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Search results 1501 to 1600 out of 1674 for Ptk2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:3821926 | B6.129P2-Ptk2<tm1.1Jtpa>
Attribute String: congenic, targeted mutation
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Strain
MGI:6335226 | C57BL/6N-Ptk2b<em1(IMPC)Wtsi>/Wtsi
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7570658 | C57BL/6N-Ptk2b<em1(IMPC)Wtsi>/WtsiIeg
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7853821 | C57BL/6N-Ptk2b<em1(IMPC)Ics>/Ics
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6771089 | C57BL/6JSmoc-Ptk2b<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6429445 | C57BL/6JSmoc-Ptk2b<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6426827 | C57BL/6JGpt-Ptk2b<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6426828 | C57BL/6JGpt-Ptk2b<em2Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7469305 | C57BL/6JGpt-Ptk2<em2Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7469306 | C57BL/6JGpt-Ptk2b<em3Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7469307 | C57BL/6JGpt-Ptk2b<em4Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7592912 | C57BL/6J-Ptk2b<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Ptk2b/Ptk2b
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: CBA.Cg-Ptk2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(Tek-cre)1Rwng/?
Background: involves: 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(Nes-cre)1Sasa/?
Background: B6.Cg-Ptk2 Tg(Nes-cre)1Sasa
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2b/Ptk2b
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: B6.129P2-Ptk2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(Tek-cre)12Flv/?
Background: involves: 129P2/OlaHsd * C3H * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: involves: 129S/SvEv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: involves: 129S/SvEv * C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(MMTV-PyVT)634Mul/?
Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2b/Ptk2b
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2b/Ptk2b
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: involves: 129X1/SvJ * CD-1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2b/Ptk2b
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
34529077 | J:326577
First Author: Zheng J
Year: 2022
Journal: J Mol Cell Biol
Title: Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner.
Volume: 13
Issue: 11
Pages: 808-821
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Publication
22508039 | J:232321
First Author: Mohebbi N
Year: 2012
Journal: Cell Physiol Biochem
Title: The proton-activated G protein coupled receptor OGR1 acutely regulates the activity of epithelial proton transport proteins.
Volume: 29
Issue: 3-4
Pages: 313-24
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Publication
20529287 | J:161610
 
First Author: Wang X
Year: 2010
Journal: BMC Genomics
Title: Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.
Volume: 11
Pages: 360
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Publication
25349423 | J:216771
First Author: Kinoshita Y
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress.
Volume: 111
Issue: 45
Pages: 16130-5
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Protein Coding Gene
MGI:109321 | Lama4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96602 | Itga3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96600 | Itga2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918605 | Col24a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2672118 | Col27a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P97927
Organism: Mus musculus/domesticus
Length: 1816  
Fragment?: false
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Protein
Q5QNQ9
Organism: Mus musculus/domesticus
Length: 1845  
Fragment?: false
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Protein
Q62469
Organism: Mus musculus/domesticus
Length: 1178  
Fragment?: false
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Protein
Q62470
Organism: Mus musculus/domesticus
Length: 1053  
Fragment?: false
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Protein
Q30D77
Organism: Mus musculus/domesticus
Length: 1733  
Fragment?: false
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Publication
29911975 | J:264145
   
