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Search results 1501 to 1600 out of 1661 for Rb1

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Type Details Score
Publication
22718244 | -
First Author: Bellacchio E
Year: 2013
Journal: J Cell Physiol
Title: Understanding the targeting of the RB family proteins by viral oncoproteins to defeat their oncogenic machinery.
Volume: 228
Issue: 2
Pages: 285-91
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Protein Domain
IPR014410 | Aden_E1A
Type: Family
Description: This group represents adenoviral early E1A proteins. The E1A protein is responsible for the transcriptional activation of the early genes with in the viral genome at the start of the infection process as well as some cellular genes [].E1A disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle []. It also induces the disassembly of the E2F1 transcription factors from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes []. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. The stimulation of the progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.
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Publication
20404145 | J:160331
First Author: Kujuro Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells.
Volume: 107
Issue: 18
Pages: 8259-64
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Protein
Q99LS0
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: false
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Publication
12800218 | -
First Author: Yue CM
Year: 2003
Journal: World J Gastroenterol
Title: Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma.
Volume: 9
Issue: 6
Pages: 1174-8
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Publication
20233222 | -
First Author: Tadross JA
Year: 2010
Journal: Br J Pharmacol
Title: Augurin stimulates the hypothalamo-pituitary-adrenal axis via the release of corticotrophin-releasing factor in rats.
Volume: 159
Issue: 8
Pages: 1663-71
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Protein Domain
IPR028173 | Augurin
Type: Family
Description: Augurin is alternatively named oesophageal cancer-related gene 4 protein. The function of this family of transmembrane proteins is to induce the senescence of oligodendrocyte and neural precursor cells, characterised by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation [, ]. Augurin is a posible hormone that has been found to stimulate the release of adrenocorticotropic hormone (ACTH) via the release of hypothalamic corticotrophin-releasing factor (CRF) [].
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Genotype
Genotype
Symbol: E2f1/E2f1 Rb1/Rb1 Tg(Rb1)1Blg/?
Background: involves: 129S2/SvPas * 129S4/SvJae
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn1a/Cdkn1a Rb1/Rb1 Tg(Rb1)1Blg/?
Background: involves: 129S2/SvPas
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn1a/Cdkn1a Rb1/Rb1<+> Tg(Rb1)1Blg/?
Background: involves: 129S2/SvPas
Zygosity: cx
Has Mutant Allele: true
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Publication
21397851 | J:169932
First Author: Maire CL
Year: 2011
Journal: Cancer Cell
Title: Glioma models: new GEMMs add "class" with genomic and expression correlations.
Volume: 19
Issue: 3
Pages: 295-7
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Allele
Tg(LPV-TAg121*E107K)#Tvd | MGI:3531488
Name: transgene insertion #, Terry Van Dyke
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(LPV-TAg121*E107K)3Tvd | MGI:3531489
Name: transgene insertion 3, Terry Van Dyke
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(LPV-TAg121*E107K)4Tvd | MGI:3531490
Name: transgene insertion 4, Terry Van Dyke
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(LPV-TAg121*E107K)5Tvd | MGI:3531491
Name: transgene insertion 5, Terry Van Dyke
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6144448 | B6D2-Tg(WAPT121)66Tvd/Nci
Attribute String: mutant stock, transgenic
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Publication
22182413 | J:180294
First Author: Wang B
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an upregulation of c-Myc target genes.
Volume: 417
Issue: 1
Pages: 601-6
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Strain
MGI:7781368 | C57BL/6JSmoc-Trp53<tm2Smoc> Rb1<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Rb1/Rb1
Background: either: 129P2/OlaHsd-Rb1 or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1
Background: either: 129P2/OlaHsd-Rb1 or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1<+>
Background: either: 129P2/OlaHsd-Rb1 or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1<+>
Background: either: 129P2/OlaHsd-Rb1 or (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * FVB/N)
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Hnf1a-RB1*)XMiu/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Publication
25755634 | J:242452
 
