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Search results 1401 to 1500 out of 5729 for Nlrp3

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Protein Coding Gene
MGI:3647286 | Brcc3dc
Type: protein_coding_gene
Organism: mouse, laboratory
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HT Experiment
E-MTAB-13601 | Retention of ES cell-derived 129 genome drives NLRP1 hypersensitivity and gene expression changes in Nlrp3-/- mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:1913869 | Atat1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1860055 | Panx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9EPB4
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
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Protein
Q9JIP4
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: false
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Protein
Q9Z1M0
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Protein Coding Gene
MGI:1918046 | Zdhhc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3582959 | Nlrp1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2445102 | Dhx33
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Nlrp3<m4Btlr> | MGI:4999611
 
Name: NLR family, pyrin domain containing 3; mutation 4, Bruce Beutler
Allele Type: Chemically induced (ENU)
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Protein Coding Gene
MGI:1916396 | Gsdmd
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913470 | Zdhhc12
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1933107 | Cptp
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2389572 | Brcc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24952504 | -
First Author: Baroja-Mazo A
Year: 2014
Journal: Nat Immunol
Title: The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.
Volume: 15
Issue: 8
Pages: 738-48
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Publication
30761102 | -
 
First Author: Chen IY
Year: 2019
Journal: Front Microbiol
Title: Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome.
Volume: 10
Pages: 50
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Publication
25607459 | -
First Author: Duong BH
Year: 2015
Journal: Immunity
Title: A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity.
Volume: 42
Issue: 1
Pages: 55-67
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Publication
34486483 | -
   
First Author: Cai B
Year: 2021
Journal: Autophagy
Title: USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3.
Pages: 1-15
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Publication
36238284 | -
 
First Author: Jiang F
Year: 2022
Journal: Front Immunol
Title: Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury.
Volume: 13
Pages: 993168
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Publication
36063115 | -
First Author: Wu X
Year: 2022
Journal: J Med Chem
Title: Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity.
Volume: 65
Issue: 18
Pages: 11985-12001
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Publication
36181338 | -
First Author: Yang Z
Year: 2023
Journal: FEBS J
Title: TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway.
Volume: 290
Issue: 6
Pages: 1549-1562
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Publication
37488647 | -
First Author: Wang Q
Year: 2023
Journal: Arthritis Res Ther
Title: Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation.
Volume: 25
Issue: 1
Pages: 126
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Publication
25327779 | -
First Author: Kim HY
Year: 2015
Journal: FEBS J
Title: Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion.
Volume: 282
Issue: 2
Pages: 259-70
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Protein Coding Gene
MGI:1923573 | Zdhhc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919429 | Fbxl2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2684861 | Nlrp1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2429943 | Gbp5
Type: protein_coding_gene
Organism: mouse, laboratory
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Pseudogene
MGI:3649299 | Gm12250
Type: pseudogene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1890645 | Nek7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1920955 | Mark4
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Nlrp3<M6Btlr> | MGI:5607728
Name: NLR family, pyrin domain containing 3; mutation 6, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Allele
Nlrp3<m12Btlr> | MGI:6284017
Name: NLR family, pyrin domain containing 3; mutation 12, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Genotype
Genotype
Symbol: Nlrp3/Nlrp3
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:2444773 | Mavs
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103064 | Ddx3x
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1934950 | Csnk1a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98874 | Txn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P10639
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
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Protein Coding Gene
MGI:96748 | Lamp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88216 | Btk
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
33460751 | -
 
First Author: Qin W
Year: 2021
Journal: J Ethnopharmacol
Title: Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.
Volume: 271
Pages: 113827
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Allele
Nlrp3<tm1Wstr> | MGI:3850069
Name: NLR family, pyrin domain containing 3; targeted mutation 1, Warren Strober
Allele Type: Targeted
Attribute String: Conditional ready
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Strain
MGI:5607775 | C57BL/6J-Nlrp3<M6Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Strain
MGI:6284018 | C57BL/6J-Nlrp3<m12Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Genotype
Genotype
Symbol: Nlrp3/Nlrp3<+>
Background: C57BL/6J-Nlrp3
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nlrp3/Nlrp3
Background: C57BL/6J-Nlrp3
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nlrp3/Nlrp3
Background: C57BL/6J-Nlrp3
Zygosity: hm
Has Mutant Allele: true
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Protein Coding Gene
MGI:2444070 | Nlrc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21978668 | -
First Author: Pinheiro AS
Year: 2011
Journal: J Mol Biol
Title: The NLRP12 pyrin domain: structure, dynamics, and functional insights.
Volume: 413
Issue: 4
Pages: 790-803
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Publication
18039395 | -
First Author: Stein C
Year: 2007
Journal: Genome Biol
Title: Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish.
Volume: 8
Issue: 11
Pages: R251
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Publication
11786556 | -
First Author: Manji GA
Year: 2002
Journal: J Biol Chem
Title: PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B.
Volume: 277
Issue: 13
Pages: 11570-5
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Protein Domain
IPR029495 | NACHT-assoc
Type: Domain
Description: This domain is frequently found associated with the NACHT domain () in fish and other vertebrates []. Proteins containing this domain include NACHT, LRR and PYD domains-containing protein 3/12 (NLRP3/12). In humans, NLRP3 (also known as PYPAF1) may function as an inducer of apoptosis []. NLRP12 is a non-inflammasome NLR (nucleotide-binding domain and leucine-rich repeat-containing receptors) that has been implicated in the regulation of Toll-like receptor-dependent nuclear factor-kappaB activation [].
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Protein Coding Gene
MGI:1927664 | Sirt2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99879 | Prkd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107700 | Casp4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98178 | Trim30a
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Nlrp3/Nlrp3<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Protein Coding Gene
MGI:96247 | Hsp90ab1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P11499
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Protein Coding Gene
MGI:96544 | Casp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926262 | Irgm2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1354386 | Lats2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1341296 | Tlr6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1333883 | Lats1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1321159 | Ppp2ca
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107729 | Igtp
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1353449 | Eif2ak2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913150 | Trem2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107170 | Ptpn22
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31019207 | J:279846
First Author: Chiozzi P
Year: 2019
Journal: Sci Rep
Title: Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine.
Volume: 9
Issue: 1
Pages: 6475
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Publication
36844454 | J:334452
First Author: Traughber CA
Year: 2023
Journal: iScience
Title: Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice.
Volume: 26
Issue: 2
Pages: 106076
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Publication
38753484 | J:350653
First Author: Tang Y
Year: 2024
Journal: Cell Rep
Title: Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia.
Volume: 43
Issue: 5
Pages: 114237
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Publication
36792584 | J:339742
First Author: Zheng X
Year: 2023
Journal: Cell Death Dis
Title: A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury.
Volume: 14
Issue: 2
Pages: 126
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Protein Coding Gene
MGI:107567 | Irgm1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97616 | Plcg2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1100508 | Kcnj8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31554824 | J:284667
First Author: Salazar-León J
Year: 2019
Journal: Sci Rep
Title: Nlrp1b1 negatively modulates obesity-induced inflammation by promoting IL-18 production.
Volume: 9
Issue: 1
Pages: 13815
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Publication
28094437 | J:240614
First Author: Lee JY
Year: 2017
Journal: FEBS Lett
Title: The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein.
Volume: 591
Issue: 3
Pages: 479-490
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Publication
33162995 | J:308316
 
