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Search results 1401 to 1500 out of 2963 for Col1a1

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Type Details Score
Publication
First Author: Keeney DS
Year: 1999
Journal: Dev Dyn
Title: Two novel sites of expression of NADPH cytochrome P450 reductase during murine embryogenesis: limb mesenchyme and developing olfactory neuroepithelia.
Volume: 216
Issue: 4-5
Pages: 511-7
Publication
First Author: Gordon JR
Year: 1994
Journal: J Exp Med
Title: Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via the Fc epsilon RI. Role for mast cell-derived transforming growth factor beta and tumor necrosis factor alpha.
Volume: 180
Issue: 6
Pages: 2027-37
Publication
First Author: Goldberg D
Year: 1995
Journal: DNA Cell Biol
Title: The osteocalcin and collagen type I (alpha 1) promoters share common basal regulatory units.
Volume: 14
Issue: 6
Pages: 519-28
Publication
First Author: Islam MQ
Year: 1995
Journal: Mamm Genome
Title: Assignment of three loci: tumor suppressor protein-53 (TP53), retinoic acid receptor A (RARA), collagen 1A1 (COL1A1) to Syrian hamster chromosome 9. Evidence that this chromosome is homologous with human chromosome 17, mouse chromosome 11, and rat chromosome 10.
Volume: 6
Issue: 12
Pages: 882-4
Publication
First Author: Bidder M
Year: 1998
Journal: J Bone Miner Res
Title: Reciprocal temporospatial patterns of Msx2 and Osteocalcin gene expression during murine odontogenesis.
Volume: 13
Issue: 4
Pages: 609-19
Publication
First Author: Amatangelo MD
Year: 2005
Journal: Am J Pathol
Title: Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts.
Volume: 167
Issue: 2
Pages: 475-88
Publication
First Author: Kawakami T
Year: 2005
Journal: Eur J Med Res
Title: Immunohistochemical characteristics of developing mandibular angle in fetal mice.
Volume: 10
Issue: 12
Pages: 547-8
Publication
First Author: Pimanda JE
Year: 2006
Journal: Mol Cell Biol
Title: Transcriptional link between blood and bone: the stem cell leukemia gene and its +19 stem cell enhancer are active in bone cells.
Volume: 26
Issue: 7
Pages: 2615-25
Publication
First Author: Roulet M
Year: 2007
Journal: Cell Tissue Res
Title: A comprehensive study of the spatial and temporal expression of the col5a1 gene in mouse embryos: a clue for understanding collagen V function in developing connective tissues.
Volume: 327
Issue: 2
Pages: 323-32
Publication
First Author: Tomkowicz B
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration.
Volume: 104
Issue: 46
Pages: 17965-70
Publication
First Author: Vukmirovic M
Year: 2013
Journal: Mol Cell Biol
Title: Serine-threonine kinase receptor-associated protein (STRAP) regulates translation of type I collagen mRNAs.
Volume: 33
Issue: 19
Pages: 3893-906
Publication
First Author: Reyhani V
Year: 2014
Journal: Biochem J
Title: Fibrin binds to collagen and provides a bridge for αVβ3 integrin-dependent contraction of collagen gels.
Volume: 462
Issue: 1
Pages: 113-23
Publication
First Author: Cheng P
Year: 2013
Journal: Development
Title: Fibronectin mediates mesendodermal cell fate decisions.
Volume: 140
Issue: 12
Pages: 2587-96
Publication
First Author: Wan L
Year: 2011
Journal: Mol Cell
Title: Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
Volume: 44
Issue: 5
Pages: 721-33
Publication
First Author: Randilini A
Year: 2021
Journal: Anat Sci Int
Title: An in situ hybridization study of decorin and biglycan mRNA in mouse osteoblasts in vivo.
Volume: 96
Issue: 2
Pages: 265-272
Publication
First Author: Zhang Y
Year: 2022
Journal: Hum Mutat
Title: Mutations in the TBX15-ADAMTS2 pathway associate with a novel soft palate dysplasia.
