MouseMine: Keyword Search

First Author:	Fujita Y
Year:	2002
Journal:	Nat Cell Biol
Title:	Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex.
Volume:	4
Issue:	3
Pages:	222-31

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Publication

18222470 | J:166580

First Author:	Koyama S
Year:	2008
Journal:	J Mol Biol
Title:	Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.
Volume:	376
Issue:	5
Pages:	1224-36

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Publication

18541670 | J:137926

First Author:	Bouska A
Year:	2008
Journal:	Mol Cell Biol
Title:	Mdm2 promotes genetic instability and transformation independent of p53.
Volume:	28
Issue:	15
Pages:	4862-74

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Publication

22733537 | -

First Author:	Tang YA
Year:	2012
Journal:	Clin Cancer Res
Title:	MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer.
Volume:	18
Issue:	16
Pages:	4325-33

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Publication

8570197 | -

First Author:	Dubs-Poterszman MC
Year:	1995
Journal:	Oncogene
Title:	MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest.
Volume:	11
Issue:	11
Pages:	2445-9

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Publication

20308078 | -

First Author:	Xu H
Year:	2010
Journal:	J Biol Chem
Title:	MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.
Volume:	285
Issue:	24
Pages:	18407-14

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Publication

19321440 | -

First Author:	Fu W
Year:	2009
Journal:	J Biol Chem
Title:	MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
Volume:	284
Issue:	21
Pages:	13987-4000

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Publication

19411066 | -

First Author:	Gu L
Year:	2009
Journal:	Cancer Cell
Title:	Regulation of XIAP translation and induction by MDM2 following irradiation.
Volume:	15
Issue:	5
Pages:	363-75

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Publication

23885265 | -

First Author:	Nag S
Year:	2013
Journal:	J Biomed Res
Title:	The MDM2-p53 pathway revisited.
Volume:	27
Issue:	4
Pages:	254-71

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Publication

21478859 | -

First Author:	Zhang Y
Year:	2011
Journal:	Nat Cell Biol
Title:	RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.
Volume:	13
Issue:	5
Pages:	623-9

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Publication

25327252 | J:245249

First Author:	DaRosa PA
Year:	2015
Journal:	Nature
Title:	Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
Volume:	517
Issue:	7533
Pages:	223-6

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Publication

8769649 | -

First Author:	Friedman JR
Year:	1996
Journal:	Genes Dev
Title:	KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
Volume:	10
Issue:	16
Pages:	2067-78

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Publication

11226167 | -

First Author:	Capili AD
Year:	2001
Journal:	EMBO J
Title:	Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains.
Volume:	20
Issue:	1-2
Pages:	165-77

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Publication

9016654 | -

First Author:	Moosmann P
Year:	1996
Journal:	Nucleic Acids Res
Title:	Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.
Volume:	24
Issue:	24
Pages:	4859-67

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Publication

16792528 | -

First Author:	Delfino FJ
Year:	2006
Journal:	Biochem J
Title:	The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase.
Volume:	399
Issue:	1
Pages:	141-50

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Publication

21642969 | -

First Author:	Goodarzi AA
Year:	2011
Journal:	Nat Struct Mol Biol
Title:	KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.
Volume:	18
Issue:	7
Pages:	831-9

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Publication

1610787 | -

First Author:	Simon E
Year:	1992
Journal:	Physiol Res
Title:	Osmoreception in the duck's brain identified by neurophysiological methods and phylogenetic structural cues.
Volume:	41
Issue:	1
Pages:	93-4

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Publication

16862143 | -

First Author:	Ziv Y
Year:	2006
Journal:	Nat Cell Biol
Title:	Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.
Volume:	8
Issue:	8
Pages:	870-6

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Publication

11959841 | -

First Author:	Schultz DC
Year:	2002
Journal:	Genes Dev
Title:	SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
Volume:	16
Issue:	8
Pages:	919-32

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Publication

11230151 | -

First Author:	Schultz DC
Year:	2001
Journal:	Genes Dev
Title:	Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.
Volume:	15
Issue:	4
Pages:	428-43

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Publication

22491012 | -

First Author:	Lee DH
Year:	2012
Journal:	EMBO J
Title:	Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response.
Volume:	31
Issue:	10
Pages:	2403-15

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Publication

23851457 | -

First Author:	Dou H
Year:	2013
Journal:	Nat Struct Mol Biol
Title:	Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3.
Volume:	20
Issue:	8
Pages:	982-986

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Publication

19549985 | J:259354

First Author:	Gruber T
Year:	2009
Journal:	Sci Signal
Title:	PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation.
Volume:	2
Issue:	76
Pages:	ra30

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Publication

18227156 | J:134206

First Author:	Qiao G
Year:	2008
Journal:	Mol Cell Biol
Title:	T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b.
Volume:	28
Issue:	7
Pages:	2470-80

