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Search results 1501 to 1600 out of 12470 for Impact

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Hits by Strain

Type Details Score
Strain
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
Strain
Attribute String: mutant strain, coisogenic, endonuclease-mediated mutation
Strain
Attribute String: endonuclease-mediated mutation, coisogenic, mutant strain
Genotype
Symbol: Mcoln3/Mcoln3<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mcoln3/Mcoln3
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Mcoln3/Mcoln3
Background: B6.Cg-Mcoln3
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Mcoln3/Mcoln3<+>
Background: B6C3Fe-a/a Hoxa13 Mcoln3/J
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Mcoln3/Mcoln3
Background: B6C3Fe-a/a Hoxa13 Mcoln3/J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Mcoln3/?
Background: involves: C3HeB/FeJLe * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Mcoln3/?
Background: involves: A/J * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Mcoln3/?
Background: involves: C57BL/6J * DBA/2J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Mcoln3/?
Background: involves: BALB/cByJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Mcoln3/?
Background: involves: C57BL/6J * CZECHII/EiJ
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Il7r/Il7r<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Ikzf1/Ikzf1 Il7r/Il7r<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Col16a1/Col16a1
Background: C57BL/6NJ-Col16a1/J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Iqca1/Iqca1
Background: C57BL/6NJ-Iqca1/J
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Eftud2/Eftud2 Trp53/Trp53<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Mcoln3/Mcoln3
Background: involves: C3HeB/FeJLe * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
Publication  
First Author: Wen Z
Year: 2021
Journal: Biochem Biophys Res Commun
Title: Deficiency for Lcn8 causes epididymal sperm maturation defects in mice.
Volume: 548
Pages: 7-13
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment
Series Id: GSE4818
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment
Series Id: GSE5333
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment
Series Id: GSE25768
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE21389
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment
Series Id: GSE10067
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE41674
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE29192
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE67985
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment
Series Id: GSE67009
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
HT Experiment
Series Id: GSE55203
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE65754
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE51643
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE46584
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE52974
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication      
First Author: Rodrigues PF
Year: 2024
Journal: Immunity
Title: Progenitors of distinct lineages shape the diversity of mature type 2 conventional dendritic cells.
Publication  
First Author: Robles Luna G
Year: 2018
Journal: J Virol
Title: Citrus Psorosis Virus Movement Protein Contains an Aspartic Protease Required for Autocleavage and the Formation of Tubule-Like Structures at Plasmodesmata.
Volume: 92
Issue: 21
Publication
First Author: Bischoff V
Year: 2010
Journal: Plant Physiol
Title: TRICHOME BIREFRINGENCE and its homolog AT5G01360 encode plant-specific DUF231 proteins required for cellulose biosynthesis in Arabidopsis.
Volume: 153
Issue: 2
Pages: 590-602
Publication
First Author: Wang GG
Year: 2009
Journal: Nature
Title: Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.
Volume: 459
Issue: 7248
Pages: 847-51
Publication
First Author: Ku DH
Year: 1991
Journal: Cell Growth Differ
Title: A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor.
Volume: 2
Issue: 4
Pages: 179-86
Publication
First Author: Krautkramer KA
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell line.
Volume: 305
Issue: 5
Pages: E600-10
Publication
First Author: Kreft B
Year: 1992
Journal: Infect Immun
Title: Aggregation substance of Enterococcus faecalis mediates adhesion to cultured renal tubular cells.
Volume: 60
Issue: 1
Pages: 25-30
Publication
First Author: Bhatty M
Year: 2015
Journal: Mol Microbiol
Title: Enterococcus faecalis pCF10-encoded surface proteins PrgA, PrgB (aggregation substance) and PrgC contribute to plasmid transfer, biofilm formation and virulence.
Volume: 95
Issue: 4
Pages: 660-77
Protein Domain
Type: Domain
Description: This entry describes an N-terminal domain found in Antigen I/II (also known antigen B, PAc or adhesin P1).The cariogenic bacterium Streptococcus mutans uses adhesin P1 to adhere to tooth surfaces, extracellular matrix components, and other bacteria. The N terminus forms a stabilizing scaffold by wrapping behind the base of P1's elongated stalk and physically 'locking' it into place. It is suggested that the N-terminal has a pronounced impact on P1 immunogenicity, antigenicity, folding, stability, and adherent function [].This domain can also found in aggregation substance (Asa1) from Enterococcus faecalis. It is a structural homologue of Streptococcus mutans Antigen I/II. It acts as an adhesin mediating cell-cell contact between different E. faecalis strains and also binding of E. faecalis to eukaryotic cells [, ].
