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Search results 1401 to 1500 out of 12470 for Impact

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Type Details Score
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment
Series Id: E-GEOD-83483
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication  
First Author: Gille S
Year: 2012
Journal: Front Plant Sci
Title: O-acetylation of plant cell wall polysaccharides.
Volume: 3
Pages: 12
Publication
First Author: Grüber A
Year: 2010
Journal: PLoS One
Title: Structural determination of functional units of the nucleotide binding domain (NBD94) of the reticulocyte binding protein Py235 of Plasmodium yoelii.
Volume: 5
Issue: 2
Pages: e9146
Publication
First Author: Delint-Ramirez I
Year: 2011
Journal: J Biol Chem
Title: Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.
Volume: 286
Issue: 38
Pages: 32962-75
Publication
First Author: Willoughby D
Year: 2012
Journal: J Cell Sci
Title: A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.
Volume: 125
Issue: Pt 23
Pages: 5850-9
Protein Domain
Type: Domain
Description: This entry represents a domain found in one of the reticulocyte binding protein homologue family members or RH proteins expressed by the malaria parasite merozoite. RH proteins recognise erythrocytes and are important in virulence. This domain has been shown to exhibit selective binding to ATP and ADP. Binding of ATP or ADP induces nucleotide-dependent structural changes in the C-terminal hinge-region of NBD94 that directly impact on the ability of the RH to bind to the red blood cells [].
Protein Domain
Type: Family
Description: Trichome birefringence-like (TBL) is a plant protein family. In Arabidopsis this family includes 46 members (TBR, TBL1-45) []. The TBL family is proposed to encode wall polysaccharide specific O-acetyltransferases [, ]. They contain a TBL domain with a conserved glycine-aspartate-serine (GDS) signature, similar to the conserved motif (GDSL) found in some esterases/lipases [, ]. Members of the TBL protein family had been shown to impact pathogen resistance, freezing tolerance, and cellulose biosynthesis [].
Protein Domain
Type: Family
Description: A-kinase anchor protein 5 (AKAP5), also known as AKAP79, is a PKA anchoring protein that binds to adenylyl cyclase type 8 (AC8) and to regulate its responsiveness to store-operated Ca(2) entry (SOCE) []. The AKAP79 and AC8 interaction may occur in lipid raft domains of the plasma membrane, with palmitoylation of AKAP79 plays an important role in targeting the AKAP to the cholesterol- and sphingolipid-rich regions of the plasma membrane where it can impact on local Ca2 -stimulated AC8 activity [].
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Allele  
Name: mucolipin 3; varitint waddler Jackson
Allele Type: Spontaneous
Publication
First Author: Beauchamp MC
Year: 2019
Journal: PLoS One
Title: Loss of function mutation of Eftud2, the gene responsible for mandibulofacial dysostosis with microcephaly (MFDM), leads to pre-implantation arrest in mouse.
Volume: 14
Issue: 7
Pages: e0219280
Strain
Attribute String: mutant strain, endonuclease-mediated mutation, coisogenic
Strain
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Strain
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
Allele
Name: IQ motif containing with AAA domain 1; endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Allele
Name: collagen, type XVI, alpha 1; endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Genotype
Symbol: Eftud2/Eftud2<+>
Background: involves: CD-1 * FVB/N
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Eftud2/Eftud2
Background: involves: CD-1 * FVB/N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Mrpl3/Mrpl3<+>
Background: C57BL/6NJ-Mrpl3/J
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mrpl3/Mrpl3
Background: C57BL/6NJ-Mrpl3/J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Pla2g7/Pla2g7
Background: C57BL/6NJ-Pla2g7/J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Mrpl3/Mrpl3
Background: C57BL/6N-Mrpl3/Mmucd
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Lareyre JJ
Year: 2001
Journal: Endocrinology
Title: Gene duplication gives rise to a new 17-kilodalton lipocalin that shows epididymal region-specific expression and testicular factor(s) regulation.
Volume: 142
Issue: 3
Pages: 1296-308
Publication
First Author: McElhinny AS
Year: 2008
Journal: Oncogene
Title: Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways.
Volume: 27
Issue: 38
Pages: 5138-47
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment
Series Id: GSE15492
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE29538
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE75907
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Takami Y
Year: 2007
Journal: Mol Biol Cell
Title: Essential role of chromatin assembly factor-1-mediated rapid nucleosome assembly for DNA replication and cell division in vertebrate cells.
Volume: 18
Issue: 1
Pages: 129-41
Publication
First Author: Quivy JP
Year: 2008
Journal: Nat Struct Mol Biol
Title: The HP1-p150/CAF-1 interaction is required for pericentric heterochromatin replication and S-phase progression in mouse cells.