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Publication

16424156 | J:126434

First Author:	Wohlfert EA
Year:	2006
Journal:	J Immunol
Title:	Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo.
Volume:	176
Issue:	3
Pages:	1316-20

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Publication

22349934 | -

First Author:	Aparicio LA
Year:	2012
Journal:	Cancer Metastasis Rev
Title:	Biological influence of Hakai in cancer: a 10-year review.
Volume:	31
Issue:	1-2
Pages:	375-86

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Publication

20657603 | -

First Author:	Liu YQ
Year:	2010
Journal:	Asian J Androl
Title:	Human RING finger protein ZNF645 is a novel testis-specific E3 ubiquitin ligase.
Volume:	12
Issue:	5
Pages:	658-66

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Publication

11560955 | -

First Author:	Billaut-Mulot O
Year:	2001
Journal:	J Clin Invest
Title:	SS-56, a novel cellular target of autoantibody responses in Sjögren syndrome and systemic lupus erythematosus.
Volume:	108
Issue:	6
Pages:	861-9

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Publication

18451177 | -

First Author:	Miyajima N
Year:	2008
Journal:	Cancer Res
Title:	TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.
Volume:	68
Issue:	9
Pages:	3486-94

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Publication

24999993 | -

First Author:	Wynne C
Year:	2014
Journal:	PLoS One
Title:	TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems.
Volume:	9
Issue:	7
Pages:	e101503

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Publication

19212346 | -

First Author:	Baek Sørensen R
Year:	2009
Journal:	J Invest Dermatol
Title:	Melanoma inhibitor of apoptosis protein (ML-IAP) specific cytotoxic T lymphocytes cross-react with an epitope from the auto-antigen SS56.
Volume:	129
Issue:	8
Pages:	1992-9

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Publication

18795805 | -

First Author:	Mrosek M
Year:	2008
Journal:	Biochemistry
Title:	Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold.
Volume:	47
Issue:	40
Pages:	10722-30

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Publication

11679633 | J:77660

First Author:	Bodine SC
Year:	2001
Journal:	Science
Title:	Identification of ubiquitin ligases required for skeletal muscle atrophy.
Volume:	294
Issue:	5547
Pages:	1704-8

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Publication

11927605 | -

First Author:	McElhinny AS
Year:	2002
Journal:	J Cell Biol
Title:	Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.
Volume:	157
Issue:	1
Pages:	125-36

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Publication

18468620 | J:307450

First Author:	Hirner S
Year:	2008
Journal:	J Mol Biol
Title:	MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies.
Volume:	379
Issue:	4
Pages:	666-77

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Publication

18364390 | -

First Author:	Capon F
Year:	2008
Journal:	Hum Mol Genet
Title:	Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.
Volume:	17
Issue:	13
Pages:	1938-45

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Publication

21571784 | -

First Author:	Bijlmakers MJ
Year:	2011
Journal:	Hum Mol Genet
Title:	Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis.
Volume:	20
Issue:	16
Pages:	3129-37

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Publication

24631332 | -

First Author:	Yang P
Year:	2014
Journal:	Immunobiology
Title:	Identification of RNF114 as a novel positive regulatory protein for T cell activation.
Volume:	219
Issue:	6
Pages:	432-9

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Protein Domain

IPR042667 | TRIM63_RING-HC

Type:

Domain

Description:

Tripartite motif-containing protein 63 (TRIM63), also known as MURF-1 is an E3 ubiquitin-protein ligase involved in ubiquitin-mediated muscle protein turnover [, ]. It is predominantly fast (type II) fibre-associated in skeletal muscle and can bind to many myofibrillar proteins, including titin, nebulin, the nebulin-related protein NRAP, troponin-I (TnI), troponin-T (TnT), myosin light chain 2 (MLC-2), myotilin, and T-cap. The early and robust upregulation of MuRF-1 is triggered by disuse, denervation, starvation, sepsis, or steroid administration resulting in skeletal muscle atrophy. It also plays a role in maintaining titin M-line integrity []. It associates with the periphery of the M-line lattice and may be involved in the regulation of the titin kinase domain []. It also participates in muscle stress response pathways and gene expression [, ]. MuRF-1 belongs to the C-II subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox2, and a coiled coil region, as well as a COS (carboxyl-terminal subgroup one signature) box, and an acidic residue-rich (AR) domain. It also harbours a MURF family-specific conserved box (MFC) between its RING-HC finger and Bbox domains [].This entry represents the C3HC4-type RING-HC finger found in TRIM63.

