Transgene
MGI:3630333 | Tg(Myh6-IGF1)34Pia
Type: transgene
Organism: mouse, laboratory
•
•
•
•
•
Publication
9714752 | J:49165
First Author: Ruyter-Spira CP
Year: 1998
Journal: Biochim Biophys Acta
Title: Nucleotide sequence of the chicken HMGI-C cDNA and expression of the HMGI-C and IGF1 genes in autosomal dwarf chicken embryos.
Volume: 1399
Issue: 1
Pages: 83-7
•
•
•
•
•
Publication
23300479 | J:197599
First Author: Pitetti JL
Year: 2013
Journal: PLoS Genet
Title: Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice.
Volume: 9
Issue: 1
Pages: e1003160
•
•
•
•
•
Publication
30509997 | J:268948
First Author: Andersson KME
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Inflammation in the hippocampus affects IGF1 receptor signaling and contributes to neurological sequelae in rheumatoid arthritis.
Volume: 115
Issue: 51
Pages: E12063-E12072
•
•
•
•
•
Interaction Experiment
Shi J (2011)
Description: The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.
•
•
•
•
•
Publication
31881377 | J:299839
 
First Author: Wang X
Year: 2020
Journal: Int Immunopharmacol
Title: Up-regulation of miR-365 promotes the apoptosis and restrains proliferation of synoviocytes through downregulation of IGF1 and the inactivation of the PI3K/AKT/mTOR pathway in mice with rheumatoid arthritis.
Volume: 79
Pages: 106067
•
•
•
•
•
Publication
22033112 | -
First Author: Shi J
Year: 2011
Journal: Dev Cell
Title: The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.
Volume: 21
Issue: 5
Pages: 835-47
•
•
•
•
•
Publication
21566652 | J:174570
First Author: Kucia M
Year: 2011
Journal: Leukemia
Title: Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging.
Volume: 25
Issue: 8
Pages: 1370-4
•
•
•
•
•
Allele
Tg(IGF1)1Jdg | MGI:1926378
Name: transgene insertion 1, John DiGiovanni
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Allele
Tg(Igf1)1Hys | MGI:1926377
Name: transgene insertion 1, Hung-Yi Su
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Publication
16099410 | -
First Author: Abmayr S
Year: 2005
Journal: Mol Ther
Title: Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery.
Volume: 12
Issue: 3
Pages: 441-50
•
•
•
•
•
Publication
16239216 | -
First Author: Staerk J
Year: 2005
Journal: J Biol Chem
Title: JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.
Volume: 280
Issue: 51
Pages: 41893-9
•
•
•
•
•
Allele
Igf1<em1Smoc> | MGI:7290351
Name: insulin-like growth factor 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Igf1)1Hys/?
Background: Swiss
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(IGF1)1Jdg/?
Background: involves: FVB * ICR
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Allele
Tg(Ins1-Igf1)1Fbos | MGI:7265012
Name: transgene insertion 1, Fatima Bosch
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Allele
Tg(Igf1-cre)PY2Gsat | MGI:5086201
Name: transgene insertion PY2, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
•
•
•
•
•
Allele
Tg(Myh6-Igf)F018Nros | MGI:5638553
Name: transgene insertion F018, Nadia Rosenthal
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Publication
15085194 | J:89214
First Author: Ruberte J
Year: 2004
Journal: J Clin Invest
Title: Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.
Volume: 113
Issue: 8
Pages: 1149-57
•
•
•
•
•
Strain
MGI:6475547 | C57BL/6JSmoc-Igf1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Allele
Tg(ACTA1-IGF1)1Rjs | MGI:3630335
Name: transgene insertion 1, Robert J Schwartz
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Allele
Tg(TTR-Igf1)1Jxu | MGI:3771966
Name: transgene insertion 1, Jianming Xu
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Strain
MGI:5523195 | STOCK Tg(Igf1-cre)PY2Gsat/Mmucd
Attribute String: mutant stock, transgenic
•
•
•
•
•
HT Experiment
E-GEOD-51866 | Gene expression data for liver, adipose, and skeletal muscle tissues of MKR and Healthy mice
Series Id: GSE51866
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
•
•
•
•
•
Publication
11282895 | J:114062
First Author: Yamashita K
Year: 2001
Journal: Circ Res
Title: Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1.
Volume: 88
Issue: 6
Pages: 609-14
•
•
•
•
•
Publication
12528713 | J:127928
First Author: Fiorotto ML
Year: 2003
Journal: FASEB J
Title: Persistent IGF-I overexpression in skeletal muscle transiently enhances DNA accretion and growth.