First Author: Tarang S
Year: 2015
Journal: Front Cell Neurosci
Title: Generation of a Retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model.
Volume: 9
Pages: 52
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Genotype
Genotype
Symbol: Apaf1/Apaf1 Rb1/Rb1 Tg(Rb1)1Blg/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Tg(Rb1)1Blg/? Trp53/Trp53
Background: involves: 129S2/SvPas
Zygosity: cx
Has Mutant Allele: true
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Publication
1395722 | J:2899
First Author: Lemieux N
Year: 1992
Journal: Cytogenet Cell Genet
Title: New gene assignments to rabbit chromosomes; implications for chromosome evolution.
Volume: 61
Issue: 2
Pages: 132-4
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Genotype
Genotype
Symbol: Calca/Calca<+> Trp53/Trp53 Rb1/Rb1 Pten/Pten
Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Trp53/Trp53 Tg(BGLAP-cre)1Clem/?
Background: involves: 129 * 129P2/OlaHsd * FVB/NJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nell1/Nell1 Rb1/Rb1 Trp53/Trp53 Tg(BGLAP-cre)1Clem/?
Background: involves: 129 * FVB/NJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Rb1/Rb1 Tg(Prdm1-cre)1Masu/?
Background: involves: C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
14966529 | J:88315
First Author: Simin K
Year: 2004
Journal: PLoS Biol
Title: pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epithelia.
Volume: 2
Issue: 2
Pages: E22
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Allele
Tg(Rb1)1Blg | MGI:3699596
Name: transgene insertion 1, Brenda L Gallie
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl1/Rbl1 Trp53/Trp53 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl1/Rbl1<+> Trp53/Trp53 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl1/Rbl1<+> Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pten/Pten Rb1/Rb1 Tg(Pbsn-cre)4Prb/?
Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pten/Pten Rb1/Rb1<+> Tg(Pbsn-cre)4Prb/?
Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pten/Pten Rb1/Rb1 Tg(Pbsn-cre)4Prb/?
Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1/Rb1 Rbl1/Rbl1 Trp53/Trp53 Tg(Chx10-EGFP/cre,-ALPP)2Clc/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
3772065 | J:8451
First Author: Sánchez ER
Year: 1986
Journal: J Hered
Title: Wild-derived Robertsonian translocation in mice. Chromosome 17, Rb (16:17)7, shows novel interactions with t-alleles.
Volume: 77
Issue: 5
Pages: 290-4
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Publication
8119578 | J:18203
First Author: Safronova LD
Year: 1993
Journal: Genetika
Title: [Disturbance of the relationship of transmission in male mice carrying the translocation Rb(8,17)1 Iem in combination with t-haplotypes].
Volume: 29
Issue: 12
Pages: 1992-9
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Publication
11861365 | J:75025
First Author: Chen D
Year: 2002
Journal: Cancer Res
Title: Genomic amplification in retinoblastoma narrowed to 0.6 megabase on chromosome 6p containing a kinesin-like gene, RBKIN.
Volume: 62
Issue: 4
Pages: 967-71
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Publication
19934342 | J:309210
First Author: Wang Y
Year: 2009
Journal: Cancer Prev Res (Phila)
Title: Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer.
Volume: 2
Issue: 12
Pages: 1059-64
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Allele
Tg(tetO-Ctsb/RB1)14Smrs | MGI:5911114
Name: transgene insertion 14, Sonia M Rocha-Sanchez
Allele Type: Transgenic
Attribute String: Dominant negative, Epitope tag, Humanized sequence, Inserted expressed sequence
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Strain
MGI:7781369 | C57BL/6JSmoc-Trp53<tm2Smoc> Smad4<tm1Smoc> Rb1<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
39394434 | J:360745
First Author: Romero R
Year: 2024
Journal: Nat Cancer
Title: The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1.
Volume: 5
Issue: 11
Pages: 1641-1659
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Publication
30674894 | J:276500
First Author: Annunziato S
Year: 2019
Journal: Nat Commun
Title: Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer.
Volume: 10
Issue: 1
Pages: 397
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Publication
37267950 | J:336652
First Author: Arora M
Year: 2023
Journal: Cell
Title: Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity.
Volume: 186
Issue: 12
Pages: 2628-2643.e21
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Publication
36696903 | J:333345
First Author: Gong Y
Year: 2023
Journal: Dev Cell
Title: Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.
Volume: 58
Issue: 3
Pages: 192-210.e11
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Publication
38676926 | J:350956
First Author: Lee S
Year: 2024
Journal: Cell Rep
Title: Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis.
Volume: 43
Issue: 5
Pages: 114146
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Publication
35393570 | J:349055
First Author: Fang L
Year: 2022
Journal: Cancer Gene Ther
Title: TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence.
Volume: 29
Issue: 10
Pages: 1463-1476
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Publication
36928314 | J:352792
 
