| Type |
Details |
Score |
| Publication |
| First Author: |
Trowe MO |
| Year: |
2013 |
| Journal: |
Development |
| Title: |
Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. |
| Volume: |
140 |
| Issue: |
11 |
| Pages: |
2299-309 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Soleilhavoup C |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
3111 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanahashi H |
| Year: |
2018 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Deletion of Lrp4 increases the incidence of microphthalmia. |
| Volume: |
506 |
| Issue: |
3 |
| Pages: |
478-484 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Puelles L |
| Year: |
2023 |
| Journal: |
Int J Mol Sci |
| Title: |
The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. |
| Volume: |
24 |
| Issue: |
11 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Long JE |
| Year: |
2009 |
| Journal: |
J Comp Neurol |
| Title: |
Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. |
| Volume: |
512 |
| Issue: |
4 |
| Pages: |
556-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Long JE |
| Year: |
2009 |
| Journal: |
Cereb Cortex |
| Title: |
Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. |
| Volume: |
19 Suppl 1 |
|
| Pages: |
i96-106 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen B |
| Year: |
2005 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. |
| Volume: |
102 |
| Issue: |
47 |
| Pages: |
17184-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Loo L |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
Single-cell transcriptomic analysis of mouse neocortical development. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
134 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chung YC |
| Year: |
2011 |
| Journal: |
Gene Expr Patterns |
| Title: |
Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. |
| Volume: |
11 |
| Issue: |
1-2 |
| Pages: |
84-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Blackshaw S |
| Year: |
2004 |
| Journal: |
PLoS Biol |
| Title: |
Genomic analysis of mouse retinal development. |
| Volume: |
2 |
| Issue: |
9 |
| Pages: |
E247 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yokoyama S |
| Year: |
2009 |
| Journal: |
Dev Cell |
| Title: |
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
| Volume: |
17 |
| Issue: |
6 |
| Pages: |
836-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gray PA |
| Year: |
2004 |
| Journal: |
Science |
| Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
| Volume: |
306 |
| Issue: |
5705 |
| Pages: |
2255-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Thompson CL |
| Year: |
2014 |
| Journal: |
Neuron |
| Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
| Volume: |
83 |
| Issue: |
2 |
| Pages: |
309-323 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Visel A |
| Year: |
2004 |
| Journal: |
Nucleic Acids Res |
| Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
| Volume: |
32 |
| Issue: |
Database issue |
| Pages: |
D552-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lennon G |
| Year: |
1999 |
| Journal: |
Database Download |
| Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GUDMAP Consortium |
| Year: |
2004 |
| Journal: |
www.gudmap.org |
| Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
284
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wallis DE |
| Year: |
1999 |
| Journal: |
Nat Genet |
| Title: |
Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly. |
| Volume: |
22 |
| Issue: |
2 |
| Pages: |
196-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ferrena A |
| Year: |
2023 |
| Journal: |
bioRxiv |
| Title: |
Six3 and Six6 jointly regulate the identities and developmental trajectories of multipotent retinal progenitor cells in the mouse retina. |
|
|
|
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Allele |
| Name: |
sine oculis-related homeobox 3; targeted mutation 1, Guillermo Oliver |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
sine oculis-related homeobox 3; targeted mutation 3, Guillermo Oliver |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
sine oculis-related homeobox 3; targeted mutation 4, Guillermo Oliver |
| Allele Type: |
Targeted |
| Attribute String: |
Inducible, Recombinase |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7717795 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-09-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1753620 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:7717797 |
| Age: |
embryonic day 12.5 |
| Image: |
1E E12.5 Pomc |
| Note: |
Expression in basal hypothalamic region neurons co-localized with Six3 expression. |
| Specimen Label: |
1E E12.5 Pomc |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7717795 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-09-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1753622 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:7717797 |
| Age: |
embryonic day 14.5 |
| Image: |
S1 E14.5 Pomc |
| Note: |
Expression in basal hypothalamic region neurons co-localized with Six3 expression. |
| Specimen Label: |
S1 E14.5 Pomc |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7717795 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-09-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1753624 |
| Pattern: |
Regionally restricted |
| Stage: |
TS24 |
| Assay Id: |
MGI:7717797 |
| Age: |
embryonic day 16.5 |
| Image: |
1E E16.5 Pomc |
| Note: |
Expression in basal hypothalamic region neurons co-localized with Six3 expression. |
| Specimen Label: |
1E E16.5 Pomc |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7717795 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-09-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1753628 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:7717797 |
| Age: |
postnatal adult |
| Image: |
S1 E18.5 Pomc |
| Note: |
Expression in basal hypothalamic region neurons co-localized with Six3 expression. |
| Specimen Label: |
S1 E18.5 Pomc |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7491709 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-06-20 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607310 |
| Pattern: |
Regionally restricted |
| Stage: |
TS10 |
| Assay Id: |
MGI:7491708 |
| Age: |
embryonic day 7.0 |
| Image: |
4E1 lateral |
| Note: |
Expression domain was lateral to the Six3 domain. |
| Specimen Label: |
4E1 lateral |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7491709 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-06-20 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607310 |
| Pattern: |
Regionally restricted |
| Stage: |
TS10 |
| Assay Id: |
MGI:7491708 |
| Age: |
embryonic day 7.0 |
| Image: |
4E1 frontal |
| Note: |
Expression domain was lateral to the Six3 domain. |
| Specimen Label: |
4E1 frontal |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Six3/Six3 |
| Background: |
involves: 129S1/Sv |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Six3/Six3 Foxg1/Foxg1<+> |
| Background: |
involves: 129S1/Sv * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Six3/Six3<+> |
| Background: |
involves: 129S1/Sv * C57BL/6 |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Six3/Six3<+> Shh/Shh<+> |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1197617 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2013-09-04 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1614013 |
| Pattern: |
Regionally restricted |
| Stage: |
TS13 |
| Assay Id: |
MGI:5504410 |
| Age: |
embryonic day 8.5 |
| Image: |
7C' |
| Note: |
Staining was maintained in a nested pattern with Six3 in the mutant embryo. |
| Specimen Label: |
7C' |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7660828 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-06-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3541923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:7660842 |
| Age: |
embryonic day 15.5 |
| Image: |
8C Six3;Nestin-cre<+> Partial loss |
| Note: |
Expression was detected in the early suprachiasmatic nucleus unilaterally in mice displaying partial Six3 deletion. |
| Specimen Label: |
8C Six3;Nestin-cre<+> Partial loss |
| Detected: |
true |
| Specimen Num: |
23 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3506129 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-06-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3541923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:7660849 |
| Age: |
embryonic day 15.5 |
| Image: |
8C Six3;Nestin-cre<+> No loss |
| Note: |
Mutant mice that retained expression of Six3 showed prominent expression in the early postmitotic suprachiasmatic nucleus. |
| Specimen Label: |
8C Six3;Nestin-cre<+> No loss |
| Detected: |
true |
| Specimen Num: |
24 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7660828 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-06-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3541923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:7660842 |
| Age: |
embryonic day 15.5 |
| Image: |
8C Six3;Nestin-cre<+> No loss |
| Note: |
Mutant mice that retained expression of Six3 showed prominent expression in the early postmitotic suprachiasmatic nucleus. |
| Specimen Label: |
8C Six3;Nestin-cre<+> No loss |
| Detected: |
true |
| Specimen Num: |
24 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3764010 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2001-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607312 |
| Pattern: |
Regionally restricted |
| Stage: |
TS12 |
| Assay Id: |
MGI:2148959 |
| Age: |
embryonic day 8.2 |
| Image: |
5C |
| Note: |
Expression in anterior head fold; partially overlaps Six3 expression in posterior forebrain. |
| Specimen Label: |
5C |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3764936 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2001-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607312 |
| Pattern: |
Regionally restricted |
| Stage: |
TS12 |
| Assay Id: |
MGI:2148960 |
| Age: |
embryonic day 8.2 |
| Image: |
5D |
| Note: |
Expression in anterior head fold; not as strong as Six3 in anterior head fold. |
| Specimen Label: |
5D |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7491656 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-06-20 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607310 |
| Pattern: |
Regionally restricted |
| Stage: |
TS10 |
| Assay Id: |
MGI:7491711 |
| Age: |
embryonic day 7.0 |
| Image: |
4F1 lateral |
| Note: |
Expressed just rostral to the node, broader than that of Six3 and extending laterally. |
| Specimen Label: |
4F1 lateral |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7491656 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-06-20 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607310 |
| Pattern: |
Regionally restricted |
| Stage: |
TS10 |
| Assay Id: |
MGI:7491711 |
| Age: |
embryonic day 7.0 |
| Image: |
4F1 frontal |
| Note: |
Expressed just rostral to the node, broader than that of Six3 and extending laterally. |
| Specimen Label: |
4F1 frontal |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3764010 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2001-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1614412 |
| Pattern: |
Regionally restricted |
| Stage: |
TS12 |
