| Type |
Details |
Score |
| Publication |
| First Author: |
Utku N |
| Year: |
2004 |
| Journal: |
J Immunol |
| Title: |
TIRC7 deficiency causes in vitro and in vivo augmentation of T and B cell activation and cytokine response. |
| Volume: |
173 |
| Issue: |
4 |
| Pages: |
2342-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mehal WZ |
| Year: |
2005 |
| Journal: |
Int Immunol |
| Title: |
TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions. |
| Volume: |
17 |
| Issue: |
5 |
| Pages: |
531-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rossi L |
| Year: |
2011 |
| Journal: |
Blood |
| Title: |
TIMP-1 deficiency subverts cell-cycle dynamics in murine long-term HSCs. |
| Volume: |
117 |
| Issue: |
24 |
| Pages: |
6479-88 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang H |
| Year: |
2020 |
| Journal: |
IUBMB Life |
| Title: |
Atg16l1 in dendritic cells is required for antibacterial defense and autophagy in murine colitis. |
| Volume: |
72 |
| Issue: |
12 |
| Pages: |
2686-2695 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fan YY |
| Year: |
2014 |
| Journal: |
Carcinogenesis |
| Title: |
Differential effects of 2- and 3-series E-prostaglandins on in vitro expansion of Lgr5+ colonic stem cells. |
| Volume: |
35 |
| Issue: |
3 |
| Pages: |
606-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou M |
| Year: |
1998 |
| Journal: |
J Reprod Immunol |
| Title: |
Expanded cohorts of maternal CD8+ T-cells specific for paternal MHC class I accumulate during pregnancy. |
| Volume: |
40 |
| Issue: |
1 |
| Pages: |
47-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Almolda B |
| Year: |
2014 |
| Journal: |
Glia |
| Title: |
Effects of astrocyte-targeted production of interleukin-6 in the mouse on the host response to nerve injury. |
| Volume: |
62 |
| Issue: |
7 |
| Pages: |
1142-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pool KD |
| Year: |
2024 |
| Journal: |
PLoS One |
| Title: |
ECRG4 mediates host response to cutaneous infection by regulating neutrophil recruitment and adhesion receptor expression. |
| Volume: |
19 |
| Issue: |
11 |
| Pages: |
e0310810 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Singh VP |
| Year: |
2015 |
| Journal: |
Sci Rep |
| Title: |
Role of mouse Wdr13 in placental growth; a genetic evidence for lifetime body weight determination by placenta during development. |
| Volume: |
5 |
|
| Pages: |
13371 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ray S |
| Year: |
2022 |
| Journal: |
Matrix Biol |
| Title: |
35kDa hyaluronan ameliorates ethanol driven loss of anti-microbial defense and intestinal barrier integrity in a TLR4-dependent manner. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Donlan AN |
| Year: |
2021 |
| Journal: |
JCI Insight |
| Title: |
IL-13 is a driver of COVID-19 severity. |
| Volume: |
6 |
| Issue: |
15 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Neumeyer V |
| Year: |
2019 |
| Journal: |
Cancers (Basel) |
| Title: |
Mutated Rnf43 Aggravates Helicobacter Pylori-Induced Gastric Pathology. |
| Volume: |
11 |
| Issue: |
3 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Song JY |
| Year: |
2020 |
| Journal: |
Sci Rep |
| Title: |
Bidirectional, non-necrotizing glomerular crescents are the critical pathology in X-linked Alport syndrome mouse model harboring nonsense mutation of human COL4A5. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
18891 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Qian Y |
| Year: |
2024 |
| Journal: |
J Neuroinflammation |
| Title: |
SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury. |
| Volume: |
21 |
| Issue: |
1 |
| Pages: |
35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu Y |
| Year: |
2003 |
| Journal: |
Dev Dyn |
| Title: |
Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors. |
| Volume: |
226 |
| Issue: |
4 |
| Pages: |
675-89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Snider D |
| Year: |
2001 |
| Journal: |
J Immunol |
| Title: |
Early intestinal Th1 inflammation and mucosal T cell recruitment during acute graft-versus-host reaction. |
| Volume: |
166 |
| Issue: |
10 |
| Pages: |
5991-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harada M |
| Year: |
2001 |
| Journal: |
Immunology |
| Title: |
Evidence of the extrathymic development of tyrosinase-related protein-2-recognizing CD8+ T cells with low avidity. |
| Volume: |
104 |
| Issue: |
1 |
| Pages: |
67-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lin YH |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
The osteopontin-CD44 survival signal involves activation of the phosphatidylinositol 3-kinase/Akt signaling pathway. |
| Volume: |
276 |
| Issue: |
49 |
| Pages: |
46024-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wong NA |
| Year: |
2002 |
| Journal: |
Am J Pathol |
| Title: |
Beta-catenin--a linchpin in colorectal carcinogenesis? |
| Volume: |
160 |
| Issue: |
2 |
| Pages: |
389-401 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Weber GF |
| Year: |
2001 |
| Journal: |
Biochim Biophys Acta |
| Title: |
The metastasis gene osteopontin: a candidate target for cancer therapy. |
| Volume: |
1552 |
| Issue: |
2 |
| Pages: |
61-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawaguchi-Miyashita M |
| Year: |
2000 |
| Journal: |
Immunology |
| Title: |
Activation of T-cell receptor-gammadelta+ cells in the intestinal epithelia of KN6 transgenic mice. |
| Volume: |
101 |
| Issue: |
1 |
| Pages: |
38-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Poetschke HL |
| Year: |
2000 |
| Journal: |
Carcinogenesis |
| Title: |
Effects of calorie restriction on thymocyte growth, death and maturation. |
| Volume: |
21 |
| Issue: |
11 |
| Pages: |
1959-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takada H |
| Year: |
1993 |
| Journal: |
J Immunol |
| Title: |
Peritoneal gamma delta T cells induced by Escherichia coli infection in mice. Correlation between Thy-1 phenotype and host minor lymphocyte-stimulating phenotype. |
| Volume: |
151 |
| Issue: |
4 |
| Pages: |
2062-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hammond DM |
| Year: |
1993 |
| Journal: |
J Exp Med |
| Title: |
Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene. |
| Volume: |
178 |
| Issue: |
6 |
| Pages: |
2225-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kapp U |
| Year: |
1994 |
| Journal: |
Ann Oncol |
| Title: |
Disseminated growth of Hodgkin's-derived cell lines L540 and L540cy in immune-deficient SCID mice. |
| Volume: |
5 Suppl 1 |
|
| Pages: |
121-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ando J |
| Year: |
1994 |
| Journal: |
Am J Physiol |
| Title: |
Shear stress inhibits adhesion of cultured mouse endothelial cells to lymphocytes by downregulating VCAM-1 expression. |
| Volume: |
267 |
| Issue: |
3 Pt 1 |
| Pages: |
C679-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Racila E |
| Year: |
1995 |
| Journal: |
J Exp Med |
| Title: |
Tumor dormancy and cell signaling. II. Antibody as an agonist in inducing dormancy of a B cell lymphoma in SCID mice. |
| Volume: |
181 |
| Issue: |
4 |
| Pages: |
1539-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou T |
| Year: |
1995 |
| Journal: |
J Exp Med |
| Title: |
Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. |
| Volume: |
182 |
| Issue: |
1 |
| Pages: |
129-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bonato VL |
| Year: |
1998 |
| Journal: |
Infect Immun |
| Title: |
Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice. |
| Volume: |
66 |
| Issue: |
1 |
| Pages: |
169-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gärdby E |
| Year: |
1998 |
| Journal: |
J Immunol |
| Title: |
Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice. |
| Volume: |
161 |
| Issue: |
1 |
| Pages: |
49-59 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Burg MA |
| Year: |
1998 |
| Journal: |
J Cell Physiol |
| Title: |
Expression of the NG2 proteoglycan enhances the growth and metastatic properties of melanoma cells. |
| Volume: |
177 |
| Issue: |
2 |
| Pages: |
299-312 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ogoshi T |
| Year: |
1998 |
| Journal: |
Jpn J Cancer Res |
| Title: |
CD44H participates in the intrahepatic growth of murine colon 26 adenocarcinoma cells. |
| Volume: |
89 |
| Issue: |
11 |
| Pages: |
1160-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mikecz K |
| Year: |
1999 |
| Journal: |
Arthritis Rheum |
| Title: |
Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis. |
| Volume: |
42 |
| Issue: |
4 |
| Pages: |
659-68 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stickeler E |
| Year: |
1999 |
| Journal: |
Oncogene |
| Title: |
Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis. |
| Volume: |
18 |
| Issue: |
24 |
| Pages: |
3574-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alonso-C LM |
| Year: |
1999 |
| Journal: |
Int Immunol |
| Title: |
Development of rat CD45+ 13-day-old fetal liver cells in SCID mouse fetal thymic organ cultures. |
| Volume: |
11 |
| Issue: |
7 |
| Pages: |
1119-29 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tewari K |
| Year: |
2004 |
| Journal: |
J Immunol |
| Title: |
Effect of chronic viral infection on epitope selection, cytokine production, and surface phenotype of CD8 T cells and the role of IFN-gamma receptor in immune regulation. |
| Volume: |
172 |
| Issue: |
3 |
| Pages: |
1491-500 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zerbe LK |
| Year: |
2004 |
| Journal: |
Mol Carcinog |
| Title: |
Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing. |
| Volume: |
41 |
| Issue: |
4 |
| Pages: |
187-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kultti A |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Hyaluronan synthesis induces microvillus-like cell surface protrusions. |
| Volume: |
281 |
| Issue: |
23 |
| Pages: |
15821-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sumoza-Toledo A |
| Year: |
2006 |
| Journal: |
Exp Cell Res |
| Title: |
Differential localization of unconventional myosin I and nonmuscle myosin II during B cell spreading. |
| Volume: |
312 |
| Issue: |
17 |
| Pages: |
3312-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao C |
| Year: |
2008 |
| Journal: |
Immunology |
| Title: |
Cachexia in the non-obese diabetic mouse is associated with CD4+ T-cell lymphopenia. |
| Volume: |
125 |
| Issue: |
1 |
| Pages: |
48-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cassese G |
| Year: |
2007 |
| Journal: |
Blood |
| Title: |
Bone marrow CD8 cells down-modulate membrane IL-7Ralpha expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment. |
| Volume: |
110 |
| Issue: |
6 |
| Pages: |
1960-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Holcmann M |
| Year: |
2009 |
| Journal: |
J Immunol |
| Title: |
Skin inflammation is not sufficient to break tolerance induced against a novel antigen. |
| Volume: |
183 |
| Issue: |
2 |
| Pages: |
1133-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bommireddy R |
| Year: |
2009 |
| Journal: |
Clin Exp Immunol |
| Title: |
Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice. |
| Volume: |
158 |
| Issue: |
3 |
| Pages: |
317-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Karunamuni G |
| Year: |
2010 |
| Journal: |
Anat Rec (Hoboken) |
| Title: |
Expression of lymphatic markers during avian and mouse cardiogenesis. |
| Volume: |
293 |
| Issue: |
2 |
| Pages: |
259-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kunita A |
| Year: |
2011 |
| Journal: |
Am J Pathol |
| Title: |
Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma. |
| Volume: |
179 |
| Issue: |
2 |
| Pages: |
1041-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang F |
| Year: |
2013 |
| Journal: |
Exp Cell Res |
| Title: |
Lectin-like oxidized LDL receptor-1 expresses in mouse bone marrow-derived mesenchymal stem cells and stimulates their proliferation. |
| Volume: |
319 |
| Issue: |
7 |
| Pages: |
1054-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chitteti BR |
| Year: |
2013 |
| Journal: |
Bone |
| Title: |
Hierarchical organization of osteoblasts reveals the significant role of CD166 in hematopoietic stem cell maintenance and function. |
| Volume: |
54 |
| Issue: |
1 |
| Pages: |
58-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharon Y |
| Year: |
2015 |
| Journal: |
Cancer Res |
| Title: |
Tumor-derived osteopontin reprograms normal mammary fibroblasts to promote inflammation and tumor growth in breast cancer. |
| Volume: |
75 |
| Issue: |
6 |
| Pages: |
963-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mori T |
| Year: |
2014 |
| Journal: |
Genes Cells |
| Title: |
Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function. |
| Volume: |
19 |
| Issue: |
8 |
| Pages: |
603-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sur S |
| Year: |
2016 |
| Journal: |
Toxicol Appl Pharmacol |
| Title: |
Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice. |
| Volume: |
300 |
|
| Pages: |
34-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GarcÃa-Peydró M |
| Year: |
2018 |
| Journal: |
J Clin Invest |
| Title: |
The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model. |
| Volume: |
128 |
| Issue: |
7 |
| Pages: |
2802-2818 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ludwig N |
| Year: |
2019 |
| Journal: |
Cancer Lett |
| Title: |
CD44(+) tumor cells promote early angiogenesis in head and neck squamous cell carcinoma. |
| Volume: |
467 |
|
| Pages: |
85-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang K |
| Year: |
2019 |
| Journal: |
Cell Mol Immunol |
| Title: |
PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision. |
| Volume: |
16 |
| Issue: |
9 |
| Pages: |
746-756 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen L |
| Year: |
2017 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification. |