First Author: Wang ME
Year: 2023
Journal: J Clin Invest
Title: RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis.
Volume: 133
Issue: 10
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Publication
28805815 | J:258019
First Author: Chow RD
Year: 2017
Journal: Nat Neurosci
Title: AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma.
Volume: 20
Issue: 10
Pages: 1329-1341
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Publication
9931482 | J:52583
First Author: Brunelli JP
Year: 1999
Journal: Gene
Title: Sequence, expression and genetic mapping of a rainbow trout retinoblastoma cDNA.
Volume: 226
Issue: 2
Pages: 175-80
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Publication
20610631 | J:162247
First Author: Bremner R
Year: 2010
Journal: Cancer Res
Title: Cyclins, Cdks, E2f, Skp2, and more at the first international RB Tumor Suppressor Meeting.
Volume: 70
Issue: 15
Pages: 6114-8
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Publication
22941188 | J:190016
First Author: Peifer M
Year: 2012
Journal: Nat Genet
Title: Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
Volume: 44
Issue: 10
Pages: 1104-10
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Publication
23334668 | J:198063
First Author: Holmfeldt L
Year: 2013
Journal: Nat Genet
Title: The genomic landscape of hypodiploid acute lymphoblastic leukemia.
Volume: 45
Issue: 3
Pages: 242-52
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Publication
25002614 | J:217924
First Author: Hinds PW
Year: 2014
Journal: Cancer Discov
Title: A little pRB can lead to big problems.
Volume: 4
Issue: 7
Pages: 764-5
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Publication
25486431 | J:224251
First Author: Zhu L
Year: 2015
Journal: Oncogene
Title: Antitumor mechanisms when pRb and p53 are genetically inactivated.
Volume: 34
Issue: 35
Pages: 4547-57
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Publication
26235627 | J:232893
First Author: Akamatsu S
Year: 2015
Journal: Cell Rep
Title: The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer.
Volume: 12
Issue: 6
Pages: 922-36
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Publication
27557444 | J:236393
   
First Author: Papale A
Year: 2016
Journal: Elife
Title: Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors.
Volume: 5
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Publication
36230849 | J:330140
 
First Author: Hopkins J
Year: 2022
Journal: Cancers (Basel)
Title: PRELP Regulates Cell-Cell Adhesion and EMT and Inhibits Retinoblastoma Progression.
Volume: 14
Issue: 19
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Publication
37244438 | J:336409
 
