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Search results 1401 to 1500 out of 1845 for Igf1

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Type Details Score
Publication
28700945 | J:255242
First Author: Templeman NM
Year: 2017
Journal: Cell Rep
Title: Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan.
Volume: 20
Issue: 2
Pages: 451-463
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Publication
29447858 | J:265059
 
First Author: Hu H
Year: 2018
Journal: Neuroscience
Title: Intrathecal Injection of scAAV9-hIGF1 Prolongs the Survival of ALS Model Mice by Inhibiting the NF-kB Pathway.
Volume: 381
Pages: 1-10
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Publication
28065828 | J:251901
First Author: Sakaguchi M
Year: 2017
Journal: Cell Metab
Title: Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor.
Volume: 25
Issue: 2
Pages: 448-462
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Publication
32694718 | J:301643
First Author: Ostermann AL
Year: 2019
Journal: Nat Metab
Title: Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer.
Volume: 1
Issue: 3
Pages: 371-389
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Publication
28683287 | J:256763
First Author: Riera CE
Year: 2017
Journal: Cell Metab
Title: The Sense of Smell Impacts Metabolic Health and Obesity.
Volume: 26
Issue: 1
Pages: 198-211.e5
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Publication
31122676 | J:278524
First Author: Zhang Y
Year: 2019
Journal: Neuron
Title: Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs.
Volume: 103
Issue: 1
Pages: 39-51.e5
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Publication
34738614 | J:316206
 
First Author: Kwon HR
Year: 2021
Journal: Development
Title: Skeletal stem cell fate defects caused by Pdgfrb activating mutation.
Volume: 148
Issue: 23
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Publication
38821060 | J:349753
First Author: McGinnis CS
Year: 2024
Journal: Cancer Cell
Title: The temporal progression of lung immune remodeling during breast cancer metastasis.
Volume: 42
Issue: 6
Pages: 1018-1031.e6
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Publication
28741471 | J:256854
   
First Author: Roselló-Díez A
Year: 2017
Journal: Elife
Title: Altered paracrine signaling from the injured knee joint impairs postnatal long bone growth.
Volume: 6
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Publication
24911144 | J:213795
First Author: Roman-Garcia P
Year: 2014
Journal: J Clin Invest
Title: Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass.
Volume: 124
Issue: 7
Pages: 2988-3002
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Publication
20534466 | J:161276
First Author: York B
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology.
Volume: 107
Issue: 24
Pages: 11122-7
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Publication
32626707 | J:312288
 
First Author: Zhao Y
Year: 2020
Journal: Front Cell Dev Biol
Title: Stimulating Factors and Origins of Precursor Cells in Traumatic Heterotopic Ossification Around the Temporomandibular Joint in Mice.
Volume: 8
Pages: 445
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Publication
26039450 | J:226125
First Author: Das S
Year: 2015
Journal: Cell Metab
Title: ATP citrate lyase improves mitochondrial function in skeletal muscle.
Volume: 21
Issue: 6
Pages: 868-76
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Publication
31991123 | J:293831
 