Volume: 43
Issue: 12
Pages: 2102-2115
Publication
First Author: Metsäranta M
Year: 1991
Journal: Biochim Biophys Acta
Title: Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs.
Volume: 1089
Issue: 2
Pages: 241-3
Publication
First Author: Luo G
Year: 1995
Journal: J Bone Miner Res
Title: The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development.
Volume: 10
Issue: 2
Pages: 325-34
Publication
First Author: Durst R
Year: 2015
Journal: Nature
Title: Mutations in DCHS1 cause mitral valve prolapse.
Volume: 525
Issue: 7567
Pages: 109-13
Publication
First Author: Neuhaus H
Year: 1994
Journal: Dev Biol
Title: Etl2, a novel putative type-I cytokine receptor expressed during mouse embryogenesis at high levels in skin and cells with skeletogenic potential.
Volume: 166
Issue: 2
Pages: 531-42
Publication
First Author: Lefebvre V
Year: 1998
Journal: EMBO J
Title: A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene.
Volume: 17
Issue: 19
Pages: 5718-33
Publication
First Author: Hutchinson KR
Year: 2013
Journal: PLoS One
Title: Cardiac fibroblast-dependent extracellular matrix accumulation is associated with diastolic stiffness in type 2 diabetes.
Volume: 8
Issue: 8
Pages: e72080
Publication
First Author: Gruber T
Year: 2021
Journal: Cell Metab
Title: Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.
Volume: 33
Issue: 6
Pages: 1155-1170.e10
Publication
First Author: Aubin J
Year: 2002
Journal: Dev Biol
Title: Cooperation of Hoxa5 and Pax1 genes during formation of the pectoral girdle.
Volume: 244
Issue: 1
Pages: 96-113
Publication
First Author: Gacheru S
Year: 1993
Journal: Arch Biochem Biophys
Title: Expression and accumulation of lysyl oxidase, elastin, and type I procollagen in human Menkes and mottled mouse fibroblasts.
Volume: 301
Issue: 2
Pages: 325-9
Publication
First Author: Wenstrup RJ
Year: 2011
Journal: J Biol Chem
Title: Regulation of collagen fibril nucleation and initial fibril assembly involves coordinate interactions with collagens V and XI in developing tendon.
Volume: 286
Issue: 23
Pages: 20455-65
Publication
First Author: Lincoln J
Year: 2006
Journal: Dev Dyn
Title: ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development.
Volume: 235
Issue: 12
Pages: 3295-305
Publication
First Author: Tremblay AM
Year: 2014
Journal: Cancer Cell
Title: The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.
Volume: 26
Issue: 2
Pages: 273-87
Publication
First Author: Xiao G
Year: 2018
Journal: Cell
Title: B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.
Volume: 173
Issue: 2
Pages: 470-484.e18
Publication
First Author: Sounni NE
Year: 2010
Journal: Dis Model Mech
Title: Stromal regulation of vessel stability by MMP14 and TGFbeta.
Volume: 3
Issue: 5-6
Pages: 317-32
Publication  
First Author: Taylor SH
Year: 2015
Journal: Elife
Title: Matrix metalloproteinase 14 is required for fibrous tissue expansion.
Volume: 4
Pages: e09345
Publication
First Author: Feinberg TY
Year: 2018
Journal: Dev Cell
Title: Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs.
Volume: 47
Issue: 2
Pages: 145-160.e6
Publication
First Author: Walsh CP
Year: 1999
Journal: Genes Dev
Title: Cytosine methylation and mammalian development.
Volume: 13
Issue: 1
Pages: 26-34
Publication
First Author: Ueda Y
Year: 2022
Journal: Exp Anim
Title: Possible testosterone redundancy for 5α-dihydrotestosterone in the masculinization of mouse external genitalia.
Volume: 71
Issue: 4
Pages: 451-459
Publication
First Author: Tummala KS
Year: 2014
Journal: Cancer Cell
Title: Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Volume: 26
Issue: 6
Pages: 826-839
Publication
First Author: Shinoda G
Year: 2013
Journal: Stem Cells
Title: Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.
