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Search results 1401 to 1500 out of 1679 for Six3

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Type Details Score
Publication
First Author: Trowe MO
Year: 2013
Journal: Development
Title: Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis.
Volume: 140
Issue: 11
Pages: 2299-309
Publication
First Author: Soleilhavoup C
Year: 2020
Journal: Nat Commun
Title: Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.
Volume: 11
Issue: 1
Pages: 3111
Publication
First Author: Tanahashi H
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Deletion of Lrp4 increases the incidence of microphthalmia.
Volume: 506
Issue: 3
Pages: 478-484
Publication  
First Author: Puelles L
Year: 2023
Journal: Int J Mol Sci
Title: The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer.
Volume: 24
Issue: 11
Publication
First Author: Long JE
Year: 2009
Journal: J Comp Neurol
Title: Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.
Volume: 512
Issue: 4
Pages: 556-72
Publication  
First Author: Long JE
Year: 2009
Journal: Cereb Cortex
Title: Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.
Volume: 19 Suppl 1
Pages: i96-106
Publication
First Author: Chen B
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.
Volume: 102
Issue: 47
Pages: 17184-9
Publication
First Author: Loo L
Year: 2019
Journal: Nat Commun
Title: Single-cell transcriptomic analysis of mouse neocortical development.
Volume: 10
Issue: 1
Pages: 134
Publication
First Author: Chung YC
Year: 2011
Journal: Gene Expr Patterns
Title: Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
Volume: 11
Issue: 1-2
Pages: 84-92
Publication
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: false
Publication
First Author: Wallis DE
Year: 1999
Journal: Nat Genet
Title: Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly.
Volume: 22
Issue: 2
Pages: 196-8
Publication      
First Author: Ferrena A
Year: 2023
Journal: bioRxiv
Title: Six3 and Six6 jointly regulate the identities and developmental trajectories of multipotent retinal progenitor cells in the mouse retina.
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Allele
Name: sine oculis-related homeobox 3; targeted mutation 1, Guillermo Oliver
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: sine oculis-related homeobox 3; targeted mutation 3, Guillermo Oliver
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Allele
Name: sine oculis-related homeobox 3; targeted mutation 4, Guillermo Oliver
Allele Type: Targeted
Attribute String: Inducible, Recombinase
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
GXD Expression
Probe: MGI:7717795
Assay Type: RNA in situ
Annotation Date: 2024-09-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753620
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7717797
Age: embryonic day 12.5
Image: 1E E12.5 Pomc
Note: Expression in basal hypothalamic region neurons co-localized with Six3 expression.
Specimen Label: 1E E12.5 Pomc
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:7717795
Assay Type: RNA in situ
Annotation Date: 2024-09-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7717797
Age: embryonic day 14.5
Image: S1 E14.5 Pomc
Note: Expression in basal hypothalamic region neurons co-localized with Six3 expression.
Specimen Label: S1 E14.5 Pomc
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:7717795
Assay Type: RNA in situ
Annotation Date: 2024-09-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753624
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7717797
Age: embryonic day 16.5
Image: 1E E16.5 Pomc
Note: Expression in basal hypothalamic region neurons co-localized with Six3 expression.
Specimen Label: 1E E16.5 Pomc
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:7717795
Assay Type: RNA in situ
Annotation Date: 2024-09-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7717797
Age: postnatal adult
Image: S1 E18.5 Pomc
Note: Expression in basal hypothalamic region neurons co-localized with Six3 expression.
Specimen Label: S1 E18.5 Pomc
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:7491709
Assay Type: RNA in situ
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607310
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:7491708
Age: embryonic day 7.0
Image: 4E1 lateral
Note: Expression domain was lateral to the Six3 domain.
Specimen Label: 4E1 lateral
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:7491709
Assay Type: RNA in situ
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607310
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:7491708
Age: embryonic day 7.0
Image: 4E1 frontal
Note: Expression domain was lateral to the Six3 domain.
Specimen Label: 4E1 frontal
Detected: true
Specimen Num: 2
Genotype
Symbol: Six3/Six3
Background: involves: 129S1/Sv
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Six3/Six3 Foxg1/Foxg1<+>
Background: involves: 129S1/Sv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Six3/Six3<+>
Background: involves: 129S1/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Six3/Six3<+> Shh/Shh<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
DO Term
GXD Expression
Probe: MGI:1197617
Assay Type: RNA in situ
Annotation Date: 2013-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614013
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:5504410
Age: embryonic day 8.5
Image: 7C'
Note: Staining was maintained in a nested pattern with Six3 in the mutant embryo.
Specimen Label: 7C'
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:7660828
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3541923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7660842
Age: embryonic day 15.5
Image: 8C Six3;Nestin-cre<+> Partial loss
Note: Expression was detected in the early suprachiasmatic nucleus unilaterally in mice displaying partial Six3 deletion.
Specimen Label: 8C Six3;Nestin-cre<+> Partial loss
Detected: true
Specimen Num: 23
GXD Expression
Probe: MGI:3506129
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3541923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7660849
Age: embryonic day 15.5
Image: 8C Six3;Nestin-cre<+> No loss
Note: Mutant mice that retained expression of Six3 showed prominent expression in the early postmitotic suprachiasmatic nucleus.
Specimen Label: 8C Six3;Nestin-cre<+> No loss
Detected: true
Specimen Num: 24
GXD Expression
Probe: MGI:7660828
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3541923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7660842
Age: embryonic day 15.5
Image: 8C Six3;Nestin-cre<+> No loss
Note: Mutant mice that retained expression of Six3 showed prominent expression in the early postmitotic suprachiasmatic nucleus.
