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Search results 1401 to 1500 out of 2672 for Mapt

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Type Details Score
Publication
18832465 | J:143439
First Author: Ittner LM
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia.
Volume: 105
Issue: 41
Pages: 15997-6002
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Publication
27427974 | J:317872
First Author: Pajares M
Year: 2016
Journal: Autophagy
Title: Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.
Volume: 12
Issue: 10
Pages: 1902-1916
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Publication
34535637 | J:331670
First Author: Mencer S
Year: 2021
Journal: Transl Psychiatry
Title: Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway.
Volume: 11
Issue: 1
Pages: 480
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Strain
MGI:2673536 | STOCK Tg(MAPT)8cPdav Mapt<tm1(EGFP)Klt>/J
Attribute String: mutant stock, transgenic, targeted mutation
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Strain
MGI:3574386 | B6.Cg-Tg(MAPT)8cPdav Mapt<tm1(EGFP)Klt>/J
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
34551296 | J:327010
First Author: Jiang S
Year: 2021
Journal: Cell Rep
Title: Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.
Volume: 36
Issue: 12
Pages: 109720
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Publication
10783293 | J:85952
First Author: Duff K
Year: 2000
Journal: Neurobiol Dis
Title: Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes.
Volume: 7
Issue: 2
Pages: 87-98
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Publication
20661273 | J:163095
First Author: Giliberto L
Year: 2010
Journal: PLoS One
Title: Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivo.
Volume: 5
Issue: 7
Pages: e11609
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Genotype
Genotype
Symbol: Mapt/Mapt Tg(MAPT)8cPdav/?
Background: involves: 129S4/SvJae * C57BL/6 * Swiss Webster
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mapt/Mapt Tg(MAPT)8cPdav/?
Background: B6.Cg-Tg(MAPT)8cPdav Mapt/J
Zygosity: cx
Has Mutant Allele: true
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Publication
19057915 | J:146318
First Author: Guerrero R
Year: 2009
Journal: Acta Neuropathol
Title: Hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human FTDP-17 Tau and lacking the PARK2 gene.
Volume: 117
Issue: 2
Pages: 159-68
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Publication
37496076 | J:338543
First Author: Farfara D
Year: 2023
Journal: J Neuroinflammation
Title: Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice.
Volume: 20
Issue: 1
Pages: 174
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Publication
36012331 | J:327939
 
