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Search results 1501 to 1600 out of 2033 for Epha4

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Type Details Score
Publication
11114734 | J:66153
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
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Publication
22967998 | J:190524
First Author: Shalom-Barak T
Year: 2012
Journal: Dev Biol
Title: Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.
Volume: 372
Issue: 1
Pages: 143-55
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Publication
11044609 | J:65651
First Author: Neidhardt L
Year: 2000
Journal: Mech Dev
Title: Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos.
Volume: 98
Issue: 1-2
Pages: 77-94
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Publication
19334288 | J:148410
First Author: Combes AN
Year: 2009
Journal: Dev Dyn
Title: Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.
Volume: 238
Issue: 5
Pages: 1033-41
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
16919269 | J:112701
First Author: Bailey PJ
Year: 2006
Journal: Exp Cell Res
Title: A global genomic transcriptional code associated with CNS-expressed genes.
Volume: 312
Issue: 16
Pages: 3108-19
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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GXD Expression
GXD Expression
Probe: MGI:1095428
Assay Type: RNA in situ
Annotation Date: 1999-06-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1615113
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:1337661
Age: embryonic day 8.5
Image: 3.B
Note: Expression is coincident with Epha4 (Sek-1) expression.
Specimen Label: 3.B
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:1095428
Assay Type: RNA in situ
Annotation Date: 1999-06-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1629713
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:1337661
Age: embryonic day 8.5
Image: 3.B
Note: Expression is coincident with Epha4 (Sek-1) expression.
Specimen Label: 3.B
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:1095428
Assay Type: RNA in situ
Annotation Date: 1999-06-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1630513
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:1337661
Age: embryonic day 8.5
Image: 3.B
Note: Expression is coincident with Epha4 (Sek-1) expression.
Specimen Label: 3.B
Detected: true
Specimen Num: 4
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Publication
37941008 | J:342371
First Author: Soliman E
Year: 2023
Journal: J Neuroinflammation
Title: Efferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/MERTK signaling following brain injury.
Volume: 20
Issue: 1
Pages: 256
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Publication
32958852 | J:296345
First Author: Greer K
Year: 2020
Journal: Sci Rep
Title: Abrogation of atypical neurogenesis and vascular-derived EphA4 prevents repeated mild TBI-induced learning and memory impairments.
Volume: 10
Issue: 1
Pages: 15374
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Publication
23983218 | -
First Author: Stiffel V
Year: 2014
Journal: J Bone Miner Res
Title: EphA4 receptor is a novel negative regulator of osteoclast activity.
Volume: 29
Issue: 4
Pages: 804-19
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Interaction Experiment
Bourgin C (2007)
Description: The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways.
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Publication
18837080 | -
First Author: Oki M
Year: 2008
Journal: World J Gastroenterol
Title: Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers.
Volume: 14
Issue: 37
Pages: 5650-6
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Publication
21542907 | -
 
First Author: Clifford MA
Year: 2011
Journal: Neural Dev
Title: EphA4 expression promotes network activity and spine maturation in cortical neuronal cultures.
Volume: 6
Pages: 21
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Publication
20678482 | -
First Author: Singla N
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations.
Volume: 399
Issue: 4
Pages: 555-9
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Publication
21931787 | -
First Author: Goldshmit Y
Year: 2011
Journal: PLoS One
Title: EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in mice.
Volume: 6
Issue: 9
Pages: e24636
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Publication
22318127 | -
First Author: Frugier T
Year: 2012
Journal: J Neuropathol Exp Neurol
Title: Expression and activation of EphA4 in the human brain after traumatic injury.
Volume: 71
Issue: 3
Pages: 242-50
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Publication
17911252 | -
First Author: Shi L
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse.
Volume: 104
Issue: 41
Pages: 16347-52
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Publication
24265799 | -
First Author: Han X
Year: 2013
Journal: PLoS One
Title: Discovery and characterization of a novel cyclic peptide that effectively inhibits ephrin binding to the EphA4 receptor and displays anti-angiogenesis activity.
Volume: 8
Issue: 11
Pages: e80183
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GXD Expression
GXD Expression
Probe: MGI:4453648
Assay Type: RNA in situ
Annotation Date: 2015-11-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5696231
Age: embryonic day 15.5
Image: 2D/F
Note: There was colocalization with Epha4 in the anterior region of the dorsal thalamus and in ventral structures.
Specimen Label: 2D/F
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5695625
Assay Type: RNA in situ
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754025
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5696230
Age: embryonic day 17.5
Image: 3C,E,F
Note: Predominantly medioventrally expressed. There was overlap in the domains of Epha4 and Epha7, but no overlap with Efna5.
Specimen Label: 3C,E,F
Detected: true
Specimen Num: 4
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Allele
Epha4<rb> | MGI:1857307
 
Name: Eph receptor A4; rabbit
Allele Type: Spontaneous
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GXD Expression
GXD Expression
Probe: MGI:4453648
Assay Type: RNA in situ
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3569825
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5696231
Age: embryonic day 17.5
Image: 3D/F
Note: Expression was detected at the ventral edge of the ventral posterior nucleus. There was overlap with Epha4 in a lateral portion.
Specimen Label: 3D/F
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:4453648
Assay Type: RNA in situ
Annotation Date: 2015-11-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5696231
Age: embryonic day 14.5
Image: 1H/J
Note: Expression was detected at the dorsal and ventral edges of the dorsal thalamus. Expression was largely distinct from cells expressing Epha4 and Epha7.
Specimen Label: 1H/J
Detected: true
Specimen Num: 1
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Publication
17875741 | -
First Author: Bourgin C
Year: 2007
Journal: J Cell Biol
Title: The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways.
Volume: 178
Issue: 7
Pages: 1295-307
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Strain
MGI:2173975 | B6 x STOCK Epha4<rb>/J
Attribute String: mutant stock, spontaneous mutation
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Strain
MGI:2163761 | C3Sn.B6-Epha4<rb>/EiGrsrJ
Attribute String: congenic, mutant strain, spontaneous mutation
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Allele
Tg(CAG-Epha4/Efna5,-mCherry)1Slp | MGI:5307247
Name: transgene insertion 1, Samuel L Pfaff
Allele Type: Transgenic
Attribute String: Reporter
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Genotype
Genotype
Symbol: Epha4/Epha4
Background: B6 x STOCK Epha4/J
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:5307259 | B6;C-Tg(CAG-Epha4/Efna5,-mCherry)1Slp/J
Attribute String: transgenic, mutant stock
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Publication
25209247 | -
First Author: Evren S
Year: 2014
Journal: Development
Title: EphA4-dependent Brachyury expression is required for dorsal mesoderm involution in the Xenopus gastrula.
Volume: 141
Issue: 19
Pages: 3649-61
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Publication
24477991 | -
First Author: Hu Y
Year: 2014
Journal: Neurosci Bull
Title: Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse.
Volume: 30
Issue: 3
Pages: 425-32
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Publication
22997698 | -
First Author: Zozulya SA
Year: 2012
Journal: Bioorg Khim
Title: [Eph family receptors as therapeutic targets].
Volume: 38
Issue: 3
Pages: 267-79
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Publication
25405504 | -
First Author: Tognolini M
Year: 2014
Journal: ACS Chem Neurosci
Title: Are we using the right pharmacological tools to target EphA4?
