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Search results 1501 to 1600 out of 3113 for Rac1

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Hits by Strain

Type Details Score
Protein
Q8BKX1
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
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Protein
S4R207
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: false
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Protein Domain
IPR034974 | SYNJ2
Type: Family
Description: Synaptojanin-2 is a ubiquitously expressed central regulatory enzyme in the phosphoinositide-signaling cascade []. As a novel Rac1 effector regulating an early step of clathrin-mediated endocytosis, synaptojanin-2 acts as a polyphosphoinositide phosphatase, directly and specifically interacting with Rac1 in a GTP-dependent manner. It mediates the inhibitory effect of Rac1 on endocytosis and plays an important role in the Rac1-mediated control of cell growth []. Synaptojanin-2 shows high sequence homology to the N-terminal Sac1p homology domain [], the central inositol 5-phosphatase domain, and the putative RNA recognition motif (RRM) of synaptojanin-1, but differs in the proline-rich region.
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Protein Domain
IPR034973 | SYNJ2_RRM
Type: Domain
Description: This entry represents the RNA recognition motif (RRM) of synaptojanin-2. Synaptojanin-2 is a ubiquitously expressed central regulatory enzyme in the phosphoinositide-signaling cascade []. As a novel Rac1 effector regulating an early step of clathrin-mediated endocytosis, synaptojanin-2 acts as a polyphosphoinositide phosphatase, directly and specifically interacting with Rac1 in a GTP-dependent manner. It mediates the inhibitory effect of Rac1 on endocytosis and plays an important role in the Rac1-mediated control of cell growth []. Synaptojanin-2 shows high sequence homology to the N-terminal Sac1p homology domain [], the central inositol 5-phosphatase domain, and the putative RNA recognition motif (RRM) of synaptojanin-1, but differs in the proline-rich region.
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Protein Coding Gene
MGI:1921268 | Als2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2146320 | Dock10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2385126 | Farp2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2684948 | Arhgap30
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88141 | Bcr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917969 | Arhgap45
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2143764 | Arhgap9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918006 | Dock4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2388284 | Plekhg3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2449975 | Iqgap2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2385001 | Fermt2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2652871 | Dock5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2446173 | Farp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106321 | Dock9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929763 | Cdc42ep1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1333857 | Arhgap31
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346328 | Def6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922665 | Arhgap12
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922989 | Mpp7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2147274 | Arap3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1921396 | Dock8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2679420 | Pak6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3028642 | Iqgap3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2684416 | Arap2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347053 | Git2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105313 | Cit
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914148 | Baiap2l1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098535 | Camk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101940 | Arhgdib
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924311 | Garre1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917747 | Arhgap17
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1354949 | Dlc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918794 | Arhgap42
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914789 | Dock6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923224 | Dock11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q920R0
Organism: Mus musculus/domesticus
Length: 1651  
Fragment?: false
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Protein
Q8R5G7
Organism: Mus musculus/domesticus
Length: 1538  
Fragment?: false
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Protein
Q9JLQ2
Organism: Mus musculus/domesticus
Length: 708  
Fragment?: false
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Protein
Q91W92
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
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Protein
Q8BVD5
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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Protein
Q91YS8
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
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Protein
Q91VS8
Organism: Mus musculus/domesticus
Length: 1065  
Fragment?: false
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Protein
P49025
Organism: Mus musculus/domesticus
Length: 2055  
Fragment?: false
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Protein
Q8CIZ9
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q8C2K1
Organism: Mus musculus/domesticus
Length: 630  
Fragment?: false
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Protein
Q4VAC9
Organism: Mus musculus/domesticus
Length: 1341  
Fragment?: false
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Protein
Q3ULB5
Organism: Mus musculus/domesticus
Length: 682  
Fragment?: false
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Protein
Q672J9
Organism: Mus musculus/domesticus
Length: 568  
Fragment?: false
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Protein
Q3TBD2
Organism: Mus musculus/domesticus
Length: 1116  
Fragment?: false
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Protein
A6X8Z5
Organism: Mus musculus/domesticus
Length: 1425  
Fragment?: false
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Protein
Q61599
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Protein
Q8CIB5
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
Q8BZ05
Organism: Mus musculus/domesticus
Length: 1703  
Fragment?: false
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Protein
F8VPU2
Organism: Mus musculus/domesticus
Length: 1048  
Fragment?: false
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Protein
Q9R0Z9
Organism: Mus musculus/domesticus
Length: 1092  
Fragment?: false
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Protein
Q8VCM2
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
Q8CJ00
Organism: Mus musculus/domesticus
Length: 444  
Fragment?: false
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Protein
Q8C0D4
Organism: Mus musculus/domesticus
Length: 838  
Fragment?: false
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Protein
