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Search results 1301 to 1400 out of 2039 for Met

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Protein Coding Gene
MGI:1329014 | Stam
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88457 | Col5a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929100 | Stam2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:700009 | Sh3gl2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919351 | Megf6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1858212 | Col5a3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1889583 | Sh3kbp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P47941
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
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Protein
Q99JI6
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
Q99LI8
Organism: Mus musculus/domesticus
Length: 775  
Fragment?: false
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Protein
Q80V70
Organism: Mus musculus/domesticus
Length: 1572  
Fragment?: false
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Protein
O88207
Organism: Mus musculus/domesticus
Length: 1838  
Fragment?: false
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Protein
Q3U962
Organism: Mus musculus/domesticus
Length: 1497  
Fragment?: false
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Protein
Q8R550
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
Q62420
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: false
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Protein
O88811
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
P70297
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
Q9JLI2
Organism: Mus musculus/domesticus
Length: 1739  
Fragment?: false
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Publication
7605632 | -
First Author: Ohta K
Year: 1995
Journal: Neuron
Title: Plexin: a novel neuronal cell surface molecule that mediates cell adhesion via a homophilic binding mechanism in the presence of calcium ions.
Volume: 14
Issue: 6
Pages: 1189-99
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Protein Domain
IPR002165 | Plexin_repeat
Type: Repeat
Description: This is a cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found in plexin () []. Two copies of the repeat are found in mahogany protein. A related Caenorhabditis elegans protein () contains four copies of the repeat, while the Met receptor contains a single copy of the repeat.
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Publication
11531697 | J:71297
First Author: Kennedy LJ
Year: 2001
Journal: Anim Genet
Title: Nomenclature for factors of the dog major histocompatibility system (DLA), 2000: second report of the ISAG DLA Nomenclature Committee.
Volume: 32
Issue: 4
Pages: 193-9
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Publication
37168572 | J:335573
First Author: Waldhart AN
Year: 2023
Journal: iScience
Title: Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP.
Volume: 26
Issue: 5
Pages: 106538
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Publication
31655257 | J:306827
 
First Author: Cassol F
Year: 2019
Journal: iScience
Title: Tracking Dynamics of Spontaneous Tumors in Mice Using Photon-Counting Computed Tomography.
Volume: 21
Pages: 68-83
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Strain
MGI:4949469 | FVB-Tg(tetO-TPR/MET,-EGFP)12Tcre/Cnrm
Attribute String: coisogenic, mutant strain, transgenic
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Allele
H3f3a<tm1Hjf> | MGI:7509717
Name: H3.3 histone A; targeted mutation 1, Hans Joerg Fehling
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Reporter
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/? Tg(Nes-cre)1Kln/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
GSE179417 | CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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Protein Domain
IPR024174 | HGF/MST1
Type: Family
Description: This entry includes hepatocyte growth factor (HGF; also called scatter factor) and HGF-like proteins (also known as macrophage stimulatory protein, MST1). Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regeneration []. HGF is essential for placental, liver, and muscle development, whereas MST1 is not required for embryogenesis, fertility, or wound healing. Genes for HGF and its receptor, the Met tyrosine kinase, are close together on chromosome 7, so that polysomy of chromosome 7 may contribute to malignancy through overproduction of both molecules. MST1 and its receptor, the Ron tyrosine kinase, are close together on chromosome 3. HGF and MST1 are closely related to plasminogen, having similar domain architecture: signal sequence followed by a PAN (formerly apple) domain, four (rather than five) kringle domains, and a trypsin domain, which appears to lack any peptidase activity.
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Protein
E0CXE9
Organism: Mus musculus/domesticus
Length: 53  
Fragment?: false
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Publication
10390613 | -
First Author: Bork P
Year: 1999
Journal: Trends Biochem Sci
Title: Domains in plexins: links to integrins and transcription factors.
