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Search results 1501 to 1600 out of 2039 for Met

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Type Details Score
Publication
19897921 | -
First Author: Mashiguchi K
Year: 2009
Journal: Biosci Biotechnol Biochem
Title: Genome-wide identification, structure and expression studies, and mutant collection of 22 early nodulin-like protein genes in Arabidopsis.
Volume: 73
Issue: 11
Pages: 2452-9
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HT Experiment
E-GEOD-39621 | Expression data from brain, liver and spleen of Npc1-/- mice
Series Id: GSE39621
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:97376 | Nras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99511 | Ptpn11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97845 | Rac1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96680 | Kras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96224 | Hras
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61411
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P32883
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P08556
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Protein
P63001
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
P35235
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
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Protein
Q8BVF9
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
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Protein
Q400C8
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
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Protein
Q8K2T1
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
Q9DC11
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
Q9DC69
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
Q91ZV7
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: false
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Protein
B1AT59
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
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Protein
B1AY86
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Protein
B1AY85
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: false
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Protein
D3YU12
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
A1L313
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Protein
B1AT60
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
A0A0R3P9C8
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
F6VSI0
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Protein
G5E8S7
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Protein
A0A172Q399
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: true
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Protein
A1L312
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
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Protein
Q3UP02
Organism: Mus musculus/domesticus
Length: 233  
Fragment?: false
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Protein
Q3U2S0
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
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Publication
13129921 | -
First Author: Min T
Year: 2003
Journal: J Biol Chem
Title: Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases and their relationship to isoflavone reductases.
Volume: 278
Issue: 50
Pages: 50714-23
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Publication
19168619 | -
First Author: Chillappagari S
Year: 2009
Journal: J Bacteriol
Title: Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis.
Volume: 191
Issue: 7
Pages: 2362-70
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Publication
16879646 | -
First Author: Peñalver-Mellado M
Year: 2006
Journal: Mol Microbiol
Title: Recruitment of a novel zinc-bound transcriptional factor by a bacterial HMGA-type protein is required for regulating multiple processes in Myxococcus xanthus.
Volume: 61
Issue: 4
Pages: 910-26
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Publication
20597090 | -
First Author: Waltersperger S
Year: 2010
Journal: Proteins
Title: Crystal structure of archaemetzincin AmzA from Methanopyrus kandleri at 1.5 A resolution.
Volume: 78
Issue: 12
Pages: 2720-3
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Publication
20561058 | -
First Author: Elías-Arnanz M
Year: 2010
Journal: FEMS Microbiol Rev
Title: The regulatory action of the myxobacterial CarD/CarG complex: a bacterial enhanceosome?
Volume: 34
Issue: 5
Pages: 764-78
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Publication
23282011 | -
First Author: Flühe L
Year: 2013
Journal: J Am Chem Soc
Title: Two [4Fe-4S] clusters containing radical SAM enzyme SkfB catalyze thioether bond formation during the maturation of the sporulation killing factor.
Volume: 135
Issue: 3
Pages: 959-62
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Publication
10656802 | -
First Author: Sivaraman J
Year: 2000
Journal: J Mol Biol
Title: Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine.
Volume: 295
Issue: 4
Pages: 939-51
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Publication
10745011 | -
First Author: Guncar G
Year: 2000
Journal: Structure
Title: Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease.
Volume: 8
Issue: 3
Pages: 305-13
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Publication
10504234 | -
First Author: Nägler DK
Year: 1999
Journal: Biochemistry
Title: Human cathepsin X: A cysteine protease with unique carboxypeptidase activity.
Volume: 38
Issue: 39
Pages: 12648-54
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Publication
10951198 | -
First Author: Klemencic I
Year: 2000
Journal: Eur J Biochem
Title: Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase.
Volume: 267
Issue: 17
Pages: 5404-12
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Publication
15737607 | -
First Author: Devanathan G
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Carboxy-monopeptidase substrate specificity of human cathepsin X.
Volume: 329
Issue: 2
Pages: 445-52
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Publication
16307485 | -
First Author: Puzer L
Year: 2005
Journal: Biol Chem
Title: Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L.
Volume: 386
Issue: 11
Pages: 1191-5
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Publication
16774752 | -
First Author: Obermajer N
Year: 2006
Journal: Exp Cell Res
Title: Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells.
Volume: 312
Issue: 13
Pages: 2515-27
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Publication
21616554 | -
First Author: Kraus S
Year: 2011
Journal: Eur J Cell Biol
Title: Cellular senescence induced by cathepsin X downregulation.
Volume: 90
Issue: 8
Pages: 678-86
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Publication
16025436 | -
First Author: Krueger S
Year: 2005
Journal: J Pathol
Title: Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer.
