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Search results 1401 to 1500 out of 1548 for Cdx2

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:1101193
Assay Type: RNA in situ
Annotation Date: 2023-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3559313
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:7545132
Age: embryonic day 8.5
Image: 1D
Note: Expressed in the posterior neural plate border, which was also Cdx1 and Cdx2 positive.
Specimen Label: 1D
Detected: true
Specimen Num: 1
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Publication
22202456 | -
First Author: Hinkel I
Year: 2012
Journal: Gastroenterology
Title: Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells.
Volume: 142
Issue: 4
Pages: 875-885.e3
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Allele
Cdx2<em1(flp)Smoc> | MGI:7288916
Name: caudal type homeobox 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
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HT Experiment
GSE115314 | The lineage-specific transcriptional regulator, CDX2, navigates a dynamic chromatin landscape to control distinct stages of intestinal development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GXD Expression
GXD Expression
Probe: MGI:6361200
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1636317
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6361315
Age: embryonic day 10.5
Image: 6G
Note: Loss of both Pdx1 and Sox9 results in ectopic Cdx2 expression. There was extensive overlap between the Pdx1 and Cdx2 domains.
Specimen Label: 6G
Detected: true
Specimen Num: 13
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Publication
16027724 | -
First Author: Gross I
Year: 2005
Journal: Oncogene
Title: Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.
Volume: 24
Issue: 54
Pages: 7955-63
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Strain
MGI:6474966 | C57BL/6JSmoc-Cdx2<em1(flp)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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HT Experiment
GSE115541 | Chromatin and tissue plasticity precede commitment to intestinal differentiation during endoderm development
 
Experiment Type: RNA-Seq
Study Type: Baseline and WT vs. Mutant
Source: GEO
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Allele
Cdx2<tm1Yxz> | MGI:5431579
Name: caudal type homeobox 2; targeted mutation 1, Yixian Zheng
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Tg(Cdx2-flpo)2Ddg | MGI:5828010
Name: transgene insertion 2, David D Ginty
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Cdx2-Isl1)#Mllo | MGI:6458934
Name: transgene insertion, Moises Mallo
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Cdx2<tm1Smoc> | MGI:7288917
Name: caudal type homeobox 2; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Cdx1<tm4.1(Cdx2)Lhn> | MGI:3848699
Name: caudal type homeobox 1; targeted mutation 4.1, David Lohnes
Allele Type: Targeted
Attribute String: Hypomorph, Inserted expressed sequence, Null/knockout
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Strain
MGI:5431895 | STOCK Cdx2<tm1Yxz>/J
Attribute String: mutant stock, targeted mutation
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Strain
MGI:5828134 | FVB/N-Tg(Cdx2-flpo)2Ddg/J
Attribute String: transgenic, mutant strain, coisogenic
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Allele
Cdx2<tm1.1Shiv> | MGI:6306312
Name: caudal type homeobox 2; targeted mutation 1.1, Ramesh Shivdasani
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Tg(Cdx2-Tgfbr1*)#Mllo | MGI:6458913
Name: transgene insertion, Moises Mallo
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Cdx2/Cdx2
Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdx2/Cdx2<+>
Background: involves: 129S4/SvJae * C57BL/6 * CD-1
Zygosity: ht
Has Mutant Allele: true
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Publication
31253634 | J:284142
 