Volume: 24
Issue: 7
Pages: 261-3
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Publication
8816464 | -
First Author: Collesi C
Year: 1996
Journal: Mol Cell Biol
Title: A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype.
Volume: 16
Issue: 10
Pages: 5518-26
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Publication
20481588 | -
First Author: Webb KJ
Year: 2010
Journal: Biochemistry
Title: Identification of protein N-terminal methyltransferases in yeast and humans.
Volume: 49
Issue: 25
Pages: 5225-35
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Publication
24090352 | J:206007
First Author: Petkowski JJ
Year: 2013
Journal: Biochem J
Title: NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.
Volume: 456
Issue: 3
Pages: 453-62
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Publication
30417120 | -
 
First Author: Dong C
Year: 2018
Journal: Commun Biol
Title: An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.
Volume: 1
Pages: 183
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Publication
26543159 | -
First Author: Wu R
Year: 2015
Journal: Genes Dev
Title: Molecular basis for histone N-terminal methylation by NRMT1.
Volume: 29
Issue: 22
Pages: 2337-42
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Publication
24347283 | -
First Author: Zimmer AL
Year: 2014
Journal: Protein Sci
Title: Three-dimensional structure of a sugar N-formyltransferase from Francisella tularensis.
Volume: 23
Issue: 3
Pages: 273-83
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Protein Domain
IPR002909 | IPT_dom
Type: Domain
Description: The IPT (Ig-like, plexins, transcription factors) domain has an immunoglobulin like fold []. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. The Ron tyrosine kinase receptor shares with the members of its subfamily (Met and Sea) a unique functional feature: the control of cell dissociation, motility, and invasion of extracellular matrices (scattering) [].
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Protein Domain
IPR039391 | Phytocyanin
Type: Family
Description: Phytocyanins are blue copper proteins found in chloropasts of higher plants. They can be further subdivided into uclacyanins, stellacyanins, plantacyanins, and early nodulins. Stellacyanins have a blue copper coordinated by two His, one Cys and one Gln. In plantacyanins and uclacyanins, the ligands of the type-I Cu sites are two His, one Cys and one Met [, , , ]. Early nodulins lack amino acid residues that coordinate Cu, so they are believed to be involved in unknown processes without binding Cu [].
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Protein Domain
IPR012073 | LytTR_MHYT
Type: Family
Description: This entry includes the CoxC protein from the CO-metabolizing bacterium Oligotropha carboxidovorans []. In the CoxC and CoxH proteins, the LytTR DNA-binding transcriptional regulator domain []is found in association with MHYT, a recently described sensor domain, which contains six transmembrane segments carrying conserved His and Met residues []. The coxCand coxHgenes flank the operon encoding the CO dehydrogenase and are involved in transcriptional regulaton of the autotrophic metabolism in Oligotropha carboxidovorans [].
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Protein Domain
IPR040660 | N_formyltrans_C
Type: Domain
Description: This is the C-terminal domain of N-formyltransferase from Francisella tularensis. N-formylated sugars are observed on O-antigens of pathogenic Gram-negative bacteria. This C-terminal domain is responsible for dimerization. In particular, the beta hairpin motif present in the domain helps create a subunit-subunit interface. The dimeric interface is characterized by a hydrophobic patch formed by Ile 195, Leu 197, Val 201, Met 203, Ile 207, Phe 223, Val 231, Val 233, Leu 235, and Leu 237 from both monomers [].
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Protein Domain
IPR013429 | Regulatory_FmdB_Zinc_ribbon
Type: Domain
Description: This entry represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB []. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.
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Protein Domain
IPR008576 | MeTrfase_NTM1
Type: Family
Description: All fungal and animal N-terminally methylated proteins contain a unique N-terminal motif, Met-(Ala/Pro/Ser)-Pro-Lys. Alpha-N-methyltransferase methylates the N terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. It catalyses mono-, di- or tri-methylation of the exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif [, , ]. Some of the substrates may be primed by NTMT2-mediated monomethylation [].