Volume: 207
Issue: 1
Pages: 32-42
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Publication
19446361 | -
First Author: Obermajer N
Year: 2009
Journal: Eur J Cell Biol
Title: Cathepsin X prevents an effective immune response against Helicobacter pylori infection.
Volume: 88
Issue: 8
Pages: 461-71
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Publication
10220586 | -
First Author: Hattori A
Year: 1999
Journal: J Biochem
Title: Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase.
Volume: 125
Issue: 5
Pages: 931-8
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Publication
10824104 | -
First Author: Schomburg L
Year: 2000
Journal: Eur J Biochem
Title: Molecular characterization of a puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP.
Volume: 267
Issue: 11
Pages: 3198-207
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Publication
20592285 | -
First Author: Georgiadou D
Year: 2010
Journal: J Immunol
Title: Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1.
Volume: 185
Issue: 3
Pages: 1584-92
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Publication
16286653 | -
First Author: Chang SC
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism.
Volume: 102
Issue: 47
Pages: 17107-12
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Publication
11056387 | -
First Author: Hattori A
Year: 2000
Journal: J Biochem
Title: Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells.
Volume: 128
Issue: 5
Pages: 755-62
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Publication
21229357 | -
First Author: Chen R
Year: 2012
Journal: Rheumatol Int
Title: The association between seven ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis involving 8,530 cases and 12,449 controls.
Volume: 32
Issue: 4
Pages: 909-14
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Publication
20953190 | -
First Author: Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2.
Year: 2010
Journal: Nat Genet
Title: A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
Volume: 42
Issue: 11
Pages: 985-90
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Publication
19110536 | -
First Author: Fung EY
Year: 2009
Journal: Genes Immun
Title: Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.
Volume: 10
Issue: 2
Pages: 188-91
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Publication
21424381 | -
First Author: Li GH
Year: 2011
Journal: Hum Genet
Title: Identification of QTL genes for BMD variation using both linkage and gene-based association approaches.
Volume: 130
Issue: 4
Pages: 539-46
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Protein Domain
IPR002084 | Met_repressor_MetJ
Type: Family
Description: Binding of a specific DNA fragment and S-adenosyl methionine (SAM) co-repressor molecules to the Escherichia coli methionine repressor (MetJ) leads to a significant reduction in dynamic flexibility of the ternary complex, with considerable entropy-enthalpy compensation, not necessarily involving any overall conformational change []. MetJ is a regulatory protein which when combined with S-adenosylmethionine (SAM) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated.MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox' sequence. MetJ forms sufficiently strong interactions with the sugar-phosphate backbone to accomodate sequence variation in natural operators. However, it is very sensitive to particular base changes in the operator. MetJ exists as a homodimer [, , ].The crystal structure of the met repressor-operator complex shows two dimeric repressor molecules bound to adjacent sites 8 base pairs apart on an 18-base-pair DNA fragment. Sequence specificity is achieved by insertion of double-stranded antiparallel protein β-ribbons into the major groove of B-form DNA, with direct hydrogen-bonding between amino-acid side chains and the base pairs. The repressor also recognises sequence-dependent distortion or flexibility of the operator phosphate backbone, conferring specificity even for inaccessible base pairs [].
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Protein Domain
IPR012962 | Pept_M54_archaemetzincn
Type: Family
Description: Peptidase family M54 (archaemetzincin or archaelysin) is a zinc-dependent aminopeptidase that contains the consensus zinc-binding sequence HEXXHXXGXXH/D and a conserved Met residue at the active site, and is thus classified as a metzincin. Archaemetzincins, first identified in archaea, are also found in bacteria and eukaryotes, including two human members, archaemetzincin-1 and -2 (AMZ1 and AMZ2). AMZ1 is mainly found in the liver and heart while AMZ2 is primarily expressed in testis and heart; both have been reported to be aminopeptidases, degrading synthetic substrates and peptides. The peptidase M54 family contains an extended metzincin concensus sequence of HEXXHXXGX3CX4CXMX17CXXC such that a second zinc ion is bound to four cysteines, thus resembling a zinc finger. Phylogenetic analysis of this family reveals a complex evolutionary process involving a series of lateral gene transfer, gene loss and genetic duplication events [, ].Archaemetzincin (from Mycococcus xanthus) seem to have evolved into a zinc-binding transcription factor fulfilling only a structuralrole [, ]. The structure of archaemetzincin from Methanopyrus kandleri has been resolved [].