First Author: Ruthig VA
Year: 2019
Journal: Development
Title: The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming.
Volume: 146
Issue: 19
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Protein Domain
IPR044462 | RBM46_DSR
Type: Domain
Description: RNA-binding protein 46 (RBM46) regulates trophectoderm specification by stabilising Cdx2 mRNA in early mouse embryos []. RBM46 contains three RNA recognition motifs (RRMs) and a C-terminal double-stranded RNA binding motif (DSR) []. This entry represents the DSR of RBM46.
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Allele
Tg(Foxa3-Cdx2)1Khk | MGI:3769381
Name: transgene insertion 1, Klaus H Kaestner
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(CDX2-flpo)#Gld | MGI:5911680
Name: transgene insertion, Martyn Goulding
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Cdx2-cre/ERT)#Mllo | MGI:6331233
Name: transgene insertion, Moises Mallo
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Strain
MGI:6428407 | C57BL/6JSmoc-Cdx2<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Cdx1/Cdx1
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdx2/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdx2/Cdx2
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdx2/Cdx2
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Allele
Tg(Cdx2-cre)R337Npln | MGI:5543474
Name: transgene insertion R337, Nicolas Pilon
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Gt(ROSA)26Sor<tm5(CDX2)Ics> | MGI:7751202
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 5, Mouse Clinical Institute
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence
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Genotype
Genotype
Symbol: Cdx2/Cdx2 Shh/Shh<+>
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdx2/Cdx2 Shh/Shh<+>
Background: involves: 129 * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdx2/Cdx2 Shh/Shh<+>
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Protein
A0A1B0GRD3
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Publication
15028844 | -
First Author: Moulton DE
Year: 2004
Journal: Pediatr Res
Title: Expression of a novel cadherin in the mouse and human intestine.
Volume: 55
Issue: 6
Pages: 927-34
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Publication
12167596 | -
First Author: Goldberg M
Year: 2002
Journal: Am J Physiol Renal Physiol
Title: Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys.
Volume: 283
Issue: 3
Pages: F454-63
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Protein Domain
IPR006820 | Caudal_activation_dom
Type: Domain
Description: This domain occurs at the N-terminal of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 () is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway []. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain ().
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Protein Domain
IPR034434 | RBM46_RRM1
Type: Domain
Description: RBM46 is also termed cancer/testis antigen 68 (CT68), a putative RNA-binding protein that shows high sequence homology with heterogeneous nuclear ribonucleoprotein R (hnRNP R) and heterogeneous nuclear ribonucleoprotein Q (hnRNP Q). Its biological function remains unclear. It has been shown to bind to and stabilize Cdx2 mRNA in early mouse embryos []. Like hnRNP R and hnRNP Q, RBM46 contains two well-defined and one degenerated RNA recognition motifs (RRMs) and a C-terminal double-stranded RNA binding motif (DSRM).This entry represents the RNA recognition motif 1 (RRM1) of RBM46.
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Protein Domain
IPR034435 | RBM46_RRM2
Type: Domain
Description: RBM46 is also termed cancer/testis antigen 68 (CT68), a putative RNA-binding protein that shows high sequence homology with heterogeneous nuclear ribonucleoprotein R (hnRNP R) and heterogeneous nuclear ribonucleoprotein Q (hnRNP Q). Its biological function remains unclear. It has been shown to bind to and stabilize Cdx2 mRNA in early mouse embryos []. Like hnRNP R and hnRNP Q, RBM46 contains two well-defined and one degenerated RNA recognition motifs (RRMs) and a C-terminal double-stranded RNA binding motif (DSRM).This entry represents the RNA recognition motif 2 (RRM2) of RBM46.
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Protein Domain
IPR030326 | Mucdhl
Type: Family
Description: Cadherin-related family member 5 (also known as Mucin and cadherin like, Mucdhl or MUPCDH) belongs to the protocadherins subgroup of the cadherin superfamily, whose members are membranous glycoproteins mediating Ca2+-dependent cell-to-cell adhesion []. The Mucdhl gene encodes several splicing isoforms that are mostly expressed in the kidney, liver, and gut [, , ]. Mucdhl is associated with Cdx2 and beta-catenin, and is linked to colorectal carcinogenesis []. It interacts with PCDH24 and plays a role in the brush border assembly [].This entry also includes cadherin-86C from the fruit fly Drosophila melanogaster.
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Publication
35299237 | J:322042
 
First Author: de Lemos L
Year: 2022
Journal: Development
Title: Epha1 is a cell-surface marker for the neuromesodermal competent population.
Volume: 149
Issue: 6
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HT Experiment
GSE216256 | Transcription factor regulomes reveal lineage regulators as bipotency activators in totipotent embryos
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-4307 | Transcription profiling of mouse inner cell mass (ICM) from a single cells derived from mouse blastocysts at E3.5
Series Id: GSE4307
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
24725409 | J:212327
First Author: Crawley SW
Year: 2014
Journal: Cell
Title: Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion.
Volume: 157
Issue: 2
Pages: 433-446
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Publication
25594031 | -
First Author: Søes S
Year: 2014
Journal: Oncoscience
Title: Hypomethylation and increased expression of the putative oncogene ELMO3 are associated with lung cancer development and metastases formation.
Volume: 1
Issue: 5
Pages: 367-74
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Protein Domain
IPR030719 | ELMO3
Type: Family
Description: This entry represents engulfment and cell motility protein 3 (ELMO3) from vertebrates. The expression of ELMO3 may be regulated by transcription factors, such as CDX2 and SP1 []. ELMO3 has been linked to lung cancer development and metastases formation [].ELMO 1-3 are orthologues of the Caenorhabditis elegans ced-12, which is required for the engulfment of dying cells and cell migration []. They are cytoplasmic adaptor proteins that interact with DOCK family guanine nucleotide exchange factors (GEFs) to promote activation of the small GTPase Rac []. ELMO proteins interact with the SH3-domain of DOCKs via an SH3-binding site to enhance the GEF activity of DOCKs. Regulatory GTPases in the Ras superfamily employ a cycle of alternating GTP binding and hydrolysis, controlled by GEFs and GTPase-activating proteins (GAPs), as essential features of their actions in cells [, ].
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Publication
15825076 | J:97350
First Author: Katz JP
Year: 2005
Journal: Gastroenterology
Title: Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach.
Volume: 128
Issue: 4
Pages: 935-45
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Allele
Tg(Pdx1-itTA)#Fto | MGI:5810712
Name: transgene insertion, Francois Tronche
Allele Type: Transgenic
Attribute String: Transactivator
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cdx2-cre)R337Npln/?
Background: involves: 129X1/SvJ * C3H * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cdx2-cre/ERT)#Mllo/?
Background: involves: 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Publication
15358215 | J:91300
First Author: Fukamachi H
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Runx3-/- gastric epithelial cells differentiate into intestinal type cells.
Volume: 321
Issue: 1
Pages: 58-64
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Publication
34582804 | J:321745
First Author: Gu W
Year: 2022
Journal: Cell Stem Cell
Title: SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling.
Volume: 29
Issue: 1
Pages: 101-115.e10
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Publication
24859262 | J:214999
First Author: Pearton DJ
Year: 2014
Journal: Dev Biol
Title: Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression.
Volume: 392
Issue: 2
Pages: 344-57
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Publication
38360902 | J:360435
First Author: Yang L
Year: 2024
Journal: Nat Commun
Title: Tissue-location-specific transcription programs drive tumor dependencies in colon cancer.
Volume: 15
Issue: 1
Pages: 1384
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Publication
38643480 | J:349471
First Author: Wang L
Year: 2024
Journal: Cell Rep
Title: Chromatin landscape instructs precise transcription factor regulome during embryonic lineage specification.
Volume: 43
Issue: 5
Pages: 114136
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Publication
31015444 | J:275538
First Author: Rispal J
Year: 2019
Journal: Nat Commun
Title: The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis.
Volume: 10
Issue: 1
Pages: 1827
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Publication
23108051 | J:191743
First Author: Li L
Year: 2012
Journal: FEBS Lett
Title: Cdk1 interplays with Oct4 to repress differentiation of embryonic stem cells into trophectoderm.
Volume: 586
Issue: 23
Pages: 4100-7
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Publication
9704932 | J:49505
First Author: Wicking C
Year: 1998
Journal: Oncogene
Title: CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer.
Volume: 17
Issue: 5
Pages: 657-9
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Publication
18536715 | J:138339
First Author: Lu CW
Year: 2008
Journal: Nat Genet
Title: Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos.
Volume: 40
Issue: 7
Pages: 921-6
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Publication
31190160 | J:279713
First Author: Xu S
Year: 2019
Journal: J Mol Histol
Title: Akt plays indispensable roles during the first cell lineage differentiation of mouse.
Volume: 50
Issue: 4
Pages: 369-374
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Publication
25173648 | J:316993
First Author: Fischedick G
Year: 2014
Journal: Stem Cell Res
Title: Nanog induces hyperplasia without initiating tumors.
Volume: 13
Issue: 2
Pages: 300-15
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Publication
39629521 | J:361283
 
