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Search results 1501 to 1600 out of 1687 for Mecp2

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Type Details Score
Publication
25227661 | -
First Author: Meng G
Year: 2014
Journal: Tumour Biol
Title: Epigenetic silencing of methyl-CpG-binding protein 2 gene affects proliferation, invasion, migration, and apoptosis of human osteosarcoma cells.
Volume: 35
Issue: 12
Pages: 11819-27
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Publication
32698189 | J:297400
First Author: Li CH
Year: 2020
Journal: Nature
Title: MeCP2 links heterochromatin condensates and neurodevelopmental disease.
Volume: 586
Issue: 7829
Pages: 440-444
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Allele
Mecp2<tm1.1Joez> | MGI:5310727
Name: methyl CpG binding protein 2; targeted mutation 1.1, Zhaolan Zhou
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Mecp2<em3Bird> | MGI:6196362
Name: methyl CpG binding protein 2; endonuclease-mediated mutation 3, Adrian Bird
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, Null/knockout, Reporter
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HT Experiment
GSE38324 | Chromatin context and ncRNA highlight physiological targets of MECP2 in brain.
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-31850 | Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function [visual cortex]
Series Id: GSE31850
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-66870 | MeCP2 binds to mCH as neurons mature, influencing transcription and onset of Rett syndrome [mRNA-Seq]
Series Id: GSE66870
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Pathway
R-MMU-9022692 | Regulation of MECP2 expression and activity
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Publication
34697294 | J:312452
First Author: Wang YM
Year: 2021
Journal: Cell Death Dis
Title: MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα.
Volume: 12
Issue: 11
Pages: 999
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Regulatory Region
MGI:7356631 | Rr295
Type: enhancer
Organism: mouse, laboratory
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Interaction Experiment
Zocchi L (2012)
Description: SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression.
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Publication
- | J:289870
     
First Author: Tillotson R
Year: 2020
Journal: bioRxiv
Title: Neuronal non-CG methylation is an essential target for MeCP2 function.
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Publication
23431031 | J:193960
First Author: Han K
Year: 2013
Journal: Genes Dev
Title: Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p.
Volume: 27
Issue: 5
Pages: 485-90
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HT Experiment
GSE83474 | Biotin tagging of MeCP2 reveals contextual insights into the Rett syndrome transcriptome
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-42895 | Loss of MeCP2 function is associated with distinct gene expression changes in the striatum
Series Id: GSE42895
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-SMDB-4087 | Transcription profiling of cerebellum from Mecp2 mutant mice to identify pathways mis-regulated by MeCP2 deficiency in Rett Syndrome
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
28743991 | J:253720
First Author: Zhang D
Year: 2017
Journal: Sci Rep
Title: Altered visual cortical processing in a mouse model of MECP2 duplication syndrome.
Volume: 7
Issue: 1
Pages: 6468
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Publication
17698499 | J:172185
First Author: Agarwal N
Year: 2007
Journal: Nucleic Acids Res
Title: MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation.
Volume: 35
Issue: 16
Pages: 5402-8
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DO Term
DOID:0060799 | syndromic X-linked intellectual disability Lubs type
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Publication
24336718 | J:204660
First Author: Jiang M
Year: 2013
Journal: J Neurosci
Title: Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome.
Volume: 33
Issue: 50
Pages: 19518-33
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Protein
Q9Z2D6-2
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Allele
Tg(MECP2)3Hzo | MGI:3815541
Name: transgene insertion 3, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Interaction Experiment
Nan X (2007)
Description: Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.
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Interaction Experiment
Goffin D (2012)
Description: Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses.
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Publication
29227625 | J:350352
First Author: Fisher NM
Year: 2018
Journal: ACS Chem Neurosci
Title: Genetic Reduction or Negative Modulation of mGlu(7) Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome.
Volume: 9
Issue: 9
Pages: 2210-2217
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HT Experiment
E-GEOD-72196 | Histone deacetylase 3 in concert with MeCP2 and FoxO regulate autism-associated behaviors
Series Id: GSE72196
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Interaction Experiment
Kernohan KD (2010)
Description: ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain.
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Allele
Mapt<tm1(Mecp2)Jae> | MGI:3043293
Name: microtubule-associated protein tau; targeted mutation 1, Rudolf Jaenisch
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Genotype
Genotype
Symbol: Tg(MECP2)3Hzo/?