First Author: Saleh B
Year: 2022
Journal: Int J Mol Sci
Title: FAK-Mediated Signaling Controls Amyloid Beta Overload, Learning and Memory Deficits in a Mouse Model of Alzheimer's Disease.
Volume: 23
Issue: 16
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Allele
Tg(Prnp-MAPT)43Vle | MGI:2385566
Name: transgene insertion 43, Virginia M Y Lee
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Prnp-MAPT)7Vle | MGI:2385580
Name: transgene insertion 7, Virginia M Y Lee
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Mapt<tm1(Mecp2)Jae> | MGI:3043293
Name: microtubule-associated protein tau; targeted mutation 1, Rudolf Jaenisch
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Allele
Tg(Thy1-MAPT)1Vln | MGI:3720113
Name: transgene insertion 1, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Thy1-MAPT)2Vln | MGI:3720114
Name: transgene insertion 2, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Thy1-MAPT)5Vln | MGI:3720115
Name: transgene insertion 5, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Mapt<tm1(MAPT)Vln> | MGI:3768527
Name: microtubule-associated protein tau; targeted mutation 1, Fred Van Leuven
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Modified isoform(s), Null/knockout
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Allele
Tg(Prnp-MAPT*P301S)PS19Vle | MGI:3768407
Name: transgene insertion PS19, Virginia M Y Lee
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Thy1-MAPT*)1Avil | MGI:3813500
Name: transgene insertion 1, J Avila
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Mapt-EGFP)JD123Gsat | MGI:4847221
Name: transgene insertion JD123, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(MAPT*S305S)4Gds | MGI:4888599
Name: transgene insertion 4, Gerard Schellenberg
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Mapt-MAPT*)#Hanr | MGI:5052111
Name: transgene insertion, Hanna Rosenmann
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:5312697 | B6.129P2-Pitx2<tm1.1Dmm>
Attribute String: targeted mutation, mutant strain
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Strain
MGI:5312688 | B6.129P2(Cg)-Pitx2<tm1.1Dmm>/J
Attribute String: mutant strain, targeted mutation, congenic
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Allele
Hprt1<tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno> | MGI:5428335
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Genoway
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Unc5d<tm1Kln> | MGI:5495472
Name: unc-5 netrin receptor D; targeted mutation 1, Rudiger Klein
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Tg(tetO-MAPT*K280,-luc)#Eman | MGI:5554185
Name: transgene insertion, Eva-Maria Mandelkow
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence, Reporter
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Allele
Tg(Prnp-MAPT*)2652Gds | MGI:5578354
Name: transgene insertion 2652, Gerard Schellenberg
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(tetO-MAPT)32Lms | MGI:5788166
Name: transgene insertion 32, Lennart Mucke
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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Allele
Tg(tetO/Prnp-MAPT)769Tli | MGI:5908815
Name: transgene insertion 769, Tong Li
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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Allele
Mapt<tm1.1(MAPT)Tcs> | MGI:6414668
Name: microtubule-associated protein tau; targeted mutation 1.1, Takaomi C Saido
Allele Type: Targeted
Attribute String: Humanized sequence
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Strain
MGI:6770926 | C57BL/6JSmoc-Mapt<em2(MAPT)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7657602 | C57BL/6J-Mapt<tm1(MAPT)Cya>/Cya
Attribute String: coisogenic, targeted mutation, mutant strain
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Genotype
Genotype
Symbol: Mapt/Mapt
Background: involves: 129S4/SvJae
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dmbx1/Dmbx1
Background: involves: 129S4/SvJae
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dmbx1/Dmbx1
Background: involves: 129S4/SvJae
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pitx2/Pitx2
Background: B6.129P2-Pitx2
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE211162 | miR-142-3p Regulates Cortical Oligodendrocyte Gene Co-expression Networks Associated with Tauopathy
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:5581709 | B6.Cg-Tg(MAPT)8cPdav Psen1<tm1Mpm> App<tm1Ck>
Attribute String: targeted mutation, transgenic, mutant strain, congenic
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Genotype
Genotype
Symbol: App/App Psen1/Psen1 Tg(MAPT)8cPdav/?
Background: B6.Cg-Tg(MAPT)8cPdav Psen1 App
Zygosity: cx
Has Mutant Allele: true
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Publication
18925637 | J:152671
First Author: McMillan P
Year: 2008
Journal: J Comp Neurol
Title: Tau isoform regulation is region- and cell-specific in mouse brain.
Volume: 511
Issue: 6
Pages: 788-803
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Publication
31733664 | J:284862
 
First Author: Hoffman JL
Year: 2019
Journal: Int Rev Neurobiol
Title: Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.
Volume: 148
Pages: 169-230
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HT Experiment
E-GEOD-55177 | Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth
Series Id: GSE55177
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-MTAB-2157 | Neuronal-specific Deficiency of the Splicing Factor Tra2b Causes p21-mediated Apoptosis in Neurogenic Areas of the Developing Mouse Brain
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
26257173 | J:272993
First Author: Goodwin M
Year: 2015
Journal: Cell Rep
Title: MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain.
Volume: 12
Issue: 7
Pages: 1159-68
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Publication
33741591 | J:317981
 
First Author: Wegmann S
Year: 2021
Journal: Sci Adv
Title: Persistent repression of tau in the brain using engineered zinc finger protein transcription factors.
Volume: 7
Issue: 12
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Publication
35992067 | J:344113
First Author: Tsumagari K
Year: 2022
Journal: iScience
Title: Co-expression network analysis of human tau-transgenic mice reveals protein modules associated with tau-induced pathologies.
Volume: 25
Issue: 8
Pages: 104832
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Publication
28093491 | J:241667
First Author: Clayton EL
Year: 2017
Journal: Hum Mol Genet
Title: Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.
Volume: 26
Issue: 5
Pages: 873-887
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Publication
25620700 | J:222897
First Author: Matarin M
Year: 2015
Journal: Cell Rep
Title: A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology.
Volume: 10
Issue: 4
Pages: 633-44
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Publication
17590238 | J:145821
First Author: Denk F
Year: 2009
Journal: Neurobiol Aging
Title: Knock-out and transgenic mouse models of tauopathies.
Volume: 30
Issue: 1
Pages: 1-13
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Publication
34018922 | J:311392
   
