| Type |
Details |
Score |
| Publication |
| First Author: |
Acevedo LM |
| Year: |
2008 |
| Journal: |
Blood |
| Title: |
Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor. |
| Volume: |
111 |
| Issue: |
5 |
| Pages: |
2674-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu H |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. |
| Volume: |
278 |
| Issue: |
13 |
| Pages: |
11520-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Continolo S |
| Year: |
2005 |
| Journal: |
Exp Cell Res |
| Title: |
The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization. |
| Volume: |
302 |
| Issue: |
2 |
| Pages: |
253-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shen S |
| Year: |
2009 |
| Journal: |
Blood |
| Title: |
The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation. |
| Volume: |
114 |
| Issue: |
1 |
| Pages: |
74-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lowin-Kropf B |
| Year: |
2002 |
| Journal: |
Eur J Immunol |
| Title: |
A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors. |
| Volume: |
32 |
| Issue: |
3 |
| Pages: |
773-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gray EJ |
| Year: |
2014 |
| Journal: |
J Biol Chem |
| Title: |
Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. |
| Volume: |
289 |
| Issue: |
51 |
| Pages: |
35397-408 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dise RS |
| Year: |
2008 |
| Journal: |
Am J Physiol Gastrointest Liver Physiol |
| Title: |
Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration. |
| Volume: |
294 |
| Issue: |
1 |
| Pages: |
G276-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee JY |
| Year: |
2011 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains. |
| Volume: |
108 |
| Issue: |
34 |
| Pages: |
14157-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feng H |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis. |
| Volume: |
109 |
| Issue: |
8 |
| Pages: |
3018-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhi H |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase. |
| Volume: |
10 |
| Issue: |
8 |
| Pages: |
e0135738 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Moore KJ |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. |
| Volume: |
277 |
| Issue: |
49 |
| Pages: |
47373-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ming Z |
| Year: |
2011 |
| Journal: |
Blood |
| Title: |
Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation. |
| Volume: |
117 |
| Issue: |
14 |
| Pages: |
3903-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hibbs ML |
| Year: |
1997 |
| Journal: |
Int J Biochem Cell Biol |
| Title: |
Lyn, a src-like tyrosine kinase. |
| Volume: |
29 |
| Issue: |
3 |
| Pages: |
397-400 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiao W |
| Year: |
2005 |
| Journal: |
J Immunol |
| Title: |
Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. |
| Volume: |
175 |
| Issue: |
10 |
| Pages: |
6885-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsantikos E |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6. |
| Volume: |
184 |
| Issue: |
3 |
| Pages: |
1348-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gross AJ |
| Year: |
2011 |
| Journal: |
Eur J Immunol |
| Title: |
Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells. |
| Volume: |
41 |
| Issue: |
12 |
| Pages: |
3645-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shah BH |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Roles of Src and epidermal growth factor receptor transactivation in transient and sustained ERK1/2 responses to gonadotropin-releasing hormone receptor activation. |
| Volume: |
278 |
| Issue: |
21 |
| Pages: |
19118-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sergeys J |
| Year: |
2020 |
| Journal: |
Exp Eye Res |
| Title: |
The retinal tyrosine kinome of diabetic Akimba mice highlights potential for specific Src family kinase inhibition in retinal vascular disease. |
| Volume: |
197 |
|
| Pages: |
108108 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Charles N |
| Year: |
2010 |
| Journal: |
Nat Med |
| Title: |
Basophils and the T helper 2 environment can promote the development of lupus nephritis. |
| Volume: |
16 |
| Issue: |
6 |
| Pages: |
701-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stadtmann A |
| Year: |
2013 |
| Journal: |
J Exp Med |
| Title: |
The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow. |
| Volume: |
210 |
| Issue: |
11 |
| Pages: |
2171-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fuhrer DK |
| Year: |
1996 |
| Journal: |
Exp Hematol |
| Title: |
Activation of Src-family protein tyrosine kinases and phosphatidylinositol 3-kinase in 3T3-L1 mouse preadipocytes by interleukin-11. |
| Volume: |
24 |
| Issue: |
2 |
| Pages: |
195-203 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu KK |
| Year: |
2011 |
| Journal: |
Cardiovasc Pathol |
| Title: |
Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src. |
| Volume: |
20 |
| Issue: |
2 |
| Pages: |
71-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brown MT |
| Year: |
1996 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Regulation, substrates and functions of src. |