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Protein Coding Gene
MGI:88453 | Col3a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88467 | Col1a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103038 | Stat3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88452 | Col2a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104580 | Rapgef1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97805 | Ptpn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97852 | Rap1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96079 | Hgf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88468 | Col1a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P08121
Organism: Mus musculus/domesticus
Length: 1464  
Fragment?: false
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Protein
Q01149
Organism: Mus musculus/domesticus
Length: 1372  
Fragment?: false
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Protein
P62835
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
P35821
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
P28481
Organism: Mus musculus/domesticus
Length: 1487  
Fragment?: false
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Protein
P11087
Organism: Mus musculus/domesticus
Length: 1453  
Fragment?: false
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Protein
P42227
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: false
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Protein
Q3UHC1
Organism: Mus musculus/domesticus
Length: 1224  
Fragment?: false
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HT Experiment
E-GEOD-6398 | Transcription profiling of heart from Lmna H222P homozygous and control mice
Series Id: GSE6398
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-6397 | Transcription profiling of mouse heart from Lmna H222P heterozygous and control mice
Series Id: GSE6397
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE142208 | Chd8 haploinsufficiency impairs early brain development and impacts protein homeostasis later in life
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:5911350 | FVB.Cg-Tg(Myh6-tTA)6Smbf Tg(tetO-TPR/MET,-EGFP)12Tcre
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:7509719 | B6.129-H3f3a<tm1Hjf>/J
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Tg(Myh6-tTA)6Smbf/? Tg(tetO-TPR/MET,-EGFP)12Tcre/?
Background: FVB.Cg-Tg(Myh6-tTA)6Smbf Tg(tetO-TPR/MET,-EGFP)12Tcre
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Islr-cre/ERT2)#Tobe/?
Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
8841393 | -
First Author: Wyborn NR
Year: 1996
Journal: Eur J Biochem
Title: Molecular characterisation of formamidase from Methylophilus methylotrophus.
Volume: 240
Issue: 2
Pages: 314-22
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Publication
11726498 | -
First Author: Stammers DK
Year: 2001
Journal: EMBO J
Title: The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
Volume: 20
Issue: 23
Pages: 6619-26
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Publication
18602114 | -
First Author: Kotaka M
Year: 2008
Journal: J Mol Biol
Title: Structural analysis of the recognition of the negative regulator NmrA and DNA by the zinc finger from the GATA-type transcription factor AreA.
Volume: 381
Issue: 2
Pages: 373-82
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Publication
18263583 | -
First Author: Zhao Y
Year: 2008
Journal: J Biol Chem
Title: An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability.
Volume: 283
Issue: 16
Pages: 11004-13
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Publication
11293413 | -
First Author: McGuirl MA
Year: 2001
Journal: J Biol Inorg Chem
Title: Expression, purification, and characterization of NosL, a novel Cu(I) protein of the nitrous oxide reductase (nos) gene cluster.
Volume: 6
Issue: 2
Pages: 189-95
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Publication
25835638 | -
First Author: Shabani M
Year: 2015
Journal: Expert Opin Ther Targets
Title: Receptor tyrosine kinase-like orphan receptor 1: a novel target for cancer immunotherapy.
Volume: 19
Issue: 7
Pages: 941-55
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Publication
25825749 | J:220532
First Author: Cerpa W
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: RoR2 functions as a noncanonical Wnt receptor that regulates NMDAR-mediated synaptic transmission.
Volume: 112
Issue: 15
Pages: 4797-802
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Publication
11713269 | J:72948
First Author: Nomi M
Year: 2001
Journal: Mol Cell Biol
Title: Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases.
Volume: 21
Issue: 24
Pages: 8329-35
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Publication
21487037 | -
First Author: Gentile A
Year: 2011
Journal: Cancer Res
Title: Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis.
Volume: 71
Issue: 8
Pages: 3132-41
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Publication
18667433 | -
First Author: Nomachi A
Year: 2008
Journal: J Biol Chem
Title: Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A.
