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Search results 1401 to 1500 out of 2147 for Dcx

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Type Details Score
Publication
23385585 | J:205752
 
First Author: Shin E
Year: 2013
Journal: Nat Commun
Title: Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation.
Volume: 4
Pages: 1440
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Allele
Dclk1<tm1.1Jgg> | MGI:3617379
Name: doublecortin-like kinase 1; targeted mutation 1.1, Joseph G Gleeson
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Rp1l1<tm1Jnz> | MGI:4354082
Name: retinitis pigmentosa 1 homolog like 1; targeted mutation 1, Jian Zuo
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:7786408 | B6.Cg-Tg(Dcx-icre/ERT2)1Mash/J
Attribute String: congenic, transgenic, mutant strain
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Genotype
Genotype
Symbol: Tg(Dcx-icre/ERT2)1Mash/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Publication
15269252 | J:109781
First Author: Liu Q
Year: 2004
Journal: J Neurosci
Title: The retinitis pigmentosa 1 protein is a photoreceptor microtubule-associated protein.
Volume: 24
Issue: 29
Pages: 6427-36
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Allele
Rp1<tm1Jnz> | MGI:2179129
 
Name: retinitis pigmentosa 1 (human); targeted mutation 1, Jian Zuo
Allele Type: Targeted
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Genotype
Genotype
Symbol: Dclk1/Dclk1
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dclk1/Dclk1<+>
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rp1l1/Rp1l1
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Publication
22159412 | -
First Author: Kaplan A
Year: 2011
Journal: J Cell Sci
Title: Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein.
Volume: 124
Issue: Pt 23
Pages: 3989-4000
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Protein Domain
IPR043188 | DCDC1
Type: Family
Description: Doublecortin domain-containing protein 1 (DCDC1), also known as DCDC5, is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. DCDC1 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC1 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8 [].
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Publication
19657028 | J:151463
First Author: Yamashita T
Year: 2009
Journal: J Neurosci
Title: Essential and synergistic roles of RP1 and RP1L1 in rod photoreceptor axoneme and retinitis pigmentosa.
Volume: 29
Issue: 31
Pages: 9748-60
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Publication
33071745 | J:321197
 
First Author: Moura DMS
Year: 2020
Journal: Front Neurosci
Title: Evidence of Progenitor Cell Lineage Rerouting in the Adult Mouse Hippocampus After Status Epilepticus.
Volume: 14
Pages: 571315
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Publication
33208869 | J:300237
First Author: Klein B
Year: 2020
Journal: Sci Rep
Title: DCX+ neuronal progenitors contribute to new oligodendrocytes during remyelination in the hippocampus.
Volume: 10
Issue: 1
Pages: 20095
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Publication
10036192 | J:53286
First Author: Sossey-Alaoui K
Year: 1999
Journal: Genomics
Title: DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX).
Volume: 56
Issue: 1
Pages: 121-6
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Publication
11960024 | J:76071
First Author: Gao J
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene.
Volume: 99
Issue: 8
Pages: 5698-703
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Publication
16126734 | J:101744
First Author: Liu J
Year: 2005
Journal: Hum Mol Genet
Title: Distinct gene expression profiles and reduced JNK signaling in retinitis pigmentosa caused by RP1 mutations.
Volume: 14
Issue: 19
Pages: 2945-58
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Allele
Hprt1<tm20(Ple53-EGFP)Ems> | MGI:3835534
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 20, Elizabeth M Simpson
Allele Type: Targeted
Attribute String: Reporter
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Allele
Tg(DCX-cre/ERT2)2Wrst | MGI:4867631
Name: transgene insertion 2, Wolfgang Wurst
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Genotype
Genotype
Symbol: Rp1/Rp1
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rp1/Rp1<+>
Background: involves: 129S7/SvEvBrd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rp1/Rp1
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
21725316 | -
First Author: Puklowski A
Year: 2011
Journal: Nat Cell Biol
Title: The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.
Volume: 13
Issue: 8
Pages: 1004-9
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Publication
18381890 | -
First Author: Hu J
Year: 2008
Journal: Genes Dev
Title: WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.
Volume: 22
Issue: 7
Pages: 866-71
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Publication
19232515 | -
First Author: Minoda Y
Year: 2009
Journal: Biochem Biophys Res Commun
Title: An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.
Volume: 381
Issue: 3
Pages: 412-7
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Protein Domain
IPR042508 | FBXW5
Type: Family
Description: FBXW5 is a F-box protein and a DDB1-binding WD40 (DWD) protein that serves as a substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes [, ]. It has also been shown to negatively regulate TAK1 MAP3K in the IL-1beta signaling pathway []. Interestingly, FBXW5 binds centriolar protein HsSAS-6 and promotes its ubiquitylation; this way FBXW5 can restrict centrosome re-duplication through degradation of HsSAS-6 [].
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Publication
21194452 | J:167201
 