| Volume: |
114 |
| Issue: |
11 |
| Pages: |
E2215-E2224 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kang DW |
| Year: |
2020 |
| Journal: |
J Pathol |
| Title: |
Phospholipase D1 inhibition sensitizes glioblastoma to temozolomide and suppresses its tumorigenicity. |
| Volume: |
252 |
| Issue: |
3 |
| Pages: |
304-316 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zaki MYW |
| Year: |
2021 |
| Journal: |
Sci Rep |
| Title: |
Key features of the environment promoting liver cancer in the absence of cirrhosis. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
16727 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Serizawa T |
| Year: |
2016 |
| Journal: |
Infect Immun |
| Title: |
Gastric Metaplasia Induced by Helicobacter pylori Is Associated with Enhanced SOX9 Expression via Interleukin-1 Signaling. |
| Volume: |
84 |
| Issue: |
2 |
| Pages: |
562-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chang PL |
| Year: |
2014 |
| Journal: |
J Dermatol Sci |
| Title: |
Osteopontin facilitates ultraviolet B-induced squamous cell carcinoma development. |
| Volume: |
75 |
| Issue: |
2 |
| Pages: |
121-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lubeseder-Martellato C |
| Year: |
2016 |
| Journal: |
Oncotarget |
| Title: |
Membranous CD24 drives the epithelial phenotype of pancreatic cancer. |
| Volume: |
7 |
| Issue: |
31 |
| Pages: |
49156-49168 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Clark SM |
| Year: |
2019 |
| Journal: |
Cytokine |
| Title: |
CD8+ T cells promote cytokine responses to stress. |
| Volume: |
113 |
|
| Pages: |
256-264 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim YD |
| Year: |
2011 |
| Journal: |
Nucleic Acids Res |
| Title: |
NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo. |
| Volume: |
39 |
| Issue: |
10 |
| Pages: |
4300-14 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
542
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
331
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
403
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim CH |
| Year: |
2016 |
| Journal: |
J Biol Chem |
| Title: |
Nuclear Speckle-related Protein 70 Binds to Serine/Arginine-rich Splicing Factors 1 and 2 via an Arginine/Serine-like Region and Counteracts Their Alternative Splicing Activity. |
| Volume: |
291 |
| Issue: |
12 |
| Pages: |
6169-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Denoeud J |
| Year: |
2011 |
| Journal: |
J Leukoc Biol |
| Title: |
Role of CD27/CD70 pathway of activation in immunity and tolerance. |
| Volume: |
89 |
| Issue: |
2 |
| Pages: |
195-203 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents the hyaluronan synthase 2 (HAS2), which plays a role in hyaluronan/hyaluronic acid (HA) synthesis []. There are three different, but related hyaluronan synthases - HAS1, HAS2 and HAS3. They are multipass transmembrane enzymes, the active sites of which protrude from the inner face of the plasma membrane. HA is an unbranched disaccharide glucuronic acid/N-acetylglucosamine polymer and is one of the main components of the extracellular matrix []. High level of HA in humans is associated with cancer progression [, ]. In vertebrates, different HA polymer length can trigger different biological responses. High-molecular-mass HA represses mitogenic signalling and has anti-inflammatory properties, while low-molecular-mass HA promotes proliferation and inflammation [, ]. A study of the naked mole rat showed that HAS2 is overexpressed in naked mole rat fibroblasts, while the expression levels of HAS1 and HAS3 are similar between mouse, human and naked mole-rat cells []. HAS2 is responsible for the synthesis of the high-molecular-mass HA (HMM-HA), which triggers ECI (early contact inhibition) via the CD44 receptor and plays a key role in mediating the cancer resistance of the naked mole rat []. |
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| Protein Domain |
| Type: |
Domain |
| Description: |
Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27, T14, S152, Tp55, S152 or LPFS2, has a key role in the generation of immunological memory via effects on T-cell expansion and survival, and B cell development [, ]. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. CD27 transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK, and mediates the signaling process through adaptor proteins TRAF2 and TRAF5. CD27-binding protein (SIVA), a pro-apoptotic protein, can bind to CD27 and may play an important role in the apoptosis induced by this receptor []. The potential role of the CD27/CD70 pathway in the course of inflammatory diseases, such as arthritis, and inflammatory bowel disease, suggests that CD70 may be a target for immune intervention. The expression of CD27 and CD44 molecules correlates with the differentiation stage of B cell precursors and has been shown to have a biological significance in acute lymphoblastic leukemia [].This entry represents the N-terminal domain of TNFRSF7. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ]. |