First Author: Fan L
Year: 2018
Journal: Elife
Title: Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.
Volume: 7
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Strain
MGI:6344787 | C57BL/6N-A<tm1Brd> Ptk2<tm1a(KOMP)Wtsi>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(KRT14-cre/ERT2)1Ipc/?
Background: involves: 129P2/OlaHsd * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2<+>
Background: involves: 129S/SvEv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Publication
26642240 | J:231935
First Author: Jabara HH
Year: 2016
Journal: Nat Genet
Title: A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
Volume: 48
Issue: 1
Pages: 74-8
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Publication
11238453 | J:67886
First Author: Ren XR
Year: 2001
Journal: J Cell Biol
Title: Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.
Volume: 152
Issue: 5
Pages: 971-84
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Publication
7499242 | J:29773
First Author: Avraham S
Year: 1995
Journal: J Biol Chem
Title: Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain.
Volume: 270
Issue: 46
Pages: 27742-51
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Publication
12771146 | J:230354
First Author: Kruljac-Letunic A
Year: 2003
Journal: J Biol Chem
Title: The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1.
Volume: 278
Issue: 32
Pages: 29560-70
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Publication
23904162 | J:205817
First Author: Okenwa C
Year: 2013
Journal: J Immunol
Title: SHP-1-Pyk2-Src protein complex and p38 MAPK pathways independently regulate IL-10 production in lipopolysaccharide-stimulated macrophages.
Volume: 191
Issue: 5
Pages: 2589-603
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Publication
29991487 | J:287818
First Author: Raghavan S
Year: 2018
Journal: Circulation
Title: Protein Kinase C? Via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6C(hi) Cells Contributes to Atherosclerosis.
Volume: 138
Issue: 21
Pages: 2395-2412
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Publication
19934023 | J:155685
First Author: Loot AE
Year: 2009
Journal: J Exp Med
Title: Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase.
Volume: 206
Issue: 13
Pages: 2889-96
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Publication
29263385 | J:258396
First Author: Lee JW
Year: 2017
Journal: Nat Commun
Title: The HIV co-receptor CCR5 regulates osteoclast function.
Volume: 8
Issue: 1
Pages: 2226
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Publication
18319399 | J:134353
First Author: Chen Y
Year: 2008
Journal: Blood
Title: A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development.
Volume: 111
Issue: 9
Pages: 4627-36
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Publication
28628896 | J:249740
 
First Author: McKeever PM
Year: 2017
Journal: Neurobiol Aging
Title: Cholinergic neuron gene expression differences captured by translational profiling in a mouse model of Alzheimer's disease.
Volume: 57
Pages: 104-119
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Publication
28385807 | J:243304
First Author: Soni D
Year: 2017
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca(2+) entry regulates disassembly of adherens junctions.
Volume: 312
Issue: 6
Pages: L1003-L1017
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Publication
24713463 | J:224957
 