Volume: 31
Issue: 8
Pages: 1563-73
Publication
First Author: Berthet E
Year: 2013
Journal: J Orthop Res
Title: Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization.
Volume: 31
Issue: 9
Pages: 1475-83
Publication
First Author: Habermehl D
Year: 2011
Journal: Mol Endocrinol
Title: Glucocorticoid activity during lung maturation is essential in mesenchymal and less in alveolar epithelial cells.
Volume: 25
Issue: 8
Pages: 1280-8
Publication
First Author: Chen Z
Year: 2020
Journal: Glia
Title: Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade.
Volume: 68
Issue: 10
Pages: 2148-2166
Publication
First Author: Berman SD
Year: 2008
Journal: Mol Cancer Res
Title: The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development.
Volume: 6
Issue: 9
Pages: 1440-51
Publication  
First Author: Wang S
Year: 2015
Journal: Nat Commun
Title: Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.
Volume: 6
Pages: 6517
Publication
First Author: Semeniak D
Year: 2016
Journal: J Cell Sci
Title: Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling.
Volume: 129
Issue: 18
Pages: 3473-84
Publication  
First Author: Mizoguchi S
Year: 2015
Journal: Mol Vis
Title: Disruption of eyelid and cornea morphogenesis by epithelial β-catenin gain-of-function.
Volume: 21
Pages: 793-803
Publication
First Author: Huang LF
Year: 1997
Journal: Dev Dyn
Title: Mouse clavicular development: analysis of wild-type and cleidocranial dysplasia mutant mice.
Volume: 210
Issue: 1
Pages: 33-40
Publication
First Author: Sugimoto Y
Year: 2013
Journal: Development
Title: Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament.
Volume: 140
Issue: 11
Pages: 2280-8
Publication
First Author: Brunner M
Year: 2018
Journal: PLoS One
Title: β1 integrins mediate the BMP2 dependent transcriptional control of osteoblast differentiation and osteogenesis.
Volume: 13
Issue: 4
Pages: e0196021
Publication
First Author: Chevalier NR
Year: 2021
Journal: Commun Biol
Title: A neural crest cell isotropic-to-nematic phase transition in the developing mammalian gut.
Volume: 4
Issue: 1
Pages: 770
Publication
First Author: Nishikawa K
Year: 2010
Journal: J Clin Invest
Title: Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation.
Volume: 120
Issue: 10
Pages: 3455-65
Publication
First Author: Lau AN
Year: 2014
Journal: EMBO J
Title: Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis.
Volume: 33
Issue: 5
Pages: 468-81
Publication
First Author: Augert A
Year: 2020
Journal: Cancer Cell
Title: MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer.
Volume: 38
Issue: 1
Pages: 97-114.e7
Publication
First Author: Annunziato S
Year: 2016
Journal: Genes Dev
Title: Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland.
Volume: 30
Issue: 12
Pages: 1470-80
Publication
First Author: Dow LE
Year: 2015
Journal: Cell
Title: Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.
Volume: 161
Issue: 7
Pages: 1539-1552
Publication
First Author: Farago AF
Year: 2012
Journal: Cell
Title: SnapShot: Lung cancer models.
Volume: 149
Issue: 1
Pages: 246-246.e1
Publication
First Author: Liu CF
Year: 2013
Journal: PLoS One
Title: A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse.
Volume: 8
Issue: 6
Pages: e65411
Publication
First Author: Matthews GM
Year: 2015
Journal: Blood
Title: Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.
Volume: 126
Issue: 21
Pages: 2392-403
Publication
First Author: Kimura H
Year: 2008
Journal: PLoS One
Title: Cthrc1 is a positive regulator of osteoblastic bone formation.
Volume: 3
Issue: 9
Pages: e3174
Publication
First Author: Wu H
Year: 2013
Journal: Cell Rep
Title: The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.
