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Search results 1301 to 1400 out of 12470 for Impact

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Type Details Score
Publication
34015468 | J:321734
 
First Author: Imeri F
Year: 2021
Journal: Matrix Biol
Title: Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
Volume: 98
Pages: 32-48
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Protein Domain
IPR036956 | Impact_N_sf
Type: Homologous_superfamily
Description: The Impact protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved from eukaryotes to archaea []. This entry represents the N-terminal domain superfamily of the Impact proteins.
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Protein Domain
IPR001498 | Impact_N
Type: Domain
Description: The Impact protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved from eukaryotes to archaea []. This entry represents the N-terminal domain of the Impact proteins.
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Publication
24991885 | -
First Author: Lührig S
Year: 2014
Journal: Stem Cells Dev
Title: Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells.
Volume: 23
Issue: 23
Pages: 2862-74
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Publication
15897321 | -
First Author: García-Martínez C
Year: 2005
Journal: Am J Physiol Cell Physiol
Title: Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells.
Volume: 288
Issue: 6
Pages: C1264-72
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Publication
21751400 | -
First Author: Junne S
Year: 2011
Journal: Biotechnol J
Title: A two-compartment bioreactor system made of commercial parts for bioprocess scale-down studies: impact of oscillations on Bacillus subtilis fed-batch cultivations.
Volume: 6
Issue: 8
Pages: 1009-17
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Publication
15123635 | -
First Author: Mizusawa N
Year: 2004
Journal: J Biol Chem
Title: Impact of replacement of D1 C-terminal alanine with glycine on structure and function of photosynthetic oxygen-evolving complex.
Volume: 279
Issue: 28
Pages: 29622-7
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Publication
11865056 | -
First Author: Conte C
Year: 2002
Journal: Mol Cell Biol
Title: Coupling of enhancer and insulator properties identified in two retrotransposons modulates their mutagenic impact on nearby genes.
Volume: 22
Issue: 6
Pages: 1767-77
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Publication
27375568 | -
 
