| Type |
Details |
Score |
| Publication |
| First Author: |
Toronto Centre for Phenogenomics |
| Year: |
2013 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Strains and alleles submitted by Toronto Centre for Phenogenomics (NorCOMM2, funded by Genome Canada and Ontario Genomics Institute OGI-051). |
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•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Memic F |
| Year: |
2018 |
| Journal: |
Gastroenterology |
| Title: |
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. |
| Volume: |
154 |
| Issue: |
3 |
| Pages: |
624-636 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory |
| Year: |
2005 |
| Journal: |
Unpublished |
| Title: |
Information obtained from The Jackson Laboratory, Bar Harbor, ME |
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•
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•
•
•
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| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
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•
•
•
•
•
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| Publication |
| First Author: |
Guo G |
| Year: |
2010 |
| Journal: |
Dev Cell |
| Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
| Volume: |
18 |
| Issue: |
4 |
| Pages: |
675-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dickinson ME |
| Year: |
2016 |
| Journal: |
Nature |
| Title: |
High-throughput discovery of novel developmental phenotypes. |
| Volume: |
537 |
| Issue: |
7621 |
| Pages: |
508-514 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gray PA |
| Year: |
2004 |
| Journal: |
Science |
| Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
| Volume: |
306 |
| Issue: |
5705 |
| Pages: |
2255-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thompson CL |
| Year: |
2014 |
| Journal: |
Neuron |
| Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
| Volume: |
83 |
| Issue: |
2 |
| Pages: |
309-323 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Visel A |
| Year: |
2004 |
| Journal: |
Nucleic Acids Res |
| Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
| Volume: |
32 |
| Issue: |
Database issue |
| Pages: |
D552-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bedogni F |
| Year: |
2021 |
| Journal: |
Front Mol Neurosci |
| Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
| Volume: |
14 |
|
| Pages: |
686034 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
International Knockout Mouse Consortium |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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•
•
•
•
•
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| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2009 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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•
•
•
•
•
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| Publication |
| First Author: |
GUDMAP Consortium |
| Year: |
2004 |
| Journal: |
www.gudmap.org |
| Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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•
•
•
•
•
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| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
•
•
•
•
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| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
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•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
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•
•
•
•
•
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| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
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•
•
•
•
•
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| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
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•
•
•
•
•
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| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
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|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Gu W |
| Year: |
2022 |
| Journal: |
Cell Stem Cell |
| Title: |
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. |
| Volume: |
29 |
| Issue: |
1 |
| Pages: |
101-115.e10 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
SATB2 augments ?Np63? in head and neck squamous cell carcinoma. |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7579005 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-01-31 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3271120 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:7579034 |
| Age: |
embryonic day 12.5 |
|
| Note: |
Co-expression with Satb2 in almost half of Satb2 expressing neurons. |
| Specimen Label: |
2d E12.5 mRNA Bcl11b |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
TNF-? inhibits SATB2 expression and osteoblast differentiation through NF-?B and MAPK pathways. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chung J |
| Year: |
2010 |
| Journal: |
EMBO Rep |
| Title: |
SATB2 augments ΔNp63α in head and neck squamous cell carcinoma. |
| Volume: |
11 |
| Issue: |
10 |
| Pages: |
777-83 |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
transcription profiling by array |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620101 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558827 |
| Pattern: |
Regionally restricted |
| Stage: |
TS27 |
| Assay Id: |
MGI:7620362 |
| Age: |
postnatal day 0 |
| Image: |
7M,N |
| Note: |
There was a striking loss of expression in the upper layers of the Satb2 mutants. |
| Specimen Label: |
7M,N |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754928 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620251 |
| Age: |
postnatal |
| Image: |
6C |
| Note: |
Satb2 mutants show a reduction in PLAP+ axons traversing the striatum. |
| Specimen Label: |
6C |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620324 |
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754928 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620322 |
| Age: |
postnatal |
| Image: |
6L |
| Note: |
Satb2 mutants show a reduction in PLAP+ axons traversing the striatum. |
| Specimen Label: |
6L |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zuo C |
| Year: |
2018 |
| Journal: |
Oncotarget |
| Title: |
TNF-α inhibits SATB2 expression and osteoblast differentiation through NF-κB and MAPK pathways. |
| Volume: |
9 |
| Issue: |
4 |
| Pages: |
4833-4850 |
|
•
•
•
•
•
|
| Allele |
| Name: |