Volume: 3
Issue: 5
Pages: 1663-77
Publication  
First Author: Wu H
Year: 2015
Journal: Nat Commun
Title: Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Volume: 6
Pages: 6239
Publication
First Author: Shin HI
Year: 2004
Journal: Endocrinology
Title: Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro.
Volume: 145
Issue: 3
Pages: 1376-85
Publication
First Author: Masago Y
Year: 2012
Journal: J Cell Sci
Title: The molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation.
Volume: 125
Issue: Pt 5
Pages: 1118-28
Publication
First Author: Bakiri L
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc.
Volume: 121
Issue: 18
Pages: e2404188121
Publication    
First Author: Lee J
Year: 2020
Journal: Elife
Title: Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses.
Volume: 9
Publication
First Author: Chang W
Year: 2020
Journal: Cell Stem Cell
Title: Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis.
Volume: 26
Issue: 5
Pages: 739-754.e8
Publication
First Author: Tummala KS
Year: 2017
Journal: Cell Rep
Title: Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells.
Volume: 19
Issue: 3
Pages: 584-600
Publication
First Author: Nagai N
Year: 2000
Journal: J Cell Biol
Title: Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis.
Volume: 150
Issue: 6
Pages: 1499-506
Publication
First Author: Chien C
Year: 2018
Journal: Connect Tissue Res
Title: Optimizing a 3D model system for molecular manipulation of tenogenesis.
Volume: 59
Issue: 4
Pages: 295-308
Publication
First Author: Hara M
Year: 2017
Journal: Nat Med
Title: Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury.
Volume: 23
Issue: 7
Pages: 818-828
Publication  
First Author: Yamaguchi H
Year: 2021
Journal: Development
Title: The molecular complex of ciliary and golgin protein is crucial for skull development.
Volume: 148
Issue: 13
Publication
First Author: Gill SE
Year: 2003
Journal: Dev Biol
Title: A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis.
Volume: 261
Issue: 2
Pages: 313-23
Publication
First Author: Pepe-Mooney BJ
Year: 2019
Journal: Cell Stem Cell
Title: Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration.
Volume: 25
Issue: 1
Pages: 23-38.e8
Publication
First Author: Pan TC
Year: 2014
Journal: J Biol Chem
Title: A mouse model for dominant collagen VI disorders: heterozygous deletion of Col6a3 Exon 16.
Volume: 289
Issue: 15
Pages: 10293-307
Publication
First Author: Schlegelmilch K
Year: 2011
Journal: Cell
Title: Yap1 acts downstream of α-catenin to control epidermal proliferation.
Volume: 144
Issue: 5
Pages: 782-95
Publication
First Author: Yue Y
Year: 2020
Journal: Nat Cell Biol
Title: Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution.
Volume: 22
Issue: 3
Pages: 332-340
Publication
First Author: Savontaus M
Year: 1996
Journal: Am J Pathol
Title: Retarded skeletal development in transgenic mice with a type II collagen mutation.
Volume: 149
Issue: 6
Pages: 2169-82
Publication
First Author: Savontaus M
Year: 1997
Journal: Lab Invest
Title: Mutation in type II collagen gene disturbs spinal development and gene expression patterns in transgenic Del1 mice.
Volume: 77
Issue: 6
Pages: 591-600
Publication
First Author: Rudolf MA
Year: 2020
Journal: J Neurosci
Title: YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice.
Volume: 40
Issue: 20
Pages: 3915-3932
Publication
First Author: Tsuji K
Year: 2006
Journal: Nat Genet
Title: BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.
Volume: 38
Issue: 12
Pages: 1424-9
Publication
First Author: Hughes AJ
Year: 2018
Journal: Dev Cell
Title: Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme.
Volume: 44
Issue: 2
Pages: 165-178.e6
Publication
First Author: Li R
Year: 2020
Journal: J Clin Invest
Title: Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface.
Volume: 130
Issue: 6
Pages: 2859-2871
Publication
First Author: Dejaeger M
Year: 2017
Journal: J Bone Miner Res
Title: Integrin-Linked Kinase Regulates Bone Formation by Controlling Cytoskeletal Organization and Modulating BMP and Wnt Signaling in Osteoprogenitors.
