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Search results 1501 to 1600 out of 1714 for Dnmt3a

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Type Details Score
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
34092059 | J:351816
First Author: Tovy A
Year: 2022
Journal: Haematologica
Title: Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.
Volume: 107
Issue: 4
Pages: 887-898
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HT Experiment
GSE164265 | Disordered N-Terminal DNMT3A Domain Is Required for Mouse Postnatal Development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE147818 | DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopment disorders [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-58261 | RNA sequencing (RNA-SEQ) of Dnmt1 and Dnmt3a conditional knockout mice
Series Id: GSE58261
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
30478443 | J:291356
First Author: Heyn P
Year: 2019
Journal: Nat Genet
Title: Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions.
Volume: 51
Issue: 1
Pages: 96-105
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Publication
32620778 | J:292959
First Author: Gao L
Year: 2020
Journal: Nat Commun
Title: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
Volume: 11
Issue: 1
Pages: 3355
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Publication
21378119 | J:182982
First Author: Van Emburgh BO
Year: 2011
Journal: Nucleic Acids Res
Title: Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants.
Volume: 39
Issue: 12
Pages: 4984-5002
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Publication
24399935 | J:321049
 
First Author: Wong M
Year: 2013
Journal: Front Cell Neurosci
Title: Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS.
Volume: 7
Pages: 279
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HT Experiment
E-GEOD-42304 | Genome-wide analysis of gene expression in the paraventricular nucleus of Sim1-Cre specific DNMT3a deletion mice
Series Id: GSE42304
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE141587 | Transcriptomic and epigenetic disruptions in excitatory neurons in Dnmt3a conditional knockout mouse
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE81191 | Gene expression profile of Dnmt1 flox/flox, Dnmt3a flox/flox, Dnmt3b flox/flox, cre negative (Wild type) and Dnmt1 flox/flox, Dnmt3a flox/flox, Dnmt3b flox/flox, Rx-cre (Triple mutant) murine retina transcriptomes
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE238226 | Combinational effect of the ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-60334 | DNA methylation analysis and expression profiling during murine embryogenesis and in embryos deficient for DNMT3A or DNMT3B
Series Id: GSE60334
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE211387 | Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration [multiome]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE199882 | Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GXD Expression
GXD Expression
Probe: MGI:3528200
Assay Type: Immunohistochemistry
Annotation Date: 2005-03-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3148228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3528300
Age: postnatal adult
Image: 5L
Note: Dnmt3a and Dnmt3b were not significantly expressed in the same spermatogonia.
Specimen Label: 5L
Detected: true
Specimen Num: 18
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Publication
15105426 | -
First Author: Suetake I
Year: 2004
Journal: J Biol Chem
Title: DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction.
Volume: 279
Issue: 26
Pages: 27816-23
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Allele
Dnmt3a<tm2Smoc> | MGI:7786850
Name: DNA methyltransferase 3A; targeted mutation 2, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Interaction Experiment
Fuks F (2001)
Description: Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription.
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Interaction Experiment
Li YQ (2006)
Description: Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair.
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Interaction Experiment
Chang Y (2011)
Description: MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
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Interaction Experiment
Li JY (2007)
Description: Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog.
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Interaction Experiment
Dhayalan A (2010)
Description: The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation.
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Interaction Experiment
Gowher H (2005)
Description: De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases.
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Protein
O88508-2
Organism: Mus musculus/domesticus
Length: 689  
Fragment?: false
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HT Experiment
E-GEOD-23512 | Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise
Series Id: GSE23512
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE19367 | Gene expression changes in mouse forebrain deficient in Dnmt1 and Dnmt3a
Series Id: E-GEOD-19367
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE49715 | Large conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a [RNA-Seq]
Series Id: E-GEOD-49715
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
33087320 | J:302211
First Author: Venugopal K
Year: 2021
Journal: Cancer Res
Title: Alterations to DNMT3A in Hematologic Malignancies.
