| Type |
Details |
Score |
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7578956 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-01-31 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1716823 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:7578990 |
| Age: |
embryonic day 15.5 |
| Image: |
1A |
| Note: |
Extensive co-localized immunostaining with Tfap2a was detected. |
| Specimen Label: |
1A |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5563339 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2020-07-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3268817 |
| Pattern: |
Not Specified |
| Stage: |
TS17 |
| Assay Id: |
MGI:6444460 |
| Age: |
embryonic day 10.5 |
| Image: |
3D |
| Note: |
Tfap2a and Nkx2-5 were not co-expressed. |
| Specimen Label: |
3D |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5563339 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2020-07-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3268817 |
| Pattern: |
Not Specified |
| Stage: |
TS17 |
| Assay Id: |
MGI:6444460 |
| Age: |
embryonic day 10.5 |
| Image: |
3A |
| Note: |
Tfap2a and Nkx2-5 were not co-expressed. |
| Specimen Label: |
3A |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5563339 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2020-07-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3673017 |
| Pattern: |
Not Specified |
| Stage: |
TS17 |
| Assay Id: |
MGI:6444460 |
| Age: |
embryonic day 10.5 |
| Image: |
3D |
| Note: |
Tfap2a and Nkx2-5 were not co-expressed. |
| Specimen Label: |
3D |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5563339 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2020-07-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3673017 |
| Pattern: |
Not Specified |
| Stage: |
TS17 |
| Assay Id: |
MGI:6444460 |
| Age: |
embryonic day 10.5 |
| Image: |
3A |
| Note: |
Tfap2a and Nkx2-5 were not co-expressed. |
| Specimen Label: |
3A |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| Pathway |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5697711 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-01-31 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1716824 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:7579054 |
| Age: |
embryonic day 16.5 |
|
| Note: |
The vast majority (>98%) of Tfap2a immunopositive cells did not co-express Ki67. |
| Specimen Label: |
not shown |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7578951 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-01-31 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1859027 |
| Pattern: |
Not Specified |
| Stage: |
TS27 |
| Assay Id: |
MGI:7579001 |
| Age: |
postnatal day 0 |
| Image: |
2F |
| Note: |
Expression was detected in horizontal cells that co-express Tfap2a (94% of Uchl1-positive cells expressed Tfap2a). |
| Specimen Label: |
2F |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7520302 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2023-08-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1707420 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:7520306 |
| Age: |
embryonic day 12.5 |
| Image: |
3E/F |
| Note: |
Coexpressed with Tfap2a in the ventricular zone. Some Tfap2b+ cells did not express Tfap2a. |
| Specimen Label: |
3E/F |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transcription factor AP-2, alpha; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5563339 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2020-07-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3268819 |
| Pattern: |
Not Specified |
| Stage: |
TS19 |
| Assay Id: |
MGI:6444460 |
| Age: |
embryonic day 11.5 |
| Image: |
3B/C |
| Note: |
Tfap2a and Nkx2-5 were not co-expressed. The flow divider was a part of the Nkx2-5-positive cell population and was present in between the most caudal pharyngeal arch arteries. |
| Specimen Label: |
3B/C |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5563339 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2020-07-23 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3268819 |
| Pattern: |
Not Specified |
| Stage: |
TS19 |
| Assay Id: |
MGI:6444460 |
| Age: |
embryonic day 11.5 |
| Image: |
3E/F |
| Note: |
Tfap2a and Nkx2-5 were not co-expressed. The flow divider was a part of the Nkx2-5-positive cell population and was present in between the most caudal pharyngeal arch arteries. |
| Specimen Label: |
3E/F |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7578956 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-01-31 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1859027 |
| Pattern: |
Regionally restricted |
| Stage: |
TS27 |
| Assay Id: |
MGI:7578990 |
| Age: |
