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Search results 1501 to 1600 out of 1648 for Dnmt3b

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Type Details Score
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
E-GEOD-19597 | Deregulated expression programs in the hypomorphic Dnmt3b mutant mice
Series Id: GSE19597
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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GXD Expression
GXD Expression
Probe: MGI:1860227
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6360284
Age: postnatal adult
Image: 3L
Note: Co-expression with Dnmt3b rarely observed.
Specimen Label: 3L
Detected: true
Specimen Num: 3
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Publication
32620778 | J:292959
First Author: Gao L
Year: 2020
Journal: Nat Commun
Title: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
Volume: 11
Issue: 1
Pages: 3355
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HT Experiment
GSE81191 | Gene expression profile of Dnmt1 flox/flox, Dnmt3a flox/flox, Dnmt3b flox/flox, cre negative (Wild type) and Dnmt1 flox/flox, Dnmt3a flox/flox, Dnmt3b flox/flox, Rx-cre (Triple mutant) murine retina transcriptomes
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-60334 | DNA methylation analysis and expression profiling during murine embryogenesis and in embryos deficient for DNMT3A or DNMT3B
Series Id: GSE60334
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
27912755 | J:240639
First Author: Tarusawa E
Year: 2016
Journal: BMC Biol
Title: Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins.
Volume: 14
Issue: 1
Pages: 103
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HT Experiment
E-GEOD-52477 | Lsh regulates LTR retrotransposon repression independent of Dnmt3b function (RNA-Seq)
Series Id: GSE52477
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
23894490 | -
First Author: Gordon CA
Year: 2013
Journal: PLoS One
Title: Inactive DNMT3B splice variants modulate de novo DNA methylation.
Volume: 8
Issue: 7
Pages: e69486
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Protein
O88509
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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GXD Expression
GXD Expression
Probe: MGI:2177286
Assay Type: Immunohistochemistry
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1734919
Pattern: Single cells
Stage: TS19
Assay Id: MGI:3528389
Age: embryonic day 11.5
Image: 3H,I
Note: The cells expressing Dnmt3b expressed CD34, and vice versa.
Specimen Label: 3H,I
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:2177286
Assay Type: Immunohistochemistry
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1633219
Pattern: Single cells
Stage: TS19
Assay Id: MGI:3528389
Age: embryonic day 11.5
Image: 3H,I
Note: The cells expressing Dnmt3b expressed CD34, and vice versa.
Specimen Label: 3H,I
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:2177286
Assay Type: Immunohistochemistry
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:3528389
Age: embryonic day 11.5
Image: 2A
Note: The cells expressing Dnmt3b expressed CD34, and vice versa.
Specimen Label: 2A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:2177286
Assay Type: Immunohistochemistry
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:3528389
Age: embryonic day 11.5
Image: 3E
Note: The cells expressing Dnmt3b expressed CD34, and vice versa.
Specimen Label: 3E
Detected: true
Specimen Num: 2
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Interaction Experiment
Velasco G (2010)
Description: Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues.
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Interaction Experiment
Xie ZH (2006)
Description: Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L.
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Interaction Experiment
Li JY (2007)
Description: Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog.
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HT Experiment
GSE115670 | yylncT acts as a gatekeeper of the mesodermal transcriptional program by local modulation of DNMT3B [mouse]
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Protein
O88509-2
Organism: Mus musculus/domesticus
Length: 839  
Fragment?: false
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Protein
O88509-3
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: false
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Protein
O88509-4
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: false
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Publication
25198254 | -
First Author: Walton EL
Year: 2014
Journal: Biology (Basel)
Title: Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for Diseases.
Volume: 3
Issue: 3
Pages: 578-605
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Allele
Dnmt3b<tm1Smoc> | MGI:7289379
Name: DNA methyltransferase 3B; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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GXD Expression
GXD Expression
Probe: MGI:3525854
Assay Type: Immunohistochemistry
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3148228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3528428
Age: postnatal adult
Image: 5L
Note: Dnmt3a and Dnmt3b were not significantly expressed in the same spermatogonia.
Specimen Label: 5L
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:3525854
Assay Type: Immunohistochemistry
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:3528428
Age: embryonic day 11.5
Image: 2F
Note: The cells expressing Dnmt3b did not express a significant amount of Dnmt3a, and vice versa.
Specimen Label: 2F
Detected: true
Specimen Num: 1
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Publication
16567415 | -
First Author: Takeshima H
Year: 2006
Journal: J Biochem
Title: Distinct DNA methylation activity of Dnmt3a and Dnmt3b towards naked and nucleosomal DNA.
Volume: 139
Issue: 3
Pages: 503-15
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Publication
12567489 | -
First Author: Yin B
Year: 1999
Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao
Title: [Cloning of full-length Dnmt3b cDNA and its alternative splicing isoforms in mouse embryo].
Volume: 21
Issue: 6
Pages: 431-8
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Publication
15105426 | -
First Author: Suetake I
Year: 2004
Journal: J Biol Chem
Title: DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction.
Volume: 279
Issue: 26
Pages: 27816-23
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Allele
Dnmt3b<tm1Enl> | MGI:2182409
Name: DNA methyltransferase 3B; targeted mutation 1, En Li
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Dnmt3b<tm6Enl> | MGI:3628446
Name: DNA methyltransferase 3B; targeted mutation 6, En Li
Allele Type: Targeted
Attribute String: Humanized sequence, Hypomorph
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Allele
Dnmt3b<tm7Enl> | MGI:3628447
Name: DNA methyltransferase 3B; targeted mutation 7, En Li
Allele Type: Targeted
Attribute String: Not Specified
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Strain
MGI:6354741 | C57BL/6JSmoc-Dnmt3b<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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HT Experiment
GSE132952 | Methylation and gene expression data from Dnmt3b+/+, Dnmt3b-/- and Dnmt3bCI/CI embryos harvested at E11.5
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
31353180 | -
First Author: Allu PK
Year: 2019
Journal: Curr Biol
Title: Structure of the Human Core Centromeric Nucleosome Complex.
Volume: 29
Issue: 16
Pages: 2625-2639.e5
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Protein Domain
IPR028931 | CENP-C_mid
Type: Domain
Description: CENP-C is a component of the centromere assembly complex in eukaryotes. CENP-C recruits the DNA methyltransferases DNMT3B, in order to establish the necessary epigenetic DNA-methylation essential for maintenance of chromatin structure and genomic stability. This entry represents the middle DNMT3B binding region of CENP-C. Binding of CENP-C and DNMT3B to DNA occurs at both centromeric and peri-centromeric satellite repeats. CENP-C and DNMT3B regulate the histone code in these regions [, , ].
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Genotype
Genotype
Symbol: Dnmt3b/Dnmt3b
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dnmt3a/Dnmt3a Dnmt3b/Dnmt3b
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dnmt3b/Dnmt3b
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dnmt3b/Dnmt3b
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dnmt3b/Dnmt3b
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dnmt3b/Dnmt3b
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dnmt3b/Dnmt3b
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0090008 | immunodeficiency-centromeric instability-facial anomalies syndrome 1
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HT Experiment
GSE203226 | Mechanisms and function of de novo DNA methylation in placental development [snRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE203291 | Mechanisms and function of de novo DNA methylation in placental development [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE80378 | Identification of genes regulated by REST in developing hearts
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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DO Term
DOID:0060918 | facioscapulohumeral muscular dystrophy 4
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Publication
22621904 | J:185714
First Author: Yamaguchi R
Year: 2012
Journal: Mol Biol Cell
Title: Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa.
Volume: 23
Issue: 14
Pages: 2671-9
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Protein
Q569E4
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
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Protein
D3YUZ7
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
G9MDF2
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
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Protein Domain
IPR029292 | MENT
Type: Family
Description: This entry represents protein MENT (methylated in normal thymocytes protein), which is involved in control of cellular proliferation. It is an onconcogenic modifier contributing to the tumour suppressor function of DNMT3B (DNA methyltransferase 3B) []. This entry also includes the mouse Pmis1 protein that may regulate sperm transport into the oviducts and function in modulating sperm-zona binding [].
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HT Experiment
GSE229225 | DNA methylation constrains nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
G3UX07
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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Protein
Q3TYD7
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
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Protein
G3UX63
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
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Protein Domain
IPR030487 | DNMT3A
Type: Family
Description: In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. DNMT3A exists in an autoinhibitory form that can be activated by the histone H3 tail in a DNMT3L-independent manner []. DNMT3A has been linked to cancers [, , ].