Volume: 15
Issue: 9
Pages: 972-9
Protein Domain
Type: Homologous_superfamily
Description: Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins that lack a DNA binding domain and exert its negative regulation of gibberellin responses through interaction with other transcription factors []. DELLAs are downregulated when gibberellins bind to their receptor GID1 [, ], which forms a complex with DELLA proteins and signals them towards 26S proteasome. The N-terminal of DELLA proteins contains conserved DELLA and TVHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins [, ].
Protein Domain
Type: Family
Description: The CAF-1 or chromatin assembly factor-1 consists of three subunits, and this is the first, or A []. The A domain is uniquely required for the progression of S phase in mouse cells [], independent of its ability to promote histone deposition []but dependent on its ability to interact with HP1 - heterochromatin protein 1-rich heterochromatin domains next to centromeres that are crucial for chromosome segregation during mitosis. This HP1-CAF-1 interaction module functions as a built-in replication control for heterochromatin, which, like a control barrier, has an impact on S-phase progression in addition to DNA-based checkpoints [].
Protein Domain
Type: Domain
Description: Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins that lack a DNA binding domain and exert its negative regulation of gibberellin responses through interaction with other transcription factors []. DELLAs are downregulated when gibberellins bind to their receptor GID1 [, ], which forms a complex with DELLA proteins and signals them towards 26S proteasome. The N-terminal of DELLA proteins contains conserved DELLA and TVHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins [, ].
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment
Series Id: GSE73552
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Publication
First Author: Cabraja M
Year: 2007
Journal: J Comp Neurol
Title: Vestibular ganglion neurons survive hair cell defects in jerker, shaker, and Varitint-waddler mutants and downregulate calretinin expression.
Volume: 504
Issue: 4
Pages: 418-26
Publication  
First Author: Hams E
Year: 2020
Journal: Front Immunol
Title: Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity.
Volume: 11
Pages: 1966
Publication  
First Author: Knolle MD
Year: 2018
Journal: Front Immunol
Title: MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
Volume: 9
Pages: 2232
Publication  
First Author: Cool T
Year: 2020
Journal: Exp Hematol
Title: Interleukin 7 receptor is required for myeloid cell homeostasis and reconstitution by hematopoietic stem cells.
Volume: 90
Pages: 39-45.e3
Publication
First Author: Murase K
Year: 2008
Journal: Nature
Title: Gibberellin-induced DELLA recognition by the gibberellin receptor GID1.
Volume: 456
Issue: 7221
Pages: 459-63
Publication
First Author: Rombolá-Caldentey B
Year: 2014
Journal: Plant Cell
Title: Arabidopsis DELLA and two HD-ZIP transcription factors regulate GA signaling in the epidermis through the L1 box cis-element.
Volume: 26
Issue: 7
Pages: 2905-19
Publication
First Author: Fukazawa J
Year: 2014
Journal: Plant Cell
Title: DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis.
Volume: 26
Issue: 7
Pages: 2920-38
Publication
First Author: Barberi T
Year: 2020
Journal: PLoS One
Title: C/EBPα induces Ebf1 gene expression in common lymphoid progenitors.
Volume: 15
Issue: 12
Pages: e0244161
Publication
First Author: Grimm C
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse.
Volume: 104
Issue: 49
Pages: 19583-8
Publication
First Author: van Aken AF
Year: 2008
Journal: J Physiol
Title: TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice.
Volume: 586
Issue: 22
Pages: 5403-18
Strain
Attribute String: spontaneous mutation, mutant strain, congenic
Strain
Attribute String: mutant stock
Strain
Attribute String: spontaneous mutation, congenic, mutant strain
Strain
Attribute String: spontaneous mutation, congenic
Strain
Attribute String: F1 hybrid, spontaneous mutation
Strain
Attribute String: mutant strain
Strain
Attribute String: F1 hybrid, mutant stock
Publication
First Author: Nagata K
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration.
Volume: 105
Issue: 1
Pages: 353-8
Publication
First Author: Cable J
Year: 1998
Journal: Hear Res
Title: Combined cochleo-saccular and neuroepithelial abnormalities in the Varitint-waddler-J (VaJ) mouse.
Volume: 123
Issue: 1-2
Pages: 125-36
Publication
First Author: Kelly VP
Year: 2005
Journal: Mol Cell Biol
Title: The distal sequence element of the selenocysteine tRNA gene is a tissue-dependent enhancer essential for mouse embryogenesis.
Volume: 25
Issue: 9
Pages: 3658-69
Publication  
First Author: Muro R
Year: 2022
Journal: Front Immunol
Title: Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation.
Volume: 13
Pages: 1045881
Strain
Attribute String: endonuclease-mediated mutation, coisogenic, mutant strain