| Type |
Details |
Score |
| Publication |
| First Author: |
Wang W |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
476 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hsieh AC |
| Year: |
2010 |
| Journal: |
Cancer Cell |
| Title: |
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. |
| Volume: |
17 |
| Issue: |
3 |
| Pages: |
249-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kuang X |
| Year: |
2009 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Deregulation of mTOR signaling is involved in thymic lymphoma development in Atm-/- mice. |
| Volume: |
383 |
| Issue: |
3 |
| Pages: |
368-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Song J |
| Year: |
2007 |
| Journal: |
Nat Immunol |
| Title: |
The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
64-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pun RY |
| Year: |
2012 |
| Journal: |
Neuron |
| Title: |
Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. |
| Volume: |
75 |
| Issue: |
6 |
| Pages: |
1022-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bonucci M |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
3200 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen E |
| Year: |
2016 |
| Journal: |
Cell Rep |
| Title: |
Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling. |
| Volume: |
15 |
| Issue: |
6 |
| Pages: |
1144-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
D'Gama AM |
| Year: |
2017 |
| Journal: |
Cell Rep |
| Title: |
Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias. |
| Volume: |
21 |
| Issue: |
13 |
| Pages: |
3754-3766 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang G |
| Year: |
2008 |
| Journal: |
Hum Mol Genet |
| Title: |
Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. |
| Volume: |
17 |
| Issue: |
11 |
| Pages: |
1540-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang J |
| Year: |
2016 |
| Journal: |
Br J Haematol |
| Title: |
mTOR Inhibition improves anaemia and reduces organ damage in a murine model of sickle cell disease. |
| Volume: |
174 |
| Issue: |
3 |
| Pages: |
461-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim SG |
| Year: |
2021 |
| Journal: |
Nat Commun |
| Title: |
Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons. |
| Volume: |
12 |
| Issue: |
1 |
| Pages: |
2695 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim JS |
| Year: |
2013 |
| Journal: |
Nat Immunol |
| Title: |
Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. |
| Volume: |
14 |
| Issue: |
6 |
| Pages: |
611-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nazio F |
| Year: |
2013 |
| Journal: |
Nat Cell Biol |
| Title: |
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. |
| Volume: |
15 |
| Issue: |
4 |
| Pages: |
406-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou M |
| Year: |
2013 |
| Journal: |
Neuron |
| Title: |
mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons. |
| Volume: |
77 |
| Issue: |
4 |
| Pages: |
647-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hu F |
| Year: |
2016 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis. |
| Volume: |
310 |
| Issue: |
11 |
| Pages: |
E994-E1002 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dai YJ |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement. |
| Volume: |
114 |
| Issue: |
20 |
| Pages: |
5237-5242 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bowling S |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
1763 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mason EC |
| Year: |
2023 |
| Journal: |
J Clin Invest |
| Title: |
Activation of mTOR signaling in adult lung microvascular progenitor cells accelerates lung aging. |
| Volume: |
133 |
| Issue: |
24 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mazei-Robison MS |
| Year: |
2011 |
| Journal: |
Neuron |
| Title: |
Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. |
| Volume: |
72 |
| Issue: |
6 |
| Pages: |
977-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Clemente CF |
| Year: |
2012 |
| Journal: |
J Mol Cell Cardiol |
| Title: |
Focal adhesion kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways. |
| Volume: |
52 |
| Issue: |
2 |
| Pages: |
493-501 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sofer A |
| Year: |
2005 |
| Journal: |
Mol Cell Biol |
| Title: |
Regulation of mTOR and cell growth in response to energy stress by REDD1. |
| Volume: |
25 |
| Issue: |
14 |
| Pages: |
5834-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Settembre C |
| Year: |
2012 |
| Journal: |
EMBO J |
| Title: |
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. |