Volume: 81
Issue: 2
Pages: 254-263
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Strain
MGI:7788678 | C57BL/6JSmoc-Dnmt3a<tm2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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HT Experiment
GSE162585 | RNAseq on Id4-GFP bright + med germ cells (~SSC) at 10dpp
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Dnmt3a<tm1Smoc> | MGI:7289378
Name: DNA methyltransferase 3A; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Dnmt3a<tm1(DNMT3A*R882H)Mbp> | MGI:7469610
Name: DNA methyltransferase 3A; targeted mutation 1, Mouse Biology Program, UC Davis
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence
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Publication
11350943 | -
First Author: Fuks F
Year: 2001
Journal: EMBO J
Title: Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription.
Volume: 20
Issue: 10
Pages: 2536-44
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Publication
16567415 | -
First Author: Takeshima H
Year: 2006
Journal: J Biochem
Title: Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA.
Volume: 139
Issue: 3
Pages: 503-15
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Publication
20547484 | -
First Author: Dhayalan A
Year: 2010
Journal: J Biol Chem
Title: The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation.
Volume: 285
Issue: 34
Pages: 26114-20
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Publication
22086334 | -
 
First Author: Chang Y
Year: 2011
Journal: Nat Commun
Title: MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Volume: 2
Pages: 533
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Publication
16026162 | -
First Author: Gowher H
Year: 2005
Journal: Biochemistry
Title: De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases.
Volume: 44
Issue: 29
Pages: 9899-904
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HT Experiment
GSE162584 | RNAseq on whole testis at 19dpp and 25dpp
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE162587 | scRNA-seq on germ cells or whole testis at 10dpp
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tg(Dnmt3a-EGFP)DH58Gsat | MGI:4847000
Name: transgene insertion DH58 GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:6354740 | C57BL/6JSmoc-Dnmt3a<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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HT Experiment
GSE212844 | NSD1 deposits Histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE141877 | Maternal DNMT3A-dependent de novo methylation of the zygotic paternal genome inhibits gene expression in the early embryo
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Strain
MGI:5003584 | STOCK Tg(Dnmt3a-EGFP)DH58Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Dnmt3a<tm1Trow> | MGI:6188116
Name: DNA methyltransferase 3A; targeted mutation 1, Jennifer Trowbridge
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence
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Allele
Tg(CAG-EGFP,-mCherry,-Dnmt3a,-Dnmt3l)akYaob | MGI:6458803
Name: transgene insertion ak, Yayoi Obata
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Allele
Tg(CAG-EGFP,-mCherry,-Dnmt3a,-Dnmt3l)qYaob | MGI:6458805
Name: transgene insertion q, Yayoi Obata
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Allele
Dnmt3a<tm1.1Miku> | MGI:7263259
Name: DNA methyltransferase 3A; targeted mutation 1.1, Mineo Kurokawa
Allele Type: Targeted
Attribute String: Conditional ready
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Publication
15861382 | -
First Author: Chen ZX
Year: 2005
Journal: J Cell Biochem
Title: Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family.
Volume: 95
Issue: 5
Pages: 902-17
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Publication
24952347 | -
 
First Author: Pacaud R
Year: 2014
Journal: Biochimie
Title: DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1.
Volume: 104
Pages: 36-49
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Protein Domain
IPR030486 | DNMT3L
Type: Family
Description: DNA (cytosine-5)-methyltransferase 3-like (DNMT3L) is an enzymatically inactive regulatory factor of de novoDNA methyltransferases DNMT3A and DNMT3AB [, , ]. It is related in sequence to DNMT3A and DNMT3B, but lacks cytosine methyltransferase activity due to the absence of catalytic residues. It recognises histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2 []. It interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences []. In mouse embryonic stem cells, DNMT3L functions as a negative regulator of methylation at promoters of bivalent genes whereas favours DNA methylation at gene bodies of housekeeping genes [].