B2RQE8
Organism: Mus musculus/domesticus
Length: 841  
Fragment?: false
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Protein
Q3UIA2
Organism: Mus musculus/domesticus
Length: 846  
Fragment?: false
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Protein
Q640N3
Organism: Mus musculus/domesticus
Length: 1101  
Fragment?: false
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Protein
Q3UQ44
Organism: Mus musculus/domesticus
Length: 1575  
Fragment?: false
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Protein
Q1HDU4
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
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Protein
Q8C5X1
Organism: Mus musculus/domesticus
Length: 1059  
Fragment?: false
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Protein
F8VQ29
Organism: Mus musculus/domesticus
Length: 1632  
Fragment?: false
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Strain
MGI:3851150 | FVB/N-Tg(Acta2-RAC1*G12V)33Pjgc/J
Attribute String: transgenic, congenic
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Publication
15614286 | J:150480
First Author: Hassanain HH
Year: 2005
Journal: Surgery
Title: Smooth muscle cell expression of a constitutive active form of human Rac 1 accelerates cutaneous wound repair.
Volume: 137
Issue: 1
Pages: 92-101
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Strain
MGI:4430613 | C57BL/6-Gt(ROSA)26Sor<tm9(Rac1*,EGFP)Rsky>/J
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Tg(Acta2-RAC1*G12V)33Pjgc/Tg(Acta2-RAC1*G12V)33Pjgc
Background: involves: C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Acta2-RAC1*G12V)33Pjgc/?
Background: involves: C57BL/6 * FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hprt1/? Tg(NPHS2-rtTA2*M2)1Jbk/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hprt1/? Tg(Nphs1-rtTA*3G)8Jhm/?
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein
Q8C3J5
Organism: Mus musculus/domesticus
Length: 1828  
Fragment?: false
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Protein
Q6ZPF3
Organism: Mus musculus/domesticus
Length: 1715  
Fragment?: false
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Protein
Q07139
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein Coding Gene
MGI:97284 | Ncf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8R1A4
Organism: Mus musculus/domesticus
Length: 2130  
Fragment?: false
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Protein
Q3LAC4
Organism: Mus musculus/domesticus
Length: 1598  
Fragment?: false
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Publication
24859337 | J:212391
First Author: Uslu VV
Year: 2014
Journal: Nat Genet
Title: Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.
Volume: 46
Issue: 7
Pages: 753-8
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Protein
Q8CIQ7
Organism: Mus musculus/domesticus
Length: 2027  
Fragment?: false
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Protein Coding Gene
MGI:97283 | Ncf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10364228 | J:55621
First Author: Hoshino M
Year: 1999
Journal: J Biol Chem
Title: Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1.
Volume: 274
Issue: 25
Pages: 17837-44
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Protein
Q64096
Organism: Mus musculus/domesticus
Length: 1149  
Fragment?: false
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Protein
Q60610
Organism: Mus musculus/domesticus
Length: 1591  
Fragment?: false
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Publication
14550769 | J:85971
First Author: Matsuo N
Year: 2003
Journal: Mol Cell Neurosci
Title: Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology.
Volume: 24
Issue: 1
Pages: 69-81
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Protein Coding Gene
MGI:1316658 | Cyba
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88574 | Cybb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR043119 | Rac1-bd_C
Type: Homologous_superfamily
Description: The Rac1-binding domain is the C-terminal portion of YpkA from Yersinia. It is an all-helical molecule consisting of two distinct subdomains connected by a linker. The N-terminal end of this domain (residues 434-615) consists of six helices organised into two three-helix bundles packed against each other. This region is involved with binding to GTPases. The C-terminal end (residues 705-732) is a novel and elongated fold consisting of four helices clustered into two pairs, and this fold carries the helix implicated in actin activation. The Rac1-binding domain mimics host guanidine nucleotide dissociation inhibitors (GDIs) of the Rho GTPases, thereby inhibiting nucleotide exchange in Rac1 and causing cytoskeletal disruption in the host [].This superfamily represents the C-terminal subdomain of the Rac1-binding domain. This domain is made up of one long, kinked helix and three smaller helices. The long helix has 2 points of contact which allow the domain to bind Rac1 at regions called Switch I and Switch II on the Rac1 protein.
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ptf1a/Ptf1a<+>
Background: involves: C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
26839364 | J:234157
First Author: Huebner RJ
Year: 2016
Journal: Development
Title: Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration.
Volume: 143
Issue: 6
Pages: 983-93
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Publication
12699622 | -
First Author: Rusk N
Year: 2003
Journal: Curr Biol
Title: Synaptojanin 2 functions at an early step of clathrin-mediated endocytosis.
Volume: 13
Issue: 8
Pages: 659-63
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Publication
20875796 | -
First Author: Zheng D
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Abba promotes PDGF-mediated membrane ruffling through activation of the small GTPase Rac1.
Volume: 401
Issue: 4
Pages: 527-32
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Publication
12900578 | -
First Author: Kutsche K
Year: 2002
Journal: Cytogenet Genome Res
Title: Microphthalmia with linear skin defects syndrome (MLS): a male with a mosaic paracentric inversion of Xp.
Volume: 99
Issue: 1-4
Pages: 297-302
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Publication
27713425 | -
 
First Author: Eccles RL
Year: 2016
Journal: Nat Commun
Title: Bimodal antagonism of PKA signalling by ARHGAP36.
Volume: 7
Pages: 12963
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Protein Domain
IPR030059 | MTSS2
Type: Family
Description: MTSS2 (also known as MTSS1-like protein, MTSS1L, or ABBA) is an I-BAR (Bin/amphipysin/Rvs) domain containing protein. BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. BAR domain proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature []. MTSS2 contains an additional C-terminal WH2 domain that binds G-actin [].MTSS2 is a regulator of actin and plasma membrane dynamics in radial glial cells []. It binds the small GTPase Rac1 through its I-BAR domain and promotes PDGF-mediated membrane ruffling by activating Rac1 [].
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Publication
11438699 | J:88664
First Author: Schenck A
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.
Volume: 98
Issue: 15
Pages: 8844-9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom