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Search results 1301 to 1400 out of 1633 for Smad2

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Hits by Strain

Type Details Score
Strain
MGI:6476337 | C57BL/6JSmoc-Smad2<tm1Smoc>/Smoc
Attribute String: coisogenic, targeted mutation, mutant strain
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Allele
Rr54<em1Axvi> | MGI:7489588
Name: Regulatory region 54; endonuclease-mediated mutation 1, Axel Visel
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Genotype
Genotype
Symbol: Smad2/Smad2
Background: involves: 129S/SvEv
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR024608 | SARA_Smad-bd
Type: Domain
Description: Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus. SARA (Smad anchor for receptor activation) recruits Smad2 to the TGF-beta receptors for phosphorylation [].This entry represents the Smad-binding domain (SBD) of SARA. This domain consists of a rigid coil, an alpha helix, and a beta strand, and interacts with Smad2 [].
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Protein Domain
IPR037145 | SARA_Smad-bd_sf
Type: Homologous_superfamily
Description: Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus. SARA (Smad anchor for receptor activation) recruits Smad2 to the TGF-beta receptors for phosphorylation [].This entry represents the Smad-binding domain (SBD) superfamily of SARA. This domain consists of a rigid coil, an alpha helix, and a beta strand, and interacts with Smad2 [].
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Protein
Q3UXU9
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
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Allele
Tgfbr1<tm1Mulm> | MGI:3767608
 
Name: transforming growth factor, beta receptor I; targeted mutation 1, Christine L Mummery
Allele Type: Targeted
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Allele
Tg(Amh-SMAD2*)2Tkw | MGI:5528705
Name: transgene insertion 2, Teresa K Woodruff
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Strain
MGI:5543943 | FVB/N-Tg(Amh-SMAD2*)#Jebu
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:6348309 | FVB/NCrl-Rr54<em1Axvi>/Mmucd
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
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Strain
MGI:7489910 | FVB-Rr54<em1Axvi>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Tgfbr1/Tgfbr1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Amh-SMAD2*)#Jebu/?
Background: FVB/N-Tg(Amh-SMAD2*)#Jebu
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr54/Rr54
Background: FVB-Rr54
Zygosity: hm
Has Mutant Allele: true
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Publication
17292623 | J:123207
First Author: Arndt S
Year: 2007
Journal: Mol Cell Neurosci
Title: Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.
Volume: 34
Issue: 4
Pages: 603-11
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Publication
16141389 | J:129226
First Author: Bristol-Gould SK
Year: 2005
Journal: Endocrinology
Title: The development of a mouse model of ovarian endosalpingiosis.
Volume: 146
Issue: 12
Pages: 5228-36
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Genotype
Genotype
Symbol: Tg(Amh-SMAD2*)2Tkw/?
Background: involves: CD-1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Amh-SMAD2*)#Jebu/? Trp53/Trp53
Background: involves: 129P2/OlaHsd * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
17272273 | -
First Author: Chen YG
Year: 2007
Journal: J Biol Chem
Title: Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling.
Volume: 282
Issue: 13
Pages: 9688-95
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Publication
12432064 | -
First Author: Hu Y
Year: 2002
Journal: J Cell Sci
Title: SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.
Volume: 115
Issue: Pt 24
Pages: 4755-63
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Protein Domain
IPR035438 | SARA/endofin
Type: Family
Description: This group represents zinc finger FYVE domain-containing proteins SARA and endofin.SARA (also known as zinc finger FYVE domain-containing protein 9) is a component of the TGFbeta pathway that functions to recruit Smad2 to the TGFbeta receptor []. Endofin (zinc finger FYVE domain-containing protein 16) facilitates TGF-beta signaling by bringing Smad4 to the proximity of the receptor complex []. Both are involved in regulating membrane trafficking in the endosomal pathway [, ].
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Publication
15388229 | J:94922
First Author: Muto E
Year: 2004
Journal: Biochimie
Title: Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates.
Volume: 86
Issue: 8
Pages: 523-31
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Publication
16054033 | -
First Author: Teleman AA
Year: 2005
Journal: Dev Cell
Title: Drosophila Melted modulates FOXO and TOR activity.
Volume: 9
Issue: 2
Pages: 271-81
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Protein Domain
IPR028762 | SKOR1
Type: Family
Description: Ski family transcriptional corepressor 1 (SKOR1), also known as ladybird homeobox corepressor 1 or fussel-15 homologue, belongs to Ski family. Like the other members, it is characterised by a Ski homologue domain and a SAND domain - a domain found in some nuclear proteins involved in chromatin-dependent transcriptional regulation. Fussel-15 is mainly expressed in the central nervous system (CNS). The Ski family of nuclear oncoproteins is known to repress transforming growth factor-beta (TGF-beta) signalling through inhibition of transcriptional activity of Smad proteins. Fussel-15 interacts with Smad1, Smad2 and Smad3 molecules and suppresses mainly BMP signalling pathway, but it has only minor effects on TGF-beta signalling [].
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Protein Domain
IPR039888 | Melted-like
Type: Family
Description: This entry includes protein melted from fruit flies and its homologues. They contain a single C-terminal PH domain that is required for membrane targeting. Melted interacts with both Tsc1 and FOXO and can recruit them to the cell membrane []. In vertebrates the melted protein homologue, veph, is expressed in the developing central nervous system []. The human homologue VEPH1 (ventricular zone-expressed PH domain-containing protein homologue 1) has been shown to inhibit TGF-beta signaling by impeding the release of activated SMAD2 from TbetaRI [].
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Publication
19398960 | J:149886
First Author: Itoh F
Year: 2009
Journal: Lab Invest
Title: Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation.
Volume: 89
Issue: 7
Pages: 800-10
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Publication
26120963 | J:225716
First Author: Schachtrup C
Year: 2015
Journal: Nat Neurosci
Title: Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.
Volume: 18
Issue: 8
Pages: 1077-80
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Protein
A0S860
Organism: Mus musculus/domesticus
Length: 706  
Fragment?: false
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Publication
32531799 | J:306879
First Author: Chen L
Year: 2020
Journal: FEBS Lett
Title: Islet-cell autoantigen 69 accelerates liver regeneration by downregulating Tgfbr1 and attenuating Tgfβ signaling in mice.
Volume: 594
Issue: 17
Pages: 2881-2893
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Publication
22796494 | J:188522
First Author: Yan G
Year: 2012
Journal: FEBS Lett
Title: MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB.
Volume: 586
Issue: 19
Pages: 3263-70
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Protein Domain
IPR003619 | MAD_homology1_Dwarfin-type
Type: Domain
Description: Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth []. The dwarfin family also includes the Drosophila protein MAD that is required for the function of decapentaplegic (DPP) and may play a role in DPP signalling. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Dpp []. This domain is also found in nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF).This entry represents the MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localisation signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx [, , ].
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Publication
20129061 | J:212798
First Author: Watanabe Y
Year: 2010
Journal: Mol Cell
Title: TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.
Volume: 37
Issue: 1
Pages: 123-34
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Publication
9335507 | J:43278
First Author: Nakao A
Year: 1997
Journal: Nature
Title: Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
Volume: 389
Issue: 6651
Pages: 631-5
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Publication
16424156 | J:126434
First Author: Wohlfert EA
Year: 2006
Journal: J Immunol
Title: Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo.
Volume: 176
Issue: 3
Pages: 1316-20
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Publication
21894148 | J:180037
First Author: Siebert N
Year: 2011
Journal: Lab Invest
Title: Erythropoietin improves skin wound healing and activates the TGF-β signaling pathway.
Volume: 91
Issue: 12
Pages: 1753-65
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Publication
36229481 | J:353711
First Author: Shen H
Year: 2022
Journal: Nat Commun
Title: The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis.
Volume: 13
Issue: 1
Pages: 6030
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Publication
19147584 | J:143706
First Author: Zeng Q
Year: 2009
Journal: Cancer Res
Title: Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development.
Volume: 69
Issue: 2
Pages: 678-86
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Publication
10708960 | J:61301
First Author: Ashcroft GS
Year: 2000
Journal: Cytokine Growth Factor Rev
Title: Loss of Smad3 modulates wound healing.
Volume: 11
Issue: 1-2
Pages: 125-31
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Publication
20304828 | J:159864
First Author: Lu L
Year: 2010
Journal: J Immunol
Title: Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells.
Volume: 184
Issue: 8
Pages: 4295-306
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Publication
21493862 | J:171338
First Author: Holm TM
Year: 2011
Journal: Science
Title: Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice.
Volume: 332
Issue: 6027
Pages: 358-61
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Publication
31289197 | J:279777
 
First Author: Arnò B
Year: 2019
Journal: J Cell Sci
Title: TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.
Volume: 132
Issue: 15
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Publication
39398242 | J:358085
First Author: Li X
Year: 2024
Journal: iScience
Title: A regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-β signaling.
Volume: 27
Issue: 10
Pages: 110938
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Publication
25266657 | J:224324
First Author: Curado F
Year: 2014
Journal: Mol Cell Biol
Title: ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells.
Volume: 34
Issue: 24
Pages: 4389-403
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Publication
15654327 | J:96049
First Author: Reynolds LE
Year: 2005
Journal: Nat Med
Title: Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.
Volume: 11
Issue: 2
Pages: 167-74
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Publication
21333552 | J:168978
First Author: Chang X
Year: 2011
Journal: Immunity
Title: The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.
Volume: 34
Issue: 2
Pages: 201-12
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Publication
24928396 | J:219439
First Author: Nomura M
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity.
Volume: 450
Issue: 1
Pages: 440-6
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Publication
24929238 | J:214985
First Author: Sun LT
Year: 2014
Journal: Dev Biol
Title: Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.
Volume: 392
Issue: 2
Pages: 182-92
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Publication
24703841 | J:211820
First Author: Bereshchenko O
Year: 2014
Journal: Cell Rep
Title: GILZ promotes production of peripherally induced Treg cells and mediates the crosstalk between glucocorticoids and TGF-β signaling.
Volume: 7
Issue: 2
Pages: 464-75
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Publication
21949412 | J:177724
First Author: Danussi C
Year: 2011
Journal: J Cell Biol
Title: EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.
Volume: 195
Issue: 1
Pages: 131-45
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Publication
32843541 | J:328080
 
First Author: Gannam ZTK
Year: 2020
Journal: Sci Signal
Title: An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.
Volume: 13
Issue: 646
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Publication
31676717 | J:282137
 
First Author: Göngrich C
Year: 2020
Journal: J Cell Biol
Title: ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons.
Volume: 219
Issue: 1
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Publication
28356385 | J:247877
First Author: Rus V
Year: 2017
Journal: J Immunol
Title: RGC-32 Promotes Th17 Cell Differentiation and Enhances Experimental Autoimmune Encephalomyelitis.
Volume: 198
Issue: 10
Pages: 3869-3877
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Publication
28400474 | J:242008
First Author: Fu G
Year: 2017
Journal: J Exp Med
Title: Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1.
Volume: 214
Issue: 5
Pages: 1453-1469
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Publication
21182936 | J:170588
First Author: Stoppani E
Year: 2011
Journal: Biochim Biophys Acta
Title: Point mutated caveolin-3 form (P104L) impairs myoblast differentiation via Akt and p38 signalling reduction, leading to an immature cell signature.
Volume: 1812
Issue: 4
Pages: 468-79
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Publication
15604265 | J:94958
First Author: Muraoka-Cook RS
Year: 2004
Journal: Cancer Res
Title: Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors.
Volume: 64
Issue: 24
Pages: 9002-11
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Publication
16916642 | J:112622
First Author: Seo SR
Year: 2006
Journal: Mol Cell
Title: Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling.
Volume: 23
Issue: 4
Pages: 547-59
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Publication
22036565 | J:182366
First Author: Mullen AC
Year: 2011
Journal: Cell
Title: Master transcription factors determine cell-type-specific responses to TGF-β signaling.
Volume: 147
Issue: 3
Pages: 565-76
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Publication
11389842 | J:190004
First Author: Yeo C
Year: 2001
Journal: Mol Cell
Title: Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms.
Volume: 7
Issue: 5
Pages: 949-57
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Publication
11170302 | J:67506
First Author: Rossmanith W
Year: 2001
Journal: Microsc Res Tech
Title: Biology of transforming growth factor beta in hepatocarcinogenesis.
Volume: 52
Issue: 4
Pages: 430-6
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Publication
10393693 | J:56152
First Author: Nakao A
Year: 1999
Journal: J Clin Invest
Title: Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice.
Volume: 104
Issue: 1
Pages: 5-11
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Publication
12839923 | J:84342
First Author: Vijayachandra K
Year: 2003
Journal: Cancer Res
Title: Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model.
Volume: 63
Issue: 13
Pages: 3447-52
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Publication
12902406 | J:85642
First Author: Owens DM
Year: 2003
Journal: J Cell Sci
Title: Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling.
Volume: 116
Issue: Pt 18
Pages: 3783-91
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Publication
14581455 | J:86330
First Author: Parisi S
Year: 2003
Journal: J Cell Biol
Title: Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells.
Volume: 163
Issue: 2
Pages: 303-14
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Publication
17768379 | J:124970
 