First Author: Koshman YE
Year: 2014
Journal: J Mol Cell Cardiol
Title: Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy.
Volume: 72
Pages: 281-91
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Publication
11274221 | J:79952
First Author: Andreev J
Year: 2001
Journal: J Biol Chem
Title: Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade.
Volume: 276
Issue: 23
Pages: 20130-5
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Publication
9988732 | J:53091
First Author: Lakkakorpi PT
Year: 1999
Journal: J Biol Chem
Title: Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone.
Volume: 274
Issue: 8
Pages: 4900-7
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Publication
16723743 | J:110354
First Author: Calle Y
Year: 2006
Journal: J Cell Sci
Title: Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.
Volume: 119
Issue: Pt 11
Pages: 2375-85
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Publication
17684059 | J:128374
First Author: Faure C
Year: 2007
Journal: J Cell Sci
Title: Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons.
Volume: 120
Issue: Pt 17
Pages: 3034-44
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Publication
19380485 | J:149899
First Author: Bruzzaniti A
Year: 2009
Journal: Mol Cell Biol
Title: Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclasts.
Volume: 29
Issue: 13
Pages: 3644-56
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Publication
18483407 | J:151384
First Author: Fisslthaler B
Year: 2008
Journal: Circ Res
Title: Inhibition of endothelial nitric oxide synthase activity by proline-rich tyrosine kinase 2 in response to fluid shear stress and insulin.
Volume: 102
Issue: 12
Pages: 1520-8
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Publication
31906693 | J:283510
First Author: Bartoli F
Year: 2020
Journal: Circulation
Title: Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca(2+) Handling After Pressure Overload.
Volume: 141
Issue: 3
Pages: 199-216
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Publication
32693110 | J:299443
First Author: Canino J
Year: 2020
Journal: Biochim Biophys Acta Mol Cell Res
Title: The proline-rich tyrosine kinase Pyk2 modulates integrin-mediated neutrophil adhesion and reactive oxygen species generation.
Volume: 1867
Issue: 10
Pages: 118799
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Publication
11238916 | J:383775
First Author: Pixley FJ
Year: 2001
Journal: Mol Cell Biol
Title: Protein tyrosine phosphatase phi regulates paxillin tyrosine phosphorylation and mediates colony-stimulating factor 1-induced morphological changes in macrophages.
Volume: 21
Issue: 5
Pages: 1795-809
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(Tek-cre)12Flv/?
Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(KRT5-cre)5132Jlj/?
Background: involves: 129X1/SvJ * C57BL/6 * CBA * DBA/2J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2<+>
Background: CBA.Cg-Ptk2
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(Tek-cre)12Flv/?
Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2<+>
Background: involves: C57BL/6 * CBA
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Trp53/Trp53
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Neurod6/Neurod6<+> Ptk2/Ptk2
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:88447 | Col11a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88446 | Col11a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q61245
Organism: Mus musculus/domesticus
Length: 1804  
Fragment?: false
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Protein
Q64739
Organism: Mus musculus/domesticus
Length: 1736  
Fragment?: false
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Publication
14739300 | J:89495
First Author: Miyazaki T
Year: 2004
Journal: J Biol Chem
Title: Src kinase activity is essential for osteoclast function.
Volume: 279
Issue: 17
Pages: 17660-6
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Publication
15786712 | J:180575
First Author: Watanabe N
Year: 2005
Journal: Mol Cell Biochem
Title: Leupaxin binds to PEST domain tyrosine phosphatase PEP.
Volume: 269
Issue: 1-2
Pages: 13-7
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Publication
26391955 | J:312571
First Author: Li J
Year: 2015
Journal: Mol Cell Biol
Title: Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition.
Volume: 35
Issue: 23
Pages: 4069-82
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Publication
17623670 | J:124948
First Author: Stuart LM
Year: 2007
Journal: J Biol Chem
Title: CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex.
Volume: 282
Issue: 37
Pages: 27392-27401
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Publication
32352382 | J:290303
   
First Author: Nguyen GT
Year: 2020
Journal: Elife
Title: SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst.
Volume: 9
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Publication
20727793 | J:163910
First Author: Davidson D
Year: 2010
Journal: Immunity
Title: The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2.
Volume: 33
Issue: 2
Pages: 167-80
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Publication
32350404 | J:331281
First Author: Xu Y
Year: 2021
Journal: Cell Mol Immunol
Title: Tyrosine phosphatase Shp2 regulates p115RhoGEF/Rho-dependent dendritic cell migration.
Volume: 18
Issue: 3
Pages: 755-757
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Publication
27354546 | J:236480
First Author: Hashimoto-Tane A
Year: 2016
Journal: J Exp Med
Title: Micro-adhesion rings surrounding TCR microclusters are essential for T cell activation.
Volume: 213
Issue: 8
Pages: 1609-25
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Publication
19416922 | J:248211
First Author: Marqu?s M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Specific function of phosphoinositide 3-kinase beta in the control of DNA replication.
Volume: 106
Issue: 18
Pages: 7525-30
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Publication
23711511 | J:202540
First Author: Martel-Gallegos G
Year: 2013
Journal: Biochim Biophys Acta
Title: Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2.
Volume: 1830
Issue: 10
Pages: 4650-9
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Publication
27796369 | J:259915
 
First Author: Chung IC
Year: 2016
Journal: Sci Rep
Title: Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis.
Volume: 6
Pages: 36214
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Strain
MGI:6446958 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> Ptk2b<em1Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Fyn/Fyn Ptk2/Ptk2<+>
Background: involves: 129X1/SvJ * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myl2/Myl2<+> Ptk2/Ptk2
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2<+> Trp53/Trp53
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:88453 | Col3a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88458 | Col5a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88452 | Col2a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88457 | Col5a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1858212 | Col5a3
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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