Background: either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mapt/Mapt
Background: B6.Cg-Mapt
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE67294 | Length-dependent gene misregulation in Rett syndrome (RNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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DO Term
DOID:0060827 | X-linked intellectual disability-psychosis-macroorchidism syndrome
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Allele
Mecp2<tm2Qcha> | MGI:7264415
Name: methyl CpG binding protein 2; targeted mutation 2, Qiang Chang
Allele Type: Targeted
Attribute String: Epitope tag
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HT Experiment
E-GEOD-33457 | Amygdalar gene expression from Mecp2-null and MECP2-transgenic mice
Series Id: GSE33457
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-59029 | Quantitative analysis of wild type and MeCP2-/y mice hippocampus miRNAs using next generation sequencing
Series Id: GSE59029
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE60219 | Transcriptional landscape of different brain regions in a Rett syndrome mouse model
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
17046689 | -
First Author: Zhou Z
Year: 2006
Journal: Neuron
Title: Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.
Volume: 52
Issue: 2
Pages: 255-69
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Publication
10518942 | -
First Author: Wakefield RI
Year: 1999
Journal: J Mol Biol
Title: The solution structure of the domain from MeCP2 that binds to methylated DNA.
Volume: 291
Issue: 5
Pages: 1055-65
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Allele
Tg(MECP2)1Hzo | MGI:3815540
Name: transgene insertion 1, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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HT Experiment
E-GEOD-11150 | Hypothalamic gene expression data from Mecp2-null and MECP2-transgenic mice
Series Id: GSE11150
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Mecp2<tm1Qcha> | MGI:7264414
Name: methyl CpG binding protein 2; targeted mutation 1, Qiang Chang
Allele Type: Targeted
Attribute String: Epitope tag, Modified isoform(s)
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Allele
Rr295<em1Hzo> | MGI:7356640
Name: regulatory region 295; endonuclease-mediated mutation 1, Huda Y Zoghbi
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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HT Experiment
E-GEOD-43689 | Long non-coding RNAs expression study of a Rett syndrome mouse model
Series Id: GSE43689
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE123372 | Chromosome topology shapes neuronal non-CG DNA methylation to influence MeCP2-mediated enhancer repression (RNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE66211 | Mecp2: an unexpected regulator of macrophage gene expression and function [RNA-Seq]
Series Id: E-GEOD-66211
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE221361 | A single-cell atlas reveals heterogeneity of meningeal immunity in a mouse model of Methyl CpG binding protein 2 deficiency
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tg(MECP2*R270X/GFP)AHzo | MGI:5491036
Name: transgene insertion A, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Tg(MECP2/EGFP)1Hzo | MGI:5588443
Name: transgene insertion 1, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Mecp2<tm1Bdlv> | MGI:6444751
Name: methyl CpG binding protein 2; targeted mutation 1, Antonio Bedalov
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Rr296<em1Hzo> | MGI:7356641
Name: regulatory region 296; endonuclease-mediated mutation 1, Huda Y Zoghbi
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Protein Domain
IPR045138 | MeCP2/MBD4
Type: Family
Description: Methyl-CpG-binding protein 2 (Mecp2) binds specifically to methylated DNA and represses transcription through the recruitment of chromatin remodeling complexes containing histone deacetylase activities [, ]. It is a multi-functional protein whose function depends on its protein partners and post-translational modifications []. Mecp2 is required for proper mitotic spindle organisation []and affects proliferation and apoptosis []. Mutations in MeCP2 gene cause an X-linked neurodevelopmental disease known as Rett syndrome [].Methyl-CpG-binding domain protein 4 (MBD4) is a mismatch-specific DNA N-glycosylase involved in DNA repair. It has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites [, ].
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Transgene
MGI:3815539 | Tg(MECP2)1Hzo
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3815538 | Tg(MECP2)3Hzo
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Tg(MECP2)1Hzo/?
Background: either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MECP2)1Hzo/?
Background: FVB-Tg(MECP2)1Hzo/J
Zygosity: ot
Has Mutant Allele: true
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HT Experiment
E-GEOD-11596 | Gene expression profiles of wild type and Mecp2-null mice in three different regions of the brain
Series Id: GSE11596
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-42987 | Hippocampal expression data from WT, KO, R270X, and G273X mice at 4 and 9 weeks
Series Id: GSE42987
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:6471040 | FVB/N-Tg(MECP2*R270X/GFP)AHzo/J
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:5588438 | FVB/N-Tg(MECP2/EGFP)1Hzo/J
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Mecp2<tm1(MECP2)Cya> | MGI:7657302
Name: methyl CpG binding protein 2; targeted mutation 1, Cyagen Biosciences
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Genotype
Genotype
Symbol: Tg(MECP2*R270X/GFP)AHzo/?
