| Type |
Details |
Score |
| Publication |
| First Author: |
Chaves MM |
| Year: |
2019 |
| Journal: |
PLoS Pathog |
| Title: |
Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4. |
| Volume: |
15 |
| Issue: |
6 |
| Pages: |
e1007887 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Anderson OA |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome. |
| Volume: |
8 |
| Issue: |
6 |
| Pages: |
e67263 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Niemi K |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway. |
| Volume: |
186 |
| Issue: |
11 |
| Pages: |
6119-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang SY |
| Year: |
2023 |
| Journal: |
Neural Regen Res |
| Title: |
The Alzheimer's disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation. |
| Volume: |
18 |
| Issue: |
2 |
| Pages: |
434-438 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu M |
| Year: |
2023 |
| Journal: |
Oxid Med Cell Longev |
| Title: |
TRIM72 Alleviates Muscle Inflammation in mdx Mice via Promoting Mitophagy-Mediated NLRP3 Inflammasome Inactivation. |
| Volume: |
2023 |
|
| Pages: |
8408574 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alfonso-Loeches S |
| Year: |
2014 |
| Journal: |
Front Cell Neurosci |
| Title: |
Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells. |
| Volume: |
8 |
|
| Pages: |
216 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Henriksbo BD |
| Year: |
2020 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTOR. |
| Volume: |
319 |
| Issue: |
1 |
| Pages: |
E110-E116 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Clénet ML |
| Year: |
2023 |
| Journal: |
Front Immunol |
| Title: |
Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome activation: therapeutic implications for ALS. |
| Volume: |
14 |
|
| Pages: |
1190219 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lonnemann N |
| Year: |
2020 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease. |
| Volume: |
117 |
| Issue: |
50 |
| Pages: |
32145-32154 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ni H |
| Year: |
2023 |
| Journal: |
Cell Death Discov |
| Title: |
XBP1 modulates endoplasmic reticulum and mitochondria crosstalk via regulating NLRP3 in renal ischemia/reperfusion injury. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang J |
| Year: |
2021 |
| Journal: |
Free Radic Biol Med |
| Title: |
PINK1/PARK2 dependent mitophagy effectively suppresses NLRP3 inflammasome to alleviate acute pancreatitis. |
| Volume: |
166 |
|
| Pages: |
147-164 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lv Z |
| Year: |
2023 |
| Journal: |
Int Immunopharmacol |
| Title: |
Trophoblastic mitochondrial DNA induces endothelial dysfunction and NLRP3 inflammasome activation: Implications for preeclampsia. |
| Volume: |
114 |
|
| Pages: |
109523 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lerner AG |
| Year: |
2012 |
| Journal: |
Cell Metab |
| Title: |
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. |
| Volume: |
16 |
| Issue: |
2 |
| Pages: |
250-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moraes-Vieira PM |
| Year: |
2020 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4. |
| Volume: |
117 |
| Issue: |
49 |
| Pages: |
31309-31318 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meng LC |
| Year: |
2022 |
| Journal: |
Int Immunopharmacol |
| Title: |
Salvianolic acid B ameliorates non-alcoholic fatty liver disease by inhibiting hepatic lipid accumulation and NLRP3 inflammasome in ob/ob mice. |
| Volume: |
111 |
|
| Pages: |
109099 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lupfer CR |
| Year: |
2014 |
| Journal: |
PLoS Pathog |
| Title: |
Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection. |
| Volume: |
10 |
| Issue: |
9 |
| Pages: |
e1004410 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Darwesh AM |
| Year: |
2019 |
| Journal: |
Int J Mol Sci |
| Title: |
Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation. |
| Volume: |
20 |
| Issue: |
14 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jessop F |
| Year: |
2017 |
| Journal: |
Toxicol Appl Pharmacol |
| Title: |
Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant NLRP3 inflammasome activity. |
| Volume: |
318 |
|
| Pages: |
58-68 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Inoue M |
| Year: |
2012 |
| Journal: |
Sci Signal |
| Title: |
Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. |
| Volume: |
5 |
| Issue: |
225 |
| Pages: |
ra38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Müller N |
| Year: |
2023 |
| Journal: |
Int J Mol Sci |
| Title: |
Lipocalin-2 Deficiency Diminishes Canonical NLRP3 Inflammasome Formation and IL-1β Production in the Subacute Phase of Spinal Cord Injury. |
| Volume: |
24 |
| Issue: |
10 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin W |
| Year: |
2023 |
| Journal: |
J Neuroinflammation |
| Title: |
TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer's disease via TFEB/TFE3 activation. |
| Volume: |
20 |
| Issue: |
1 |
| Pages: |
21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Z |
| Year: |
2024 |
| Journal: |
J Neuroinflammation |
| Title: |
Herpes simplex virus 1 accelerates the progression of Alzheimer's disease by modulating microglial phagocytosis and activating NLRP3 pathway. |
| Volume: |
21 |
| Issue: |
1 |
| Pages: |
176 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dong X |
| Year: |
2021 |
| Journal: |