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Protein Domain

IPR042656 | TRIM68_RING-HC

Type:

Domain

Description:

TRIM68 is an E3 ubiquitin-protein ligase that negatively regulates Toll-like receptor (TLR)- and RIG-I-like receptor (RLR)-driven type I interferon production by degrading TRK fused gene (TFG), a novel driver of IFN-beta downstream of anti-viral detection systems []. It also functions as a cofactor for androgen receptor-mediated transcription through regulating ligand-dependent transcription of androgen receptor in prostate cancer cells []. Moreover, TRIM68 is a cellular target of autoantibody responses in Sjogren"s syndrome (SS), as well as systemic lupus erythematosus (SLE). It is also an auto-antigen for T cells in SS and SLE [, ]. TRIM68 belongs the C-IV subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, a B-box, and two coiled coil domains, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain. This entry represents the C3HC4-type RING-HC finger found in TRIM68.

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Protein Domain

IPR042699 | TRIM58_RING-HC

Type:

Domain

Description:

TRIM58, also known as protein BIA2, is an erythroid E3 ubiquitin-protein ligase induced during late erythropoiesis. It binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. It may participate in the erythroblast enucleation process through regulation of nuclear polarization. TRIM58 belongs to the C-IV subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain [].

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Protein Domain

IPR042716 | RNF114_RING-HC

Type:

Domain

Description:

RNF114 (also known as Znf313) is a p21(WAF1)-targeting ubiquitin E3 ligase that interacts with X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) and may play a role in p53-mediated cell-fate decisions [, ]. It is involved in immune response to double-stranded RNA in disease pathogenesis []. Moreover, RNF114 interacts with A20 and modulates its ubiquitination []. It negatively regulates nuclear factor-kappaB (NF-kappaB)-dependent transcription and positively regulates T-cell activation []. RNF114 may play a putative role in the regulation of immune responses, since it corresponds to a novel psoriasis susceptibility gene, ZNF313 []. RNF114, together with three closely related proteins: RNF125, RNF138 and RNF166, forms a novel family of ubiquitin ligases with a C3HC4-type RING-HC finger, a C2HC-, and two C2H2-type zinc fingers, as well as a ubiquitin interacting motif (UIM).

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Protein Domain

IPR040100 | RNF208_RING-HC

Type:	Domain
Description:	RNF208 is an E3 ubiquitin-protein ligase whose activity can be modulated by S-nitrosylation. It contains a C3HC4-type RING-HC finger [].

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Protein Domain

IPR039520 | CBL-B_RING-HC

Type:

Domain

Description:

Cbl-b, also known as RNF56, has been identified as a regulator of antigen-specific, T cell-intrinsic, peripheral immune tolerance, a state also known as clonal anergy. It may inhibit activation of the p85 subunit of phosphoinositide 3-kinase (PI3K), protein kinase C-theta (PKC-theta) []and negatively regulates T-cell receptor-induced transcription factor nuclear factor kappaB (NF-kappaB) activation []. In addition, Cbl-b may target multiple signaling molecules involved in transforming growth factor (TGF)-beta-mediated transactivation pathways []. Cbl-b contains a tyrosine-kinase-binding domain (TKB, also known as the phosphotyrosine binding PTB domain, is composed of a four helix-bundle, a Ca2+ binding EF-hand and a highly variant SH2 domain), a proline rich domain, a nuclear localization signal, a C3HC4-type RING-HC finger and an ubiquitin-associated (UBA) domain []. This entry represents the C3HC4-type RING-HC finger.

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Allele

Tg(Igh-VHyHEL10/Ighm/Ighd)2Ccg | MGI:5574489

Name:	transgene insertion 2, Christopher C Goodnow
Allele Type:	Transgenic
Attribute String:	Inserted expressed sequence

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Transgene

MGI:5574483 | Tg(Igh-VHyHEL10/Ighm/Ighd)2Ccg

Type:	transgene
Organism:	mouse, laboratory

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Publication

11418600 | -

First Author:	Fotinou C
Year:	2001
Journal:	J Biol Chem
Title:	The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin.
Volume:	276
Issue:	34
Pages:	32274-81

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Publication

18400985 | J:345037

First Author:	Qu Z
Year:	2008
Journal:	Am J Physiol Cell Physiol
Title:	Bestrophin Cl- channels are highly permeable to HCO3-.
Volume:	294
Issue:	6
Pages:	C1371-7

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Publication

10760602 | J:66306

First Author:	Hermey G
Year:	2000
Journal:	Biochim Biophys Acta
Title:	Alternative splicing of murine SorCS leads to two forms of the receptor that differ completely in their cytoplasmic tails.
Volume:	1491
Issue:	1-3
Pages:	350-4

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Publication

8631704 | -

First Author:	Marykwas DL
Year:	1996
Journal:	J Bacteriol
Title:	A mutational analysis of the interaction between FliG and FliM, two components of the flagellar motor of Escherichia coli.
Volume:	178
Issue:	5
Pages:	1289-94