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| Publication |
| First Author: |
Alferink J |
| Year: |
1995 |
| Journal: |
Int Immunol |
| Title: |
Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance. |
| Volume: |
7 |
| Issue: |
2 |
| Pages: |
331-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chandrakesan P |
| Year: |
2013 |
| Journal: |
PLoS One |
| Title: |
Differential effects of β-catenin and NF-κB interplay in the regulation of cell proliferation, inflammation and tumorigenesis in response to bacterial infection. |
| Volume: |
8 |
| Issue: |
11 |
| Pages: |
e79432 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tucker B |
| Year: |
2008 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Elevated MMP Expression in the MRL Mouse Retina Creates a Permissive Environment for Retinal Regeneration. |
| Volume: |
49 |
| Issue: |
4 |
| Pages: |
1686-95 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Makwana M |
| Year: |
2007 |
| Journal: |
J Neurosci |
| Title: |
Endogenous transforming growth factor beta 1 suppresses inflammation and promotes survival in adult CNS. |
| Volume: |
27 |
| Issue: |
42 |
| Pages: |
11201-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diamond RA |
| Year: |
1997 |
| Journal: |
J Immunol |
| Title: |
Different developmental arrest points in RAG-2 -/- and SCID thymocytes on two genetic backgrounds: developmental choices and cell death mechanisms before TCR gene rearrangement. |
| Volume: |
158 |
| Issue: |
9 |
| Pages: |
4052-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shmelkov SV |
| Year: |
2008 |
| Journal: |
J Clin Invest |
| Title: |
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. |
| Volume: |
118 |
| Issue: |
6 |
| Pages: |
2111-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schulien I |
| Year: |
2019 |
| Journal: |
Cell Death Differ |
| Title: |
The transcription factor c-Jun/AP-1 promotes liver fibrosis during non-alcoholic steatohepatitis by regulating Osteopontin expression. |
| Volume: |
26 |
| Issue: |
9 |
| Pages: |
1688-1699 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim SH |
| Year: |
2023 |
| Journal: |
Autophagy |
| Title: |
Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease. |
| Volume: |
19 |
| Issue: |
8 |
| Pages: |
2318-2337 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cekic C |
| Year: |
2014 |
| Journal: |
Cancer Res |
| Title: |
Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment. |
| Volume: |
74 |
| Issue: |
24 |
| Pages: |
7250-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bhadra R |
| Year: |
2010 |
| Journal: |
PLoS One |
| Title: |
Absence of both IL-7 and IL-15 severely impairs the development of CD8 T cell response against Toxoplasma gondii. |
| Volume: |
5 |
| Issue: |
5 |
| Pages: |
e10842 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ruff CA |
| Year: |
2012 |
| Journal: |
J Neurochem |
| Title: |
Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate. |
| Volume: |
121 |
| Issue: |
4 |
| Pages: |
607-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Escher P |
| Year: |
2008 |
| Journal: |
Mol Vis |
| Title: |
Differential neuroglycan C expression during retinal degeneration in Rpe65-/- mice. |
| Volume: |
14 |
|
| Pages: |
2126-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Montes-Casado M |
| Year: |
2021 |
| Journal: |
Int J Mol Sci |
| Title: |
The PI-3-Kinase P110α Catalytic Subunit of T Lymphocytes Modulates Collagen-Induced Arthritis. |
| Volume: |
22 |
| Issue: |
12 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Soh S |
| Year: |
2023 |
| Journal: |
Cell Commun Signal |
| Title: |
Adiponectin affects the migration ability of bone marrow-derived mesenchymal stem cells via the regulation of hypoxia inducible factor 1α. |
| Volume: |
21 |
| Issue: |
1 |
| Pages: |
158 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zuchtriegel G |
| Year: |
2015 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Spatiotemporal expression dynamics of selectins govern the sequential extravasation of neutrophils and monocytes in the acute inflammatory response. |
| Volume: |
35 |
| Issue: |
4 |
| Pages: |