First Author: Hirono N
Year: 2025
Journal: Development
Title: Fate specification triggers a positive feedback loop of TEAD-YAP and NANOG to promote epiblast formation in preimplantation embryos.
Volume: 152
Issue: 1
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Publication
37134150 | J:340335
First Author: Pocratsky AM
Year: 2023
Journal: Sci Transl Med
Title: Pathophysiology of Dyt1-Tor1a dystonia in mice is mediated by spinal neural circuit dysfunction.
Volume: 15
Issue: 694
Pages: eadg3904
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Strain
MGI:5810713 | C57BL/6-Tg(Pdx1-itTA)#Fto/Orl
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Gdf11/Gdf11 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cdx2-cre/ERT)#Mllo/?
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Protein
P86049
Organism: Mus musculus/domesticus
Length: 533  
Fragment?: false
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Protein
S4R2P5
Organism: Mus musculus/domesticus
Length: 470  
Fragment?: false
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Protein
S4R1Y9
Organism: Mus musculus/domesticus
Length: 485  
Fragment?: false
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Publication
22367590 | J:345436
First Author: Iha M
Year: 2012
Journal: Reproduction
Title: Effect of ectopic expression of homeoprotein EGAM1C on the cell morphology, growth, and differentiation in a mouse embryonic stem cell line, MG1.19 cells.
Volume: 143
Issue: 4
Pages: 477-89
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Publication
15520178 | J:93806
First Author: Mutoh H
Year: 2004
Journal: Cancer Res
Title: Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice.
Volume: 64
Issue: 21
Pages: 7740-7
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Publication
28057861 | J:239530
First Author: Hashimoto K
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior.
Volume: 114
Issue: 4
Pages: 758-763
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Publication
30859181 | J:281697
First Author: Souris JS
Year: 2019
Journal: Carcinogenesis
Title: A novel mouse model of sporadic colon cancer induced by combination of conditional Apc genes and chemical carcinogen in the absence of Cre recombinase.
Volume: 40
Issue: 11
Pages: 1376-1386
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Publication
16309666 | J:104169
First Author: Pilon N
Year: 2006
Journal: Dev Biol
Title: Cdx4 is a direct target of the canonical Wnt pathway.
Volume: 289
Issue: 1
Pages: 55-63
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Publication
10938132 | J:63927
First Author: Houle M
Year: 2000
Journal: Mol Cell Biol
Title: Retinoic acid regulation of Cdx1: an indirect mechanism for retinoids and vertebral specification.
Volume: 20
Issue: 17
Pages: 6579-86
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Publication
18583459 | J:138615
First Author: Saito H
Year: 2008
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Regulatory mechanism governing the diurnal rhythm of intestinal H+/peptide cotransporter 1 (PEPT1).
Volume: 295
Issue: 2
Pages: G395-402
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Publication
38893159 | J:349875
 
First Author: Ghobashi AH
Year: 2024
Journal: Cancers (Basel)
Title: Single-Cell Profiling Reveals the Impact of Genetic Alterations on the Differentiation of Inflammation-Induced Murine Colon Tumors.
Volume: 16
Issue: 11
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Publication
23769888 | J:199069
First Author: Feng Y
Year: 2013
Journal: Am J Pathol
Title: Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation.
Volume: 183
Issue: 2
Pages: 493-503
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Publication
31295506 | J:294408
 
First Author: Jafek JL
Year: 2019
Journal: Exp Hematol
Title: Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia.
Volume: 76
Pages: 38-48.e2
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Publication
19350679 | J:159449
First Author: Yuri S
Year: 2009
Journal: Stem Cells
Title: Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant trophectoderm gene expression.
Volume: 27
Issue: 4
Pages: 796-805
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Publication
22902753 | J:199754
First Author: Kuzmichev AN
Year: 2012
Journal: Curr Biol
Title: Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells.
Volume: 22
Issue: 18
Pages: 1705-10
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Publication
23955559 | J:203837
First Author: Mazzoni EO
Year: 2013
Journal: Nat Neurosci
Title: Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals.
Volume: 16
Issue: 9
Pages: 1191-1198
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Publication
22815676 | J:189619
First Author: Dou W
Year: 2012
Journal: PLoS One
Title: Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis.
Volume: 7
Issue: 7
Pages: e36075
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Publication
20554762 | J:182860
First Author: Parfitt DE
Year: 2010
Journal: Mol Biol Cell
Title: Epigenetic modification affecting expression of cell polarity and cell fate genes to regulate lineage specification in the early mouse embryo.
Volume: 21
Issue: 15
Pages: 2649-60
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Publication
16980957 | J:113650
First Author: Zhang J
Year: 2006
Journal: Nat Cell Biol
Title: Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1.
Volume: 8
Issue: 10
Pages: 1114-23
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Publication
20980403 | J:168150
First Author: Lin SC
Year: 2010
Journal: Development
Title: Klf5 regulates lineage formation in the pre-implantation mouse embryo.
Volume: 137
Issue: 23
Pages: 3953-63
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Publication
22679103 | J:258252
First Author: Raghoebir L
Year: 2012
Journal: J Mol Cell Biol
Title: SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype.
Volume: 4
Issue: 6
Pages: 377-85
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Publication
37219942 | J:338869
 
First Author: Song H
Year: 2023
Journal: JCI Insight
Title: High-fat diet plus HNF1A variant promotes polyps by activating β-catenin in early-onset colorectal cancer.
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Title: Gut-like structures from mouse embryonic stem cells as an in vitro model for gut organogenesis preserving developmental potential after transplantation.
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Journal: Neoplasia
Title: The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine.
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