| Assay Id: |
MGI:2148959 |
| Age: |
embryonic day 8.2 |
| Image: |
5C |
| Note: |
Expression in anterior head fold; partially overlaps Six3 expression in posterior forebrain. |
| Specimen Label: |
5C |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1197617 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2013-09-04 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1614413 |
| Pattern: |
Regionally restricted |
| Stage: |
TS13 |
| Assay Id: |
MGI:5504410 |
| Age: |
embryonic day 8.5 |
| Image: |
7C' |
| Note: |
Staining was maintained in a nested pattern with Six3 in the mutant embryo. |
| Specimen Label: |
7C' |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3506129 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-06-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1753622 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:7660849 |
| Age: |
embryonic day 14.5 |
| Image: |
4 E14.5 |
| Note: |
Expression was present in discrete bilateral regions distal to the third ventricle within the broader Six3 domain. |
| Specimen Label: |
4 E14.5 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3506129 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-06-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3541923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:7660849 |
| Age: |
embryonic day 15.5 |
| Image: |
8C Six3;Nestin-cre<+> Partial loss |
| Note: |
Expression was retained in the early suprachiasmatic nucleus unilaterally in mice displaying partial Six3 deletion. Loss of expression was only observed in regions lacking Six3. |
| Specimen Label: |
8C Six3;Nestin-cre<+> Partial loss |
| Detected: |
true |
| Specimen Num: |
23 |
|
•
•
•
•
•
|
| CL Term |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 69, Yasuhide Furuta |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 22, Yasuhide Furuta |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
transgenic, mutant strain |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Elshatory Y |
| Year: |
2008 |
| Journal: |
J Neurosci |
| Title: |
The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. |
| Volume: |
28 |
| Issue: |
13 |
| Pages: |
3291-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li B |
| Year: |
2024 |
| Journal: |
Neurobiol Dis |
| Title: |
Overexpression of Bmp4 induces microphthalmia by disrupting embryonic neural retina. |
| Volume: |
201 |
|
| Pages: |
106654 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion OF35, GENSAT Project at Rockefeller University |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Yongsu Jeong |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion, Yongsu Jeong |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, congenic, transgenic |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The human SIX protein family consists of six members (SIX1-SIX6), all of which contain two protein domains: a DNA binding homeobox domain and a SIX domain, which binds downstream effector molecules. They are thought to be transcription factors required for proper eye development [].This entry includes Homeobox proteins SIX3 and SIX6.SIX3 is a transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on target genes. During brain development, it maintains anterior forebrain identity and is required for neuroretinal specification and ependymal cell maturation []. It is also involved in eye development [, ]and pituitary development []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou Y |
| Year: |
2018 |
| Journal: |
Hum Mol Genet |
| Title: |
A splicing mutation in aryl hydrocarbon receptor associated with retinitis pigmentosa. |
| Volume: |
27 |
| Issue: |
14 |
| Pages: |
2563-2572 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sarkar H |
| Year: |
2024 |
| Journal: |
Biochim Biophys Acta Mol Basis Dis |
| Title: |
Loss of REP1 impacts choroidal melanogenesis and vasculogenesis in choroideremia. |
| Volume: |
1870 |
| Issue: |
2 |
| Pages: |
166963 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grishanin RN |
| Year: |
2008 |
| Journal: |
Mol Cell Neurosci |
| Title: |
Retinal TrkB receptors regulate neural development in the inner, but not outer, retina. |
| Volume: |
38 |
| Issue: |
3 |
| Pages: |
431-43 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Chm/? Tg(Six3-cre)69Frty/? |
| Background: |
involves: 129X1/SvJ * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Chm/Chm Tg(Six3-cre)69Frty/? |
| Background: |
involves: 129X1/SvJ * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Eomes/Eomes Tg(Six3-cre)69Frty/? |
| Background: |
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pax6/Pax6 Tg(Six3-cre)69Frty/? |
| Background: |
involves: 129P2/OlaHsd * ICR |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ahr/Ahr Tg(Six3-cre)69Frty/? |
| Background: |
Not Specified |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ptpn11/Ptpn11 Tg(Six3-cre)69Frty/? |
| Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tmem30a/Tmem30a Tg(Six3-cre)69Frty/? |
| Background: |
involves: 129/SvEv * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Macf1/Macf1 Tg(Six3-cre)69Frty/? |
| Background: |
involves: 129 * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Fzd5/Fzd5 Tg(Six3-cre)69Frty/? |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Arl3/Arl3 Tg(Six3-cre)69Frty/? |
| Background: |
involves: C57BL/6N * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Adam10/Adam10 Tg(Six3-cre)69Frty/? |
| Background: |
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mettl3/Mettl3 Tg(Six3-cre)69Frty/? |
| Background: |
involves: C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|