postnatal day 0 |
| Image: |
2D |
| Note: |
Strong expression was detected in the future horizontal cell layer. Extensive overlap between Tfap2a and Tfap2b expression was observed (80% of immunopositive cells). In the outer retina, putative horizontal cells exhibiting strong Tfap2b signal were weakly stained for Tfap2a. |
| Specimen Label: |
2D |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
437
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Allele |
| Name: |
transcription factor AP-2, alpha; targeted mutation 2.1, Trevor Williams |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Hypomorph |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Allele |
| Name: |
hedgehog acyltransferase; transgene insertion 1, Trevor Williams |
| Allele Type: |
Transgenic |
| Attribute String: |
Null/knockout, Recombinase |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tfap2a/Tfap2a |
| Background: |
involves: 129S1/Sv * Black Swiss |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tfap2a/Tfap2a<+> |
| Background: |
involves: 129S1/Sv * Black Swiss |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
292
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tfap2a/Tfap2a |
| Background: |
involves: 129S1/Sv * Black Swiss |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Callier P |
| Year: |
2014 |
| Journal: |
PLoS Genet |
| Title: |
Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling. |
| Volume: |
10 |
| Issue: |
5 |
| Pages: |
e1004340 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Coumoul X |
| Year: |
2005 |
| Journal: |
Nucleic Acids Res |
| Title: |
Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. |
| Volume: |
33 |
| Issue: |
11 |
| Pages: |
e102 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hhat/Hhat<+> Shh/Shh<+> |
| Background: |
involves: 129S1/Sv * 129X1/SvJ |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hhat/Hhat |
| Background: |
Not Specified |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline and WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tfap2a/Tfap2a Hhat/? |
| Background: |
Not Specified |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hhat/Hhat<+> Ptch1/Ptch1<+> |
| Background: |
involves: 129S1/Sv * 129X1/SvJ |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Fgf8/Fgf8<+> Tfap2a/Tfap2a |
| Background: |
involves: 129P2/OlaHsd * 129S1/Sv * Black Swiss |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Malaab M |
| Year: |
2022 |
| Journal: |
Ann Rheum Dis |
| Title: |
Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis. |
| Volume: |
81 |
| Issue: |
2 |
| Pages: |
268-277 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McDade SS |
| Year: |
2012 |
| Journal: |
Nucleic Acids Res |
| Title: |
Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. |
| Volume: |
40 |
| Issue: |
15 |
| Pages: |
7190-206 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iulianella A |
| Year: |
2018 |
| Journal: |
Dev Dyn |
| Title: |
Ventral neural patterning in the absence of a Shh activity gradient from the floorplate. |
| Volume: |
247 |
| Issue: |
1 |
| Pages: |
170-184 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu J |
| Year: |
2012 |
| Journal: |
Genesis |
| Title: |
Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway. |
| Volume: |
50 |
| Issue: |
2 |
| Pages: |
102-11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yun K |
| Year: |
2017 |
| Journal: |
Differentiation |
| Title: |
Hydronephrosis in the Wnt5a-ablated kidney is caused by an abnormal ureter-bladder connection. |
| Volume: |
94 |
|
| Pages: |
1-7 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hhat/Hhat<+> |
| Background: |
involves: 129S4/SvJaeSor |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kitagaki J |
| Year: |
2011 |
| Journal: |
Development |
| Title: |
FGF8 is essential for formation of the ductal system in the male reproductive tract. |
| Volume: |
138 |
| Issue: |
24 |
| Pages: |
5369-78 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Hhat/Hhat H2az2/H2az2<+> |
| Background: |
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kurosaka H |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling. |
| Volume: |
10 |
| Issue: |
3 |
| Pages: |
e0120821 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dennis JF |
| Year: |
2012 |
| Journal: |
PLoS Genet |
| Title: |
Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. |
| Volume: |
8 |
| Issue: |
10 |
| Pages: |
e1002927 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Regard JB |
| Year: |
2013 |
| Journal: |
Nat Med |
| Title: |
Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. |
| Volume: |
19 |
| Issue: |
11 |
| Pages: |
1505-12 |
|
•
•
•
•
•
|