| Volume: |
1287 |
| Issue: |
2-3 |
| Pages: |
121-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marie-Cardine A |
| Year: |
1998 |
| Journal: |
FEBS Lett |
| Title: |
SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. |
| Volume: |
435 |
| Issue: |
1 |
| Pages: |
55-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takahashi T |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation. |
| Volume: |
278 |
| Issue: |
43 |
| Pages: |
42225-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bourette RP |
| Year: |
2005 |
| Journal: |
Cell Signal |
| Title: |
Macrophage colony-stimulating factor receptor induces tyrosine phosphorylation of SKAP55R adaptor and its association with actin. |
| Volume: |
17 |
| Issue: |
8 |
| Pages: |
941-9 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
403
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yasue T |
| Year: |
1997 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5. |
| Volume: |
94 |
| Issue: |
19 |
| Pages: |
10307-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brian BF 4th |
| Year: |
2022 |
| Journal: |
Sci Adv |
| Title: |
A dominant function of LynB kinase in preventing autoimmunity. |
| Volume: |
8 |
| Issue: |
16 |
| Pages: |
eabj5227 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hughan SC |
| Year: |
2014 |
| Journal: |
J Biol Chem |
| Title: |
Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice. |
| Volume: |
289 |
| Issue: |
8 |
| Pages: |
5051-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kriz V |
| Year: |
2007 |
| Journal: |
Dev Dyn |
| Title: |
Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero. |
| Volume: |
236 |
| Issue: |
9 |
| Pages: |
2485-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Savino MT |
| Year: |
2013 |
| Journal: |
J Leukoc Biol |
| Title: |
The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development. |
| Volume: |
93 |
| Issue: |
4 |
| Pages: |
549-59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gambino V |
| Year: |
2013 |
| Journal: |
Aging Cell |
| Title: |
Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging. |
| Volume: |
12 |
| Issue: |
3 |
| Pages: |
435-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Trinei M |
| Year: |
2002 |
| Journal: |
Oncogene |
| Title: |
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. |
| Volume: |
21 |
| Issue: |
24 |
| Pages: |
3872-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Soliman MA |
| Year: |
2014 |
| Journal: |
Sci Signal |
| Title: |
The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism. |
| Volume: |
7 |
| Issue: |
313 |
| Pages: |
ra17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mokhtari D |
| Year: |
2009 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice. |
| Volume: |
387 |
| Issue: |
3 |
| Pages: |
553-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shi Y |
| Year: |
2009 |
| Journal: |
Biochem Cell Biol |
| Title: |
Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils. |
| Volume: |
87 |
| Issue: |
1 |
| Pages: |
207-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ogawa A |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Structure of the carboxyl-terminal Src kinase, Csk. |
| Volume: |
277 |
| Issue: |
17 |
| Pages: |
14351-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rosenfeldt HM |
| Year: |
2001 |
| Journal: |
FASEB J |
| Title: |
EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. |
| Volume: |
15 |
| Issue: |
14 |
| Pages: |
2649-59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suzuki Y |
| Year: |
1997 |
| Journal: |
J Immunol |
| Title: |
HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. |
| Volume: |
158 |
| Issue: |
6 |
| Pages: |
2736-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gold MJ |
| Year: |
2015 |
| Journal: |
J Allergy Clin Immunol |
| Title: |
Lineage-specific regulation of allergic airway inflammation by the lipid phosphatase Src homology 2 domain-containing inositol 5-phosphatase (SHIP-1). |
| Volume: |
136 |
| Issue: |
3 |
| Pages: |
725-736.e2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kashiwada M |
| Year: |
2006 |
| Journal: |
J Immunol |
| Title: |
Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development. |
| Volume: |
176 |
| Issue: |
7 |
| Pages: |
3958-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Langbeheim H |
| Year: |
1980 |
| Journal: |
Virology |
| Title: |
Identification of a normal vertebrate cell protein related to the p21 src of Harvey murine sarcoma virus. |
| Volume: |
106 |
| Issue: |
2 |
| Pages: |
292-300 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Duffy HS |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1. |
| Volume: |
282 |
| Issue: |
13 |
| Pages: |
9789-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gortat A |
| Year: |
2012 |
| Journal: |
J Biol Chem |
| Title: |
Single point mutation in Bin/Amphiphysin/Rvs (BAR) sequence of endophilin impairs dimerization, membrane shaping, and Src homology 3 domain-mediated partnership. |
| Volume: |
287 |
| Issue: |
6 |
| Pages: |
4232-47 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pleiman CM |