Volume: 5
Issue: 12
Pages: 1146-7
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Protein Domain
IPR030602 | EphA4_SAM
Type: Domain
Description: This entry represents the SAM domain of EPH-A4. It is a C-terminal potential protein-protein interaction domain [].Ephrin receptors (Ephs) are a group of receptor tyrosine kinases that are activated in response to binding ephrin ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells [].Ephrin type-A receptor 4 (EphA4) is highly promiscuou; it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands []. It is involved in development [, ], supporting spine maturation [, , ], axon guidance [, ]and assembly of neuronal locomotor circuits [, ]. EphA4 is the most abundant ephrin receptor in the nervous system. Mice lacking the EphA4 exhibit pronounced axonal regeneration and functional recovery following spinal cord injury [, , ]. In humans EphA4 has been proposed to be a key actor in neurodegenerative diseases, such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) []. Inhibition of the EphA4-ephrin interaction has been considered as a useful strategy for promoting axon regeneration in the nervous system and a pharmacological tool to treat neurodegenerative disease patients [, ]. EphA4 also plays a role in human cancers. Overexpression of EphA4 is observed in many human cancers []. For instance, overexpression of EphA4 is associated with gastric cancer invasion and recurrence []. Antagonising Eph-ephrin interactions by interfering with the Eph receptor/ephrin system has been suggested to be used in anti-angiogenic cancer therapies [, ]. EphA4 is also a potent negative regulator of osteoclastic activity [].
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Publication
19306875 | J:147984
First Author: Takeuchi S
Year: 2009
Journal: FEBS Lett
Title: Beta2-chimaerin binds to EphA receptors and regulates cell migration.
Volume: 583
Issue: 8
Pages: 1237-42
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Publication
9886291 | -
First Author: Stapleton D
Year: 1999
Journal: Nat Struct Biol
Title: The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization.
Volume: 6
Issue: 1
Pages: 44-9
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Publication
12094214 | -
First Author: Kullander K
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: Mechanisms and functions of Eph and ephrin signalling.
Volume: 3
Issue: 7
Pages: 475-86
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Publication
25370417 | J:221209
First Author: Vaiyapuri S
Year: 2015
Journal: Blood
Title: EphB2 regulates contact-dependent and contact-independent signaling to control platelet function.
Volume: 125
Issue: 4
Pages: 720-30
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Publication
18093944 | J:129166
First Author: Fawcett JP
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Nck adaptor proteins control the organization of neuronal circuits important for walking.
Volume: 104
Issue: 52
Pages: 20973-8
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Publication
20474079 | J:168862
First Author: Hara Y
Year: 2010
Journal: Stem Cells
Title: Impaired hippocampal neurogenesis and vascular formation in ephrin-A5-deficient mice.
Volume: 28
Issue: 5
Pages: 974-83
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Publication
36791184 | J:357328
First Author: Ba R
Year: 2023
Journal: Sci Adv
Title: FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium.
Volume: 9
Issue: 7
Pages: eade2441
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Publication
12115675 | J:77467
First Author: Pickles JO
Year: 2002
Journal: J Comp Neurol
Title: Complementary and layered expression of Ephs and ephrins in developing mouse inner ear.
Volume: 449
Issue: 3
Pages: 207-16
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Publication
35725568 | J:341704
First Author: Bhatia S
Year: 2022
Journal: Nat Commun
Title: EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
Volume: 13
Issue: 1
Pages: 3535
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Protein
Q8CCR7
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: true
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Publication
15507211 | -
First Author: Canagarajah B
Year: 2004
Journal: Cell
Title: Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin.
Volume: 119
Issue: 3
Pages: 407-18
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Publication
23673634 | -
 
First Author: Gutierrez-Uzquiza A
Year: 2013
Journal: Nat Commun
Title: Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.
Volume: 4
Pages: 1849
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Publication
22726444 | J:186252
First Author: Riccomagno MM
Year: 2012
Journal: Cell
Title: The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.
Volume: 149
Issue: 7
Pages: 1594-606
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Publication
19542617 | -
First Author: Simón AM
Year: 2009
Journal: J Alzheimers Dis
Title: Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.
Volume: 17
Issue: 4
Pages: 773-86
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Publication
16939977 | -
First Author: Liu BP
Year: 2006
Journal: Philos Trans R Soc Lond B Biol Sci
Title: Extracellular regulators of axonal growth in the adult central nervous system.
Volume: 361
Issue: 1473
Pages: 1593-610
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Publication
19249276 | -
First Author: Frank CA
Year: 2009
Journal: Neuron
Title: A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels.
Volume: 61
Issue: 4
Pages: 556-69
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Publication
20152127 | J:167656
First Author: Shi L
Year: 2010
Journal: Neuron
Title: Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction.
