Type |
Details |
Score |
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6197250 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2018-09-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754420 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6197274 |
Age: |
embryonic day 11.5 |
|
Note: |
Co-localized with Itgb1 in neuroepithelial cells. |
Specimen Label: |
S6 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7431095 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-02-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3268828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:7431102 |
Age: |
postnatal adult |
Image: |
2C (right) |
Note: |
Expression co-localized with Itgb1 in costamere at sarcolemmal membrane. |
Specimen Label: |
2C (right) |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
Allele |
Name: |
integrin beta 1 (fibronectin receptor beta); endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Allele |
Name: |
integrin beta 1 (fibronectin receptor beta); targeted mutation 3, Reinhard Fassler |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
integrin beta 1 (fibronectin receptor beta); targeted mutation 1.1, Elaine Fuchs |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb1/Itgb1 |
Background: |
involves: 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
88
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
490
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
528
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
396
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 []. |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb1/Itgb1 |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
606
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents protein SCAI from metazoans and plants. SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 []. |
|
•
•
•
•
•
|
Allele |
Name: |
integrin beta 1 (fibronectin receptor beta); targeted mutation 5.1, Reinhard Fassler |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb1/Itgb1 |
Background: |
involves: 129X1/SvJ |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
integrin beta 3; targeted mutation 2, Ararat J Ablooglu |
Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb1/Itgb1 |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb3/Itgb3 |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb1/Itgb1 Tg(Ttr-cre)1Hadj/? |
Background: |
involves: 129X1/SvJ * C57BL/6J * CBA/J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
138
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
286
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimmel BE |
Year: |
1990 |
Journal: |
Genes Dev |
Title: |
The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. |
Volume: |
4 |
Issue: |
5 |
Pages: |
712-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paço A |
Year: |
2020 |
Journal: |
Cancers (Basel) |
Title: |
Roles of the HOX Proteins in Cancer Invasion and Metastasis. |
Volume: |
13 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Vogel M |
Year: |
2016 |
Journal: |
Am J Med Genet A |
Title: |
Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis. |
Volume: |
170 |
Issue: |
7 |
Pages: |
1813-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stefanovic S |
Year: |
2020 |
Journal: |
Elife |
Title: |
Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiation. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Roux M |
Year: |
2015 |
Journal: |
Dev Biol |
Title: |
Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development. |
Volume: |
406 |
Issue: |
2 |
Pages: |
247-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roux M |
Year: |
2017 |
Journal: |
Mech Dev |
Title: |
Hoxa1 and Hoxb1 are required for pharyngeal arch artery development. |
Volume: |
143 |
|
Pages: |
1-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han L |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma. |
Volume: |
10 |
Issue: |
11 |
Pages: |
e0142387 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaffran S |
Year: |
2018 |
Journal: |
Genesis |
Title: |
Ectopic expression of Hoxb1 induces cardiac and craniofacial malformations. |
Volume: |
56 |
Issue: |
6-7 |
Pages: |
e23221 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tischfield MA |
Year: |
2005 |
Journal: |
Nat Genet |
Title: |
Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development. |
Volume: |
37 |
Issue: |
10 |
Pages: |
1035-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park H |
Year: |
2011 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Homeobox D1 regulates angiogenic functions of endothelial cells via integrin β1 expression. |
Volume: |
408 |
Issue: |
1 |
Pages: |
186-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bosley TM |
Year: |
2008 |
Journal: |
Am J Med Genet A |
Title: |
The clinical spectrum of homozygous HOXA1 mutations. |
Volume: |
146A |
Issue: |
10 |
Pages: |
1235-40 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents a group of homeobox proteins, including HOX-A1/B1/D1 (HXA1/B1/D1) and related proteins from animals. The homeobox domain is a DNA binding domain. Human HOX genes are critical for development of the central nervous system []. They have been also implicated in vascular development and angiogenesis, particularly with regulation of genes involved in cell-cell or cell-extracellular matrix (ECM) interactions []. HXA1 has been linked to the Bosley-Salih-Alorainy syndrome (BSAS) or the Athabascan brainstem dysgenesis syndrome (ABDS) []. HXB1 is a transcription factor that play important roles in early vertebrate development [, , , , ]and its expression is associated with tumours [, ]. HOXD1 plays a significant role in endothelial cell functions by regulating the expression of ITGB1 [].Homeobox protein rough from Drosophila melanogaster is a member of this group of proteins. It is required to establish the unique cell identity of photoreceptors R2 and R5 and consequently for ommatidial assembly in the developing eye imaginal disk in the organism [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Chou J |
Year: |
2013 |
Journal: |
Nat Cell Biol |
Title: |
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. |
Volume: |
15 |
Issue: |
2 |
Pages: |
201-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brandt DT |
Year: |
2009 |
Journal: |
Nat Cell Biol |
Title: |
SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. |
Volume: |
11 |
Issue: |
5 |
Pages: |
557-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ablooglu AJ |
Year: |
2009 |
Journal: |
Blood |
Title: |
Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. |
Volume: |
113 |
Issue: |
15 |
Pages: |
3585-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao Z |
Year: |
2015 |
Journal: |
Blood |
Title: |
Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor. |
Volume: |
125 |
Issue: |
12 |
Pages: |
1995-2004 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb1/Itgb1 Tg(KRT5-cre)5132Jlj/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Edil3/? Itgb1/Itgb1 |
Background: |
involves: 129X1/SvJ * C57BL/6J * CBA/J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Sosa LJ |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance. |
Volume: |
8 |
Issue: |
5 |
Pages: |
e64521 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu Q |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo. |
Volume: |
38 |
Issue: |
2 |
Pages: |
373-385 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun Y |
Year: |
2022 |
Journal: |
Theranostics |
Title: |
Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling. |
Volume: |
12 |
Issue: |
17 |
Pages: |
7307-7318 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tajiri Y |
Year: |
2010 |
Journal: |
Biol Reprod |
Title: |
Tubulointerstitial nephritis antigen-like 1 is expressed in the uterus and binds with integrins in decidualized endometrium during postimplantation in mice. |
Volume: |
82 |
Issue: |
2 |
Pages: |
263-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wagner JUG |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report. |
Volume: |
38 |
Issue: |
5 |
Pages: |
1170-1177 |
|
•
•
•
•
•
|
Publication |
First Author: |
Riffo E |
Year: |
2022 |
Journal: |
Front Cell Dev Biol |
Title: |
The Sall2 transcription factor promotes cell migration regulating focal adhesion turnover and integrin β1 expression. |
Volume: |
10 |
|
Pages: |
1031262 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sevilla-Movilla S |
Year: |
2020 |
Journal: |
J Pathol |
Title: |
Upregulated expression and function of the α4β1 integrin in multiple myeloma cells resistant to bortezomib. |
Volume: |
252 |
Issue: |
1 |
Pages: |
29-40 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
27
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
328
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
297
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
331
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
337
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
336
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
336
 |
Fragment?: |
false |
|
•
•
•
•
•
|