First Author: Zhang J
Year: 2010
Journal: BMC Neurosci
Title: A powerful transgenic tool for fate mapping and functional analysis of newly generated neurons.
Volume: 11
Pages: 158
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Publication
17409237 | J:164052
First Author: Walker TL
Year: 2007
Journal: J Neurosci
Title: The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells.
Volume: 27
Issue: 14
Pages: 3734-42
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Publication
32994174 | J:302523
 
First Author: Saaltink DJ
Year: 2020
Journal: eNeuro
Title: Doublecortin-Like Is Implicated in Adult Hippocampal Neurogenesis and in Motivational Aspects to Escape from an Aversive Environment in Male Mice.
Volume: 7
Issue: 5
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Strain
MGI:4835662 | B6.129P2(Cg)-Hprt1<tm20(Ple53-EGFP)Ems>/Mmjax
Attribute String: targeted mutation, mutant strain, congenic
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Allele
Tg(Dcx-cre/ERT2)DC-F18Zqx | MGI:5438982
Name: transgene insertion DC-F18, Zhi-Qi Xiong
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Allele
Tg(Dcx-cre/ERT2)DC-F30Zqx | MGI:5438991
Name: transgene insertion DC-F30, Zhi-Qi Xiong
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Genotype
Genotype
Symbol: Rp1/Rp1
Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hprt1/?
Background: B6.129P2(Cg)-Hprt1/Mmjax
Zygosity: ot
Has Mutant Allele: true
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Publication
16684769 | J:114886
First Author: Ohmae S
Year: 2006
Journal: J Biol Chem
Title: Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.
Volume: 281
Issue: 29
Pages: 20427-39
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Publication
23281133 | J:202730
First Author: Davidson AE
Year: 2013
Journal: Hum Mutat
Title: RP1L1 variants are associated with a spectrum of inherited retinal diseases including retinitis pigmentosa and occult macular dystrophy.
Volume: 34
Issue: 3
Pages: 506-14
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Publication
26617501 | J:244263
 
First Author: Garrett L
Year: 2015
Journal: Front Behav Neurosci
Title: Conditional Reduction of Adult Born Doublecortin-Positive Neurons Reversibly Impairs Selective Behaviors.
Volume: 9
Pages: 302
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Genotype
Genotype
Symbol: Dclk1/Dclk1<+> Dcx/?
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dclk1/Dclk1<+> Dcx/Dcx
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dclk1/Dclk1 Dcx/?
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dclk1/Dclk1 Dcx/Dcx
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dclk1/Dclk1 Dcx/Dcx<+>
Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rp1/Rp1<+> Rp1l1/Rp1l1<+>
Background: involves: 129S7/SvEvBrd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Dcx-icre/ERT2)1Mash/?
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Dcx-icre/ERT2)1Mash/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Protein
Q9JLV2
Organism: Mus musculus/domesticus
Length: 797  
Fragment?: false
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Protein
Q3TDP6
Organism: Mus musculus/domesticus
Length: 797  
Fragment?: false
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Protein
Q571F0
Organism: Mus musculus/domesticus
Length: 815  
Fragment?: true
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Protein
Q3TB80
Organism: Mus musculus/domesticus
Length: 764  
Fragment?: true
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Protein
A2BHQ5
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
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Protein
Q8CEB0
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Publication
35046482 | J:318899
First Author: Nakagawa K
Year: 2022
Journal: Sci Rep
Title: Endoplasmic reticulum stress contributes to the decline in doublecortin expression in the immature neurons of mice with long-term obesity.
Volume: 12
Issue: 1
Pages: 1022
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Publication
31374821 | J:290153
 