| Volume: |
31 |
| Issue: |
5 |
| Pages: |
1095-108 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Procaccini C |
| Year: |
2012 |
| Journal: |
J Immunol |
| Title: |
Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses. |
| Volume: |
189 |
| Issue: |
6 |
| Pages: |
2941-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiang Q |
| Year: |
2011 |
| Journal: |
Cancer Res |
| Title: |
mTOR kinase inhibitor AZD8055 enhances the immunotherapeutic activity of an agonist CD40 antibody in cancer treatment. |
| Volume: |
71 |
| Issue: |
12 |
| Pages: |
4074-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee JH |
| Year: |
2012 |
| Journal: |
Eur J Immunol |
| Title: |
Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability. |
| Volume: |
42 |
| Issue: |
10 |
| Pages: |
2683-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
D'Armiento J |
| Year: |
2016 |
| Journal: |
Cancer Res |
| Title: |
Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation. |
| Volume: |
76 |
| Issue: |
4 |
| Pages: |
844-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ravichandran K |
| Year: |
2014 |
| Journal: |
Hum Mol Genet |
| Title: |
An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2. |
| Volume: |
23 |
| Issue: |
18 |
| Pages: |
4919-31 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharma D |
| Year: |
2020 |
| Journal: |
J Immunol |
| Title: |
RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling. |
| Volume: |
205 |
| Issue: |
10 |
| Pages: |
2778-2785 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Milam MR |
| Year: |
2007 |
| Journal: |
Am J Obstet Gynecol |
| Title: |
Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model. |
| Volume: |
196 |
| Issue: |
3 |
| Pages: |
247.e1-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kramer K |
| Year: |
2018 |
| Journal: |
Genesis |
| Title: |
Rapamycin rescues BMP mediated midline craniosynostosis phenotype through reduction of mTOR signaling in a mouse model. |
| Volume: |
56 |
| Issue: |
6-7 |
| Pages: |
e23220 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schroeder E |
| Year: |
2019 |
| Journal: |
Mol Neurobiol |
| Title: |
Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers. |
| Volume: |
56 |
| Issue: |
6 |
| Pages: |
4151-4162 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ding M |
| Year: |
2018 |
| Journal: |
Mol Cancer Res |
| Title: |
The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer. |
| Volume: |
16 |
| Issue: |
4 |
| Pages: |
682-695 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tong WH |
| Year: |
2022 |
| Journal: |
Heliyon |
| Title: |
Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia. |
| Volume: |
8 |
| Issue: |
8 |
| Pages: |
e10371 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Clegg NJ |
| Year: |
2011 |
| Journal: |
PLoS One |
| Title: |
MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors. |
| Volume: |
6 |
| Issue: |
3 |
| Pages: |
e17449 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma A |
| Year: |
2014 |
| Journal: |
Hum Mol Genet |
| Title: |
Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality. |
| Volume: |
23 |
| Issue: |
3 |
| Pages: |
693-705 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang B |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. |
| Volume: |
8 |
| Issue: |
2 |
| Pages: |
e57445 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aboudehen K |
| Year: |
2018 |
| Journal: |
J Biol Chem |
| Title: |
Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling. |
| Volume: |
293 |
| Issue: |
24 |
| Pages: |
9388-9398 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ge Y |
| Year: |
2009 |
| Journal: |
Am J Physiol Cell Physiol |
| Title: |
mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms. |
| Volume: |
297 |
| Issue: |
6 |
| Pages: |
C1434-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Crutcher E |
| Year: |
2019 |
| Journal: |
Sci Rep |
| Title: |
mTOR and autophagy pathways are dysregulated in murine and human models of Schaaf-Yang syndrome. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
15935 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mencer S |
| Year: |
2021 |
| Journal: |
Transl Psychiatry |
| Title: |
Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
480 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mleczko-Sanecka K |
| Year: |
2014 |
| Journal: |
Blood |
| Title: |
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. |
| Volume: |
123 |
| Issue: |
10 |
| Pages: |
1574-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rai P |
| Year: |