899-910 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang X |
| Year: |
2018 |
| Journal: |
Cardiovasc Res |
| Title: |
A disintegrin and metalloproteinase 15-mediated glycocalyx shedding contributes to vascular leakage during inflammation. |
| Volume: |
114 |
| Issue: |
13 |
| Pages: |
1752-1763 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yocum GT |
| Year: |
2017 |
| Journal: |
Am J Physiol Lung Cell Mol Physiol |
| Title: |
GABAA receptor α4-subunit knockout enhances lung inflammation and airway reactivity in a murine asthma model. |
| Volume: |
313 |
| Issue: |
2 |
| Pages: |
L406-L415 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Doolen S |
| Year: |
2023 |
| Journal: |
F1000Res |
| Title: |
Validation and in vivo characterization of research antibodies for Moesin, CD44, Midkine, and sFRP-1. |
| Volume: |
12 |
|
| Pages: |
1070 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bittner-Eddy PD |
| Year: |
2019 |
| Journal: |
Front Immunol |
| Title: |
Cre-loxP Reporter Mouse Reveals Stochastic Activity of the Foxp3 Promoter. |
| Volume: |
10 |
|
| Pages: |
2228 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Houser MC |
| Year: |
2022 |
| Journal: |
Front Immunol |
| Title: |
Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system. |
| Volume: |
13 |
|
| Pages: |
1056417 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Da Rosa LC |
| Year: |
2018 |
| Journal: |
Diabetologia |
| Title: |
B cell depletion reduces T cell activation in pancreatic islets in a murine autoimmune diabetes model. |
| Volume: |
61 |
| Issue: |
6 |
| Pages: |
1397-1410 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Glant TT |
| Year: |
2001 |
| Journal: |
Arthritis Rheum |
| Title: |
Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice: evidence of genetically acquired resistance to autoimmune disease. |
| Volume: |
44 |
| Issue: |
3 |
| Pages: |
682-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wadsworth S |
| Year: |
1992 |
| Journal: |
J Immunol |
| Title: |
Developmentally regulated expression of the beta 4 integrin on immature mouse thymocytes. |
| Volume: |
149 |
| Issue: |
2 |
| Pages: |
421-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ishii E |
| Year: |
1993 |
| Journal: |
Leukemia |
| Title: |
The induction of CD10 on a pre-B leukemia cell line occurs with progression of the disease in scid mice. |
| Volume: |
7 |
| Issue: |
10 |
| Pages: |
1592-601 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Antica M |
| Year: |
1994 |
| Journal: |
Blood |
| Title: |
Thymic stem cells in mouse bone marrow. |
| Volume: |
84 |
| Issue: |
1 |
| Pages: |
111-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Azuara V |
| Year: |
1997 |
| Journal: |
Eur J Immunol |
| Title: |
A novel subset of adult gamma delta thymocytes that secretes a distinct pattern of cytokines and expresses a very restricted T cell receptor repertoire. |
| Volume: |
27 |
| Issue: |
2 |
| Pages: |
544-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fuse Y |
| Year: |
1997 |
| Journal: |
Infect Immun |
| Title: |
CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria in murine listeriosis. |
| Volume: |
65 |
| Issue: |
5 |
| Pages: |
1883-91 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schneider MK |
| Year: |
1998 |
| Journal: |
Scand J Immunol |
| Title: |
CD4-CD8-C.B-17 SCID thymocytes enter the CD4+CD8+ stage in the presence of neonatally grafted T cells. |
| Volume: |
47 |
| Issue: |
5 |
| Pages: |
466-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith SH |
| Year: |
2002 |
| Journal: |
Vet Pathol |
| Title: |
A comparative review of melanocytic neoplasms. |
| Volume: |
39 |
| Issue: |
6 |
| Pages: |
651-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Poggio P |
| Year: |
2014 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Osteopontin-CD44v6 interaction mediates calcium deposition via phospho-Akt in valve interstitial cells from patients with noncalcified aortic valve sclerosis. |
| Volume: |
34 |
| Issue: |
9 |
| Pages: |
2086-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chao T |
| Year: |
2019 |
| Journal: |
Front Genet |
| Title: |
Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice. |
| Volume: |
10 |
|
| Pages: |
124 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mikolajczyk TP |
| Year: |
2019 |
| Journal: |
Br J Pharmacol |
| Title: |
1,2,3,4,6-Penta-O-galloyl-β-d-glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II-induced hypertension. |
| Volume: |
176 |
| Issue: |
12 |
| Pages: |
1951-1965 |
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