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Protein Domain
IPR033520 | ERAP1
Type: Family
Description: Endoplasmic reticulum aminopeptidase 1 (ERAP1 or PILS; MEROPS identifier M01.018) is an aminopeptidase with a preference to release Leu or Met from the N terminus of a peptide, but can hydrolyze Phe, Tyr, Ile or Cys bonds but poorly [, ]. The aminopeptidase is insensitive to inhibition by puromycin (which inhibits cytosol alanyl aminopeptidase and dipeptidyl-peptidases II and IV) and is also known as puromycin-insensitive leucyl-specific aminopeptidase or PILS-AP [, ]. In humans, ERAP1 associates with another aminopeptidase, ERAP2, in the endoplasmic reticulum and both participate in the processing of MHC-presented peptides []. Peptides generated by degradation of proteins by the proteasome bind to a transporter associated with antigen presentation (TAP) and are exported across the plasma membrane from the cytoplasm to the endoplasmic reticulum where they are trimmed by the ERAP aminopeptidases and cystinyl aminopeptidase to be 8-11 amino acids in length which then associate with the MHC complex and beta2-microglobulin []. ERAP1 is most active with peptides 9-16 residues long, but activity drops once a peptide optimal for antigen presentation is achieved. This molecular ruler effect is achieved by binding the C terminus of the substrate peptide close to the active site []. ERAP1 may also function in blood pressure regulation because it cleaves angiotensin II to the tripeptide His-Pro-Phe via angiotensin II and IV intermediates, and converts kallidin to bradykinin []. ERAP1 has been associated with several human diseases, including ankylosing spondylitis [], psoriasis [], type 1 diabetes []and osteoporsis [].
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Protein Domain
IPR030915 | rSAM_SkfB
Type: Family
Description: Spore formation by the bacterium Bacillus subtilis is a stress response triggered by nutrient limitation. Two operons are strongly induced at the start of sporulation; one of them is skf (for sporulation killing factor). skf produces a killing factor which, together with a signaling protein, act cooperatively to block sister cells from sporulating and cause them to lyse, providing a source of nutrients to support the sporulation process [].The first gene of the skf operon, skfA, encodes a small peptide. SkfA induces the lysis of sibling cells that have not entered the sporulation pathway []. The product of the second gene, skfB, encodes a radical SAM enzyme. SkfB creates a sactipeptide (sulfur-to-α-carbon) crosslink of Cys-4 to Met-12 of the mature form of SkfA. In Paenibacillus larvae subsp larvae B-3650, the Met is replaced by Leu, so the modification must be different. SkfB has 2 4Fe-4S clusters, one in its radical SAM domain () and one in a region that somewhat resembles the SPASM domain () [].
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Protein Domain
IPR023453 | Met_repressor_MetJ_dom_sf
Type: Homologous_superfamily
Description: Binding of a specific DNA fragment and S-adenosyl methionine (SAM) co-repressor molecules to the Escherichia coli methionine repressor (MetJ) leads to a significant reduction in dynamic flexibility of the ternary complex, with considerable entropy-enthalpy compensation, not necessarily involving any overall conformational change []. MetJ is a regulatory protein which when combined with S-adenosylmethionine (SAM) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated.MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox' sequence. MetJ forms sufficiently strong interactions with the sugar-phosphate backbone to accomodate sequence variation in natural operators. However, it is very sensitive to particular base changes in the operator. MetJ exists as a homodimer [, , ].The crystal structure of the met repressor-operator complex shows two dimeric repressor molecules bound to adjacent sites 8 base pairs apart on an 18-base-pair DNA fragment. Sequence specificity is achieved by insertion of double-stranded antiparallel protein β-ribbons into the major groove of B-form DNA, with direct hydrogen-bonding between amino-acid side chains and the base pairs. The repressor also recognises sequence-dependent distortion or flexibility of the operator phosphate backbone, conferring specificity even for inaccessible base pairs [].
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Protein Domain
IPR033157 | CTSZ
Type: Family
Description: Cathepsin Z (also known as Cathepsin X , and MEROPS identifier C01.013) is predominantly a cysteine-type carboxypeptidase with limited endopeptidase or dipeptidyl-peptidase activity, mainly against synthetic substrates [, ]. The substrate specificity has been examined by peptide scanning and shows that proline is not tolerated in the P1 or P1' positions and poorly accepted in P2, and Tyr, Met and Cys are marginally prefered in P2, P1 and P1' [, ].Cathepsin X is synthesized as an inactive zymogen, but the propeptide lacks the ERFNIN motif characteristic of lysosomal cysteine peptidases. A disulfide bridge can be formed between the proregion and the enzyme which leads to inactivation of the zymogen by the formation of a reversible covalent bond with the active site residue []. From the crystal structure of the mature enzyme, a short, five-residue 'mini-loop' which includes the motif His-Xaa-Xaa-Xaa-Tyr restricts access to the S2' binding pocket, and it is the histidine that confers carboxypeptidase activity []. Rotation of the histidine ring permits dipeptidyl-peptidase substrates to bind. The presence of an exposed RGD motif allows binding to beta3-integrin []and the enzyme may have a role in cell signalling. Cathepsin X deficiency leads to accelerated cell senescence []. Cathepsin X also regulates the immune response to Helicobacter pylori infection [, ].