Volume: 17
Issue: 1
Pages: 59-60
•
•
•
•
•
Publication
12424223 | J:127934
First Author: Rabinovsky ED
Year: 2003
Journal: FASEB J
Title: Targeted expression of IGF-1 transgene to skeletal muscle accelerates muscle and motor neuron regeneration.
Volume: 17
Issue: 1
Pages: 53-5
•
•
•
•
•
Publication
17174053 | J:123196
First Author: Payne AM
Year: 2007
Journal: Exp Gerontol
Title: Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice.
Volume: 42
Issue: 4
Pages: 309-19
•
•
•
•
•
Publication
12937290 | J:133811
First Author: Gonzalez E
Year: 2003
Journal: J Physiol
Title: Insulin-like growth factor-1 prevents age-related decrease in specific force and intracellular Ca2+ in single intact muscle fibres from transgenic mice.
Volume: 552
Issue: Pt 3
Pages: 833-44
•
•
•
•
•
Strain
MGI:3639124 | FVB/N-Tg(Myh6-IGF1)34Pia
Attribute String: coisogenic, mutant strain, transgenic
•
•
•
•
•
Publication
10325238 | J:55446
First Author: Li B
Year: 1999
Journal: Circ Res
Title: Insulin-like growth factor-1 attenuates the detrimental impact of nonocclusive coronary artery constriction on the heart.
Volume: 84
Issue: 9
Pages: 1007-19
•
•
•
•
•
Publication
14709156 | J:87943
First Author: Norby FL
Year: 2004
Journal: J Endocrinol
Title: Transgenic overexpression of insulin-like growth factor I prevents streptozotocin-induced cardiac contractile dysfunction and beta-adrenergic response in ventricular myocytes.
Volume: 180
Issue: 1
Pages: 175-82
•
•
•
•
•
Publication
11375343 | J:126133
First Author: Kajstura J
Year: 2001
Journal: Diabetes
Title: IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress.
Volume: 50
Issue: 6
Pages: 1414-24
•
•
•
•
•
Publication
9529164 | J:126160
First Author: Redaelli G
Year: 1998
Journal: Circ Res
Title: Effects of constitutive overexpression of insulin-like growth factor-1 on the mechanical characteristics and molecular properties of ventricular myocytes.
Volume: 82
Issue: 5
Pages: 594-603
•
•
•
•
•
Publication
14726476 | J:96615
First Author: Torella D
Year: 2004
Journal: Circ Res
Title: Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression.
Volume: 94
Issue: 4
Pages: 514-24
•
•
•
•
•
Publication
9329962 | J:126162
First Author: Li Q
Year: 1997
Journal: J Clin Invest
Title: Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.
Volume: 100
Issue: 8
Pages: 1991-9
•
•
•
•
•
Publication
17085535 | J:120607
First Author: Li Q
Year: 2007
Journal: Am J Physiol Heart Circ Physiol
Title: Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage.
Volume: 292
Issue: 3
Pages: H1398-403
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(ACTA1-IGF1)1Rjs/?
Background: involves: FVB
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(Myh6-IGF1)34Pia/?
Background: FVB/N-Tg(Myh6-IGF1)34Pia
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Publication
24076600 | J:205290
First Author: Sartori R
Year: 2013
Journal: Nat Genet
Title: BMP signaling controls muscle mass.
Volume: 45
Issue: 11
Pages: 1309-18
•
•
•
•
•
Publication
17928169 | J:172978
First Author: Ye J
Year: 2007
Journal: Gene
Title: FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy.
Volume: 404
Issue: 1-2
Pages: 53-60
•
•
•
•
•
Protein Domain
IPR031890 | Fbxo30/Fbxo40
Type: Family
Description: This entry includes F-box only protein 30 (Fbxo30) []and F-box only protein 40 (Fbxo40) []. Fbxo30 is a ubiquitin ligase required for muscle loss, hence it is also known as muscle ubiquitin ligase of the SCF complex in atrophy-1 (MUSA1) []. Fbxo40 id an E3 ubiquitin ligase that induces IRS1 ubiquitination and breakdown specifically in skeletal muscle cells and only upon IGF1 (insulin-like growth factor 1) stimulation [].
•
•
•
•
•
HT Experiment
E-GEOD-15293 | Gene expression profiling of temporal lobes of wfs1 deficient mice in two different genetic background
Series Id: GSE15293
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
HT Experiment
GSE220985 | mRNA data - Unique miRNome and Transcriptome Profiles Underlie Microvascular Heterogeneity in Mouse Kidney
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
•
•
•
•
•
HT Experiment
GSE220986 | smallRNA data - Unique miRNome and Transcriptome Profiles Underlie Microvascular Heterogeneity in Mouse Kidney
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
•
•
•
•
•
Publication
21540290 | J:174898
First Author: Zerrad-Saadi A
Year: 2011
Journal: Endocrinology
Title: GH receptor plays a major role in liver regeneration through the control of EGFR and ERK1/2 activation.
