| Type |
Details |
Score |
| Publication |
| First Author: |
International Committee on Standardized Genetic Nomenclature for Mice |
| Year: |
1993 |
|
| Title: |
Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2018 |
| Journal: |
Database Release |
| Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Velocigene |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| MP Term |
|
•
•
•
•
•
|
| MP Term |
|
•
•
•
•
•
|
| MP Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Béchade C |
| Year: |
2014 |
| Journal: |
Glia |
| Title: |
NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation. |
| Volume: |
62 |
| Issue: |
6 |
| Pages: |
956-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu H |
| Year: |
2022 |
| Journal: |
Redox Biol |
| Title: |
HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3. |
| Volume: |
56 |
|
| Pages: |
102461 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE29192 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yagishita Y |
| Year: |
2014 |
| Journal: |
Diabetes |
| Title: |
Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice. |
| Volume: |
63 |
| Issue: |
2 |
| Pages: |
605-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Myint KM |
| Year: |
2006 |
| Journal: |
Diabetes |
| Title: |
RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin. |
| Volume: |
55 |
| Issue: |
9 |
| Pages: |
2510-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Noguchi N |
| Year: |
2008 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
FKBP12.6 disruption impairs glucose-induced insulin secretion. |
| Volume: |
371 |
| Issue: |
4 |
| Pages: |
735-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamamoto Y |
| Year: |
2001 |
| Journal: |
J Clin Invest |
| Title: |
Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. |
| Volume: |
108 |
| Issue: |
2 |
| Pages: |
261-8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6277916 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2019-02-12 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3284724 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:6277920 |
| Age: |
embryonic day 16.5 |
|
| Note: |
Similar expression to that of Nos2 in region of myenteric plexus. |
| Specimen Label: |
3D |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6277919 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2019-02-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2692220 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:6277923 |
| Age: |
embryonic day 12.5 |
|
| Note: |
Authors report initial expression correlates with Nos2 expression, but occurs later and is not as strong. |
| Specimen Label: |
2F |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6277916 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2019-02-12 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2692224 |
| Pattern: |
Regionally restricted |
| Stage: |
TS24 |
| Assay Id: |
MGI:6277920 |
| Age: |
embryonic day 16.5 |
|
| Note: |
Authors state expression starts to intensify. Similar expression to that of Nos2 in region of myenteric plexus. |
| Specimen Label: |
3C |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 40, Hiroshi Okamoto |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| GO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Foster MW |
| Year: |
2013 |
| Journal: |
Nitric Oxide |
| Title: |
Proteomic analysis of the NOS2 interactome in human airway epithelial cells. |
| Volume: |
34 |
|
| Pages: |
37-46 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1144
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Ins2-Nos2)40Okam/? |
| Background: |
involves: C57BL/6 * CD-1 * DBA/2 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Ins2-Nos2)40Okam/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ager/Ager<+> Tg(Ins2-Nos2)40Okam/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ager/Ager Tg(Ins2-Nos2)40Okam/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Ins2-Nos2)40Okam/? Tg(Kdr-AGER)102Hyam/? |
| Background: |
involves: C57BL/6J * CBA/J * CD-1 * DBA/2 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Allele |
| Name: |
nitric oxide synthase 2, inducible; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Transgene |
| Type: |
transgene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Transgene |
| Type: |
transgene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
nitric oxide synthase 2, inducible; targeted mutation 1, Victor E Laubach |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant stock |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 31, Hiroshi Okamoto |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Hiroshi Okamoto |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Masao Kaneki |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nos2/Nos2 |
| Background: |
B6.129P2-Nos2 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nos2/Nos2 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nos2/Nos2 |
| Background: |
B6.129P2-Nos2/J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nos2/Nos2 |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nos2/Nos2 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nos2/Nos2 |
| Background: |
B6;129P2-Nos2/J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suzuki S |
| Year: |
2020 |
| Journal: |
Endocr J |
| Title: |
Expression and pathophysiological significance of carbohydrate response element binding protein (ChREBP) in the renal tubules of diabetic kidney. |
| Volume: |
67 |
| Issue: |
3 |
| Pages: |
335-345 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kishi S |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
SOX9 protein induces a chondrogenic phenotype of mesangial cells and contributes to advanced diabetic nephropathy. |
| Volume: |
286 |
| Issue: |
37 |
| Pages: |
32162-9 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Alain Bessis |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase, Reporter |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Ins2-Nos2)31Okam/? |
| Background: |
involves: C57BL/6 * CD-1 * DBA/2 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Alb-Nos2)1Mkan/? |
| Background: |
FVB-Tg(Alb-Nos2)1Mkan |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation, chemically induced mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation, spontaneous mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, targeted mutation, transgenic |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Jack A Elias |
| Allele Type: |
Transgenic |
| Attribute String: |
Inducible, Inserted expressed sequence, Transactivator |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Apc/Apc<+> Nos2/Nos2 |
| Background: |
B6.Cg-Nos2 Apc |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Apc/Apc<+> Nos2/Nos2<+> |
| Background: |
B6.Cg-Nos2 Apc |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nos2/Nos2 Tg(MMTV-PyVT)634Mul/? |
| Background: |
B6.Cg-Nos2 Tg(MMTV-PyVT)634Mul |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nos2/Nos2 Tg(MMTV-PyVT)634Mul/? |
| Background: |
FVB.Cg-Nos2 Tg(MMTV-PyVT)634Mul |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
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| Genotype |
| Symbol: |
Nos2/Nos2 Tg(APPSWE)2576Kha/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * SJL |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
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| Genotype |
| Symbol: |
Nos2/Nos2 Nos3/Nos3 |
| Background: |
B6.129P2-Nos3 Nos2 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
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| Genotype |
| Symbol: |
Adh5/Adh5 Nos2/Nos2 |
| Background: |
involves: 129 * 129P2/OlaHsd |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
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| Strain |
| Attribute String: |
coisogenic, mutant strain, spontaneous mutation, targeted mutation, congenic |
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| Publication |
| First Author: |
Hjoberg J |
| Year: |
2004 |
| Journal: |
J Appl Physiol (1985) |
| Title: |
Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness. |
| Volume: |
97 |
| Issue: |
1 |
| Pages: |
249-59 |
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| Genotype |
| Symbol: |
Nos2/Nos2 Tg(RHO-VEGFA)V-6Camp/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
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| Genotype |
| Symbol: |
Nos1/Nos1 Nos2/Nos2 |
| Background: |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
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| Genotype |
| Symbol: |
Il10/Il10 Nos2/Nos2 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
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