First Author: Hayrapetyan H
Year: 2016
Journal: Front Microbiol
Title: Comparative Genomics of Iron-Transporting Systems in Bacillus cereus Strains and Impact of Iron Sources on Growth and Biofilm Formation.
Volume: 7
Pages: 842
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Publication
25999311 | -
First Author: Zandarashvili L
Year: 2015
Journal: FEBS Lett
Title: Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1.
Volume: 589
Issue: 15
Pages: 1748-53
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Publication
23159368 | -
First Author: Sienski G
Year: 2012
Journal: Cell
Title: Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression.
Volume: 151
Issue: 5
Pages: 964-80
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Publication
25162314 | -
First Author: Bruhn O
Year: 2014
Journal: Expert Opin Drug Metab Toxicol
Title: Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.
Volume: 10
Issue: 10
Pages: 1337-54
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Publication
24642864 | -
First Author: Maurya SR
Year: 2014
Journal: PLoS One
Title: Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial β-barrel anion channel hVDAC-2.
Volume: 9
Issue: 3
Pages: e92183
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Publication
23385459 | -
First Author: Hilario E
Year: 2013
Journal: Acta Crystallogr D Biol Crystallogr
Title: Structure of the C-terminal half of human XPB helicase and the impact of the disease-causing mutation XP11BE.
Volume: 69
Issue: Pt 2
Pages: 237-46
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Publication
24211571 | -
First Author: Venza M
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Impact of DNA methyltransferases on the epigenetic regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in malignant melanoma.
Volume: 441
Issue: 4
Pages: 743-50
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Publication
20211623 | -
First Author: Yeom SY
Year: 2010
Journal: FEBS Lett
Title: Interaction of testisin with maspin and its impact on invasion and cell death resistance of cervical cancer cells.
Volume: 584
Issue: 8
Pages: 1469-75
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Publication
18313693 | -
First Author: Cordier F
Year: 2008
Journal: J Mol Biol
Title: Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation.
Volume: 377
Issue: 5
Pages: 1419-32
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Publication
14563862 | -
First Author: Steinhuber A
Year: 2003
Journal: J Bacteriol
Title: Molecular architecture of the regulatory Locus sae of Staphylococcus aureus and its impact on expression of virulence factors.
Volume: 185
Issue: 21
Pages: 6278-86
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Publication
30120216 | -
First Author: Milev MP
Year: 2018
Journal: J Med Genet
Title: Bi-allelic mutations in TRAPPC2L result in a neurodevelopmental disorder and have an impact on RAB11 in fibroblasts.
Volume: 55
Issue: 11
Pages: 753-764
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Publication
21593558 | -
First Author: Hopkins PC
Year: 2011
Journal: J Alzheimers Dis
Title: The impact of a novel apolipoprotein E and amyloid-β protein precursor-interacting protein on the production of amyloid-β.
Volume: 26
Issue: 2
Pages: 239-53
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Strain
MGI:5607607 | BALB/cJ-Myo5a<d-l34J>/GrsrJ
Attribute String: mutant strain, spontaneous mutation, coisogenic
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Allele
Rorb<hstp-2J> | MGI:7495931
Name: RAR-related orphan receptor beta; high stepper 2 Jackson
Allele Type: Spontaneous
Attribute String: Modified isoform(s), Null/knockout
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Allele
n-TUtca2<tm1.1Mym> | MGI:7660538
Name: nuclear encoded tRNA selenocysteine 2 (anticodon TCA); targeted mutation 1.1, Masayuki Yamamoto
Allele Type: Targeted
Attribute String: No functional change
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Genotype
Genotype
Symbol: n-TUtca2/n-TUtca2
Background: either: (involves: C57BL/6) or (involves: C57BL/6 * DBA) or (involves: ICR)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: BALB/cJ-Myo5a/GrsrJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: BALB/cJ * CAST/EiJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: n-TUtca2/n-TUtca2<+>
Background: either: (involves: C57BL/6) or (involves: C57BL/6 * DBA) or (involves: ICR)
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: n-TUtca2/n-TUtca2
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE120310 | Effect of neuronal primary cilia on axonal tract development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-MTAB-6861 | Transcriptomic analysis of the developing cerebellum in a mouse model for SRD5A3-CDG
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-MTAB-7065 | Small RNA profiling of TUT4 and TUT7-deficient mouse pachytene-diplotene cells
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE181326 | 3' sequencing of placenta form Mbnl2 and Mbnl3 KOs
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE198416 | The thyroid hormone clearing type 3 deiodinase protects from cardiac congenital abnormalities
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE235520 | IL-3 receptor signaling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE77896 | Pdx1-Oc1 cooperatively drive the induction of the endocrine pancreatic program
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE181320 | Placenta transcriptomics of Mbnl2 and Mbnl3 KOs (RNA-seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GO Term
GO:0019812 | type I site-specific deoxyribonuclease complex
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Publication
23869404 | -
First Author: Beck J
Year: 2013
Journal: Mol Microbiol
Title: Woronin bodies, their impact on stress resistance and virulence of the pathogenic mould Aspergillus fumigatus and their anchoring at the septal pore of filamentous Ascomycota.
Volume: 89
Issue: 5
Pages: 857-71
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Publication
18260827 | -
First Author: He Y
Year: 2008
Journal: Biochem J
Title: N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2).
Volume: 412
Issue: 1
Pages: 45-55
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Publication
15716274 | -
First Author: Hitomi K
Year: 2005
Journal: J Biol Chem
Title: Tetrameric architecture of the circadian clock protein KaiB. A novel interface for intermolecular interactions and its impact on the circadian rhythm.
Volume: 280
Issue: 19
Pages: 19127-35
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Publication
16525888 | -
First Author: Albrecht V
Year: 2006
Journal: Plant Mol Biol
Title: Characterization of the snowy cotyledon 1 mutant of Arabidopsis thaliana: the impact of chloroplast elongation factor G on chloroplast development and plant vitality.
Volume: 60
Issue: 4
Pages: 507-18
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Publication
27364758 | -
 
First Author: de Vrind V
Year: 2016
Journal: Eur J Pharmacol
Title: Interactions between calcium channels and SK channels in midbrain dopamine neurons and their impact on pacemaker regularity: Contrasting roles of N- and L-type channels.
Volume: 788
Pages: 274-279
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Publication
17620296 | -
First Author: Onnockx S
Year: 2008
Journal: J Cell Physiol
Title: The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners.
Volume: 214
Issue: 1
Pages: 260-72
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Publication
35682566 | J:327558
 
First Author: Hafizi R
Year: 2022
Journal: Int J Mol Sci
Title: Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells.
Volume: 23
Issue: 11
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Publication
- | J:248572
       