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Protein
Q3UPF6
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: true
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Protein
Q9CRZ7
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: true
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Publication
18701705 | -
First Author: Cohen RL
Year: 2008
Journal: Mol Biol Cell
Title: Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein.
Volume: 19
Issue: 10
Pages: 4480-91
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Protein Domain
IPR030488 | DNMT3B_ADD
Type: Domain
Description: This entry represents the ADD domain of DNMT3B. The ADD domain is composed of three clearly distinguishable modules that packtogether through extensive hydrophobic interactions to form a single globulardomain. Packed against this GATA-like finger is a second subdomain,which binds two zinc ions and closely resembles the structure reported forseveral PHD fingers. Finally, there is a long C-terminal α-helix that runsout from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain closetogether. This combination of fused GATA-like and PHD fingers within a singledomain is thus far unique [, ].In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. Many DNMT3B isoforms from alternative splicing have been described, among which DNMT3B3 stimulates the basal activity of DNMT3 enzymes, but partially inhibits the stimulatory effect of DNMT3L, whereas DNMT3B4 significantly impairs de novo methylation [, ]. DNMT3B is involved in development and is associated with several diseases, including cancers [].
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HT Experiment
GSE130735 | Genome-wide roles of DNA methyltransferases in mouse embryos
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
21304883 | -
First Author: Sharma S
Year: 2011
Journal: PLoS Genet
Title: Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance.
Volume: 7
Issue: 2
Pages: e1001286
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Publication
1 | -
First Author: Makar AB
Year: 1975
Journal: Biochem Med
Title: Formate assay in body fluids: application in methanol poisoning.
Volume: 13
Issue: 2
Pages: 117-26
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Publication
2 | -
First Author: Bose KS
Year: 1975
Journal: Biochem Biophys Res Commun
Title: Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution.
Volume: 66
Issue: 4
Pages: 1173-9
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Publication
25416277 | J:221203
First Author: Mayle A
Year: 2015
Journal: Blood
Title: Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Volume: 125
Issue: 4
Pages: 629-38
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Publication
25416276 | J:221204
First Author: Celik H
Year: 2015
Journal: Blood
Title: Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation.
Volume: 125
Issue: 4
Pages: 619-28
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Publication
25383530 | -
First Author: Guo X
Year: 2015
Journal: Nature
Title: Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.
Volume: 517
Issue: 7536
Pages: 640-4
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Publication
25358520 | -
First Author: Santos GC Jr
Year: 2015
Journal: J Cell Biochem
Title: Epigenetic modifications, chromatin distribution and TP53 transcription in a model of breast cancer progression.
Volume: 116
Issue: 4
Pages: 533-41
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Protein Domain
IPR044108 | ADD_DNMT3A
Type: Domain
Description: In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. DNMT3A exists in an autoinhibitory form that can be activated by the histone H3 tail in a DNMT3L-independent manner []. DNMT3A has been linked to cancers [, , ].This entry represents the ADDz domain found in DNA (cytosine-5)-methyltransferase 3A (DNMT3A). The ADD domain is composed of three clearly distinguishable modules that pack together through extensive hydrophobic interactions to form a single globular domain. Packed against this GATA-like finger is a second subdomain, which binds two zinc ions and closely resembles the structure reported for several PHD fingers. Finally, there is a long C-terminal α-helix that runs out from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain close together. This combination of fused GATA-like and PHD fingers within a single domain is thus far unique [, ].The ADD domains of the DNMT3 family have a decisive role in blocking DNMT activity in the areas of the genome with chromatin containing methylated H3K4. Furthermore, the ADD domain of DNMMT3A (ADD-3A) competes with the chromodomain (CD) of heterochromatin protein 1 alpha (HP1alpha, CDHP1alpha) for binding to the H3 tail. The DNA methyltransferase (DNMT) 3 family members DNMT3A and DNMT3B and the DNMT3-like non-enzymatic regulatory factor DNMT3L, are involved in de-novo establishment of DNA methylation patterns in early mammalian development [, ].
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Publication
19834512 | -
First Author: Otani J
Year: 2009
Journal: EMBO Rep
Title: Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain.
Volume: 10
Issue: 11
Pages: 1235-41
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Publication
36045674 | J:327921
 
First Author: Luo Y
Year: 2022
Journal: Front Immunol
Title: EZH2 restricts Tcf7 DNA methylation and promotes TFH differentiation during acute viral infection.