Clin Transl Med |
| Title: |
Vitamin D3 ameliorates nitrogen mustard-induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway. |
| Volume: |
11 |
| Issue: |
2 |
| Pages: |
e312 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumar B |
| Year: |
2018 |
| Journal: |
Mol Ther |
| Title: |
Complement-Mediated Activation of the NLRP3 Inflammasome and Its Inhibition by AAV-Mediated Delivery of CD59 in a Model of Uveitis. |
| Volume: |
26 |
| Issue: |
6 |
| Pages: |
1568-1580 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pajarillo E |
| Year: |
2023 |
| Journal: |
J Biol Chem |
| Title: |
The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. |
| Volume: |
299 |
| Issue: |
7 |
| Pages: |
104879 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li LH |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP. |
| Volume: |
12 |
| Issue: |
7 |
| Pages: |
e0182057 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Qiao S |
| Year: |
2020 |
| Journal: |
Cancer Lett |
| Title: |
Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer. |
| Volume: |
491 |
|
| Pages: |
162-179 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cheng Y |
| Year: |
2020 |
| Journal: |
Int Immunopharmacol |
| Title: |
Ghrelin attenuates secondary brain injury following intracerebral hemorrhage by inhibiting NLRP3 inflammasome activation and promoting Nrf2/ARE signaling pathway in mice. |
| Volume: |
79 |
|
| Pages: |
106180 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yuan X |
| Year: |
2020 |
| Journal: |
Front Cell Dev Biol |
| Title: |
Reversal of Endothelial Extracellular Vesicle-Induced Smooth Muscle Phenotype Transition by Hypercholesterolemia Stimulation: Role of NLRP3 Inflammasome Activation. |
| Volume: |
8 |
|
| Pages: |
597423 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu C |
| Year: |
2023 |
| Journal: |
Redox Biol |
| Title: |
CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-κB pathway. |
| Volume: |
68 |
|
| Pages: |
102960 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shao BZ |
| Year: |
2014 |
| Journal: |
CNS Neurosci Ther |
| Title: |
Activating cannabinoid receptor 2 alleviates pathogenesis of experimental autoimmune encephalomyelitis via activation of autophagy and inhibiting NLRP3 inflammasome. |
| Volume: |
20 |
| Issue: |
12 |
| Pages: |
1021-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zou Y |
| Year: |
2022 |
| Journal: |
Front Immunol |
| Title: |
Targeting PCSK9 Ameliorates Graft Vascular Disease in Mice by Inhibiting NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells. |
| Volume: |
13 |
|
| Pages: |
894789 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Q |
| Year: |
2020 |
| Journal: |
Immunol Cell Biol |
| Title: |
Hyperglycemia aggravates acute liver injury by promoting liver-resident macrophage NLRP3 inflammasome activation via the inhibition of AMPK/mTOR-mediated autophagy induction. |
| Volume: |
98 |
| Issue: |
1 |
| Pages: |
54-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dagvadorj J |
| Year: |
2021 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation. |
| Volume: |
118 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ge S |
| Year: |
2021 |
| Journal: |
Int J Mol Sci |
| Title: |
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs. |
| Volume: |
22 |
| Issue: |
22 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jessop F |
| Year: |
2016 |
| Journal: |
Toxicol Appl Pharmacol |
| Title: |
Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure. |
| Volume: |
309 |
|
| Pages: |
101-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu DM |
| Year: |
2021 |
| Journal: |
Front Pharmacol |
| Title: |
Autophagy Induced by Micheliolide Alleviates Acute Irradiation-Induced Intestinal Injury via Inhibition of the NLRP3 Inflammasome. |
| Volume: |
12 |
|
| Pages: |
773150 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oleszycka E |
| Year: |
2023 |
| Journal: |
Front Immunol |
| Title: |
Bile acids induce IL-1α and drive NLRP3 inflammasome-independent production of IL-1β in murine dendritic cells. |
| Volume: |
14 |
|
| Pages: |
1285357 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
A20 restricts ubiquitination of pro-interleukin-1 protein complexes and suppresses NLRP3 inflammasome activity. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinsons disease. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wei Z |
| Year: |
2021 |
| Journal: |
Free Radic Biol Med |
| Title: |
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation. |
| Volume: |
167 |
|
| Pages: |
243-257 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2023 |
| Journal: |
Free Radic Biol Med |
| Title: |
Macrophage CAPN4 regulates CVB3-induced cardiac inflammation and injury by promoting NLRP3 inflammasome activation and phenotypic transformation to the inflammatory subtype. |
| Volume: |
208 |
|
| Pages: |
430-444 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vogel S |
| Year: |
2021 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
NLRP3 inflammasome and bruton tyrosine kinase inhibition interferes with upregulated platelet aggregation and in vitro thrombus formation in sickle cell mice. |
| Volume: |
555 |
|
| Pages: |
196-201 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou B |
| Year: |
2020 |
| Journal: |
Oxid Med Cell Longev |
| Title: |
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway. |
| Volume: |
2020 |
|
| Pages: |
6384803 |
|
•