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Strain
MGI:6188123 | B6(Cg)-Dnmt3a<tm1Trow>/J
Attribute String: targeted mutation, mutant strain
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Allele
Tg(CAG-EGFP,-mCherry,-Dnmt3a,-Dnmt3l)#Yaob | MGI:6458812
Name: transgene insertion, Yayoi Obata
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Protein Domain
IPR044108 | ADD_DNMT3A
Type: Domain
Description: In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. DNMT3A exists in an autoinhibitory form that can be activated by the histone H3 tail in a DNMT3L-independent manner []. DNMT3A has been linked to cancers [, , ].This entry represents the ADDz domain found in DNA (cytosine-5)-methyltransferase 3A (DNMT3A). The ADD domain is composed of three clearly distinguishable modules that pack together through extensive hydrophobic interactions to form a single globular domain. Packed against this GATA-like finger is a second subdomain, which binds two zinc ions and closely resembles the structure reported for several PHD fingers. Finally, there is a long C-terminal α-helix that runs out from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain close together. This combination of fused GATA-like and PHD fingers within a single domain is thus far unique [, ].The ADD domains of the DNMT3 family have a decisive role in blocking DNMT activity in the areas of the genome with chromatin containing methylated H3K4. Furthermore, the ADD domain of DNMMT3A (ADD-3A) competes with the chromodomain (CD) of heterochromatin protein 1 alpha (HP1alpha, CDHP1alpha) for binding to the H3 tail. The DNA methyltransferase (DNMT) 3 family members DNMT3A and DNMT3B and the DNMT3-like non-enzymatic regulatory factor DNMT3L, are involved in de-novo establishment of DNA methylation patterns in early mammalian development [, ].
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HT Experiment
GSE229225 | DNA methylation constrains nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE130735 | Genome-wide roles of DNA methyltransferases in mouse embryos
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
39423815 | J:358051
First Author: Liu M
Year: 2024
Journal: Cancer Cell
Title: IL-1 signaling in aging and cancer: An inflammaging feedback loop unveiled.
Volume: 42
Issue: 11
Pages: 1820-1822
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Protein Domain
IPR040552 | DNMT3_ADD
Type: Domain
Description: This is a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, AD-DATRX) found in DNMT3A proteins. The ADD domain is composed of three clearly distinguishable modules that packtogether through extensive hydrophobic interactions to form a single globulardomain. Packed against this GATA-like finger is a second subdomain,which binds two zinc ions and closely resembles the structure reported forseveral PHD fingers. Finally, there is a long C-terminal α-helix that runsout from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain closetogether. This combination of fused GATA-like and PHD fingers within a singledomain is thus far unique [, ].The ADD domains of the DNMT3 family have a decisive role in blocking DNMT activity in the areas of the genome with chromatin containing methylated H3K4. Furthermore, the ADD domain of DNMMT3A (ADD-3A) competes with the chromodomain (CD) of heterochromatin protein 1 alpha (HP1alpha, CDHP1alpha) for binding to the H3 tail. The DNA methyltransferase (DNMT) 3 family members DNMT3A and DNMT3B and the DNMT3-like non-enzymatic regulatory factor DNMT3L, are involved in de-novo establishment of DNA methylation patterns in early mammalian development [, ].
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HT Experiment
GSE97314 | Microarray analysis of mouse skeletal muscle atrophied by aging
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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Strain
MGI:6286131 | B6.Cg-Dnmt3a<tm1Trow> Tg(Mx1-cre)1Cgn
Attribute String: targeted mutation, mutant strain, congenic
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Genotype
Genotype
Symbol: Dnmt3a/Dnmt3a<+> Tg(Mx1-cre)1Cgn/?
Background: B6.Cg-Dnmt3a Tg(Mx1-cre)1Cgn
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
E-GEOD-76261 | DNA demethylation by Tet dioxygenases controls gastrula patterning by regulating Lefty-Nodal signaling
Series Id: GSE76261
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
19834512 | -
First Author: Otani J
Year: 2009
Journal: EMBO Rep
Title: Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain.
Volume: 10
Issue: 11
Pages: 1235-41
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Publication
17609377 | -
First Author: Argentaro A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
Volume: 104
Issue: 29
Pages: 11939-44
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HT Experiment
GSE148150 | NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE94089 | DNA methylation regulates nephron progenitor cell renewal and differentiation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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