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Publication
7929423 | J:21117
First Author: Dickson R
Year: 1994
Journal: J Biol Chem
Title: Cloning, expression, and purification of a functional nonacetylated mammalian mitochondrial chaperonin 10.
Volume: 269
Issue: 43
Pages: 26858-64
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Publication
8917520 | J:36568
First Author: Tucker KL
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene.
Volume: 93
Issue: 23
Pages: 12920-5
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Publication
21574244 | J:174238
First Author: Rorick NK
Year: 2011
Journal: Am J Med Genet A
Title: Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome.
Volume: 155A
Issue: 6
Pages: 1314-21
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Publication
29408807 | J:261178
First Author: Yousaf R
Year: 2018
Journal: J Clin Invest
Title: Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.
Volume: 128
Issue: 4
Pages: 1509-1522
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Publication
20668449 | J:163318
First Author: Tooley CE
Year: 2010
Journal: Nature
Title: NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
Volume: 466
Issue: 7310
Pages: 1125-8
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Publication
9488442 | J:45939
First Author: Jakubczak JL
Year: 1998
Journal: Mol Cell Biol
Title: NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo.
Volume: 18
Issue: 3
Pages: 1275-83
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Publication
9114055 | J:40164
First Author: Zhu X
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects.
Volume: 94
Issue: 9
Pages: 4704-9
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Publication
15934926 | J:117578
First Author: Armstrong SD
Year: 2005
Journal: Biochem J
Title: Structural and functional differences in isoforms of mouse major urinary proteins: a male-specific protein that preferentially binds a male pheromone.
Volume: 391
Issue: Pt 2
Pages: 343-50
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Publication
8262979 | J:16038
First Author: Chen Y
Year: 1993
Journal: J Biol Chem
Title: Structure, chromosomal localization, and expression pattern of the murine Magp gene.
Volume: 268
Issue: 36
Pages: 27381-9
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Publication
11032833 | J:69270
First Author: van Adelsberg J
Year: 2001
Journal: J Biol Chem
Title: Activation of hepatocyte growth factor (HGF) by endogenous HGF activator is required for metanephric kidney morphogenesis in vitro.
Volume: 276
Issue: 18
Pages: 15099-106
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Publication
23418353 | J:213100
First Author: Smith CJ
Year: 2013
Journal: J Cell Sci
Title: The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.
Volume: 126
Issue: Pt 6
Pages: 1366-80
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Publication
12189154 | J:79876
First Author: Benarafa C
Year: 2002
Journal: J Biol Chem
Title: Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1).
Volume: 277
Issue: 44
Pages: 42028-33
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Publication
11024178 | J:65210
First Author: Kaneko KJ
Year: 2000
Journal: Nucleic Acids Res
Title: Soggy, a spermatocyte-specific gene, lies 3.8 kb upstream of and antipodal to TEAD-2, a transcription factor expressed at the beginning of mouse development.
Volume: 28
Issue: 20
Pages: 3982-90
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Publication
10681516 | J:60677
First Author: Rampazzo C
Year: 2000
Journal: J Biol Chem
Title: Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells.
Volume: 275
Issue: 8
Pages: 5409-15
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Publication
19850054 | J:203404
First Author: Sadanandam A
Year: 2010
Journal: Microvasc Res
Title: Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis.
Volume: 79
Issue: 1
Pages: 1-9
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Publication
12706888 | J:83211
 
First Author: Shimizu K
Year: 2003
Journal: Gene
Title: Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP gene.
Volume: 307
Pages: 51-62
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Publication
22493272 | J:183834
First Author: Kashio M
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions.
Volume: 109
Issue: 17
Pages: 6745-50
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Publication
1718822 | J:698
First Author: Inglis JD
Year: 1991
Journal: Gene
Title: Isolation of two cDNAs encoding novel alpha 1-antichymotrypsin-like proteins in a murine chondrocytic cell line.
Volume: 106
Issue: 2
Pages: 213-20
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Publication
24038871 | J:202837
First Author: Rowton M
Year: 2013
Journal: Dev Dyn
Title: Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis.
Volume: 242
Issue: 11
Pages: 1332-44
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Publication
11814676 | J:74471
First Author: Hanas JS
Year: 2002
Journal: Gene
Title: cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA.
Volume: 282
Issue: 1-2
Pages: 43-52
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Publication
12011424 | J:76577
First Author: Than ME
Year: 2002
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