special AT-rich sequence binding protein 2; targeted mutation 1.1, Samuel L Pfaff |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7620104 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-04-12 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3558828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7620298 |
| Age: |
postnatal day 4 |
| Image: |
5B |
| Note: |
Satb2 conditional knockouts show reduced Tbr1 in layers 6 and 5, and a loss of Tbr1 in the upper layers. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Allele |
| Name: |
special AT-rich sequence binding protein 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5447971 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2023-02-10 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3284226 |
| Pattern: |
Regionally restricted |
| Stage: |
TS26 |
| Assay Id: |
MGI:7432928 |
| Age: |
embryonic day 18.5 |
| Image: |
5C Kat7lox/lox NesCreT/+ |
| Note: |
Cells expressing Ctip2 (Bcl11b) only were overrepresented in superficial layers. Abnormally high number of cells co-expressing Ctip2 and Satb2 in superficial layers. |
| Specimen Label: |
5C Kat7lox/lox NesCreT/+ |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion MO23, GENSAT Project at Rockefeller University |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion MO18, GENSAT Project at Rockefeller University |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seo J |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
Nuclear matrix binding regulates SATB1-mediated transcriptional repression. |
| Volume: |
280 |
| Issue: |
26 |
| Pages: |
24600-9 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
74
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dobreva G |
| Year: |
2003 |
| Journal: |
Genes Dev |
| Title: |
SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression. |
| Volume: |
17 |
| Issue: |
24 |
| Pages: |
3048-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pavan Kumar P |
| Year: |
2006 |
| Journal: |
Mol Cell |
| Title: |
Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. |
| Volume: |
22 |
| Issue: |
2 |
| Pages: |
231-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zarate YA |
| Year: |
2017 |
| Journal: |
Clin Genet |
| Title: |
Genotype and phenotype in 12 additional individuals with SATB2-associated syndrome. |
| Volume: |
92 |
| Issue: |
4 |
| Pages: |
423-429 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zarate YA |
| Year: |
2017 |
| Journal: |
Am J Med Genet A |
| Title: |
SATB2-associated syndrome: Mechanisms, phenotype, and practical recommendations. |
| Volume: |
173 |
| Issue: |
2 |
| Pages: |
327-337 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sunkara KP |
| Year: |
2018 |
| Journal: |
Biomed Pharmacother |
| Title: |
Functional relevance of SATB1 in immune regulation and tumorigenesis. |
| Volume: |
104 |
|
| Pages: |
87-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Frömberg A |
| Year: |
2018 |
| Journal: |
Cancer Lett |
| Title: |
The Special AT-rich Sequence Binding Protein 1 (SATB1) and its role in solid tumors. |
| Volume: |
417 |
|
| Pages: |
96-111 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes SATB1/2 from animals. SATB1 is a global gene regulator that acts as a "docking site"for several chromatin remodeling enzymes and recruits corepressors (HDACs) or coactivators (HATs) directly to promoters []. SATB1 can bind DNA specifically to the consensus SATB1-binding sequence (CSBS) consisting of two 5'-TAATA-3' half-sites that are arranged as inverted repeats flanking a central cytosine or guanine. It can also bind DNA non-specifically []. SATB1 has been shown to bind to the nuclear matrix attachment regions (MARs) of the immunoglobulin heavy chain intronic enhancer [], while SATB2 has been shown to bind to the MARs of the endogenous immunoglobulin micro locus in pre-B cells and enhances gene expression [].SATB1 is an identified oncogene, its increased expression is associated with poor prognosis in many cancers []. Mutations in the SATB2 gene cause SATB2-associated syndrome (SAS), characterised by developmental delay/intellectual disability with absent or limited speech development, craniofacial abnormalities, behavioral problems, dysmorphic features, and palatal and dental abnormalities [, ]. |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Satb2/Satb2<+> |
| Background: |
involves: 129S6/SvEvTac * C57BL/6NCrl |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
GEO |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
154
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gil-Sanz C |
| Year: |
2015 |
| Journal: |
Neuron |
| Title: |
Lineage Tracing Using Cux2-Cre and Cux2-CreERT2 Mice. |
| Volume: |
86 |
| Issue: |
4 |
| Pages: |
1091-1099 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sweeney NT |
| Year: |
2019 |
| Journal: |
J Comp Neurol |
| Title: |
Expression of transcription factors divides retinal ganglion cells into distinct classes. |
| Volume: |
527 |
| Issue: |
1 |
| Pages: |
225-235 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cánovas J |
| Year: |
2015 |
| Journal: |
J Neurosci |
| Title: |
The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by CTIP1/BCL11a. |
| Volume: |
35 |
| Issue: |
19 |
| Pages: |
7552-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feng J |
| Year: |
2017 |
| Journal: |
Development |
| Title: |
BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. |
| Volume: |
144 |
| Issue: |
14 |
| Pages: |
2560-2569 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Addison WN |
| Year: |
2019 |
| Journal: |
Mol Cell Biol |
| Title: |
Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation. |
| Volume: |
39 |
| Issue: |
8 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grady F |
| Year: |
2020 |
| Journal: |
Cereb Cortex |
| Title: |
Direct Parabrachial-Cortical Connectivity. |
| Volume: |
30 |
| Issue: |
9 |
| Pages: |
4811-4833 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin F |
| Year: |
2024 |
| Journal: |
Sci Rep |
| Title: |
POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels specific populations of retinal ganglion cells. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
10096 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Loy B |
| Year: |
2011 |
| Journal: |
J Neurosci |
| Title: |
p38α and p38β mitogen-activated protein kinases determine cholinergic transdifferentiation of sympathetic neurons. |
| Volume: |
31 |
| Issue: |
34 |
| Pages: |
12059-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tantirigama ML |
| Year: |
2016 |
| Journal: |
J Comp Neurol |
| Title: |
Fezf2 expression in layer 5 projection neurons of mature mouse motor cortex. |
| Volume: |
524 |
| Issue: |
4 |
| Pages: |
829-45 |
|
•
•
•
•
•
|