Type |
Details |
Score |
Publication |
First Author: |
Aguilera C |
Year: |
2011 |
Journal: |
Nature |
Title: |
c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex. |
Volume: |
469 |
Issue: |
7329 |
Pages: |
231-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sancho R |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. |
Volume: |
28 |
Issue: |
13 |
Pages: |
1843-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sarper SE |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Runx1-Stat3 signaling regulates the epithelial stem cells in continuously growing incisors. |
Volume: |
8 |
Issue: |
1 |
Pages: |
10906 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto S |
Year: |
2013 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling. |
Volume: |
305 |
Issue: |
3 |
Pages: |
G241-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karaca G |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e83987 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aparicio-Domingo P |
Year: |
2015 |
Journal: |
J Exp Med |
Title: |
Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage. |
Volume: |
212 |
Issue: |
11 |
Pages: |
1783-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ragab M |
Year: |
2024 |
Journal: |
Sci Rep |
Title: |
Azathioprine promotes intestinal epithelial cell differentiation into Paneth cells and alleviates ileal Crohn's disease severity. |
Volume: |
14 |
Issue: |
1 |
Pages: |
12879 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2015 |
Journal: |
Front Cell Neurosci |
Title: |
Dynamic expression of Lgr6 in the developing and mature mouse cochlea. |
Volume: |
9 |
|
Pages: |
165 |
|
•
•
•
•
•
|
Publication |
First Author: |
Norum JH |
Year: |
2015 |
Journal: |
Dev Biol |
Title: |
A conditional transgenic mouse line for targeted expression of the stem cell marker LGR5. |
Volume: |
404 |
Issue: |
2 |
Pages: |
35-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu W |
Year: |
2020 |
Journal: |
Biochem Biophys Res Commun |
Title: |
ACE2 contributes to the maintenance of mouse epithelial barrier function. |
Volume: |
533 |
Issue: |
4 |
Pages: |
1276-1282 |
|
•
•
•
•
•
|
Publication |
First Author: |
Holik AZ |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine. |
Volume: |
10 |
Issue: |
7 |
Pages: |
e1004453 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ang CH |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Lgr5+ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis. |
Volume: |
116 |
Issue: |
39 |
Pages: |
19530-19540 |
|
•
•
•
•
•
|
Publication |
First Author: |
Snyder JC |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness. |
Volume: |
292 |
Issue: |
17 |
Pages: |
7208-7222 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin X |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
R-spondin substitutes for neuronal input for taste cell regeneration in adult mice. |
Volume: |
118 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Westendorp F |
Year: |
2021 |
Journal: |
Oncogene |
Title: |
Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation. |
Volume: |
40 |
Issue: |
9 |
Pages: |
1628-1643 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li W |
Year: |
2020 |
Journal: |
JCI Insight |
Title: |
MUC1-C drives stemness in progression of colitis to colorectal cancer. |
Volume: |
5 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Deng F |
Year: |
2018 |
Journal: |
Cell Death Dis |
Title: |
YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury. |
Volume: |
9 |
Issue: |
2 |
Pages: |
153 |
|
•
•
•
•
•
|
Publication |
First Author: |
Akcora D |
Year: |
2013 |
Journal: |
Stem Cell Res |
Title: |
The CSF-1 receptor fashions the intestinal stem cell niche. |
Volume: |
10 |
Issue: |
2 |
Pages: |
203-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wizenty J |
Year: |
2022 |
Journal: |
EMBO J |
Title: |
Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis. |
Volume: |
41 |
Issue: |
13 |
Pages: |
e109996 |
|
•
•
•
•
•
|
Publication |
First Author: |
Imaimatsu K |
Year: |
2023 |
Journal: |
Development |
Title: |
Partial male-to-female reprogramming of mouse fetal testis by Sertoli cell ablation. |
Volume: |
150 |
Issue: |
14 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kwiatkowski E |
Year: |
2023 |
Journal: |
Cancers (Basel) |
Title: |
Expression of Stem Cell Markers in High-LET Space Radiation-Induced Intestinal Tumors in Apc(1638N/+) Mouse Intestine. |
Volume: |
15 |
Issue: |
17 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kobayashi M |
Year: |
2024 |
Journal: |
Int J Mol Sci |
Title: |
Anorectal Remodeling in the Transitional Zone with Increased Expression of LGR5, SOX9, SOX2, and Keratin 13 and 5 in a Dextran Sodium Sulfate-Induced Mouse Model of Ulcerative Colitis. |
Volume: |
25 |
Issue: |
23 |
|
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tigar/Tigar Apc/Apc Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJae |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apc/Apc Elp3/Elp3 Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apc/Apc Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gata6os/Gata6os Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gata6os/Gata6os Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+> |
Background: |
B6.129-Gt(ROSA)26Sor Lgr5 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCrl |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJaeSor |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NCrl |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ihh/Ihh Lgr5/Lgr5<+> |
Background: |
involves: 129S/SvEv * C57BL/6NTac * ICR |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang D |
Year: |
2013 |
Journal: |
Genes Dev |
Title: |
Structural basis for R-spondin recognition by LGR4/5/6 receptors. |
Volume: |
27 |
Issue: |
12 |
Pages: |
1339-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huynh D |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response. |
Volume: |
8 |
Issue: |
2 |
Pages: |
e56951 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schlieve CR |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Vascular Endothelial Growth Factor (VEGF) Bioavailability Regulates Angiogenesis and Intestinal Stem and Progenitor Cell Proliferation during Postnatal Small Intestinal Development. |
Volume: |
11 |
Issue: |
3 |
Pages: |
e0151396 |
|
•
•
•
•
•
|
Publication |
First Author: |
Van Landeghem L |
Year: |
2012 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation. |
Volume: |
302 |
Issue: |
10 |
Pages: |
G1111-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vomhof-DeKrey EE |
Year: |
2023 |
Journal: |
Biochem Biophys Rep |
Title: |
Vil-Cre specific Slfn3KO mice exhibit sex-specific differences in lung, stomach, cecum, kidney, and proximal colon differentiation markers and Slfn family members expression levels. |
Volume: |
36 |
|
Pages: |
101552 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hsu SY |
Year: |
1998 |
Journal: |
Mol Endocrinol |
Title: |
Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. |
Volume: |
12 |
Issue: |
12 |
Pages: |
1830-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chandrakesan P |
Year: |
2014 |
Journal: |
Oncogene |
Title: |
Utility of a bacterial infection model to study epithelial-mesenchymal transition, mesenchymal-epithelial transition or tumorigenesis. |
Volume: |
33 |
Issue: |
20 |
Pages: |
2639-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishikawa K |
Year: |
2022 |
Journal: |
Gastroenterology |
Title: |
Identification of Quiescent LGR5(+) Stem Cells in the Human Colon. |
Volume: |
163 |
Issue: |
5 |
Pages: |
1391-1406.e24 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Lgr5/Lgr5 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Col1a1/Col1a1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rpap3/Rpap3 Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Lgr5/Lgr5<+> Stk26/Stk26 |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Alpi/Alpi<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Lgr5/Lgr5<+> |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
228
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
221
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
228
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
243
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Geng H |
Year: |
2018 |
Journal: |
Gastroenterology |
Title: |
In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration. |
Volume: |
155 |
Issue: |
1 |
Pages: |
144-155 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wong CC |
Year: |
2020 |
Journal: |
Gastroenterology |
Title: |
In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance. |
Volume: |
159 |
Issue: |
6 |
Pages: |
2163-2180.e6 |
|
•
•
•
•
•
|