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Search results 1301 to 1400 out of 5729 for Nlrp3

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Type Details Score
Publication
First Author: Chaves MM
Year: 2019
Journal: PLoS Pathog
Title: Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4.
Volume: 15
Issue: 6
Pages: e1007887
DO Term
Publication
First Author: Anderson OA
Year: 2013
Journal: PLoS One
Title: A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome.
Volume: 8
Issue: 6
Pages: e67263
Publication
First Author: Niemi K
Year: 2011
Journal: J Immunol
Title: Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway.
Volume: 186
Issue: 11
Pages: 6119-28
Publication
First Author: Wang SY
Year: 2023
Journal: Neural Regen Res
Title: The Alzheimer's disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation.
Volume: 18
Issue: 2
Pages: 434-438
Publication  
First Author: Wu M
Year: 2023
Journal: Oxid Med Cell Longev
Title: TRIM72 Alleviates Muscle Inflammation in mdx Mice via Promoting Mitophagy-Mediated NLRP3 Inflammasome Inactivation.
Volume: 2023
Pages: 8408574
Publication  
First Author: Alfonso-Loeches S
Year: 2014
Journal: Front Cell Neurosci
Title: Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells.
Volume: 8
Pages: 216
Publication
First Author: Henriksbo BD
Year: 2020
Journal: Am J Physiol Endocrinol Metab
Title: Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTOR.
Volume: 319
Issue: 1
Pages: E110-E116
Publication  
First Author: Clénet ML
Year: 2023
Journal: Front Immunol
Title: Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome activation: therapeutic implications for ALS.
Volume: 14
Pages: 1190219
Publication
First Author: Lonnemann N
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
Volume: 117
Issue: 50
Pages: 32145-32154
Publication
First Author: Ni H
Year: 2023
Journal: Cell Death Discov
Title: XBP1 modulates endoplasmic reticulum and mitochondria crosstalk via regulating NLRP3 in renal ischemia/reperfusion injury.
Volume: 9
Issue: 1
Pages: 69
Publication  
First Author: Zhang J
Year: 2021
Journal: Free Radic Biol Med
Title: PINK1/PARK2 dependent mitophagy effectively suppresses NLRP3 inflammasome to alleviate acute pancreatitis.
Volume: 166
Pages: 147-164
Publication  
First Author: Lv Z
Year: 2023
Journal: Int Immunopharmacol
Title: Trophoblastic mitochondrial DNA induces endothelial dysfunction and NLRP3 inflammasome activation: Implications for preeclampsia.
Volume: 114
Pages: 109523
Publication
First Author: Lerner AG
Year: 2012
Journal: Cell Metab
Title: IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Volume: 16
Issue: 2
Pages: 250-64
Publication
First Author: Moraes-Vieira PM
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4.
Volume: 117
Issue: 49
Pages: 31309-31318
Publication  
First Author: Meng LC
Year: 2022
Journal: Int Immunopharmacol
Title: Salvianolic acid B ameliorates non-alcoholic fatty liver disease by inhibiting hepatic lipid accumulation and NLRP3 inflammasome in ob/ob mice.
Volume: 111
Pages: 109099
Publication
First Author: Lupfer CR
Year: 2014
Journal: PLoS Pathog
Title: Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection.
Volume: 10
Issue: 9
Pages: e1004410
Publication  
First Author: Darwesh AM
Year: 2019
Journal: Int J Mol Sci
Title: Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation.
Volume: 20
Issue: 14
Publication  
First Author: Jessop F
Year: 2017
Journal: Toxicol Appl Pharmacol
Title: Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant NLRP3 inflammasome activity.
Volume: 318
Pages: 58-68
Publication
First Author: Inoue M
Year: 2012
Journal: Sci Signal
Title: Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
Volume: 5
Issue: 225
Pages: ra38
Publication  
First Author: Müller N
Year: 2023
Journal: Int J Mol Sci
Title: Lipocalin-2 Deficiency Diminishes Canonical NLRP3 Inflammasome Formation and IL-1β Production in the Subacute Phase of Spinal Cord Injury.
Volume: 24
Issue: 10
Publication
First Author: Lin W
Year: 2023
Journal: J Neuroinflammation
Title: TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer's disease via TFEB/TFE3 activation.
Volume: 20
Issue: 1
Pages: 21
Publication
First Author: Wang Z
Year: 2024
Journal: J Neuroinflammation
Title: Herpes simplex virus 1 accelerates the progression of Alzheimer's disease by modulating microglial phagocytosis and activating NLRP3 pathway.
Volume: 21
Issue: 1
Pages: 176
Publication
First Author: Dong X
Year: 2021
Journal: Clin Transl Med
Title: Vitamin D3 ameliorates nitrogen mustard-induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway.