First Author: Mensching L
Year: 2019
Journal: Int J Mol Sci
Title: Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice.
Volume: 20
Issue: 15
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Protein
Q9D1B8
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Protein
J3KML0
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: false
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Protein
K3W4L8
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Protein
A0A1Y7VIY3
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: true
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Publication
10401003 | J:57151
First Author: Guillonneau X
Year: 1999
Journal: Hum Mol Genet
Title: A nonsense mutation in a novel gene is associated with retinitis pigmentosa in a family linked to the RP1 locus.
Volume: 8
Issue: 8
Pages: 1541-6
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Protein
F7BCK0
Organism: Mus musculus/domesticus
Length: 340  
Fragment?: true
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Protein
A0A1Y7VLK4
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Publication
10749977 | -
First Author: Sapir T
Year: 2000
Journal: Hum Mol Genet
Title: Doublecortin mutations cluster in evolutionarily conserved functional domains.
Volume: 9
Issue: 5
Pages: 703-12
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Publication
10441322 | -
First Author: Horesh D
Year: 1999
Journal: Hum Mol Genet
Title: Doublecortin, a stabilizer of microtubules.
Volume: 8
Issue: 9
Pages: 1599-610
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Publication
31647533 | J:287622
First Author: Benedetti B
Year: 2020
Journal: Cereb Cortex
Title: Functional Integration of Neuronal Precursors in the Adult Murine Piriform Cortex.
Volume: 30
Issue: 3
Pages: 1499-1515
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Publication
26478908 | J:239861
 
First Author: Villasana LE
Year: 2015
Journal: eNeuro
Title: Functional Integration of Adult-Born Hippocampal Neurons after Traumatic Brain Injury(1,2,3).
Volume: 2
Issue: 5
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Publication
30233313 | J:312009
 
First Author: Lima da Cruz RV
Year: 2018
Journal: Front Mol Neurosci
Title: A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus.
Volume: 11
Pages: 312
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Protein Domain
IPR036572 | Doublecortin_dom_sf
Type: Homologous_superfamily
Description: X-linked lissencephaly is a severe brain malformation affecting males. Recently it has been demonstrated that the doublecortin gene is implicated in this disorder []. Doublecortin was found to bind to the microtubule cytoskeleton. In vivo and in vitro assays show that Doublecortin stabilises microtubules and causes bundling []. Doublecortin is a basic protein with an iso-electric point of 10, typical of microtubule-binding proteins. However, its sequence contains no known microtubule-binding domain(s).The detailed sequence analysis of Doublecortin and Doublecortin-like proteins allowed the identification of an evolutionarily conserved Doublecortin (DC) domain, which is ubiquitin-like. This domain is found in the N terminus of proteins and consists of one or two tandemly repeated copies of an around 80 amino acids region. It has been suggested that the first DC domain of Doublecortin binds tubulin and enhances microtubule polymerisation [].Some proteins known to contain a DC domain are listed below:Doublecortin. It is required for neuronal migration []. A large number of point mutations in the human DCX gene leading to lissencephaly are located within the DC domains [].Human serine/threonine-protein kinase DCAMKL1. It is a probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain [, ].Retinitis pigmentosa 1 protein. It is required for the differentiation of photoreceptor cells. Mutation in the human RP1 gene cause retinitis pigmentosa of type 1 [, ].
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Protein Domain
IPR003533 | Doublecortin_dom
Type: Domain
Description: X-linked lissencephaly is a severe brain malformation affecting males. Recently it has been demonstrated that the doublecortin gene is implicated in this disorder []. Doublecortin was found to bind to the microtubule cytoskeleton. In vivo and in vitro assays show that Doublecortin stabilises microtubules and causes bundling []. Doublecortin is a basic protein with an iso-electric point of 10, typical of microtubule-binding proteins. However, its sequence contains no known microtubule-binding domain(s).The detailed sequence analysis of Doublecortin and Doublecortin-like proteins allowed the identification of an evolutionarily conserved Doublecortin (DC) domain, which is ubiquitin-like. This domain is found in the N terminus of proteins and consists of one or two tandemly repeated copies of an around 80 amino acids region. It has been suggested that the first DC domain of Doublecortin binds tubulin and enhances microtubule polymerisation [].Some proteins known to contain a DC domain are listed below:Doublecortin. It is required for neuronal migration []. A large number of point mutations in the human DCX gene leading to lissencephaly are located within the DC domains [].Human serine/threonine-protein kinase DCAMKL1. It is a probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain [, ].Retinitis pigmentosa 1 protein. It is required for the differentiation of photoreceptor cells. Mutation in the human RP1 gene cause retinitis pigmentosa of type 1 [, ].
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Publication
19453629 | J:149445
First Author: Bilasy SE
Year: 2009
Journal: Eur J Neurosci
Title: Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect.
Volume: 29
Issue: 10
Pages: 1994-2008
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Publication
18172194 | J:131040
First Author: Pechnick RN
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus.
Volume: 105
Issue: 4
Pages: 1358-63
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Publication
35704312 | J:329973
First Author: Li X
Year: 2022
Journal: FASEB J
Title: Transient early life growth hormone exposure permanently alters brain, muscle, liver, macrophage, and adipocyte status in long-lived Ames dwarf mice.
Volume: 36
Issue: 7
Pages: e22394
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Publication
23165119 | J:206552
 