2013 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
mTOR plays a critical role in p53-induced oxidative kidney cell injury in HIVAN. |
| Volume: |
305 |
| Issue: |
3 |
| Pages: |
F343-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee JH |
| Year: |
2021 |
| Journal: |
Int J Mol Sci |
| Title: |
n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway. |
| Volume: |
22 |
| Issue: |
12 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiong X |
| Year: |
2014 |
| Journal: |
Neurobiol Dis |
| Title: |
PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways. |
| Volume: |
66 |
|
| Pages: |
43-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang Y |
| Year: |
2024 |
| Journal: |
Mol Cell Endocrinol |
| Title: |
Branched-chain amino acid catabolic defect promotes α-cell proliferation via activating mTOR signaling. |
| Volume: |
582 |
|
| Pages: |
112143 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Martin PY |
| Year: |
2020 |
| Journal: |
Prog Neurobiol |
| Title: |
mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment. |
| Volume: |
193 |
|
| Pages: |
101846 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang J |
| Year: |
2008 |
| Journal: |
Mol Cell Biol |
| Title: |
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. |
| Volume: |
28 |
| Issue: |
12 |
| Pages: |
4104-15 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li X |
| Year: |
2015 |
| Journal: |
Brain Res |
| Title: |
p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling. |
| Volume: |
1605 |
|
| Pages: |
31-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Van Rechem C |
| Year: |
2015 |
| Journal: |
Cancer Discov |
| Title: |
A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR inhibitors. |
| Volume: |
5 |
| Issue: |
3 |
| Pages: |
245-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koo J |
| Year: |
2015 |
| Journal: |
Mol Cell Biol |
| Title: |
mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation. |
| Volume: |
35 |
| Issue: |
13 |
| Pages: |
2344-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aoyagi T |
| Year: |
2015 |
| Journal: |
Am J Physiol Heart Circ Physiol |
| Title: |
Cardiac mTOR rescues the detrimental effects of diet-induced obesity in the heart after ischemia-reperfusion. |
| Volume: |
308 |
| Issue: |
12 |
| Pages: |
H1530-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Caccamo A |
| Year: |
2018 |
| Journal: |
Neurobiol Aging |
| Title: |
Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease. |
| Volume: |
68 |
|
| Pages: |
59-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ueda Y |
| Year: |
2019 |
| Journal: |
Sci Rep |
| Title: |
Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
6374 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park JW |
| Year: |
2019 |
| Journal: |
Stem Cells |
| Title: |
Inhibition of mTOR by Rapamycin Aggravates Corneal Epithelial Stem Cell Deficiency by Upregulating Inflammatory Response. |
| Volume: |
37 |
| Issue: |
9 |
| Pages: |
1212-1222 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miesen L |
| Year: |
2020 |
| Journal: |
Sci Rep |
| Title: |
Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
8580 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sokolov AM |
| Year: |
2020 |
| Journal: |
Hum Mol Genet |
| Title: |
The amino acid transporter Slc7a5 regulates the mTOR pathway and is required for granule cell development. |
| Volume: |
29 |
| Issue: |
18 |
| Pages: |
3003-3013 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu Q |
| Year: |
2024 |
| Journal: |
J Clin Invest |
| Title: |
Evi1 governs Kdm6b-mediated histone demethylation to regulate the Laptm4b-driven mTOR pathway in hematopoietic progenitor cells. |
| Volume: |
134 |
| Issue: |
24 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dibble CC |
| Year: |
2009 |
| Journal: |
Mol Cell Biol |
| Title: |
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. |
| Volume: |
29 |
| Issue: |
21 |
| Pages: |
5657-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun IH |
| Year: |
2018 |
| Journal: |
J Immunol |
| Title: |
mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells. |
| Volume: |
201 |
| Issue: |
2 |
| Pages: |
481-492 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Parihar M |
| Year: |
2020 |
| Journal: |
Aging Pathobiol Ther |
| Title: |
Sex-dependent lifespan extension of Apc (Min/+) FAP mice by chronic mTOR inhibition. |
| Volume: |
2 |
| Issue: |
4 |
| Pages: |
187-194 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jaeschke A |
| Year: |
2002 |
| Journal: |
J Cell Biol |
| Title: |