Volume: 65
Issue: 2
Pages: 204-16
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Protein Domain
IPR037860 | RhoGAP_chimaerin
Type: Domain
Description: This entry represents the RhoGAP (GTPase-activator protein [GAP]for Rho-like small GTPases) domain of chimaerins.Chimaerin is a family of GTPase activating proteins for the small G-protein Rac. Chimaerin family members have been implicated in development, neuritogenesis and cancer []. Several isoforms have been found: alpha1-chimaerin (formerly known as n-chimaerin) and alpha2-chimaerin are alternatively spliced products of a single gene, as are beta1- and beta2-chimaerin []. Both alpha-chimaerin isoforms share identical diacylglycerol-binding (C1) and RacGAP domains. Alpha1- and beta1-chimerin have a relatively short N-terminal region that does not encode any recognizable domains, whereas alpha2- and beta2-chimerin both include a functional SH2 domain that can bind to phosphotyrosine motifs within receptors. It has been shown that alpha-chimaerins inactivate Rac and the alpha1-chimaerin isoform contributes to dendritic retraction events in cultured neurons. Alpha2-chimaerin is an effector for EphA4 in cortical and spinal motor circuits []. Beta2-Chimaerin mediates axonal pruning in the hippocampus [].
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Protein Domain
IPR035840 | Chimaerin_SH2
Type: Domain
Description: Chimaerin is a family of GTPase activating proteins for the small G-protein Rac. Chimaerin family members have been implicated in development, neuritogenesis and cancer []. Several isoforms have been found: alpha1-chimaerin (formerly known as n-chimaerin) and alpha2-chimaerin are alternatively spliced products of a single gene, as are beta1- and beta2-chimaerin []. Both alpha-chimaerin isoforms share identical diacylglycerol-binding (C1) and RacGAP domains. Alpha1- and beta1-chimerin have a relatively short N-terminal region that does not encode any recognizable domains, whereas alpha2- and beta2-chimerin both include a functional SH2 domain that can bind to phosphotyrosine motifs within receptors. It has been shown that alpha-chimaerins inactivate Rac and the alpha1-chimaerin isoform contributes to dendritic retraction events in cultured neurons. Alpha2-chimaerin is an effector for EphA4 in cortical and spinal motor circuits []. Beta2-Chimaerin mediates axonal pruning in the hippocampus [].This entry represents the SH2 domain of alpha2-chimerin and beta2-chimerin.
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Protein Domain
IPR034270 | EphA4_rcpt_lig-bd
Type: Domain
Description: This entry represents the ligand-binding domain found in ephrin type-A receptor 4 (EphA4). A loss of EphA4, as well as EphB2, precedes memory decline in a murine model of Alzheimers disease []. EphA4 has been shown to have a negative effect on axon regeneration and functional restoration in corticospinal lesions and has been implicated in circadian sleep regulation [, ].Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands [, ]. Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) [].
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Protein Domain
IPR017356 | CHN1/CHN2
Type: Family
Description: Chimaerin is a family of GTPase activating proteins for the small G-protein Rac. Chimaerin family members have been implicated in development, neuritogenesis and cancer []. Several isoforms have been found: alpha1-chimaerin (formerly known as n-chimaerin) and alpha2-chimaerin are alternatively spliced products of a single gene, as are beta1- and beta2-chimaerin []. Both alpha-chimaerin isoforms share identical diacylglycerol-binding (C1) and RacGAP domains. Alpha1- and beta1-chimerin have a relatively short N-terminal region that does not encode any recognizable domains, whereas alpha2- and beta2-chimerin both include a functional SH2 domain that can bind to phosphotyrosine motifs within receptors. It has been shown that alpha-chimaerins inactivate Rac and the alpha1-chimaerin isoform contributes to dendritic retraction events in cultured neurons. Alpha2-chimaerin is an effector for EphA4 in cortical and spinal motor circuits []. Beta2-Chimaerin mediates axonal pruning in the hippocampus [].This entry includes alpha-chimaerin (Chn1) and beta-chimaerin (Chn2) from animals.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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