First Author: Genoway
Year: 2017
Title: Generation of Sphk1 and Sphk2
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HT Experiment
GSE205128 | Molecular and behavioral consequences of Ube3a gene overdosage in mice
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE210266 | Nos1ap constitutive null mice embryonic day 13.5 heart transcriptome
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Hyal3<tm1Btr> | MGI:6108181
Name: hyaluronoglucosaminidase 3; targeted mutation 1, Barbara Triggs-Raine
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
H2-Ab1<g7-em1Mvw> | MGI:6156109
Name: histocompatibility 2, class II antigen A, beta 1; endonuclease-mediated mutation 1, Michael Wiles
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7507149 | B6.Cg-Rorb<hstp-2J>/GrsrJ
Attribute String: spontaneous mutation, mutant strain, congenic
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Genotype
Genotype
Symbol: Rorb/Rorb
Background: B6.Cg-Rorb/GrsrJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: n-TUtca2/n-TUtca2
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:2135945 | Lcn8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0023290 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025462 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025439 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025409 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025435 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0025196 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2135945 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025879 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024659 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025174 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025307 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025269 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025393 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025300 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025938 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024407 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024728 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024748 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0024207 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
34328598 | J:338441
First Author: Gong QQ
Year: 2021
Journal: Mol Biol Rep
Title: Epididymal initial segment-specific Cre recombinase activity in Lcn8-Cre knock-in mice.
Volume: 48
Issue: 8
Pages: 6015-6023
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Publication
18335052 | -
First Author: Santos AF
Year: 2008
Journal: PLoS One
Title: Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients.
Volume: 3
Issue: 3
Pages: e1781
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Protein Domain
IPR010661 | RVT_thumb
Type: Domain
Description: This domain is known as the thumb domain. It is composed of a four helix bundle []. Reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. Reverse transcriptase often occurs in a polyprotein; with integrase, ribonuclease H and/or protease, which is cleaved before the enzyme takes action. The impact of antiretroviral treatment on the first 400 amino acids of HIV reverse transcriptase is good. Little is known, however, of the antiretroviral drug impact on the C-terminal domains of Pol, which includes the thumb, connection and RNase H []. Evidence suggests that these might be well conserved domains.
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HT Experiment
GSE199074 | Next Generation Sequencing Facilitates Quantitative Analysis of Transcriptomes of Skeletal Muscle-Specific Akt Knockout Mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-36743 | In vivo and in vitro investigations of heterozygous nebulin knock-out mice reveal similarities with mild human form of nemaline myopathy [mRNA]
Series Id: GSE36743
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-36741 | In vivo and in vitro investigations of heterozygous nebulin knock-out mice reveal similarities with mild human form of nemaline myopathy [miRNA]
Series Id: GSE36741
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE172000 | The type 3 deiodinase contributes to the reduced sensitivity of the fetal brain to thyroid hormone
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE157667 | Effect of maternal iron deficiency on placental transcriptome in mouse
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE224780 | An integrated multiorgan feed-forward metabolic response exacerbates muscle wasting and lipid accumulation in human mitochondrial myopathies
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-MTAB-4726 | Transcription profiling by high throughput sequencing of pancreatic beta cells from wild type and Abcc8 knockout mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-MTAB-11110 | Changes in mRNA levels in the colons of QSOX1 knockout mice compared to wild type
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-MTAB-8643 | Effects of increased intracellular calcium and overnutrition on pancreatic beta cell transcriptome
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
28342805 | -
 
First Author: Salazar J
Year: 2017
Journal: Arch Biochem Biophys
Title: Phosphoethanolamine addition to the Heptose I of the Lipopolysaccharide modifies the inner core structure and has an impact on the binding of Polymyxin B to the Escherichia coli outer membrane.
Volume: 620
Pages: 28-34
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Publication
18762256 | J:144606
First Author: Atmuri V
Year: 2008
Journal: Matrix Biol
Title: Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation.
Volume: 27
Issue: 8
Pages: 653-60
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Allele
Il7r<tm1.1(icre)Hrr> | MGI:4441349
Name: interleukin 7 receptor; targeted mutation 1.1, Hans-Reimer Rodewald
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Mrpl3<em1(IMPC)J> | MGI:5662430
Name: mitochondrial ribosomal protein L3; endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Pla2g7<em1(IMPC)J> | MGI:5662431
Name: phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma); endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6108353 | 129-Hyal3<tm1Btr>
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Eftud2<em2Lajm> | MGI:6358539
Name: elongation factor Tu GTP binding domain containing 2; endonuclease-mediated mutation 2, Loydie Anne Jerome-Majewska
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
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Genotype
Genotype
Symbol: Hyal3/Hyal3
Background: 129-Hyal3
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hyal3/Hyal3
Background: involves: 129 * CD-1
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:2182335 | Cables2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0024778 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026991 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026957 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026966 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026707 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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