Volume: 13
Pages: 942465
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HT Experiment
GSE204906 | Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during early mammalian organogenesis [10X_Dnmt]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
P49452
Organism: Mus musculus/domesticus
Length: 906  
Fragment?: false
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Publication
17609377 | -
First Author: Argentaro A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX.
Volume: 104
Issue: 29
Pages: 11939-44
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HT Experiment
E-GEOD-76261 | DNA demethylation by Tet dioxygenases controls gastrula patterning by regulating Lefty-Nodal signaling
Series Id: GSE76261
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
21553025 | J:201510
First Author: Roberts AR
Year: 2011
Journal: Chromosoma
Title: Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo.
Volume: 120
Issue: 4
Pages: 377-85
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Publication
33235983 | J:319943
First Author: Wei G
Year: 2020
Journal: iScience
Title: The PWWP2A Histone Deacetylase Complex Represses Intragenic Spurious Transcription Initiation in mESCs.
Volume: 23
Issue: 11
Pages: 101741
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Publication
10857753 | J:62173
First Author: Aapola U
Year: 2000
Journal: Genomics
Title: Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.
Volume: 65
Issue: 3
Pages: 293-8
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Publication
29323282 | J:308602
First Author: Hanna CW
Year: 2018
Journal: Nat Struct Mol Biol
Title: MLL2 conveys transcription-independent H3K4 trimethylation in oocytes.
Volume: 25
Issue: 1
Pages: 73-82
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Publication
22138693 | J:179661
First Author: Challen GA
Year: 2011
Journal: Nat Genet
Title: Dnmt3a is essential for hematopoietic stem cell differentiation.
Volume: 44
Issue: 1
Pages: 23-31
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Publication
22011581 | J:180053
First Author: Gao Q
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.
Volume: 108
Issue: 44
Pages: 18061-6
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Publication
22094255 | J:178953
First Author: O'Hagan HM
Year: 2011
Journal: Cancer Cell
Title: Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.
Volume: 20
Issue: 5
Pages: 606-19
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Publication
14973270 | J:88571
First Author: Sado T
Year: 2004
Journal: Development
Title: De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation.
Volume: 131
Issue: 5
Pages: 975-82
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Publication
23153537 | J:194384
First Author: Mishra A
Year: 2012
Journal: Cancer Cell
Title: Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation.
Volume: 22
Issue: 5
Pages: 645-55
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Publication
24336466 | J:207899
 
First Author: Dan J
Year: 2013
Journal: Sci Rep
Title: Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells.
Volume: 3
Pages: 3492
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Publication
27184841 | J:235758
First Author: Yang J
Year: 2016
Journal: Cell Rep
Title: Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs.
Volume: 15
Issue: 8
Pages: 1809-21
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Publication
31015495 | J:275556
First Author: Sendžikaitė G
Year: 2019
Journal: Nat Commun
Title: A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice.
Volume: 10
Issue: 1
Pages: 1884
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Publication
34518230 | J:310976
 
First Author: Kinoshita M
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory.
Volume: 118
Issue: 38
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Protein
G3UXY2
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: true
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Protein
Q3UWR0
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Protein
G3UZN5
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: true
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Protein
G3UZF8
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
G3UZK0
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
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Protein Domain
IPR040552 | DNMT3_ADD
Type: Domain
Description: This is a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, AD-DATRX) found in DNMT3A proteins. The ADD domain is composed of three clearly distinguishable modules that packtogether through extensive hydrophobic interactions to form a single globulardomain. Packed against this GATA-like finger is a second subdomain,which binds two zinc ions and closely resembles the structure reported forseveral PHD fingers. Finally, there is a long C-terminal α-helix that runsout from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain closetogether. This combination of fused GATA-like and PHD fingers within a singledomain is thus far unique [, ].The ADD domains of the DNMT3 family have a decisive role in blocking DNMT activity in the areas of the genome with chromatin containing methylated H3K4. Furthermore, the ADD domain of DNMMT3A (ADD-3A) competes with the chromodomain (CD) of heterochromatin protein 1 alpha (HP1alpha, CDHP1alpha) for binding to the H3 tail. The DNA methyltransferase (DNMT) 3 family members DNMT3A and DNMT3B and the DNMT3-like non-enzymatic regulatory factor DNMT3L, are involved in de-novo establishment of DNA methylation patterns in early mammalian development [, ].
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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