First Author: Hu S
Year: 2020
Journal: Brain Res
Title: Knock down of lncRNA H19 promotes axon sprouting and functional recovery after cerebral ischemic stroke.
Volume: 1732
Pages: 146681
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Publication
26025657 | J:311070
First Author: Simon CM
Year: 2015
Journal: Acta Neuropathol
Title: Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy.
Volume: 130
Issue: 3
Pages: 373-87
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Protein Domain
IPR022350 | Insulin-like_growth_factor
Type: Family
Description: The insulin family of proteins groups together several evolutionarily related active peptides []: these include insulin [, ], relaxin [, ], insect prothoracicotropic hormone (bombyxin) [], insulin-like growth factors (IGF1 and IGF2) [, ], mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP) (gene INSL4), locust insulin-related peptide (LIRP), molluscan insulin-related peptides (MIP) and Caenorhabditis elegans insulin-like peptides. The 3D structures of a number of family members have been determined [, , ]. The fold comprises two polypeptide chains (A and B) linked by two disulphide bonds: all share a conserved arrangement of 4 cysteines in their A chain, the first of which is linked by a disulphide bond to the third, while the second and fourth are linked by interchain disulphide bonds to cysteines in the B chain. The IGFs, or somatomedins, play a key role in pre-adolescent mammalian growth. IGFI expression is regulated by growth hormone and mediates post-natal growth []. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency), an autosomal recessive disorder characterised by growth retardation, sensorineural deafness and mental retardation []. IGF2 appears to be induced by placental lactogen and is thought to play a role in foetal development [].
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Protein Domain
IPR022341 | IGF-I
Type: Family
Description: The insulin family of proteins groups together several evolutionarily related active peptides []: these include insulin [, ], relaxin [, ], insect prothoracicotropic hormone (bombyxin) [], insulin-like growth factors (IGF1 and IGF2) [, ], mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP) (gene INSL4), locust insulin-related peptide (LIRP), molluscan insulin-related peptides (MIP) and Caenorhabditis elegans insulin-like peptides. The 3D structures of a number of family members have been determined [, , ]. The fold comprises two polypeptide chains (A and B) linked by two disulphide bonds: all share a conserved arrangement of 4 cysteines in their A chain, the first of which is linked by a disulphide bond to the third, while the second and fourth are linked by interchain disulphide bonds to cysteines in the B chain. The IGFs, or somatomedins, play a key role in pre-adolescent mammalian growth. IGFI expression is regulated by growth hormone and mediates post-natal growth []. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency), an autosomal recessive disorder characterised by growth retardation, sensorineural deafness and mental retardation [].
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Publication
6382022 | -
First Author: Dull TJ
Year: 1984
Journal: Nature
Title: Insulin-like growth factor II precursor gene organization in relation to insulin gene family.
Volume: 310
Issue: 5980
Pages: 777-81
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Protein
B1ATS7
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
B1ATS8
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: true
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Protein
Q5SUW0
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
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Protein Domain
IPR039665 | PH_APBB1IP
Type: Domain
Description: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP) consists of a Ras-associated (RA) domain, a PH domain, a family-specific BPS region, and a C-terminal SH2 domain. Grb7, Grb10 and Grb14 are paralogues that are also present in this entry []. These adapter proteins bind a variety of receptor tyrosine kinases, including the insulin and insulin-like growth factor-1 (IGF1) receptors. Grb10 and Grb14 are important tissue-specific negative regulators of insulin and IGF1 signaling based and may contribute to type 2 (non-insulin-dependent) diabetes in humans. RA-PH function as a single structural unit and is dimerized via a helical extension of the PH domain. The PH domain here are proposed to bind phosphoinositides non-cannonically and are unlikely to bind an activated GTPase []. The tandem RA-PH domains are present in a second adapter-protein family, MRL proteins, Caenorhabditis elegansprotein MIG-1012, the mammalian proteins RIAM and lamellipodin and the Drosophila melanogasterprotein Pico12, all of which are Ena/VASP-binding proteins involved in actin-cytoskeleton rearrangement.PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane []. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
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Publication
19907080 | J:155099
First Author: Touvier T
Year: 2009
Journal: J Clin Invest
Title: LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.
Volume: 119
Issue: 12
Pages: 3830-8
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Publication
22367546 | J:181684
First Author: Kanfi Y
Year: 2012
Journal: Nature
Title: The sirtuin SIRT6 regulates lifespan in male mice.
Volume: 483
Issue: 7388
Pages: 218-21
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Publication
23695157 | J:201107
First Author: Al-Qusairi L
Year: 2013
Journal: FASEB J
Title: Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways.
Volume: 27
Issue: 8
Pages: 3384-94
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Publication
38673910 | J:352309
 
First Author: Zhou AX
Year: 2024
Journal: Int J Mol Sci
Title: Renal Endothelial Single-Cell Transcriptomics Reveals Spatiotemporal Regulation and Divergent Roles of Differential Gene Transcription and Alternative Splicing in Murine Diabetic Nephropathy.
Volume: 25
Issue: 8
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Publication
22927639 | J:189249
First Author: Jiao Y
Year: 2012
Journal: Mol Cell Biol
Title: Mex3c mutation reduces adiposity and increases energy expenditure.
Volume: 32
Issue: 21
Pages: 4350-62
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Publication
22535770 | J:188646
First Author: Yusta B
Year: 2012
Journal: Endocrinology
Title: Intestinotrophic glucagon-like peptide-2 (GLP-2) activates intestinal gene expression and growth factor-dependent pathways independent of the vasoactive intestinal peptide gene in mice.
Volume: 153
Issue: 6
Pages: 2623-32
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Publication
37656189 | J:345919
First Author: Iwanaga Y
Year: 2023
Journal: Mamm Genome
Title: A nonsense mutation in mouse Adamtsl2 causes uterine hypoplasia and an irregular estrous cycle.
Volume: 34
Issue: 4
Pages: 559-571
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Publication
17611229 | J:124114
First Author: Lee J
Year: 2007
Journal: Development
Title: Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes.
Volume: 134
Issue: 15
Pages: 2795-806
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Publication
26878170 | J:232423
First Author: Teramachi J
Year: 2016
Journal: J Clin Invest
Title: Measles virus nucleocapsid protein increases osteoblast differentiation in Paget's disease.
Volume: 126
Issue: 3
Pages: 1012-22
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Publication
33247205 | J:299698
First Author: Grundmann SM
Year: 2020
Journal: Sci Rep
Title: High-phosphorus diets reduce aortic lesions and cardiomyocyte size and modify lipid metabolism in Ldl receptor knockout mice.
Volume: 10
Issue: 1
Pages: 20748
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Publication
25070661 | J:316742
First Author: Yuan R
Year: 2015
Journal: J Gerontol A Biol Sci Med Sci
Title: Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1.
Volume: 70
Issue: 7
Pages: 817-26
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Publication
18614544 | J:138868
First Author: Hegedus B
Year: 2008
Journal: Hum Mol Genet
Title: Neurofibromin regulates somatic growth through the hypothalamic-pituitary axis.
Volume: 17
Issue: 19
Pages: 2956-66
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Publication
22792392 | J:189640
First Author: Trierweiler C
Year: 2012
Journal: PLoS One
Title: The transcription factor c-Jun protects against liver damage following activated β-Catenin signaling.
Volume: 7
Issue: 7
Pages: e40638
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Publication
19500727 | J:151425
First Author: Keisala T
Year: 2009
Journal: J Steroid Biochem Mol Biol
Title: Premature aging in vitamin D receptor mutant mice.
Volume: 115
Issue: 3-5
Pages: 91-7
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Publication
20038803 | J:156696
First Author: Takeda N
Year: 2010
Journal: J Clin Invest
Title: Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.
Volume: 120
Issue: 1
Pages: 254-65
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Publication
36125265 | J:330376
First Author: Riehle C
Year: 2022
Journal: Mol Cell Biol
Title: Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart.
Volume: 42
Issue: 10
Pages: e0016322
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Publication
29883366 | J:270882
First Author: Rowland ME
Year: 2018
Journal: Aging (Albany NY)
Title: Inactivation of hepatic ATRX in Atrx Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine.
Volume: 10
Issue: 6
Pages: 1223-1238
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Publication
34971379 | J:324529
 