First Author: Okada Y
Year: 2007
Journal: Mol Vis
Title: TNFalpha suppression of corneal epithelium migration.
Volume: 13
Pages: 1428-35
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Publication
16394011 | J:126440
First Author: Xiao YQ
Year: 2006
Journal: J Immunol
Title: Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production.
Volume: 176
Issue: 2
Pages: 1209-17
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Publication
18783722 | J:141269
First Author: Wang B
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes.
Volume: 376
Issue: 2
Pages: 288-92
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Publication
21496456 | J:172061
First Author: Wanninger J
Year: 2011
Journal: FEBS Lett
Title: Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes.
Volume: 585
Issue: 9
Pages: 1338-44
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Publication
25683711 | J:222039
     
First Author: Prunier C
Year: 2015
Journal: Cell Rep
Title: Disruption of the PHRF1 Tumor Suppressor Network by PML-RARα Drives Acute Promyelocytic Leukemia Pathogenesis.
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Publication
26351675 | J:226902
First Author: Hachisuga M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Hyperglycemia impairs left-right axis formation and thereby disturbs heart morphogenesis in mouse embryos.
Volume: 112
Issue: 38
Pages: E5300-7
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Publication
29490279 | J:271128
First Author: Zhao Y
Year: 2018
Journal: Cell Rep
Title: USP2a Supports Metastasis by Tuning TGF-β Signaling.
Volume: 22
Issue: 9
Pages: 2442-2454
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Publication
37059312 | J:340602
First Author: Zhao Y
Year: 2023
Journal: Biochim Biophys Acta Mol Basis Dis
Title: USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Volume: 1869
Issue: 6
Pages: 166713
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Publication
11546807 | -
First Author: Seet LF
Year: 2001
Journal: J Biol Chem
Title: Endofin, an endosomal FYVE domain protein.
Volume: 276
Issue: 45
Pages: 42445-54
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Protein
A2A8R0
Organism: Mus musculus/domesticus
Length: 1397  
Fragment?: false
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Publication
12208849 | J:78819
First Author: Sterner-Kock A
Year: 2002
Journal: Genes Dev
Title: Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.
Volume: 16
Issue: 17
Pages: 2264-73
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Publication
24627487 | J:213178
First Author: Nakano N
Year: 2014
Journal: J Biol Chem
Title: C18 ORF1, a novel negative regulator of transforming growth factor-β signaling.
Volume: 289
Issue: 18
Pages: 12680-92
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Publication
20881059 | J:182937
First Author: Penheiter SG
Year: 2010
Journal: Mol Biol Cell
Title: Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2.
Volume: 21
Issue: 22
Pages: 4009-19
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Publication
15356634 | J:92664
First Author: Lin HK
Year: 2004
Journal: Nature
Title: Cytoplasmic PML function in TGF-beta signalling.
Volume: 431
Issue: 7005
Pages: 205-11
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Publication
10331191 | J:57220
First Author: Kano K
Year: 1999
Journal: J Vet Med Sci
Title: Cloning and studies of the mouse cDNA encoding Smad3.
Volume: 61
Issue: 3
Pages: 213-9
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Publication
9335505 | J:43279
First Author: Imamura T
Year: 1997
Journal: Nature
Title: Smad6 inhibits signalling by the TGF-beta superfamily.
Volume: 389
Issue: 6651
Pages: 622-6
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Publication
19218245 | J:149064
First Author: Wang G
Year: 2009
Journal: J Biol Chem
Title: Transforming growth factor-{beta}-inducible phosphorylation of Smad3.
Volume: 284
Issue: 15
Pages: 9663-73
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Publication
10458166 | J:114795
First Author: Zhu H
Year: 1999
Journal: Nature
Title: A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.
Volume: 400
Issue: 6745
Pages: 687-93
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Publication
25750188 | J:251060
First Author: Awwad K
Year: 2015
Journal: Cardiovasc Res
Title: Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis.
Volume: 106
Issue: 2
Pages: 284-94
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Publication
15374947 | J:93668
First Author: Swallow CJ
Year: 2004
Journal: Cancer Res
Title: alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression.
Volume: 64
Issue: 18
Pages: 6402-9
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Publication
15728512 | J:97722
First Author: Ruiz PA
Year: 2005
Journal: J Immunol
Title: IL-10 gene-deficient mice lack TGF-beta/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis.
Volume: 174
Issue: 5
Pages: 2990-9
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Publication
17595316 | J:125355
First Author: Li Q
Year: 2007
Journal: Mol Endocrinol
Title: SMAD3 regulates gonadal tumorigenesis.
Volume: 21
Issue: 10
Pages: 2472-86
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Publication
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