Volume: 283
Issue: 41
Pages: 27973-81
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Publication
16788729 | -
First Author: Hughes JA
Year: 2006
Journal: Can J Microbiol
Title: In vivo hydrolysis of S-adenosyl-L-methionine in Escherichia coli increases export of 5-methylthioribose.
Volume: 52
Issue: 6
Pages: 599-602
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Publication
19576567 | J:154237
First Author: Schultz JM
Year: 2009
Journal: Am J Hum Genet
Title: Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.
Volume: 85
Issue: 1
Pages: 25-39
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Protein Domain
IPR016290 | S-AdoMet_hydrolase
Type: Family
Description: This entry represents S-adenosyl-L-methionine (SAM) hydrolases (), which catalyse the hydrolysis of S-adenosyl-L-methionine, cleaving it to form L-homoserine and methylthioadenosine. This enzyme is produced by Bacteriophage T3, which infects Escherichia coli cells. SAM hydrolase can remove S-adenosylmethionine from the E. coli cell, thereby inhibiting a variety of SAM-related activities, such as dam and dcm methylase-directed DNA modifications and the synthesis of spermidine from putrescine []. Expression of SAM hydrolase in T3-transformed E. coli induces the met regulon by cleaving the SAM co-repressor to form 5'-methylthioadenosine, which is then cleaved to produce 5-methylthioribose [].
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Protein Domain
IPR016247 | Tyr_kinase_rcpt_ROR
Type: Family
Description: The Ror family of receptor tyrosine kinases consists of two structurally related proteins, Ror1 and Ror2. Ror1 is a pseudokinase that acts as a substrate for the oncogenic tyrosine kinase Met []. It is expressed during development []. It shows no significant expression in normal adult tissues, but it is selectively overexpressed in a number of malignancies []. Ror2 functions as a Wnt receptor required to maintain basal NMDAR-mediated synaptic transmission []. For a time its ligand remained elusive, hence the name receptor tyrosine kinase-like orphan receptor-2 (Ror2). It is now established that Wnt5A acts a ligand for Ror2 [].
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Protein Domain
IPR027284 | Hepatocyte_GF
Type: Family
Description: Hepatocyte growth factor (HGF) is an activating ligand of the tyrosine kinase receptor Met. It activates Met by binding and promoting its dimerisation. This activation has been linked to promoting the invasive growth of many tumour types []. HGF acts as growth factor for a broad spectrum of tissues and cell types and has no detectable protease activity [].Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39). A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information [].
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Protein Domain
IPR036344 | FIP_sf
Type: Homologous_superfamily
Description: FIP-Fve (Fungal Immunomodulatory Protein Fve) is a major fruiting body protein from Flammulina velutipes, a mushroom possessing immunomodulatory activity []. It stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and oedema, enhances transcription of IL-2, IFN-gamma and TNF-alpha, and haemagglutinates red blood cells. It appears to be a lectin with specificity for complex cell-surface carbohydrates. Fve adopts a tertiary structure consisting of an immunoglobulin-like β-sandwich, with seven strands arranged in two beta sheets, in a Greek-key topology. It forms a non-covalently linked homodimer containing no Cys, His or Met residues; dimerisation occurs by 3-D domain swapping of the N-terminal helices and is stabilised predominantly by hydrophobic interactions [].
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Protein Domain
IPR015339 | Immunomodulatory_FIP-Fve_fun
Type: Family
Description: FIP-Fve (Fungal Immunomodulatory Protein Fve) is a major fruiting body protein from Flammulina velutipes, a mushroom possessing immunomodulatory activity []. It stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and oedema, enhances transcription of IL-2, IFN-gamma and TNF-alpha, and haemagglutinates red blood cells. It appears to be a lectin with specificity for complex cell-surface carbohydrates. Fve adopts a tertiary structure consisting of an immunoglobulin-like β-sandwich, with seven strands arranged in two beta sheets, in a Greek-key topology. It forms a non-covalently linked homodimer containing no Cys, His or Met residues; dimerisation occurs by 3-D domain swapping of the N-terminal helices and is stabilised predominantly by hydrophobic interactions [].