First Author: Stallings CE
Year: 2022
Journal: Endocrinology
Title: FOXO Transcription Factors Are Required for Normal Somatotrope Function and Growth.
Volume: 163
Issue: 2
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Publication
29610318 | J:261816
First Author: Xu H
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis.
Volume: 115
Issue: 16
Pages: 4228-4233
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Publication
37463909 | J:351252
First Author: Post LA
Year: 2023
Journal: Sci Rep
Title: Inceptor as a regulator of brain insulin sensitivity.
Volume: 13
Issue: 1
Pages: 11582
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Publication
29068127 | J:351780
First Author: Lin KH
Year: 2018
Journal: Environ Toxicol
Title: The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple-transgenic Alzheimer's disease model mice.
Volume: 33
Issue: 1
Pages: 83-92
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Publication
32611235 | J:299141
First Author: Seneviratne A
Year: 2020
Journal: Circ Res
Title: Hematoma Resolution In Vivo Is Directed by Activating Transcription Factor 1.
Volume: 127
Issue: 7
Pages: 928-944
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Publication
20947509 | J:167586
First Author: Xuan S
Year: 2010
Journal: J Biol Chem
Title: Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.
Volume: 285
Issue: 52
Pages: 41044-50
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Publication
30888862 | J:275683
First Author: Czaja W
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Myostatin regulates pituitary development and hepatic IGF1.
Volume: 316
Issue: 6
Pages: E1036-E1049
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Publication
22999939 | J:196226
First Author: Jing X
Year: 2012
Journal: Cell Rep
Title: Crosstalk of humoral and cell-cell contact-mediated signals in postnatal body growth.
Volume: 2
Issue: 3
Pages: 652-65
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Publication
28586424 | J:248189
First Author: Hewitt SC
Year: 2017
Journal: Endocrinology
Title: Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1.
Volume: 158
Issue: 8
Pages: 2427-2435
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Publication
20032200 | J:163661
First Author: DeMambro VE
Year: 2010
Journal: J Endocrinol
Title: A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis.
Volume: 204
Issue: 3
Pages: 241-53
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Publication
11116089 | J:66233
First Author: Brockmann GA
Year: 2000
Journal: Genome Res
Title: Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice.
Volume: 10
Issue: 12
Pages: 1941-57
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Publication
31262748 | J:278518
 
First Author: Villar-Lorenzo A
Year: 2019
Journal: Dis Model Mech
Title: Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury.
Volume: 12
Issue: 7
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Publication
22160220 | J:311775
 
First Author: Murillo-Cuesta S
Year: 2012
Journal: Mol Med
Title: Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function.
Volume: 18
Pages: 260-9
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Publication
21926467 | J:178490
First Author: Sadagurski M
Year: 2011
Journal: J Clin Invest
Title: IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease.
Volume: 121
Issue: 10
Pages: 4070-81
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Publication
31318893 | J:277295
First Author: Jin J
Year: 2019
Journal: PLoS One
Title: Igf1R/InsR function is required for axon extension and corpus callosum formation.
Volume: 14
Issue: 7
Pages: e0219362
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Publication
17416680 | J:121640
First Author: Okada T
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.
Volume: 104
Issue: 21
Pages: 8977-82
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Publication
33539533 | J:302242
 