First Author: Zhang X
Year: 2021
Journal: Elife
Title: Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
Volume: 10
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Strain
MGI:2165256 | B6D2-Tg(Prnp-MAPT)43Vle/J
Attribute String: transgenic, mutant stock
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Allele
Tg(Tuba1-MAPT)14Vle | MGI:2385585
Name: transgene insertion 14, Virginia M Y Lee
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
15053964 | J:89017
First Author: Macknin JB
Year: 2004
Journal: Brain Res
Title: Olfactory dysfunction occurs in transgenic mice overexpressing human tau protein.
Volume: 1000
Issue: 1-2
Pages: 174-8
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Strain
MGI:5427824 | B6.Cg-Mapt<tm1(Mecp2)Jae>/LimmJ
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5318993 | B6.Cg-Mapt<tm1(Mecp2)Jae>
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:3771472 | FVB/N-Tg(Thy1-MAPT)1Vln
Attribute String: coisogenic, mutant strain, transgenic
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Publication
12196569 | J:134698
First Author: Künzi V
Year: 2002
Journal: J Neurosci
Title: Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau.
Volume: 22
Issue: 17
Pages: 7471-7
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Allele
Tg(Thy1-MAPT*P301L)2Vln | MGI:3768525
Name: transgene insertion 2, Fred Van Leuven
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:3771373 | FVB.Cg-Mapt<tm1(MAPT)Vln>
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:5553124 | B6.Cg-Tg(Prnp-MAPT*P301S)PS19Vle/J
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:5514166 | B6.Cg-Tg(Prnp-MAPT*P301S)PS19Vle
Attribute String: congenic, mutant strain, transgenic
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Strain
MGI:3769675 | B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J
Attribute String: mutant stock, transgenic
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Publication
17270732 | J:119741
First Author: Yoshiyama Y
Year: 2007
Journal: Neuron
Title: Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model.
Volume: 53
Issue: 3
Pages: 337-51
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Publication
29106033 | J:256429
 
First Author: Vagnozzi AN
Year: 2018
Journal: Aging Cell
Title: Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice.
Volume: 17
Issue: 1
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Publication
34130857 | J:311436
     
First Author: Kazim SF
Year: 2021
Journal: Biol Psychiatry
Title: Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures.
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Publication
37373253 | J:337435
 
First Author: Kunze LH
Year: 2023
Journal: Int J Mol Sci
Title: Long-Term Pioglitazone Treatment Has No Significant Impact on Microglial Activation and Tau Pathology in P301S Mice.
Volume: 24
Issue: 12
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Publication
30677432 | J:282555
 
First Author: Merchán-Rubira J
Year: 2019
Journal: Neurosci Lett
Title: Peripheral nervous system effects in the PS19 tau transgenic mouse model of tauopathy.
Volume: 698
Pages: 204-208
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Publication
36271092 | J:355352
First Author: Rickner HD
Year: 2022
Journal: Nat Commun
Title: Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model.
Volume: 13
Issue: 1
Pages: 6275
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Publication
30404654 | J:278402
First Author: Zhang B
Year: 2018
Journal: Mol Neurodegener
Title: A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.
Volume: 13
Issue: 1
Pages: 59
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Publication
36990137 | J:355353
 
First Author: Du K
Year: 2023
Journal: Exp Neurol
Title: Activation of TRPV4 induces intraneuronal tau hyperphosphorylation via cholesterol accumulation.
Volume: 364
Pages: 114392
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Publication
33101187 | J:355350
 
First Author: Jiang L
Year: 2020
Journal: Front Neurol
Title: Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins.
Volume: 11
Pages: 579434
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Publication
37853497 | J:355349
First Author: Yukawa K
Year: 2023
Journal: Acta Neuropathol Commun
Title: Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice.
Volume: 11
Issue: 1
Pages: 166
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Publication
34655981 | J:355359
 
First Author: Patel H
Year: 2022
Journal: Neurobiol Aging
Title: Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy.
Volume: 109
Pages: 52-63
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Publication
26802771 | J:285790
 