Protein Domain
Type: Family
Description: The Ret finger protein-like (RFPL) protein family members includes RFPL1, RFPL2, RFPL3 and RFPL4. In humans, RFPL transcripts can be detected at the onset of neurogenesis in differentiating human embryonic stem cells, and in the developing human neocortex []. The human RFPL1, 2, 3 genes have a role in neocortex development. RFPL1 is a primate-specific target gene of Pax6, a key transcription factor for pancreas, eye and neocortex development. Human RFPL1, 2 and 3 are reported to impact on cell number, specifically through the RFPL-defining motif (RDM) and SPRY domains []. The RFPL4 (also known as RFPL4A) gene encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells and interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway [].
Protein Domain
Type: Family
Description: Arl2 (Arf-like 2) GTPases are members of the Arf family that bind GDP and GTP with very low affinity. Unlike most Arf family proteins, Arl2 is not myristoylated at its N-terminal helix. The protein PDE-delta, first identified in photoreceptor rod cells, binds specifically to Arl2 and is structurally very similar to RhoGDI. Despite the high structural similarity between Arl2 and Rho proteins and between PDE-delta and RhoGDI, the interactions between the GTPases and their effectors are very different. In its GTP bound form, Arl2 interacts with the protein Binder of Arl2 (BART), and thecomplex is believed to play a role in mitochondrial adenine nucleotide transport []. In its GDP bound form, Arl2 interacts with tubulin- folding Cofactor D; this interaction is believed to play a role in regulation of microtubule dynamics that impact the cytoskeleton, cell division, and cytokinesis [].This entry also includes Alp41 from fission yeasts which is essential for the cofactor-dependent biogenesis of microtubules [].
Protein Domain
Type: Domain
Description: TCF-19, also termed transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells []. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand [].TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3 [].
Protein Domain
Type: Domain
Description: This entry represents the C-terminal region found in viral movement proteins (MP) of the 30K type. This region has been suggested to be conserved in secondary structure in Ophioviruses Mps. It contains two parts, (i) a long segment with the potential to form an α-helix (alphaB), rich in charged residues, and (ii) a region highly variable in sequence downstream of alphaB.The C-terminal region corresponds to the protease domain which contains a strictly conserved DTG tripeptide, also found in related aspartic retroviral proteases. This protease is required for autocleavage of the Movement Protein of ophioviruses in an N-terminal part that supports movement of viral particles through the plant, and this C-terminal part which retains protease activity []. contains a strictly conserved DTG tripeptide which is probably conserved for functional, rather than structural reasons. Mutations in the aspartate residue in the core domain had an impact on cell to cell movement [].
Publication
First Author: Kohlstaedt LA
Year: 1992
Journal: Science
Title: Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor.
Volume: 256
Issue: 5065
Pages: 1783-90
Publication
First Author: Hamilton BA
Year: 2001
Journal: Cell
Title: Of mice and genome sequence.
Volume: 107
Issue: 1
Pages: 13-6
Publication
First Author: Roberts J
Year: 2023
Journal: J Immunol
Title: Retinoic Acid-Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation.
Volume: 211
Issue: 4
Pages: 626-632
HT Experiment
Series Id: GSE32935
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
HT Experiment  
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
Protein
Organism: Mus musculus/domesticus
Length: 1020  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
Publication
First Author: Nam Y
Year: 2006
Journal: Cell
Title: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Volume: 124
Issue: 5
Pages: 973-83
Publication
First Author: Kovall RA
Year: 2008
Journal: Oncogene
Title: More complicated than it looks: assembly of Notch pathway transcription complexes.
Volume: 27
Issue: 38
Pages: 5099-109
Publication
First Author: Shen H
Year: 2006
Journal: Genes Dev
Title: The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Volume: 20
Issue: 6
Pages: 675-88
Publication
First Author: Zhao Y
Year: 2007
Journal: J Biol Chem
Title: The notch regulator MAML1 interacts with p53 and functions as a coactivator.
Volume: 282
Issue: 16
Pages: 11969-81
Publication
First Author: Alves-Guerra MC
Year: 2007
Journal: Cancer Res
Title: Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival.
Volume: 67
Issue: 18
Pages: 8690-8
Publication
First Author: Chiang MY
Year: 2006
Journal: Mol Cell Biol
Title: Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.
Volume: 26
Issue: 16
Pages: 6261-71
Publication
First Author: Wu L
Year: 2007
Journal: Blood
Title: The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.
Volume: 110
Issue: 10
Pages: 3618-23
Publication
First Author: Liu H
Year: 2009
Journal: Circ Res
Title: NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1.
Volume: 104
Issue: 4
Pages: 466-75
Publication
First Author: Wu L
Year: 2005
Journal: EMBO J
Title: Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.
Volume: 24
Issue: 13
Pages: 2391-402
Publication
First Author: Fryer CJ
Year: 2004
Journal: Mol Cell
Title: Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
Volume: 16
Issue: 4
Pages: 509-20