First Author: Schoeller EL
Year: 2021
Journal: Endocrinology
Title: Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1.
Volume: 162
Issue: 4
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Publication
32381739 | J:288754
First Author: Zhang Z
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome.
Volume: 117
Issue: 21
Pages: 11829-11835
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Publication
37340054 | J:355428
First Author: Baghdadi M
Year: 2023
Journal: Sci Rep
Title: Sex-specific effects of Cre expression in Syn1Cre mice.
Volume: 13
Issue: 1
Pages: 10037
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Publication
34021242 | J:306414
First Author: Malawsky DS
Year: 2021
Journal: Commun Biol
Title: Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile.
Volume: 4
Issue: 1
Pages: 616
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Publication
28957322 | J:248408
First Author: Shu L
Year: 2017
Journal: PLoS Genet
Title: Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States.
Volume: 13
Issue: 9
Pages: e1007040
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Publication
26100875 | J:223741
First Author: Shahmoradi A
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex.
Volume: 112
Issue: 27
Pages: E3582-9
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Publication
27145011 | J:239731
First Author: Dionne DA
Year: 2016
Journal: Endocrinology
Title: Caloric Restriction Paradoxically Increases Adiposity in Mice With Genetically Reduced Insulin.
Volume: 157
Issue: 7
Pages: 2724-34
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Publication
30576429 | J:273133
First Author: Neirijnck Y
Year: 2019
Journal: Endocrinology
Title: Tumor Suppressor PTEN Regulates Negatively Sertoli Cell Proliferation, Testis Size, and Sperm Production In Vivo.
Volume: 160
Issue: 2
Pages: 387-398
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Publication
25605333 | J:224288
First Author: Tontonoz P
Year: 2015
Journal: Mol Cell Biol
Title: The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice.
Volume: 35
Issue: 7
Pages: 1125-38
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Publication
27129272 | J:235018
First Author: Tando T
Year: 2016
Journal: J Biol Chem
Title: Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy.
Volume: 291
Issue: 23
Pages: 12184-94
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Publication
22558322 | J:187274
First Author: Ma X
Year: 2012
Journal: PLoS One
Title: Impact of treadmill running and sex on hippocampal neurogenesis in the mouse model of amyotrophic lateral sclerosis.
Volume: 7
Issue: 4
Pages: e36048
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Publication
30084987 | J:270014
First Author: Radovic SM
Year: 2019
Journal: Biol Reprod
Title: Insulin/IGF1 signaling regulates the mitochondrial biogenesis markers in steroidogenic cells of prepubertal testis, but not ovary.
Volume: 100
Issue: 1
Pages: 253-267
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Publication
21979052 | J:177432
First Author: Hua Y
Year: 2011
Journal: Nature
Title: Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model.
Volume: 478
Issue: 7367
Pages: 123-6
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Publication
24014320 | J:234758
First Author: Sahashi K
Year: 2013
Journal: EMBO Mol Med
Title: Pathological impact of SMN2 mis-splicing in adult SMA mice.
Volume: 5
Issue: 10
Pages: 1586-601
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Publication
25100745 | J:232465
First Author: Pascual-Lucas M
Year: 2014
Journal: EMBO Mol Med
Title: Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice.
Volume: 6
Issue: 10
Pages: 1246-62
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Publication
19497867 | J:150064
First Author: Cybulski N
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: mTOR complex 2 in adipose tissue negatively controls whole-body growth.
Volume: 106
Issue: 24
Pages: 9902-7
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Publication
19805143 | J:153681
First Author: Mao J
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues.
Volume: 106
Issue: 41
Pages: 17576-81
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Publication
31185266 | J:288970
 
First Author: Martin A
Year: 2019
Journal: Biochimie
Title: Fibroblast deficiency of insulin-like growth factor 1 receptor type 1 (IGF1R) impairs initial steps of murine pheochromocytoma development.
Volume: 163
Pages: 108-116
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Publication
15226426 | J:91573
First Author: McMullen JR
Year: 2004
Journal: Mol Cell Biol
Title: Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy.
Volume: 24
Issue: 14
Pages: 6231-40
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Publication
28323915 | J:247027
First Author: Hjortebjerg R
Year: 2017
Journal: Endocrinology
Title: Insulin, IGF-1, and GH Receptors Are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice With Modified GH Action.
Volume: 158
Issue: 5
Pages: 1406-1418
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Publication
16054319 | J:104965
First Author: Masternak MM
Year: 2005
Journal: Exp Gerontol
Title: Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice.
Volume: 40
Issue: 8-9
Pages: 679-84
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