| Year: |
1994 |
| Journal: |
Science |
| Title: |
Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit. |
| Volume: |
263 |
| Issue: |
5153 |
| Pages: |
1609-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kannan S |
| Year: |
2008 |
| Journal: |
J Immunol |
| Title: |
Cholesterol-rich membrane rafts and Lyn are involved in phagocytosis during Pseudomonas aeruginosa infection. |
| Volume: |
180 |
| Issue: |
4 |
| Pages: |
2396-408 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yamashita Y |
| Year: |
2007 |
| Journal: |
J Immunol |
| Title: |
Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses. |
| Volume: |
179 |
| Issue: |
2 |
| Pages: |
740-3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wolter J |
| Year: |
2016 |
| Journal: |
J Thromb Haemost |
| Title: |
Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system. |
| Volume: |
14 |
| Issue: |
11 |
| Pages: |
2212-2226 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tedesco S |
| Year: |
2020 |
| Journal: |
Diabetes |
| Title: |
Pharmacologic PPAR-γ Activation Reprograms Bone Marrow Macrophages and Partially Rescues HSPC Mobilization in Human and Murine Diabetes. |
| Volume: |
69 |
| Issue: |
7 |
| Pages: |
1562-1572 |
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•
•
•
•
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| Publication |
| First Author: |
Mukherjee M |
| Year: |
2012 |
| Journal: |
EMBO J |
| Title: |
Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. |
| Volume: |
31 |
| Issue: |
5 |
| Pages: |
1308-19 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Wahle JA |
| Year: |
2007 |
| Journal: |
J Immunol |
| Title: |
Inappropriate recruitment and activity by the Src homology region 2 domain-containing phosphatase 1 (SHP1) is responsible for receptor dominance in the SHIP-deficient NK cell. |
| Volume: |
179 |
| Issue: |
12 |
| Pages: |
8009-15 |
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•
•
•
•
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| Publication |
| First Author: |
Katz S |
| Year: |
2008 |
| Journal: |
Arch Biochem Biophys |
| Title: |
Purinergic (ATP) signaling stimulates JNK1 but not JNK2 MAPK in osteoblast-like cells: contribution of intracellular Ca2+ release, stress activated and L-voltage-dependent calcium influx, PKC and Src kinases. |
| Volume: |
477 |
| Issue: |
2 |
| Pages: |
244-52 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Vashistha H |
| Year: |
2012 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. |
| Volume: |
303 |
| Issue: |
12 |
| Pages: |
F1629-40 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Kasirer-Friede A |
| Year: |
2010 |
| Journal: |
Blood |
| Title: |
Role for ADAP in shear flow-induced platelet mechanotransduction. |
| Volume: |
115 |
| Issue: |
11 |
| Pages: |
2274-82 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Xiao W |
| Year: |
2008 |
| Journal: |
J Clin Invest |
| Title: |
Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. |
| Volume: |
118 |
| Issue: |
3 |
| Pages: |
924-34 |
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•
•
•
•
|
| Publication |
| First Author: |
Baruzzi A |
| Year: |
2012 |
| Journal: |
Eur J Immunol |
| Title: |
The tyrosine kinase Abl is a component of macrophage podosomes and is required for podosome formation and function. |
| Volume: |
42 |
| Issue: |
10 |
| Pages: |
2720-6 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Nataraja C |
| Year: |
2021 |
| Journal: |
Front Immunol |
| Title: |
GILZ Regulates the Expression of Pro-Inflammatory Cytokines and Protects Against End-Organ Damage in a Model of Lupus. |
| Volume: |
12 |
|
| Pages: |
652800 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Lyn/Lyn |
| Background: |
involves: C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fujii Y |
| Year: |
2003 |
| Journal: |
FEBS Lett |
| Title: |
Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. |
| Volume: |
540 |
| Issue: |
1-3 |
| Pages: |
111-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Silver KL |
| Year: |
2007 |
| Journal: |
Eur J Immunol |
| Title: |
MyD88-dependent autoimmune disease in Lyn-deficient mice. |
| Volume: |
37 |
| Issue: |
10 |
| Pages: |
2734-43 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Gu H |
| Year: |
2003 |
| Journal: |
J Cell Biol |
| Title: |
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis. |
| Volume: |
161 |
| Issue: |
6 |
| Pages: |
1151-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hibbs ML |
| Year: |
1995 |
| Journal: |
Gene |
| Title: |
Identification of a duplication of the mouse Lyn gene. |
| Volume: |
156 |
| Issue: |
2 |
| Pages: |
175-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Podhipleux N |
| Year: |
1995 |
| Journal: |
Oncogene |
| Title: |
Isolation and characterization of the murine C-FGR genomic locus: exons IB-XII. |
| Volume: |
11 |
| Issue: |
4 |
| Pages: |
781-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zaleskas VM |
| Year: |
2006 |
| Journal: |
PLoS One |
| Title: |
Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. |
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