Volume: 152
Issue: 7
Pages: 2731-41
•
•
•
•
•
Protein
F2Z3X7
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: true
•
•
•
•
•
Protein
Q3TS23
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: false
•
•
•
•
•
Publication
15469846 | -
First Author: Lafuente EM
Year: 2004
Journal: Dev Cell
Title: RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.
Volume: 7
Issue: 4
Pages: 585-95
•
•
•
•
•
Protein Domain
IPR039664 | GRB/APBB1IP
Type: Family
Description: Proteins in this entry consist of a Ras-associated (RA) domain, a PH domain, a family-specific BPS region, and a C-terminal SH2 domain. Grb7, Grb10 and Grb14 are paralogues that are also present in this entry []. These adapter proteins bind a variety of receptor tyrosine kinases, including the insulin and insulin-like growth factor-1 (IGF1) receptors. Grb10 and Grb14 are important tissue-specific negative regulators of insulin and IGF1 signaling based and may contribute to type 2 (non-insulin-dependent) diabetes in humans. RA-PH function as a single structural unit and is dimerized via a helical extension of the PH domain. The PH domain here are proposed to bind phosphoinositides non-cannonically and are unlikely to bind an activated GTPase []. This entry also includes APBB1IP (also known as RIAM), which functions in the signal transduction from Ras activation to actin cytoskeletal remodelling [].
•
•
•
•
•
HT Experiment
GSE144519 | Inceptor counteracts insulin signalling in beta-cells to control glycaemia
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Publication
16123266 | J:101199
First Author: Kurosu H
Year: 2005
Journal: Science
Title: Suppression of aging in mice by the hormone Klotho.
Volume: 309
Issue: 5742
Pages: 1829-33
•
•
•
•
•
Publication
17996864 | J:130123
First Author: Gatza CE
Year: 2008
Journal: Dev Biol
Title: Altered mammary gland development in the p53+/m mouse, a model of accelerated aging.
Volume: 313
Issue: 1
Pages: 130-41
•
•
•
•
•
Publication
22051242 | J:218881
First Author: Vinciguerra M
Year: 2012
Journal: Aging Cell
Title: mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart.
Volume: 11
Issue: 1
Pages: 139-49
•
•
•
•
•
Publication
8857020 | -
First Author: Woods KA
Year: 1996
Journal: N Engl J Med
Title: Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.
Volume: 335
Issue: 18
Pages: 1363-7
•
•
•
•
•
Publication
23217713 | J:193333
First Author: Ruas JL
Year: 2012
Journal: Cell
Title: A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.
Volume: 151
Issue: 6
Pages: 1319-31
•
•
•
•
•
Publication
31428695 | J:288816
 
First Author: Cottage CT
Year: 2019
Journal: Commun Biol
Title: Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice.
Volume: 2
Pages: 307
•
•
•
•
•
Publication
15935586 | J:104954
First Author: Masternak MM
Year: 2005
Journal: Exp Gerontol
Title: Effect of every other day feeding diet on gene expression in normal and in long-lived Ames dwarf mice.
Volume: 40
Issue: 6
Pages: 491-7
•
•
•
•
•
Publication
28623308 | J:264415
First Author: Rymut SM
Year: 2017
Journal: Sci Rep
Title: Improved Growth Patterns in Cystic Fibrosis Mice after Loss of Histone Deacetylase 6.
Volume: 7
Issue: 1
Pages: 3676
•
•
•
•
•
Publication
28351623 | J:250625
First Author: Thakur S
Year: 2017
Journal: Biochem Biophys Res Commun
Title: IGF-1 receptor haploinsufficiency leads to age-dependent development of metabolic syndrome.
Volume: 486
Issue: 4
Pages: 937-944
•
•
•
•
•
Publication
29187405 | J:256353
First Author: Yang Y
Year: 2018
Journal: Cancer Res
Title: HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1.
Volume: 78
Issue: 2
Pages: 422-435
•
•
•
•
•
Publication
30718296 | J:272959
First Author: Ieronymaki E
Year: 2019
Journal: J Immunol
Title: Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype.
Volume: 202
Issue: 6
Pages: 1786-1797
•
•
•
•
•
Publication
24275180 | J:211889
First Author: Kararigas G
Year: 2014
Journal: Mol Cell Endocrinol
Title: Estrogen modulates cardiac growth through an estrogen receptor α-dependent mechanism in healthy ovariectomized mice.
Volume: 382
Issue: 2
Pages: 909-14
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom