Type |
Details |
Score |
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
606
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents protein SCAI from metazoans and plants. SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 []. |
|
•
•
•
•
•
|
Allele |
Name: |
integrin beta 1 (fibronectin receptor beta); targeted mutation 5.1, Reinhard Fassler |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb1/Itgb1 |
Background: |
involves: 129X1/SvJ |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
integrin beta 3; targeted mutation 2, Ararat J Ablooglu |
Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb1/Itgb1 |
Background: |
involves: 129S1/Sv * 129X1/SvJ |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb3/Itgb3 |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb1/Itgb1 Tg(Ttr-cre)1Hadj/? |
Background: |
involves: 129X1/SvJ * C57BL/6J * CBA/J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
138
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
286
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimmel BE |
Year: |
1990 |
Journal: |
Genes Dev |
Title: |
The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. |
Volume: |
4 |
Issue: |
5 |
Pages: |
712-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paço A |
Year: |
2020 |
Journal: |
Cancers (Basel) |
Title: |
Roles of the HOX Proteins in Cancer Invasion and Metastasis. |
Volume: |
13 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Vogel M |
Year: |
2016 |
Journal: |
Am J Med Genet A |
Title: |
Homozygous HOXB1 loss-of-function mutation in a large family with hereditary congenital facial paresis. |
Volume: |
170 |
Issue: |
7 |
Pages: |
1813-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stefanovic S |
Year: |
2020 |
Journal: |
Elife |
Title: |
Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiation. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Roux M |
Year: |
2015 |
Journal: |
Dev Biol |
Title: |
Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development. |
Volume: |
406 |
Issue: |
2 |
Pages: |
247-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roux M |
Year: |
2017 |
Journal: |
Mech Dev |
Title: |
Hoxa1 and Hoxb1 are required for pharyngeal arch artery development. |
Volume: |
143 |
|
Pages: |
1-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han L |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma. |
Volume: |
10 |
Issue: |
11 |
Pages: |
e0142387 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaffran S |
Year: |
2018 |
Journal: |
Genesis |
Title: |
Ectopic expression of Hoxb1 induces cardiac and craniofacial malformations. |
Volume: |
56 |
Issue: |
6-7 |
Pages: |
e23221 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tischfield MA |
Year: |
2005 |
Journal: |
Nat Genet |
Title: |
Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development. |
Volume: |
37 |
Issue: |
10 |
Pages: |
1035-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park H |
Year: |
2011 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Homeobox D1 regulates angiogenic functions of endothelial cells via integrin β1 expression. |
Volume: |
408 |
Issue: |
1 |
Pages: |
186-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bosley TM |
Year: |
2008 |
Journal: |
Am J Med Genet A |
Title: |
The clinical spectrum of homozygous HOXA1 mutations. |
Volume: |
146A |
Issue: |
10 |
Pages: |
1235-40 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents a group of homeobox proteins, including HOX-A1/B1/D1 (HXA1/B1/D1) and related proteins from animals. The homeobox domain is a DNA binding domain. Human HOX genes are critical for development of the central nervous system []. They have been also implicated in vascular development and angiogenesis, particularly with regulation of genes involved in cell-cell or cell-extracellular matrix (ECM) interactions []. HXA1 has been linked to the Bosley-Salih-Alorainy syndrome (BSAS) or the Athabascan brainstem dysgenesis syndrome (ABDS) []. HXB1 is a transcription factor that play important roles in early vertebrate development [, , , , ]and its expression is associated with tumours [, ]. HOXD1 plays a significant role in endothelial cell functions by regulating the expression of ITGB1 [].Homeobox protein rough from Drosophila melanogaster is a member of this group of proteins. It is required to establish the unique cell identity of photoreceptors R2 and R5 and consequently for ommatidial assembly in the developing eye imaginal disk in the organism [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Chou J |
Year: |
2013 |
Journal: |
Nat Cell Biol |
Title: |
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. |
Volume: |
15 |
Issue: |
2 |
Pages: |
201-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brandt DT |
Year: |
2009 |
Journal: |
Nat Cell Biol |
Title: |
SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. |
Volume: |
11 |
Issue: |
5 |
Pages: |
557-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu Q |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo. |
Volume: |
38 |
Issue: |
2 |
Pages: |
373-385 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sosa LJ |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance. |
Volume: |
8 |
Issue: |
5 |
Pages: |
e64521 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun Y |
Year: |
2022 |
Journal: |
Theranostics |
Title: |
Ninj2 regulates Schwann cells development by interfering laminin-integrin signaling. |
Volume: |
12 |
Issue: |
17 |
Pages: |
7307-7318 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ablooglu AJ |
Year: |
2009 |
Journal: |
Blood |
Title: |
Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. |
Volume: |
113 |
Issue: |
15 |
Pages: |
3585-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liao Z |
Year: |
2015 |
Journal: |
Blood |
Title: |
Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor. |
Volume: |
125 |
Issue: |
12 |
Pages: |
1995-2004 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Itgb1/Itgb1 Tg(KRT5-cre)5132Jlj/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Tajiri Y |
Year: |
2010 |
Journal: |
Biol Reprod |
Title: |
Tubulointerstitial nephritis antigen-like 1 is expressed in the uterus and binds with integrins in decidualized endometrium during postimplantation in mice. |
Volume: |
82 |
Issue: |
2 |
Pages: |
263-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wagner JUG |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report. |
Volume: |
38 |
Issue: |
5 |
Pages: |
1170-1177 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Edil3/? Itgb1/Itgb1 |
Background: |
involves: 129X1/SvJ * C57BL/6J * CBA/J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Riffo E |
Year: |
2022 |
Journal: |
Front Cell Dev Biol |
Title: |
The Sall2 transcription factor promotes cell migration regulating focal adhesion turnover and integrin β1 expression. |
Volume: |
10 |
|
Pages: |
1031262 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sevilla-Movilla S |
Year: |
2020 |
Journal: |
J Pathol |
Title: |
Upregulated expression and function of the α4β1 integrin in multiple myeloma cells resistant to bortezomib. |
Volume: |
252 |
Issue: |
1 |
Pages: |
29-40 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
27
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
328
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
297
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
331
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
337
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
336
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
336
|
Fragment?: |
false |
|
•
•
•
•
•
|