•
•
•
•
|
| Allele |
| Name: |
NLR family, pyrin domain containing 3; endonuclease-mediated mutation 3, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chimin P |
| Year: |
2017 |
| Journal: |
J Lipid Res |
| Title: |
Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis. |
| Volume: |
58 |
| Issue: |
9 |
| Pages: |
1797-1807 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen L |
| Year: |
2019 |
| Journal: |
Mol Med Rep |
| Title: |
Downregulation of FSTL‑1 attenuates the inflammation injury during Streptococcus pneumoniae infection by inhibiting the NLRP3 and TLR4/NF‑κB signaling pathway. |
| Volume: |
20 |
| Issue: |
6 |
| Pages: |
5345-5352 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu XL |
| Year: |
2020 |
| Journal: |
Int Immunopharmacol |
| Title: |
Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress. |
| Volume: |
84 |
|
| Pages: |
106559 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dhar R |
| Year: |
2021 |
| Journal: |
Free Radic Biol Med |
| Title: |
Phosphodiesterase 4B is required for NLRP3 inflammasome activation by positive feedback with Nrf2 in the early phase of LPS- induced acute lung injury. |
| Volume: |
176 |
|
| Pages: |
378-391 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang Z |
| Year: |
2022 |
| Journal: |
Int Immunopharmacol |
| Title: |
Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis. |
| Volume: |
113 |
| Issue: |
Pt B |
| Pages: |
109430 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li Q |
| Year: |
2023 |
| Journal: |
Am J Pathol |
| Title: |
Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis. |
| Volume: |
193 |
| Issue: |
2 |
| Pages: |
213-232 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
de Oliveira P |
| Year: |
2022 |
| Journal: |
J Neurosci |
| Title: |
Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice. |
| Volume: |
42 |
| Issue: |
16 |
| Pages: |
3494-3509 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kongsomboonvech AK |
| Year: |
2020 |
| Journal: |
PLoS Pathog |
| Title: |
Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5. |
| Volume: |
16 |
| Issue: |
8 |
| Pages: |
e1008327 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
767
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
336
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
415
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
397
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimers disease by maintaining the phagocytic function of microglia. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adamiak M |
| Year: |
2019 |
| Journal: |
Leukemia |
| Title: |
Novel evidence that an alternative complement cascade pathway is involved in optimal mobilization of hematopoietic stem/progenitor cells in Nlrp3 inflammasome-dependent manner. |
| Volume: |
33 |
| Issue: |
12 |
| Pages: |
2967-2970 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1033
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang X |
| Year: |
2020 |
| Journal: |
Circulation |
| Title: |
SNO-MLP (S-Nitrosylation of Muscle LIM Protein) Facilitates Myocardial Hypertrophy Through TLR3 (Toll-Like Receptor 3)-Mediated RIP3 (Receptor-Interacting Protein Kinase 3) and NLRP3 (NOD-Like Receptor Pyrin Domain Containing 3) Inflammasome Activation. |
| Volume: |
141 |
| Issue: |
12 |
| Pages: |
984-1000 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ratajczak MZ |
| Year: |
2023 |
| Journal: |
Leukemia |
| Title: |
Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner. |
| Volume: |
37 |
| Issue: |
6 |
| Pages: |
1401-1405 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suetomi T |
| Year: |
2018 |
| Journal: |
Circulation |
| Title: |
Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca2+/Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling. |
| Volume: |
138 |
| Issue: |
22 |
| Pages: |
2530-2544 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-?B signaling and NLRP3 inflammasome activation. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nieto-Torres JL |
| Year: |
2015 |
| Journal: |
Virology |
| Title: |
Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome. |
| Volume: |
485 |
|
| Pages: |
330-9 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Juliana C |
| Year: |
2012 |
| Journal: |
J Biol Chem |
| Title: |
Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. |
| Volume: |
287 |
| Issue: |
43 |
| Pages: |
36617-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu T |
| Year: |
2022 |
| Journal: |
Cell Death Differ |
| Title: |
Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin Y |
| Year: |
2022 |
| Journal: |
EMBO Rep |
| Title: |
TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization. |
| Volume: |
23 |
| Issue: |
11 |
| Pages: |
e54569 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yan YQ |
| Year: |
2023 |
| Journal: |
Aging Cell |
| Title: |
Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease. |
| Volume: |
22 |
| Issue: |
6 |
| Pages: |
e13834 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Siu KL |
| Year: |
2019 |
| Journal: |
FASEB J |
| Title: |
Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC. |
| Volume: |
33 |
| Issue: |
8 |
| Pages: |
8865-8877 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Prkaca/Prkaca<+> Prkar1a/Prkar1a<+> |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nlrp3/Nlrp3<+> |
| Background: |
involves: 129 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|