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. |
| Volume: |
159 |
| Issue: |
2 |
| Pages: |
217-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Z |
| Year: |
2019 |
| Journal: |
Cancer Res |
| Title: |
4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. |
| Volume: |
79 |
| Issue: |
7 |
| Pages: |
1438-1450 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Peng K |
| Year: |
2020 |
| Journal: |
J Mol Cell Cardiol |
| Title: |
IRF-1 mediates the suppressive effects of mTOR inhibition on arterial endothelium. |
| Volume: |
140 |
|
| Pages: |
30-41 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mroueh FM |
| Year: |
2019 |
| Journal: |
FASEB J |
| Title: |
Unmasking the interplay between mTOR and Nox4: novel insights into the mechanism connecting diabetes and cancer. |
| Volume: |
33 |
| Issue: |
12 |
| Pages: |
14051-14066 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Srivastava IN |
| Year: |
2016 |
| Journal: |
Neurobiol Dis |
| Title: |
mTOR pathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy. |
| Volume: |
85 |
|
| Pages: |
144-154 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Avet-Rochex A |
| Year: |
2014 |
| Journal: |
PLoS Genet |
| Title: |
Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control. |
| Volume: |
10 |
| Issue: |
9 |
| Pages: |
e1004624 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bornstein R |
| Year: |
2022 |
| Journal: |
Neurobiol Dis |
| Title: |
Differential effects of mTOR inhibition and dietary ketosis in a mouse model of subacute necrotizing encephalomyelopathy. |
| Volume: |
163 |
|
| Pages: |
105594 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Betz C |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. |
| Volume: |
110 |
| Issue: |
31 |
| Pages: |
12526-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yao Y |
| Year: |
2016 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Role of Ragulator in the Regulation of Mechanistic Target of Rapamycin Signaling in Podocytes and Glomerular Function. |
| Volume: |
27 |
| Issue: |
12 |
| Pages: |
3653-3665 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang W |
| Year: |
2009 |
| Journal: |
Cancer Res |
| Title: |
Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a Pten-deficient mouse model of prostate cancer. |
| Volume: |
69 |
| Issue: |
18 |
| Pages: |
7466-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yuan T |
| Year: |
2017 |
| Journal: |
Diabetologia |
| Title: |
Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes. |
| Volume: |
60 |
| Issue: |
4 |
| Pages: |
668-678 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shi Q |
| Year: |
2022 |
| Journal: |
J Neurosci |
| Title: |
Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model. |
| Volume: |
42 |
| Issue: |
27 |
| Pages: |
5294-5313 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Van Skike CE |
| Year: |
2021 |
| Journal: |
J Neurosci |
| Title: |
mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease. |
| Volume: |
41 |
| Issue: |
19 |
| Pages: |
4305-4320 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Łyszkiewicz M |
| Year: |
2019 |
| Journal: |
Front Immunol |
| Title: |
LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking. |
| Volume: |
10 |
|
| Pages: |
497 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
145
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hartman TR |
| Year: |
2009 |
| Journal: |
Oncogene |
| Title: |
The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis. |
| Volume: |
28 |
| Issue: |
13 |
| Pages: |
1594-604 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Johnson SC |
| Year: |
2013 |
| Journal: |
Science |
| Title: |
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. |
| Volume: |
342 |
| Issue: |
6165 |
| Pages: |
1524-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang L |
| Year: |
2022 |
| Journal: |
Nutrients |
| Title: |
Vasorin Deletion in C57BL/6J Mice Induces Hepatocyte Autophagy through Glycogen-Mediated mTOR Regulation. |
| Volume: |
14 |
| Issue: |
17 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ben-Sahra I |
| Year: |
2013 |
| Journal: |
Science |
| Title: |
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. |
| Volume: |
339 |
| Issue: |
6125 |
| Pages: |
1323-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang F |
| Year: |
2017 |
| Journal: |
Elife |
| Title: |
A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice. |
| Volume: |
6 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gong X |
| Year: |
2015 |
| Journal: |
Hum Mol Genet |
| Title: |
Activating the translational repressor 4E-BP or reducing S6K-GSK3β activity prevents accelerated axon growth induced by hyperactive mTOR in vivo. |
| Volume: |
24 |
| Issue: |
20 |
| Pages: |
5746-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gnanapradeepan K |
| Year: |
2020 |
| Journal: |
Elife |
| Title: |
Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser. |
| Volume: |
9 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mok-Lin E |
| Year: |
2018 |
| Journal: |
Sci Rep |
| Title: |
Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
588 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo Y |
| Year: |
2013 |
| Journal: |
Mol Cancer Res |
| Title: |
Equivalent benefit of rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis. |
| Volume: |
11 |
| Issue: |
5 |
| Pages: |
467-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Contreras CM |
| Year: |
2010 |
| Journal: |
Dis Model Mech |
| Title: |
Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. |
| Volume: |
3 |
| Issue: |
3-4 |
| Pages: |
181-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Antoch MP |
| Year: |
2020 |
| Journal: |
Oncotarget |
| Title: |
Superior cancer preventive efficacy of low versus high dose of mTOR inhibitor in a mouse model of prostate cancer. |
| Volume: |
11 |
| Issue: |
15 |
| Pages: |
1373-1387 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
LaSarge CL |
| Year: |
2019 |
| Journal: |
Exp Neurol |
| Title: |
Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors? |
| Volume: |
321 |
|
| Pages: |
113029 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mercier I |
| Year: |
2012 |
| Journal: |
Am J Pathol |
| Title: |
Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. |
| Volume: |
181 |
| Issue: |
1 |
| Pages: |
278-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Singh PK |
| Year: |
2013 |
| Journal: |
Mol Biol Cell |
| Title: |
Activation of serum/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease. |
| Volume: |
24 |
| Issue: |
24 |
| Pages: |
3776-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bou-Tayeh B |
| Year: |
2021 |
| Journal: |
Front Immunol |
| Title: |
Chronic IL-15 Stimulation and Impaired mTOR Signaling and Metabolism in Natural Killer Cells During Acute Myeloid Leukemia. |
| Volume: |
12 |
|
| Pages: |
730970 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ding X |
| Year: |
2014 |
| Journal: |
Am J Pathol |
| Title: |
Critical role of the mTOR pathway in development and function of myeloid-derived suppressor cells in lal-/- mice. |
| Volume: |
184 |
| Issue: |
2 |
| Pages: |
397-408 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yurchenko E |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. |
| Volume: |
7 |
| Issue: |
4 |
| Pages: |
e35572 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoshida T |
| Year: |
2010 |
| Journal: |
Nat Med |
| Title: |
Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. |
| Volume: |
16 |
| Issue: |
7 |
| Pages: |
767-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Syu LJ |
| Year: |
2016 |
| Journal: |
Oncotarget |
| Title: |
Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways. |
| Volume: |
7 |
| Issue: |
9 |
| Pages: |
10255-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rocchi A |
| Year: |
2016 |
| Journal: |
Acta Neuropathol |
| Title: |
Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet. |
| Volume: |
132 |
| Issue: |
1 |
| Pages: |
127-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao Y |
| Year: |
2018 |
| Journal: |
Mucosal Immunol |
| Title: |
GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3. |
| Volume: |
11 |
| Issue: |
3 |
| Pages: |
752-762 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lieberman OJ |
| Year: |
2020 |
| Journal: |
Front Cell Neurosci |
| Title: |
mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum Disorders. |
| Volume: |
14 |
|
| Pages: |
70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Habib SL |
| Year: |
2010 |
| Journal: |
Eur J Cancer |
| Title: |
Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition. |
| Volume: |
46 |
| Issue: |
15 |
| Pages: |
2806-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang HL |
| Year: |
2013 |
| Journal: |
Biochim Biophys Acta |
| Title: |
XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons. |
| Volume: |
1832 |
| Issue: |
4 |
| Pages: |
585-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ng TL |
| Year: |
2012 |
| Journal: |
Cell Death Differ |
| Title: |
The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis. |
| Volume: |
19 |
| Issue: |
3 |
| Pages: |
501-10 |
|
•
•
•
•
•
|