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Publication

8051048 | -

First Author:	Sankaran K
Year:	1994
Journal:	J Biol Chem
Title:	Lipid modification of bacterial prolipoprotein. Transfer of diacylglyceryl moiety from phosphatidylglycerol.
Volume:	269
Issue:	31
Pages:	19701-6

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Publication

2202727 | -

First Author:	Hayashi S
Year:	1990
Journal:	J Bioenerg Biomembr
Title:	Lipoproteins in bacteria.
Volume:	22
Issue:	3
Pages:	451-71

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Publication

22193161 | -

First Author:	Cullen PJ
Year:	2011
Journal:	Nat Cell Biol
Title:	Sorting nexins provide diversity for retromer-dependent trafficking events.
Volume:	14
Issue:	1
Pages:	29-37

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Publication

4405752 | J:30972

First Author:	Wolff GL
Year:	1973
Journal:	Genetics
Title:	Influence of background genome on enzymatic characteristics of yellow (A v -, A vy -) mice.
Volume:	73
Issue:	1
Pages:	109-23

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Publication

28453662 | J:262511

First Author:	Huang JY
Year:	2018
Journal:	Cereb Cortex
Title:	mGluR5 Tunes NGF/TrkA Signaling to Orient Spiny Stellate Neuron Dendrites Toward Thalamocortical Axons During Whisker-Barrel Map Formation.
Volume:	28
Issue:	6
Pages:	1991-2006

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Publication

24694595 | J:311896

First Author:	Ruppersburg CC
Year:	2014
Journal:	Mol Biol Cell
Title:	The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis.
Volume:	25
Issue:	11
Pages:	1793-807

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Publication

- | J:233450

First Author:	Nam K-H
Year:	2016
Journal:	MGI Direct Data Submission
Title:	Direct Data Submission for Alleles from the KRIBB Institute

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Publication

11053021 | J:65659

First Author:	Kim C
Year:	2000
Journal:	Am J Physiol Lung Cell Mol Physiol
Title:	Hoxa-5 in mouse developing lung: cell-specific expression and retinoic acid regulation.
Volume:	279
Issue:	5
Pages:	L863-71

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Publication

1847899 | J:33290

First Author:	Zimmerer EJ
Year:	1991
Journal:	Immunogenetics
Title:	Structural and genetic properties of the Eb recombinational hotspot in the mouse.
Volume:	33
Issue:	2
Pages:	132-40

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Publication

1920613 | J:11505

First Author:	Reuss FU
Year:	1991
Journal:	J Virol
Title:	cDNA sequence and genomic characterization of intracisternal A-particle-related retroviral elements containing an envelope gene.
Volume:	65
Issue:	11
Pages:	5702-9

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Publication

8527412 | J:26837

First Author:	Jolly CJ
Year:	1995
Journal:	Int Immunol
Title:	Expression of a TCR V beta 8.2 polypeptide from the unrearranged gene in a murine lymphoid precursor cell line.
Volume:	7
Issue:	7
Pages:	1147-56

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Publication

9046429 | J:42246

First Author:	Jolly CJ
Year:	1997
Journal:	Immunol Cell Biol
Title:	Specific transcription of the unrearranged TCR V beta 8.2 gene in lymphoid tissues occurs independently of V(D)J rearrangement.
Volume:	75
Issue:	1
Pages:	13-20

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Publication

9357553 | J:43596

First Author:	Sandhu JK
Year:	1997
Journal:	Mutat Res
Title:	Mutagenicity and cytotoxicity of reactive oxygen and nitrogen species in the MN-11 murine tumor cell line.
Volume:	379
Issue:	2
Pages:	241-52

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Publication

22547677 | J:186673

First Author:	Martinez-Zamudio R
Year:	2012
Journal:	Mol Cell Biol
Title:	Histone ADP-ribosylation facilitates gene transcription by directly remodeling nucleosomes.
Volume:	32
Issue:	13
Pages:	2490-502

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Publication

24551086 | J:213071

First Author:	Petvises S
Year:	2014
Journal:	PLoS One
Title:	Characterisation of dendritic cells arising from progenitors endogenous to murine spleen.
Volume:	9
Issue:	2
Pages:	e88311

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Publication

- | J:23471

First Author:	Bonner JJ
Year:	1975
Journal:	Immunogenetics
Title:	Cleft palate susceptibility linked to histocompatibility-2 (H-2) in the mouse.
Volume:	2

Pages:	213-18

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Publication

- | J:35005

First Author:	Bergeron AJ
Year:	1996
Journal:	J Endotoxin Res
Title:	Reclassification of the BXH11/Ty mouse as an endotoxin- hyporesponsive strain.
Volume:	3
Issue:	2
Pages:	165-8

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Publication

- | J:61614

First Author:	Sowden MP
Year:	1997
Journal:	GenBank Submission
Title:	Mus musculus betaine homocysteine methyl transferase (BHMT) mRNA, complete cds


Pages:	AF033381