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Protein Domain
IPR008030 | NmrA-like
Type: Domain
Description: NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA []. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. It lacks most of the active site residues of the SDR (short-chain dehydrogenases/reductases) family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG [].This domain can also be found in other atypical SDRs, such as HSCARG (an NADPH sensor) []and PCBER (phenylcoumaran benzylic ether reductase) [].
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Protein Domain
IPR008719 | N2O_reductase_NosL
Type: Family
Description: NosL is one of the accessory proteins of the nos (nitrous oxide reductase) gene cluster. NosL is a monomeric protein of 18,540 MW that specifically and stoichiometrically binds Cu(I). The copper ion in NosL is ligated by a Cys residue, and one Met and one His are thought to serve as the other ligands. It is possible that NosL is a copper chaperone involved in metallocentre assembly [].This entry also contains HTH-type transcriptional repressors, including YcnK. YcnK may act as a negative transcriptional regulator of YcnJ inthe presence of copper and may use copper as a corepressor. The gene, ycnK, is significantly induced under copper-limiting conditions [].
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HT Experiment
E-GEOD-30651 | Conditional elimination of c-Met signaling in the liver aggravates oxidative stress and cholestasis, and deregulates lipid metabolism, under a high cholesterol diet
Series Id: GSE30651
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:88508 | Crk
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108088 | Gab1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88279 | Cbl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P22682
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
Q64010
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Protein
Q9QYY0
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Publication
12948495 | -
First Author: Paaventhan P
Year: 2003
Journal: J Mol Biol
Title: A 1.7A structure of Fve, a member of the new fungal immunomodulatory protein family.
Volume: 332
Issue: 2
Pages: 461-70
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Publication
7705335 | -
First Author: Ko JL
Year: 1995
Journal: Eur J Biochem
Title: A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence.
Volume: 228
Issue: 2
Pages: 244-9
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Publication
10449582 | -
First Author: Bourgis F
Year: 1999
Journal: Plant Cell
Title: S-methylmethionine plays a major role in phloem sulfur transport and is synthesized by a novel type of methyltransferase.
Volume: 11
Issue: 8
Pages: 1485-98
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Publication
7673218 | -
First Author: James F
Year: 1995
Journal: J Biol Chem
Title: Purification and properties of S-adenosyl-L-methionine:L-methionine S-methyltransferase from Wollastonia biflora leaves.
Volume: 270
Issue: 38
Pages: 22344-50
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Protein Domain
IPR025779 | Met_S-MeTrfase
Type: Family
Description: This entry represents the methionine S-methyltransferase () family, which catalyse the S-methylmethionine (SMM) biosynthesis from adenosyl-L-homocysteine (AdoMet) and methionine []. All flowering plants produce S-methylmethionine (SMM) from Met and have a separate mechanism to convert SMM back to Met. The functions of SMM and the reasons for its interconversion with Met are unknown []. Methyltransferases (EC [intenz:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.
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Publication
2835267 | J:32329
First Author: Tuteja N
Year: 1988
Journal: FEBS Lett
Title: Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA and corresponding amino acid sequence.
Volume: 232
Issue: 1
Pages: 182-6
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Publication
3026173 | J:8556
First Author: Naylor SL
Year: 1986
Journal: Am J Hum Genet
Title: Linkage of cystic fibrosis locus and polymorphic DNA markers in 14 families.
Volume: 39
Issue: 6
Pages: 707-12
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Publication
1562359 | J:853
First Author: Sweet A
Year: 1992
Journal: Biochem Med Metab Biol
Title: A potential animal model for studying CF heterozygote advantage: genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice.
Volume: 47
Issue: 1
Pages: 97-102
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