Volume: 32
Issue: 10
Pages: 2087-2102
Publication
First Author: von Gise A
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy.
Volume: 109
Issue: 7
Pages: 2394-9
Publication
First Author: Dacquin R
Year: 2004
Journal: Dev Dyn
Title: Knock-in of nuclear localised beta-galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar.
Volume: 229
Issue: 4
Pages: 826-34
Publication
First Author: Wiradjaja F
Year: 2013
Journal: Dis Model Mech
Title: Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice.
Volume: 6
Issue: 6
Pages: 1426-33
Publication
First Author: Kikuchi M
Year: 2016
Journal: PLoS One
Title: Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice.
Volume: 11
Issue: 7
Pages: e0159375
Publication  
First Author: Jardé T
Year: 2016
Journal: Nat Commun
Title: Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.
Volume: 7
Pages: 13207
Publication
First Author: Pischon N
Year: 2009
Journal: Calcif Tissue Int
Title: Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype.
Volume: 85
Issue: 2
Pages: 119-26
Publication
First Author: Mäki JM
Year: 2005
Journal: Am J Pathol
Title: Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues.
Volume: 167
Issue: 4
Pages: 927-36
Publication  
First Author: Murugapoopathy V
Year: 2021
Journal: Int J Mol Sci
Title: Osr1 Is Required for Mesenchymal Derivatives That Produce Collagen in the Bladder.
Volume: 22
Issue: 22
Publication
First Author: Holster T
Year: 2007
Journal: J Biol Chem
Title: Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice.
Volume: 282
Issue: 4
Pages: 2512-9
Publication
First Author: Murata K
Year: 2013
Journal: Endocrinology
Title: Effect of lactation on postpartum cardiac function of pregnancy-associated hypertensive mice.
Volume: 154
Issue: 2
Pages: 597-602
Publication
First Author: Hsiao EC
Year: 2010
Journal: J Bone Miner Res
Title: Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.
Volume: 25
Issue: 3
Pages: 584-93
Publication
First Author: Zou W
Year: 2011
Journal: Nat Cell Biol
Title: The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid.
Volume: 13
Issue: 1
Pages: 59-65
Publication
First Author: Shukunami C
Year: 2018
Journal: Sci Rep
Title: Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes.
Volume: 8
Issue: 1
Pages: 3155
Publication  
First Author: Jiang Q
Year: 2020
Journal: Int J Mol Sci
Title: Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis.
Volume: 21
Issue: 7
Publication
First Author: Boettger T
Year: 2009
Journal: J Clin Invest
Title: Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster.
Volume: 119
Issue: 9
Pages: 2634-47
Publication
First Author: Sun P
Year: 2020
Journal: Sci Adv
Title: Regulation of body length and bone mass by Gpr126/Adgrg6.
Volume: 6
Issue: 12
Pages: eaaz0368
Publication
First Author: Buck M
Year: 1996
Journal: Am J Pathol
Title: Tumor necrosis factor-alpha inhibits collagen alpha1(I) gene expression and wound healing in a murine model of cachexia.
Volume: 149
Issue: 1
Pages: 195-204
Publication
First Author: Unda FJ
Year: 2000
Journal: Dev Dyn
Title: Dissection of the odontoblast differentiation process in vitro by a combination of FGF1, FGF2, and TGFbeta1.
Volume: 218
Issue: 3
Pages: 480-9
Publication  
First Author: Tsirka SE
Year: 1993
Journal: Biochem J
Title: Multiple active conformers of mouse ornithine decarboxylase.
Volume: 293 ( Pt 1)
Pages: 289-95
Publication
First Author: Govoni KE
Year: 2006
Journal: Growth Horm IGF Res
Title: Regulation of insulin-like growth factor binding protein-5, four and a half lim-2, and a disintegrin and metalloprotease-9 expression in osteoblasts.
Volume: 16
Issue: 1
Pages: 49-56