Background: involves: 129P2/OlaHsd * FVB
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr295/Rr295
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr296/Rr296
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Publication
31133783 | J:280973
 
First Author: Zhou C
Year: 2019
Journal: Front Neurosci
Title: Atypical Response Properties of the Auditory Cortex of Awake MECP2-Overexpressing Mice.
Volume: 13
Pages: 439
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Protein Coding Gene
MGI:1314872 | Hipk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9QZR5
Organism: Mus musculus/domesticus
Length: 1196  
Fragment?: false
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Protein
Q3UGS3
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
A0A0N4SV30
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
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Publication
10930409 | -
First Author: Petronzelli F
Year: 2000
Journal: J Biol Chem
Title: Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase.
Volume: 275
Issue: 42
Pages: 32422-9
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Strain
MGI:3817213 | FVB-Tg(MECP2)3Hzo/J
Attribute String: transgenic, coisogenic
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Allele
Tg(MECP2*G273X/GFP)AHzo | MGI:5491039
Name: transgene insertion A, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Tg(MECP2*R306C/EGFP)1Hzo | MGI:5588452
Name: transgene insertion 1, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(MECP2*R111G/EGFP)1Hzo | MGI:5588460
Name: transgene insertion 1, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Mecp2<tm5.1Joez> | MGI:5896330
Name: methyl CpG binding protein 2; targeted mutation 5.1, Zhaolan Zhou
Allele Type: Targeted
Attribute String: Epitope tag, No functional change
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Strain
MGI:7657660 | C57BL/6N-Mecp2<tm1(MECP2)Cya>/Cya
Attribute String: coisogenic, targeted mutation, mutant strain
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Genotype
Genotype
Symbol: Tg(MECP2)3Hzo/?
Background: involves: FVB
Zygosity: ot
Has Mutant Allele: true
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Protein Coding Gene
MGI:2138281 | Lbr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107157 | Sin3a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q3U9G9
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
Q60520
Organism: Mus musculus/domesticus
Length: 1274  
Fragment?: false
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Publication
23220634 | J:194417
First Author: Yang T
Year: 2012
Journal: Sci Transl Med
Title: Overexpression of methyl-CpG binding protein 2 impairs T(H)1 responses.
Volume: 4
Issue: 163
Pages: 163ra158
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HT Experiment
GSE113901 | Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing (Single-cell or single-nuclei RNA sequencing)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-24320 | Genome-wide Analysis Reveals Mecp2-dependent Regulation of MicroRNAs in a Mouse Model of Rett Syndrome (high-throughput sequencing)
Series Id: GSE24320
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:1097691 | Hdac2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P70288
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
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Allele
Mecp2<tm1.1Bird> | MGI:2137311
Name: methyl CpG binding protein 2; targeted mutation 1.1, Adrian Bird
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:5427824 | B6.Cg-Mapt<tm1(Mecp2)Jae>/LimmJ
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5318993 | B6.Cg-Mapt<tm1(Mecp2)Jae>
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:6471044 | FVB/N-Tg(MECP2*G273X/GFP)AHzo/J
Attribute String: transgenic, mutant strain, coisogenic
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Allele
Mecp2<tm1.1Jtc> | MGI:5568206
Name: methyl CpG binding protein 2; targeted mutation 1.1, Joseph T Coyle
Allele Type: Targeted
Attribute String: Humanized sequence
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Strain
MGI:5588440 | FVB/N-Tg(MECP2*R306C/EGFP)1Hzo/J
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:5588441 | FVB/N-Tg(MECP2*R111G/EGFP)1Hzo/J
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Mecp2<tm3.1Joez> | MGI:5790795
Name: methyl CpG binding protein 2; targeted mutation 3.1, Zhaolan Zhou
Allele Type: Targeted
Attribute String: Epitope tag, Humanized sequence
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Allele
Mecp2<tm4.1Joez> | MGI:5790796
Name: methyl CpG binding protein 2; targeted mutation 4.1, Zhaolan Zhou
Allele Type: Targeted
Attribute String: Epitope tag, Humanized sequence
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Strain
MGI:5896341 | B6.129(FVB)-Mecp2<tm5.1Joez>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:7311652 | B6.129(FVB)-Mecp2<tm5.1Joez>
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Mecp2<em7.1Bird> | MGI:6437877
Name: methyl CpG binding protein 2; endonuclease-mediated mutation 7.1, Adrian Bird
Allele Type: Endonuclease-mediated
Attribute String: Reporter
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Genotype
Genotype
Symbol: Mapt/Mapt
Background: involves: 129/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mapt/Mapt<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MECP2*G273X/GFP)AHzo/?
Background: involves: 129P2/OlaHsd * FVB
Zygosity: ot
Has Mutant Allele: true
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