First Author: Xiao XL
Year: 2013
Journal: Brain Res
Title: Metabotropic glutamate receptor 5 (mGluR5) regulates proliferation and differentiation of neuronal progenitors in the developmental hippocampus.
Volume: 1493
Pages: 1-12
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Publication
21983279 | J:234594
First Author: Wu MD
Year: 2012
Journal: Brain Behav Immun
Title: Adult murine hippocampal neurogenesis is inhibited by sustained IL-1β and not rescued by voluntary running.
Volume: 26
Issue: 2
Pages: 292-300
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Publication
16914687 | J:111657
First Author: Ganat YM
Year: 2006
Journal: J Neurosci
Title: Early postnatal astroglial cells produce multilineage precursors and neural stem cells in vivo.
Volume: 26
Issue: 33
Pages: 8609-21
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Publication
34569932 | J:321403
   
First Author: Lim J
Year: 2021
Journal: Elife
Title: ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain.
Volume: 10
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Publication
38097125 | J:351160
 
First Author: Kim SH
Year: 2024
Journal: Brain Res
Title: Neuronal IGF-1 overexpression restores hippocampal newborn cell survival and recent CFC memory consolidation in Ca(v)1.3 knock-out mice.
Volume: 1825
Pages: 148712
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Publication
30333718 | J:276139
 
First Author: Yau SY
Year: 2018
Journal: Front Neurosci
Title: Adiponectin Mediates Running-Restored Hippocampal Neurogenesis in Streptozotocin-Induced Type 1 Diabetes in Mice.
Volume: 12
Pages: 679
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Publication
17400200 | J:122504
 
First Author: Lazic SE
Year: 2007
Journal: Brain Res
Title: Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients.
Volume: 1151
Pages: 219-26
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Publication
19494148 | J:155647
First Author: Guo F
Year: 2009
Journal: J Neurosci
Title: Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo.
Volume: 29
Issue: 22
Pages: 7256-70
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Publication
28400715 | J:310582
 
First Author: Boulanger JJ
Year: 2017
Journal: Front Neurosci
Title: Doublecortin in Oligodendrocyte Precursor Cells in the Adult Mouse Brain.
Volume: 11
Pages: 143
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Publication
17466019 | J:141723
First Author: Ozen I
Year: 2007
Journal: Eur J Neurosci
Title: Proliferating neuronal progenitors in the postnatal hippocampus transiently express the proneural gene Ngn2.
Volume: 25
Issue: 9
Pages: 2591-603
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Publication
27226325 | J:235666
First Author: Grebbin BM
Year: 2016
Journal: Development
Title: Pbx1 is required for adult subventricular zone neurogenesis.
Volume: 143
Issue: 13
Pages: 2281-91
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Publication
26792809 | J:284713
 
First Author: Li H
Year: 2016
Journal: Biosci Rep
Title: Abca7 deletion does not affect adult neurogenesis in the mouse.
Volume: 36
Issue: 2
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Publication
23575827 | J:196675
First Author: Diaz F
Year: 2013
Journal: J Neurosci
Title: Apoptosis of glutamatergic neurons fails to trigger a neurogenic response in the adult neocortex.
Volume: 33
Issue: 15
Pages: 6278-84
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Publication
17584854 | J:124438
First Author: Poirier K
Year: 2007
Journal: Hum Mutat
Title: Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A).
Volume: 28
Issue: 11
Pages: 1055-64
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Publication
32703308 | J:311240
First Author: Liu Q
Year: 2020
Journal: Alzheimers Res Ther
Title: Intracranial alternating current stimulation facilitates neurogenesis in a mouse model of Alzheimer's disease.
Volume: 12
Issue: 1
Pages: 89
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Publication
23727388 | J:201541
 
First Author: Yao Y
Year: 2013
Journal: Neurosci Lett
Title: Suppression of cytochrome P450 reductase expression promotes astrocytosis in subventricular zone of adult mice.
Volume: 548
Pages: 84-9
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