Specimen Label: 8C Six3;Nestin-cre<+> No loss
Detected: true
Specimen Num: 24
GXD Expression
Probe: MGI:3764010
Assay Type: RNA in situ
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607312
Pattern: Regionally restricted
Stage: TS12
Assay Id: MGI:2148959
Age: embryonic day 8.2
Image: 5C
Note: Expression in anterior head fold; partially overlaps Six3 expression in posterior forebrain.
Specimen Label: 5C
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3764936
Assay Type: RNA in situ
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607312
Pattern: Regionally restricted
Stage: TS12
Assay Id: MGI:2148960
Age: embryonic day 8.2
Image: 5D
Note: Expression in anterior head fold; not as strong as Six3 in anterior head fold.
Specimen Label: 5D
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:7491656
Assay Type: RNA in situ
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607310
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:7491711
Age: embryonic day 7.0
Image: 4F1 lateral
Note: Expressed just rostral to the node, broader than that of Six3 and extending laterally.
Specimen Label: 4F1 lateral
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:7491656
Assay Type: RNA in situ
Annotation Date: 2023-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607310
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:7491711
Age: embryonic day 7.0
Image: 4F1 frontal
Note: Expressed just rostral to the node, broader than that of Six3 and extending laterally.
Specimen Label: 4F1 frontal
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3764010
Assay Type: RNA in situ
Annotation Date: 2001-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614412
Pattern: Regionally restricted
Stage: TS12
Assay Id: MGI:2148959
Age: embryonic day 8.2
Image: 5C
Note: Expression in anterior head fold; partially overlaps Six3 expression in posterior forebrain.
Specimen Label: 5C
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:1197617
Assay Type: RNA in situ
Annotation Date: 2013-09-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614413
Pattern: Regionally restricted
Stage: TS13
Assay Id: MGI:5504410
Age: embryonic day 8.5
Image: 7C'
Note: Staining was maintained in a nested pattern with Six3 in the mutant embryo.
Specimen Label: 7C'
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:3506129
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7660849
Age: embryonic day 14.5
Image: 4 E14.5
Note: Expression was present in discrete bilateral regions distal to the third ventricle within the broader Six3 domain.
Specimen Label: 4 E14.5
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:3506129
Assay Type: RNA in situ
Annotation Date: 2024-06-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3541923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7660849
Age: embryonic day 15.5
Image: 8C Six3;Nestin-cre<+> Partial loss
Note: Expression was retained in the early suprachiasmatic nucleus unilaterally in mice displaying partial Six3 deletion. Loss of expression was only observed in regions lacking Six3.
Specimen Label: 8C Six3;Nestin-cre<+> Partial loss
Detected: true
Specimen Num: 23
CL Term
Allele
Name: transgene insertion 69, Yasuhide Furuta
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: transgene insertion 22, Yasuhide Furuta
Allele Type: Transgenic
Attribute String: Recombinase
Strain
Attribute String: transgenic, mutant stock
Strain
Attribute String: transgenic, mutant strain
Publication
First Author: Elshatory Y
Year: 2008
Journal: J Neurosci
Title: The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons.
Volume: 28
Issue: 13
Pages: 3291-7
Publication  
First Author: Li B
Year: 2024
Journal: Neurobiol Dis
Title: Overexpression of Bmp4 induces microphthalmia by disrupting embryonic neural retina.
Volume: 201
Pages: 106654
Allele
Name: transgene insertion OF35, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion, Yongsu Jeong
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion, Yongsu Jeong
Allele Type: Transgenic
Attribute String: Recombinase
Strain
Attribute String: mutant strain, congenic, transgenic
Protein Domain
Type: Family
Description: The human SIX protein family consists of six members (SIX1-SIX6), all of which contain two protein domains: a DNA binding homeobox domain and a SIX domain, which binds downstream effector molecules. They are thought to be transcription factors required for proper eye development [].This entry includes Homeobox proteins SIX3 and SIX6.SIX3 is a transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on target genes. During brain development, it maintains anterior forebrain identity and is required for neuroretinal specification and ependymal cell maturation []. It is also involved in eye development [, ]and pituitary development [].
Publication
First Author: Zhou Y
Year: 2018
Journal: Hum Mol Genet
Title: A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa.
Volume: 27
Issue: 14
Pages: 2563-2572
Publication
First Author: Sarkar H
Year: 2024
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Loss of REP1 impacts choroidal melanogenesis and vasculogenesis in choroideremia.
Volume: 1870
Issue: 2
Pages: 166963
Publication
First Author: Grishanin RN
Year: 2008
Journal: Mol Cell Neurosci
Title: Retinal TrkB receptors regulate neural development in the inner, but not outer, retina.
Volume: 38
Issue: 3
Pages: 431-43
Strain
Attribute String: mutant stock, transgenic
Genotype
Symbol: Chm/? Tg(Six3-cre)69Frty/?
Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Chm/Chm Tg(Six3-cre)69Frty/?
Background: involves: 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Eomes/Eomes Tg(Six3-cre)69Frty/?
Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Pax6/Pax6 Tg(Six3-cre)69Frty/?
Background: involves: 129P2/OlaHsd * ICR
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ahr/Ahr Tg(Six3-cre)69Frty/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ptpn11/Ptpn11 Tg(Six3-cre)69Frty/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tmem30a/Tmem30a Tg(Six3-cre)69Frty/?
Background: involves: 129/SvEv * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Macf1/Macf1 Tg(Six3-cre)69Frty/?
Background: involves: 129 * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Fzd5/Fzd5 Tg(Six3-cre)69Frty/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Arl3/Arl3 Tg(Six3-cre)69Frty/?
Background: involves: C57BL/6N * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Adam10/Adam10 Tg(Six3-cre)69Frty/?
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Mettl3/Mettl3 Tg(Six3-cre)69Frty/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO