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Search results 1501 to 1600 out of 1720 for Gata2

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Type Details Score
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE134439 | Mapping Gata2 enhancer-dependent developmental trajectories by single-cell RNA-sequencing
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Gata2<tm3.1Sho> | MGI:4837902
 
Name: GATA binding protein 2; targeted mutation 3.1, Stuart Orkin
Allele Type: Targeted
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Publication
39068217 | J:353579
First Author: Jin Z
Year: 2024
Journal: Oncogene
Title: GATA2 promotes castration-resistant prostate cancer development by suppressing IFN-β axis-mediated antitumor immunity.
Volume: 43
Issue: 34
Pages: 2595-2610
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lncRNA Gene
MGI_C57BL6J_6721593 | -
Type: lncRNA_gene
Organism: mouse, laboratory
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Publication
39281699 | J:359017
First Author: Keles M
Year: 2024
Journal: Mol Ther Nucleic Acids
Title: Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling.
Volume: 35
Issue: 3
Pages: 102306
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Publication
24703906 | J:210807
First Author: Yamazaki H
Year: 2014
Journal: Cancer Cell
Title: A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression.
Volume: 25
Issue: 4
Pages: 415-27
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Publication
35286385 | J:326022
First Author: Li L
Year: 2022
Journal: Blood
Title: HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression.
Volume: 139
Issue: 18
Pages: 2797-2815
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Publication
18448565 | J:136715
First Author: Lohmann F
Year: 2008
Journal: Development
Title: Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment.
Volume: 135
Issue: 12
Pages: 2071-82
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Publication
31533351 | J:303395
 
First Author: Ohneda K
Year: 2019
Journal: Int J Mol Sci
Title: Mouse Tryptase Gene Expression is Coordinately Regulated by GATA1 and GATA2 in Bone Marrow-Derived Mast Cells.
Volume: 20
Issue: 18
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HT Experiment
GSE39300 | Gene expression changes in embryonic PECAM-1+ cells from Gata2 +9.5 enhancer targeted mice
Series Id: E-GEOD-39300
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Regulatory Region
MGI:7330386 | Rr249
Type: enhancer
Organism: mouse, laboratory
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Regulatory Region
MGI:7331506 | Rr251
Type: TF_binding_site
Organism: mouse, laboratory
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Regulatory Region
MGI:6840235 | Rr127
Type: enhancer
Organism: mouse, laboratory
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DO Term
DOID:0111947 | immunodeficiency 21
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HT Experiment
GSE184045 | Lymphatic endothelial cell identity is controlled by a GATA2 bound enhancer (Microarray)
 
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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HT Sample
GSM2829000
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 10.5
Stage: 17
Structure . Name: aorta-gonad-mesonephros
Notes: Sorted CD31+ cKit+ cells with intermediate levels of Gata2 reporter expression
Curation Status: Curated
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HT Sample
GSM2829001
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 10.5
Stage: 17
Structure . Name: aorta-gonad-mesonephros
Notes: Sorted CD31+ cKit+ cells with intermediate levels of Gata2 reporter expression
Curation Status: Curated
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HT Sample
GSM2829002
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 10.5
Stage: 17
Structure . Name: aorta-gonad-mesonephros
Notes: Sorted CD31+ cKit+ cells with intermediate levels of Gata2 reporter expression
Curation Status: Curated
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HT Sample
GSM2829003
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 10.5
Stage: 17
Structure . Name: aorta-gonad-mesonephros
Notes: Sorted CD31+ cKit+ cells with high levels of Gata2 reporter expression
Curation Status: Curated
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HT Sample
GSM2829004
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 10.5
Stage: 17
Structure . Name: aorta-gonad-mesonephros
Notes: Sorted CD31+ cKit+ cells with high levels of Gata2 reporter expression
Curation Status: Curated
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HT Sample
GSM2829005
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 10.5
Stage: 17
Structure . Name: aorta-gonad-mesonephros
Notes: Sorted CD31+ cKit+ cells with high levels of Gata2 reporter expression
Curation Status: Curated
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HT Experiment
GSE76254 | Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitors
Series Id: E-GEOD-76254
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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CL Term
CL:0000557 | granulocyte monocyte progenitor cell
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Publication
21892158 | -
First Author: Ostergaard P
Year: 2011
Journal: Nat Genet
Title: Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome).
Volume: 43
Issue: 10
Pages: 929-31
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Publication
21892162 | -
First Author: Hahn CN
Year: 2011
Journal: Nat Genet
Title: Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia.
Volume: 43
Issue: 10
Pages: 1012-7
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DO Term
DOID:0081083 | acute myeloid leukemia with inv(3) (q21.3;q26.2) or t(3;3) (q21.3;q26.2)
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Publication
32241909 | J:292104
First Author: Ray S
Year: 2020
Journal: J Biol Chem
Title: Sterile α-motif domain requirement for cellular signaling and survival.
Volume: 295
Issue: 20
Pages: 7113-7125
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Publication
21670465 | -
First Author: Hsu AP
Year: 2011
Journal: Blood
Title: Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome.
Volume: 118
Issue: 10
Pages: 2653-5
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Allele
Rr250<em1Ebres> | MGI:6363029
Name: regulatory region 250; endonuclease-mediated mutation 1, Emery H Bresnick
Allele Type: Endonuclease-mediated
Attribute String: Hypomorph, Modified regulatory region
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HT Experiment
GSE89354 | Gene expression differences between Gata2cko and wt mouse rhombomere 1
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE208110 | Gene expression differences between Gata2cko and wt mouse midbrain
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE127702 | Transcripts identified by microarray analysis that were deregulated in E14.5 Tbx18cre/+;Gata2fl/fl (Gata2cKO) ureters
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Allele
Rr249<tm1.1Ebres> | MGI:5466176
 
Name: regulatory region 249; targeted mutation 1.1, Emery H Bresnick
Allele Type: Targeted
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Allele
Rr251<tm2.1Ebres> | MGI:5605695
Name: regulatory region 251; targeted mutation 2.1, Emery H Bresnick
Allele Type: Targeted
Attribute String: Modified regulatory region, No functional change
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Allele
Rr127<tm3.1Ebres> | MGI:6194744
Name: regulatory region 127; targeted mutation 3.1, Emery H Bresnick
Allele Type: Targeted
Attribute String: Modified regulatory region
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Strain
MGI:6363065 | C57BL/6N-Rr250<em1Ebres>
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
35713400 | J:326600
   
First Author: Ray S
Year: 2022
Journal: Elife
Title: Functional requirements for a Samd14-capping protein complex in stress erythropoiesis.
Volume: 11
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Genotype
Genotype
Symbol: Rr250/Rr250
Background: C57BL/6N-Rr250
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr249/Rr249<+>
Background: involves: C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr249/Rr249
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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GXD Expression
GXD Expression
Probe: MGI:1339609
Assay Type: RNA in situ
Annotation Date: 1999-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:1342723
Age: embryonic day 10.5
Image: 2.E
Note: Expression is detected in a narrow column of cells lining the floor plate and a more lateral column, which abuts the former domain from rostral hindbrain to r4. Expression is fainter than that of Gata2 close to the floor plate from the r1/r2 boundary.
Specimen Label: 2.E
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:2148090
Assay Type: Immunohistochemistry
Annotation Date: 1999-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:1342769
Age: embryonic day 10.5
Image: 2.G
Note: Protein is detected in the locus coeruleus, in the ventral column of motor neuron precursers, which extends caudally from rostral r2. Isl1 expression coincides with that of Gata2 in r4, but extends more ventrally in other parts of the neural tube.
Specimen Label: 2.G
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:2148090
Assay Type: Immunohistochemistry
Annotation Date: 1999-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609217
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:1342769
Age: embryonic day 10.5
Image: 2.G
Note: Protein is detected in the locus coeruleus, in the ventral column of motor neuron precursers, which extends caudally from rostral r2. Isl1 expression coincides with that of Gata2 in r4, but extends more ventrally in other parts of the neural tube.
Specimen Label: 2.G
Detected: true
Specimen Num: 1
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HT Experiment
GSE130156 | Global chromatin occupancy and epigenetic signature analysis reveal new insights into the function of GATA1 N-terminus in erythropoiesis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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MP Term
MP:0013697 | decreased granulocyte monocyte progenitor cell number
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MP Term
MP:0013696 | increased granulocyte monocyte progenitor cell number
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MP Term
MP:0013694 | abnormal granulocyte monocyte progenitor cell morphology
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MP Term
MP:0013695 | abnormal granulocyte monocyte progenitor cell number
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MP Term
MP:0013698 | absent granulocyte monocyte progenitor cells
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Allele
Tg(Gata2-GFP)#Jeng | MGI:7414244
Name: transgene insertion, James Douglas Engel
Allele Type: Transgenic
Attribute String: Reporter
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Genotype
Genotype
Symbol: Rr249/Rr249<+>
Background: involves: 129 * BALB/cJ * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr249/Rr249
Background: involves: 129 * BALB/cJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr251/Rr251
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr127/Rr127
Background: involves: 129S1/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr127/Rr127
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE179790 | Conditionally Pathogenic Genetic Variants of a Hematopoietic Disease-Suppressing Enhancer
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
1638017 | -
First Author: Orkin SH
Year: 1992
Journal: Blood
Title: GATA-binding transcription factors in hematopoietic cells.
Volume: 80
Issue: 3
Pages: 575-81
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Protein Domain
IPR016374 | TF_GATA-2/3
Type: Family
Description: GATA transcription factors mediate processes of development, differentiation, and gene expression in multiple tissues and cell types. Vertebrate GATA factors have two highly conserved zinc finger motifs and recognise a six-nucleotide motif T/AGATAG/A in target genes. They are separated into two subfamilies: 1) GATA1, GATA2, and GATA3 and 2) GATA4, GATA5, and GATA6. Members of the GATA1/2/3 subfamily are expressed in developing blood cells, where they regulate differentiation-specific gene expression in hematopoiesis []. This entry represents the GATA2 and GATA3.
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Allele
Tg(RP23-333I12)#Jeng | MGI:7414207
Name: transgene insertion, James Douglas Engel
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Rr249/Rr249
Background: involves: C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Allele
Angptl7<em1Pli> | MGI:6712191
Name: angiopoietin-like 7; endonuclease-mediated mutation 1, Peng Li
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout, Reporter
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HT Experiment
GSE96059 | Next Generation sequencing and quantitative transcriptomic analysis in -77+/+ and -77-/- erythroid precursors
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
22624710 | J:189302
First Author: Barbacid M
Year: 2012
Journal: Cancer Cell
Title: Opening a new GATAway for treating KRAS-driven lung tumors.
Volume: 21
Issue: 5
Pages: 598-600
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Allele
Npm1<tm1Trow> | MGI:6285874
Name: nucleophosmin 1; targeted mutation 1, Jennifer Trowbridge
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence
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Allele
Fbxo21<em1Smbk> | MGI:7444787
Name: F-box protein 21; endonuclease-mediated mutation 1, Shannon M Buckley
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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HT Experiment
GSE234943 | Single nucleus multiome (RNAseq and ATACseq) of male mouse pituitary
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
15659346 | -
First Author: Cantor AB
Year: 2005
Journal: Semin Cell Dev Biol
Title: Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins.
Volume: 16
Issue: 1
Pages: 117-28
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Publication
17936744 | -
First Author: Sorrentino RP
Year: 2007
Journal: Dev Biol
Title: The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila.
Volume: 311
Issue: 2
Pages: 311-23
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Protein Domain
IPR039746 | FOG
Type: Family
Description: This entry represents the FOG (Friend of GATA) family, whose members are zinc finger cofactors that regulate GATA factor-activated gene transcription. There are two FOG proteins in mammals, FOG1 and FOG2. They are essential cofactors that act via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3 []. In mice, FOG1 is expressed predominantly within the hematopoietic system, while FOG2 is expressed outside of blood, mostly in heart, brain, gonads, and liver [].This entry also includes the FOG homologue from fruit flies, U-shaped (Ush), which is expressed in circulating and lymph gland hemocytes, where it plays a critical role in controlling blood cell proliferation and differentiation [].
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Protein Coding Gene
MGI:3605801 | Angptl7
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Angptl7/Angptl7
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fbxo21/Fbxo21 Commd10/Commd10<+>
Background: B6.Cg-Fbxo21 Commd10
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
E-GEOD-79451 | Gene expression in mouse thyrotrope adenoma: transcription elongation factor stimulates proliferation
Series Id: GSE79451
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE37515 | Gene expression signatures for fractions of E7.5 whole embryos based on Endoglin and Flk-1 markers
Series Id: E-GEOD-37515
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
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HT Experiment
GSE139052 | Single-cell RNA-seq of sorted E11.5 AGM HSCs
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE214389 | Single cell RNA sequencing analysis using embryonic day 9.5 placenta from control and GATA DKO mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Coding Gene
MGI:1924223 | Fbxo21
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Cd74/Cd74<+> Lmo2/Lmo2<+> Smim3/Smim3<+>
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Smim3/Smim3<+> Cd74/Cd74<+> Lmo2/Lmo2<+> Trp53/Trp53<+>
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ercc1/Ercc1
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ercc1/Ercc1
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ercc1/Ercc1
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Npm1/Npm1<+>
Background: B6.Cg-Gt(ROSA)26Sor Npm1
Zygosity: cn
Has Mutant Allele: true
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Publication
10812068 | J:62202
First Author: Bora RS
Year: 2000
Journal: FEBS Lett
Title: Genomic structure and promoter analysis of putative mouse acetyl-CoA transporter gene.
Volume: 473
Issue: 2
Pages: 169-72
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Publication
30332639 | J:269779
First Author: Cha B
Year: 2018
Journal: Cell Rep
Title: Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling.
Volume: 25
Issue: 3
Pages: 571-584.e5
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Publication
34459852 | J:323679
 
First Author: Cova G
Year: 2021
Journal: J Exp Med
Title: Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.
Volume: 218
Issue: 10
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Publication
30842549 | J:276884
First Author: Kidoya H
Year: 2019
Journal: Nat Commun
Title: Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis.
Volume: 10
Issue: 1
Pages: 1072
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Publication
26051941 | J:336341
First Author: Pina C
Year: 2015
Journal: Cell Rep
Title: Single-Cell Network Analysis Identifies DDIT3 as a Nodal Lineage Regulator in Hematopoiesis.
Volume: 11
Issue: 10
Pages: 1503-10
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Publication
21245161 | J:168147
First Author: Taoudi S
Year: 2011
Journal: Genes Dev
Title: ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification.
Volume: 25
Issue: 3
Pages: 251-62
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Publication
35172146 | J:327076
First Author: Du C
Year: 2022
Journal: Cell Rep
Title: Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance.
Volume: 38
Issue: 7
Pages: 110392
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Publication
25873173 | J:220302
First Author: Shih AH
Year: 2015
Journal: Cancer Cell
Title: Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.
Volume: 27
Issue: 4
Pages: 502-15
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Publication
31484061 | J:280583
First Author: Ito K
Year: 2019
Journal: Cell Rep
Title: Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis.
Volume: 28
Issue: 10
Pages: 2480-2490.e4
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Publication
20179324 | J:162598
First Author: Gustafson B
Year: 2010
Journal: J Biol Chem
Title: Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance.
Volume: 285
Issue: 18
Pages: 14031-41
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Publication
25217645 | J:218807
First Author: Cui H
Year: 2014
Journal: J Biol Chem
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