Volume: 11
Issue: 2
Pages: e312
Publication
First Author: Kumar B
Year: 2018
Journal: Mol Ther
Title: Complement-Mediated Activation of the NLRP3 Inflammasome and Its Inhibition by AAV-Mediated Delivery of CD59 in a Model of Uveitis.
Volume: 26
Issue: 6
Pages: 1568-1580
Publication
First Author: Pajarillo E
Year: 2023
Journal: J Biol Chem
Title: The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction.
Volume: 299
Issue: 7
Pages: 104879
Publication
First Author: Li LH
Year: 2017
Journal: PLoS One
Title: A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP.
Volume: 12
Issue: 7
Pages: e0182057
Publication  
First Author: Qiao S
Year: 2020
Journal: Cancer Lett
Title: Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer.
Volume: 491
Pages: 162-179
Publication  
First Author: Cheng Y
Year: 2020
Journal: Int Immunopharmacol
Title: Ghrelin attenuates secondary brain injury following intracerebral hemorrhage by inhibiting NLRP3 inflammasome activation and promoting Nrf2/ARE signaling pathway in mice.
Volume: 79
Pages: 106180
Publication  
First Author: Yuan X
Year: 2020
Journal: Front Cell Dev Biol
Title: Reversal of Endothelial Extracellular Vesicle-Induced Smooth Muscle Phenotype Transition by Hypercholesterolemia Stimulation: Role of NLRP3 Inflammasome Activation.
Volume: 8
Pages: 597423
Publication  
First Author: Liu C
Year: 2023
Journal: Redox Biol
Title: CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-κB pathway.
Volume: 68
Pages: 102960
Publication
First Author: Shao BZ
Year: 2014
Journal: CNS Neurosci Ther
Title: Activating cannabinoid receptor 2 alleviates pathogenesis of experimental autoimmune encephalomyelitis via activation of autophagy and inhibiting NLRP3 inflammasome.
Volume: 20
Issue: 12
Pages: 1021-8
Publication  
First Author: Zou Y
Year: 2022
Journal: Front Immunol
Title: Targeting PCSK9 Ameliorates Graft Vascular Disease in Mice by Inhibiting NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells.
Volume: 13
Pages: 894789
Publication
First Author: Wang Q
Year: 2020
Journal: Immunol Cell Biol
Title: Hyperglycemia aggravates acute liver injury by promoting liver-resident macrophage NLRP3 inflammasome activation via the inhibition of AMPK/mTOR-mediated autophagy induction.
Volume: 98
Issue: 1
Pages: 54-66
Publication  
First Author: Dagvadorj J
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation.
Volume: 118
Issue: 1
Publication  
First Author: Ge S
Year: 2021
Journal: Int J Mol Sci
Title: MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Volume: 22
Issue: 22
Publication  
First Author: Jessop F
Year: 2016
Journal: Toxicol Appl Pharmacol
Title: Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure.
Volume: 309
Pages: 101-10
Publication  
First Author: Wu DM
Year: 2021
Journal: Front Pharmacol
Title: Autophagy Induced by Micheliolide Alleviates Acute Irradiation-Induced Intestinal Injury via Inhibition of the NLRP3 Inflammasome.
Volume: 12
Pages: 773150
Publication  
First Author: Oleszycka E
Year: 2023
Journal: Front Immunol
Title: Bile acids induce IL-1α and drive NLRP3 inflammasome-independent production of IL-1β in murine dendritic cells.
Volume: 14
Pages: 1285357
Interaction Experiment
Description: A20 restricts ubiquitination of pro-interleukin-1 protein complexes and suppresses NLRP3 inflammasome activity.
Interaction Experiment
Description: The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3.
Interaction Experiment
Description: Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination.
Interaction Experiment
Description: Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.
Interaction Experiment
Description: HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
Interaction Experiment
Description: Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases.
Interaction Experiment
Description: YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3.
Interaction Experiment
Description: USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3.
Interaction Experiment
Description: Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinsons disease.
Interaction Experiment
Description: Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury.
Interaction Experiment
Description: MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism.
Interaction Experiment
Description: Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity.
Interaction Experiment
Description: TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway.
Interaction Experiment
Description: Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3.
Interaction Experiment
Description: Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation.
Publication  
First Author: Wei Z
Year: 2021
Journal: Free Radic Biol Med
Title: Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Volume: 167
Pages: 243-257
Publication  
First Author: Wang Y
Year: 2023
Journal: Free Radic Biol Med
Title: Macrophage CAPN4 regulates CVB3-induced cardiac inflammation and injury by promoting NLRP3 inflammasome activation and phenotypic transformation to the inflammatory subtype.