First Author: Giaccone G
Year: 2023
Journal: Semin Cancer Biol
Title: Current knowledge of small cell lung cancer transformation from non-small cell lung cancer.
Volume: 94
Pages: 1-10
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Publication
35967587 | J:345785
First Author: Jin Y
Year: 2022
Journal: Natl Sci Rev
Title: Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis.
Volume: 9
Issue: 7
Pages: nwab232
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Strain
MGI:6160072 | B6;129-Tg(tetO-Ctsb/RB1)14Smrs/J
Attribute String: transgenic, mutant stock
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Publication
12391155 | -
First Author: Yochum GS
Year: 2002
Journal: Mol Cell Biol
Title: Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split.
Volume: 22
Issue: 22
Pages: 7868-76
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Publication
14506250 | -
First Author: Tominaga K
Year: 2003
Journal: J Biol Chem
Title: MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner.
Volume: 278
Issue: 49
Pages: 49618-24
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Publication
20870719 | -
First Author: Saddic LA
Year: 2010
Journal: J Biol Chem
Title: Methylation of the retinoblastoma tumor suppressor by SMYD2.
Volume: 285
Issue: 48
Pages: 37733-40
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Publication
17108971 | J:245303
First Author: Huang J
Year: 2006
Journal: Nature
Title: Repression of p53 activity by Smyd2-mediated methylation.
Volume: 444
Issue: 7119
Pages: 629-32
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Publication
22241783 | J:179899
First Author: Donlin LT
Year: 2012
Journal: Genes Dev
Title: Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.
Volume: 26
Issue: 2
Pages: 114-9
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Publication
26826421 | -
 
First Author: Ohtomo-Oda R
Year: 2016
Journal: Hum Pathol
Title: SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas.
Volume: 49
Pages: 145-55
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Publication
27655694 | J:240508
First Author: Bagislar S
Year: 2016
Journal: Oncotarget
Title: Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis.
Volume: 7
Issue: 41
Pages: 66398-66415
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Protein Domain
IPR038012 | MRGX
Type: Family
Description: Mortality factor 4-like protein 2 (MORF4L2 or MRGX) is a component of the NuA4 histone acetyltransferase complex []and the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones []. MRGX interacts with MRFAP1 and RB1 and represses the B-myb promoter in EJ cells but activates it in HeLa cells []. MRGX contains an MRG domain.The NuA4 histone acetyltransferase complex (also known as the TRRAP/TIP60-containing histone acetyltransferase complex) acetylates nucleosomal histones H4 and H2A thereby activating selected genes for transcription and is a a key regulator of transcription, cellular response to DNA damage and cell cycle control []. In yeast, where the complex was first identified, NuA4 consists of at least ACT1, ARP4, YAF9, VID21, SWC4, EAF3, EAF5, EAF6, EAF7, EPL1, ESA1, TRA1 and YNG2 []. In humans, the complex is composed of the histone acetyltransferase KAT5 (also known as TIP60) plus the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, MAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 [].
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Protein Domain
IPR044419 | SMYD2_SET
Type: Domain
Description: This entry represents the SET domain of SET and MYND domain-containing protein 2 (SMYD2). SMYD2 functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1 [, ]. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organisation in both skeletal and cardiac muscles via Hsp90 methylation []. SMYD2 overexpression is associated with tumour cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas []. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML) [].The SMYD family consists of five members including SMYD1/2/3/4/5. They contain two highly conserved structural and functional domains, the SET and MYND domains. The SET domain is involved in lysine methylation, while the MYND domain is involved in protein-protein interaction. They are essential in several mammalian developmental pathways [, , , ].
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Publication
30484104 | J:307676
First Author: Hollern DP
Year: 2019
Journal: Breast Cancer Res Treat
Title: A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.
Volume: 174
Issue: 1
Pages: 143-155
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Publication
28134624 | J:242936
First Author: Kent LN
Year: 2017
Journal: J Clin Invest
Title: Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma.
Volume: 127
Issue: 3
Pages: 830-842
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Publication
28847987 | J:317020
First Author: Akeno N
Year: 2017
Journal: Mol Cancer Ther
Title: TRP53 Mutants Drive Neuroendocrine Lung Cancer Through Loss-of-Function Mechanisms with Gain-of-Function Effects on Chemotherapy Response.
Volume: 16
Issue: 12
Pages: 2913-2926
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Publication
31930396 | J:298073
First Author: Shi M
Year: 2020
Journal: Biol Reprod
Title: Inactivation of TRP53, PTEN, RB1, and/or CDH1 in the ovarian surface epithelium induces ovarian cancer transformation and metastasis.
Volume: 102
Issue: 5
Pages: 1055-1064
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