First Author: O'Riordan CE
Year: 2020
Journal: Front Immunol
Title: X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure.
Volume: 11
Pages: 581758
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Publication
29222907 | J:272650
     
First Author: Xia M
Year: 2017
Journal: J Neurochem
Title: The ameliorative effect of fluoxetine on neuroinflammation induced by sleep deprivation.
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Publication
35563010 | J:324552
 
First Author: Bernardazzi C
Year: 2022
Journal: Int J Mol Sci
Title: The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome.
Volume: 23
Issue: 9
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Publication
32592165 | J:297562
First Author: Saeki A
Year: 2020
Journal: Immunology
Title: Gasdermin D-independent release of interleukin-1β by living macrophages in response to mycoplasmal lipoproteins and lipopeptides.
Volume: 161
Issue: 2
Pages: 114-122
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Publication
36065376 | J:334997
 
First Author: Ma EB
Year: 2022
Journal: Mediators Inflamm
Title: Gasdermin D Deficiency Does Not Protect Mice from High-Fat Diet-Induced Glucose Intolerance and Adipose Tissue Inflammation.
Volume: 2022
Pages: 7853482
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Publication
38515158 | J:346990
First Author: Lu J
Year: 2024
Journal: Cell Commun Signal
Title: Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF-κB pathway.
Volume: 22
Issue: 1
Pages: 187
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Publication
38395698 | J:358316
First Author: Huang S
Year: 2024
Journal: Immunity
Title: Disruption of the Na(+)/K(+)-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety.
Volume: 57
Issue: 3
Pages: 495-512.e11
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Publication
24492532 | J:244194
 
First Author: Van Opdenbosch N
Year: 2014
Journal: Nat Commun
Title: Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.
Volume: 5
Pages: 3209
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Publication
31467036 | J:282786
First Author: Li S
Year: 2019
Journal: J Exp Med
Title: Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.
Volume: 216
Issue: 11
Pages: 2562-2581
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Publication
34395445 | J:334451
 
First Author: Opoku E
Year: 2021
Journal: Front Cell Dev Biol
Title: Gasdermin D Mediates Inflammation-Induced Defects in Reverse Cholesterol Transport and Promotes Atherosclerosis.
Volume: 9
Pages: 715211
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Protein Coding Gene
MGI:1346861 | Mapk8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31167564 | J:340180
First Author: Clement M
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis-Brief Report.
Volume: 39
Issue: 8
Pages: 1645-1651
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Publication
38409076 | J:345713
First Author: Rifat A
Year: 2024
Journal: J Neuroinflammation
Title: Differential contribution of THIK-1 K(+) channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia.
Volume: 21
Issue: 1
Pages: 58
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Publication
36375694 | J:334371
 
First Author: Ossola B
Year: 2023
Journal: Neuropharmacology
Title: Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome.
Volume: 224
Pages: 109330
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Protein Coding Gene
MGI:105384 | Hspa8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108005 | Myd88
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30010623 | J:265433
First Author: D'Addio F
Year: 2018
Journal: J Clin Invest
Title: P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes.
Volume: 128
Issue: 8
Pages: 3490-3503
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Publication
30361383 | J:268622
First Author: Orning P
Year: 2018
Journal: Science
Title: Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Volume: 362
Issue: 6418
Pages: 1064-1069
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Publication
36367942 | J:359970
First Author: Wu YH
Year: 2022
Journal: Sci Adv
Title: Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells.
Volume: 8
Issue: 45
Pages: eabn9912
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Publication
30589883 | J:333171
First Author: Cerqueira DM
Year: 2018
Journal: PLoS Pathog
Title: Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection.
Volume: 14
Issue: 12
Pages: e1007519
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Publication
33157038 | J:302472
First Author: Ghosh S
Year: 2020
Journal: Cell
Title: β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway.
Volume: 183
Issue: 6
Pages: 1520-1535.e14
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