First Author: Jiang T
Year: 2016
Journal: Neuropharmacology
Title: TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Volume: 105
Pages: 196-206
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Publication
22423084 | J:213839
First Author: Zhang B
Year: 2012
Journal: J Neurosci
Title: The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.
Volume: 32
Issue: 11
Pages: 3601-11
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Publication
23325240 | J:213838
First Author: Iba M
Year: 2013
Journal: J Neurosci
Title: Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy.
Volume: 33
Issue: 3
Pages: 1024-37
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Publication
27974162 | J:262440
First Author: Kaufman SK
Year: 2016
Journal: Neuron
Title: Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo.
Volume: 92
Issue: 4
Pages: 796-812
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Publication
25862635 | J:248375
First Author: Stancu IC
Year: 2015
Journal: Acta Neuropathol
Title: Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.
Volume: 129
Issue: 6
Pages: 875-94
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Publication
34116706 | J:355357
First Author: Sun XY
Year: 2021
Journal: J Neuroinflammation
Title: Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.
Volume: 18
Issue: 1
Pages: 131
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Publication
21803337 | J:175758
 
First Author: Yata K
Year: 2011
Journal: Brain Res
Title: Astrocytic neuroprotection through induction of cytoprotective molecules; a proteomic analysis of mutant P301S tau-transgenic mouse.
Volume: 1410
Pages: 12-23
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Publication
36563857 | J:355372
First Author: Park G
Year: 2023
Journal: J Biol Chem
Title: Neurodegeneration risk factor, EIF2AK3 (PERK), influences tau protein aggregation.
Volume: 299
Issue: 2
Pages: 102821
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Publication
21889983 | J:179843
First Author: Yoshiyama Y
Year: 2012
Journal: Neurobiol Dis
Title: Anticholinergics boost the pathological process of neurodegeneration with increased inflammation in a tauopathy mouse model.
Volume: 45
Issue: 1
Pages: 329-36
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Publication
36341365 | J:355371
 
First Author: Kim J
Year: 2022
Journal: Front Immunol
Title: Inhibiting EGFR/HER-2 ameliorates neuroinflammatory responses and the early stage of tau pathology through DYRK1A.
Volume: 13
Pages: 903309
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Publication
37897723 | J:355354
First Author: Meng L
Year: 2023
Journal: Cell Rep
Title: The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy.
Volume: 42
Issue: 11
Pages: 113342
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Publication
36807141 | J:355373
First Author: Yan M
Year: 2023
Journal: Cell Rep
Title: Cofilin promotes tau pathology in Alzheimer's disease.
Volume: 42
Issue: 2
Pages: 112138
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Publication
34547169 | J:351265
First Author: Wang W
Year: 2021
Journal: Aging Cell
Title: Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model.
Volume: 20
Issue: 10
Pages: e13456
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Publication
36096190 | J:355370
 
First Author: Buscho S
Year: 2022
Journal: Exp Eye Res
Title: Longitudinal characterization of retinal vasculature alterations with optical coherence tomography angiography in a mouse model of tauopathy.
Volume: 224
Pages: 109240
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Publication
35718229 | J:355369
 
First Author: Larson T
Year: 2022
Journal: Behav Brain Res
Title: Mice expressing P301S mutant human tau have deficits in interval timing.
Volume: 432
Pages: 113967
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Publication
35174546 | J:336972
First Author: Stancu IC
Year: 2022
Journal: Glia
Title: The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model.
Volume: 70
Issue: 6
Pages: 1117-1132
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Publication
39232030 | J:355356
First Author: León-Espinosa G
Year: 2024
Journal: Sci Rep
Title: Phosphorylated Tau at T181 accumulates in the serum of hibernating Syrian hamsters and rapidly disappears after arousal.
Volume: 14
Issue: 1
Pages: 20562
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Publication
38238309 | J:355355
First Author: Yu Q
Year: 2024
Journal: Cell Death Dis
Title: Glucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain.
Volume: 15
Issue: 1
Pages: 73
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Publication
34727983 | J:312852
First Author: Blaudin de Thé FX
Year: 2021
Journal: Acta Neuropathol Commun
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Year: 2021
Journal: Neuroscience
Title: Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice.
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First Author: Wang H
Year: 2016
Journal: eNeuro
Title: TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits.
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Title: Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model.
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