Volume: 208
Pages: 430-444
Publication  
First Author: Vogel S
Year: 2021
Journal: Biochem Biophys Res Commun
Title: NLRP3 inflammasome and bruton tyrosine kinase inhibition interferes with upregulated platelet aggregation and in vitro thrombus formation in sickle cell mice.
Volume: 555
Pages: 196-201
Publication  
First Author: Zhou B
Year: 2020
Journal: Oxid Med Cell Longev
Title: FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
Volume: 2020
Pages: 6384803
Allele
Name: NLR family, pyrin domain containing 3; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Chimin P
Year: 2017
Journal: J Lipid Res
Title: Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.
Volume: 58
Issue: 9
Pages: 1797-1807
Publication
First Author: Chen L
Year: 2019
Journal: Mol Med Rep
Title: Downregulation of FSTL‑1 attenuates the inflammation injury during Streptococcus pneumoniae infection by inhibiting the NLRP3 and TLR4/NF‑κB signaling pathway.
Volume: 20
Issue: 6
Pages: 5345-5352
Publication  
First Author: Wu XL
Year: 2020
Journal: Int Immunopharmacol
Title: Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress.
Volume: 84
Pages: 106559
Publication  
First Author: Dhar R
Year: 2021
Journal: Free Radic Biol Med
Title: Phosphodiesterase 4B is required for NLRP3 inflammasome activation by positive feedback with Nrf2 in the early phase of LPS- induced acute lung injury.
Volume: 176
Pages: 378-391
Publication
First Author: Zhang Z
Year: 2022
Journal: Int Immunopharmacol
Title: Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis.
Volume: 113
Issue: Pt B
Pages: 109430
Publication
First Author: Li Q
Year: 2023
Journal: Am J Pathol
Title: Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis.
Volume: 193
Issue: 2
Pages: 213-232
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: de Oliveira P
Year: 2022
Journal: J Neurosci
Title: Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.
Volume: 42
Issue: 16
Pages: 3494-3509
Publication
First Author: Kongsomboonvech AK
Year: 2020
Journal: PLoS Pathog
Title: Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.
Volume: 16
Issue: 8
Pages: e1008327
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 336  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
Interaction Experiment
Description: Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimers disease by maintaining the phagocytic function of microglia.
Publication
First Author: Adamiak M
Year: 2019
Journal: Leukemia
Title: Novel evidence that an alternative complement cascade pathway is involved in optimal mobilization of hematopoietic stem/progenitor cells in Nlrp3 inflammasome-dependent manner.
Volume: 33
Issue: 12
Pages: 2967-2970
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Protein
Organism: Mus musculus/domesticus
Length: 1033  
Fragment?: false
Publication
First Author: Tang X
Year: 2020
Journal: Circulation
Title: SNO-MLP (S-Nitrosylation of Muscle LIM Protein) Facilitates Myocardial Hypertrophy Through TLR3 (Toll-Like Receptor 3)-Mediated RIP3 (Receptor-Interacting Protein Kinase 3) and NLRP3 (NOD-Like Receptor Pyrin Domain Containing 3) Inflammasome Activation.
Volume: 141
Issue: 12
Pages: 984-1000
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Ratajczak MZ
Year: 2023
Journal: Leukemia
Title: Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner.
Volume: 37
Issue: 6
Pages: 1401-1405
Publication
First Author: Suetomi T
Year: 2018
Journal: Circulation
Title: Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca2+/Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling.
Volume: 138
Issue: 22
Pages: 2530-2544
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Interaction Experiment
Description: Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-?B signaling and NLRP3 inflammasome activation.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Nieto-Torres JL
Year: 2015
Journal: Virology
Title: Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome.
Volume: 485
Pages: 330-9
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Juliana C
Year: 2012
Journal: J Biol Chem
Title: Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation.
Volume: 287
Issue: 43
Pages: 36617-22
Publication      
First Author: Xu T
Year: 2022
Journal: Cell Death Differ
Title: Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation.
Publication
First Author: Lin Y
Year: 2022
Journal: EMBO Rep
Title: TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.
Volume: 23
Issue: 11
Pages: e54569
Publication
First Author: Yan YQ
Year: 2023
Journal: Aging Cell
Title: Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease.
Volume: 22
Issue: 6
Pages: e13834
Publication
First Author: Siu KL
Year: 2019
Journal: FASEB J
Title: Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC.
Volume: 33
Issue: 8
Pages: 8865-8877
Genotype
Symbol: Prkaca/Prkaca<+> Prkar1a/Prkar1a<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Nlrp3/Nlrp3<+>
Background: involves: 129
Zygosity: ht
Has Mutant Allele: true
DO Term
DO Term