| Type |
Details |
Score |
| Publication |
| First Author: |
Butti R |
| Year: |
2021 |
| Journal: |
Oncogene |
| Title: |
Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression. |
| Volume: |
40 |
| Issue: |
11 |
| Pages: |
2002-2017 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chu F |
| Year: |
2018 |
| Journal: |
Clin Exp Immunol |
| Title: |
MicroRNA-126 deficiency enhanced the activation and function of CD4(+) T cells by elevating IRS-1 pathway. |
| Volume: |
191 |
| Issue: |
2 |
| Pages: |
166-179 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Granata V |
| Year: |
2023 |
| Journal: |
Int J Mol Sci |
| Title: |
Genetic Deficiency of the Long Pentraxin 3 Affects Osteogenesis and Osteoclastogenesis in Homeostatic and Inflammatory Conditions. |
| Volume: |
24 |
| Issue: |
23 |
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
179
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
198
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
211
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
211
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
85
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
348
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
109
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
145
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
198
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
206
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
164
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
208
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
197
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
286
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
348
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
206
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
347
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
143
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
111
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
97
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
145
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
168
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ding YH |
| Year: |
1998 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Zinc-dependent dimers observed in crystals of human endostatin. |
| Volume: |
95 |
| Issue: |
18 |
| Pages: |
10443-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Blundell CD |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding. |
| Volume: |
278 |
| Issue: |
49 |
| Pages: |
49261-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Teriete P |
| Year: |
2004 |
| Journal: |
Mol Cell |
| Title: |
Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. |
| Volume: |
13 |
| Issue: |
4 |
| Pages: |
483-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sasaki T |
| Year: |
2000 |
| Journal: |
J Mol Biol |
| Title: |
Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity. |
| Volume: |
301 |
| Issue: |
5 |
| Pages: |
1179-90 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
552
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
40
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
37
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
121
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dickmanns A |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme. |
| Volume: |
280 |
| Issue: |
15 |
| Pages: |
15180-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McMahon SA |
| Year: |
2005 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
The C-type lectin fold as an evolutionary solution for massive sequence variation. |
| Volume: |
12 |
| Issue: |
10 |
| Pages: |
886-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kastin AJ |
| Year: |
1976 |
| Journal: |
Mayo Clin Proc |
| Title: |
Some questions related to melanocyte-stimulating hormone. |
| Volume: |
51 |
| Issue: |
10 |
| Pages: |
632-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tian X |
| Year: |
2013 |
| Journal: |
Nature |
| Title: |
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. |
| Volume: |
499 |
| Issue: |
7458 |
| Pages: |
346-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Toole BP |
| Year: |
2004 |
| Journal: |
Nat Rev Cancer |
| Title: |
Hyaluronan: from extracellular glue to pericellular cue. |
| Volume: |
4 |
| Issue: |
7 |
| Pages: |
528-39 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lipponen P |
| Year: |
2001 |
| Journal: |
Eur J Cancer |
| Title: |
High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer. |
| Volume: |
37 |
| Issue: |
7 |
| Pages: |
849-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Han BK |
| Year: |
2016 |
| Journal: |
Semin Arthritis Rheum |
| Title: |
The CD27-CD70 pathway and pathogenesis of autoimmune disease. |
| Volume: |
45 |
| Issue: |
4 |
| Pages: |
496-501 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
Lectins occur in plants, animals, bacteria and viruses. Initially described for their carbohydrate-binding activity [], they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions []. There are at least twelve structural families of lectins, of which C-type (Ca+-dependent) lectins is one. C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NKgroup transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [].The term 'C-type lectin domain' was introduced to distinguish a carbohydrate-recognition domain (CRD) which is present in all Ca2+-dependent lectins, but not in other types of animal lectins. However, there are proteins with modules similar in overall structure to CRDs that serve functions other than sugar binding. Therefore, a more general term C-type lectin-like domain was introduced to refer to such domains, although both terms are sometimes used interchangeably [].This superfamily represents a structural domain found in C-type lectins, as well as in other proteins, including:The C-terminal domain of invasin []and intimin [].Link domain, which includes the Link module of tumor necrosis factor-inducible gene 6 protein (TSG-6) [](a hyaladherin with important roles in inflammation and ovulation) and the hyaluronan binding domain of CD44 (which contains extra N-terminal β-strand and C-terminal β-hairpin) []. The Link domain may have emerged as a result of a deletion of the long loop region from an ancestral canonical C-type lectin domain [].Endostatin []and the endostatin domain of collagen alpha 1 (XV) [], these domains being decorated with many insertions in the common fold. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
Lectins occur in plants, animals, bacteria and viruses. Initially described for their carbohydrate-binding activity [], they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions []. There are at least twelve structural families of lectins, of which C-type (Ca+-dependent) lectins is one. C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [].This entry represents a structural domainfound in C-type lectins, as well as in other proteins, including:The N-terminal domain of aerolysin []and the N-terminal domain of the S2/S3 subunit of pertussis toxin [].The C-terminal domain of invasin []and intimin [].Link domain, which includes the Link module of TSG-6 [](a hyaladherin with important roles in inflammation and ovulation) and the hyaluronan binding domain of CD44 (which contains extra N-terminal β-strand and C-terminal β-hairpin) [].Endostatin []and the endostatin domain of collagen alpha 1 (XV) [], these domains being decorated with many insertions in the common fold.The noncollagenous (NC1) domain of collagen IV, which consists of a duplication of the C-type lectin domain, with segment swapping within and between individual domains [].Sulphatase-modifying factors (C-alpha-formyglycine-generating enzyme), where the fold is decorated with many additional structures [, ].The C-terminal domain of the major tropism determinant (Mtd), where the fold is decorated with many additional structures, and has an overall similarity to the sulphatase modifying factor family but lacking the characteristic disulphide []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
210
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
619
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Riehl TE |
| Year: |
2020 |
| Journal: |
Am J Physiol Gastrointest Liver Physiol |
| Title: |
Hyaluronic acid promotes Lgr5+ stem cell proliferation and crypt fission through TLR4 and PGE2 transactivation of EGFR. |
| Volume: |
319 |
| Issue: |
1 |
| Pages: |
G63-G73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cui Z |
| Year: |
2019 |
| Journal: |
Matrix Biol |
| Title: |
The Receptor for Hyaluronan-Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury. |
| Volume: |
78-79 |
|
| Pages: |
255-271 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alquraini A |
| Year: |
2017 |
| Journal: |
Arthritis Res Ther |
| Title: |
The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes. |
| Volume: |
19 |
| Issue: |
1 |
| Pages: |
89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Southgate TD |
| Year: |
2010 |
| Journal: |
PLoS One |
| Title: |
CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells. |
| Volume: |
5 |
| Issue: |
4 |
| Pages: |
e9982 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hobbs MV |
| Year: |
1993 |
| Journal: |
J Immunol |
| Title: |
Patterns of cytokine gene expression by CD4+ T cells from young and old mice. |
| Volume: |
150 |
| Issue: |
8 Pt 1 |
| Pages: |
3602-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kennedy JD |
| Year: |
1995 |
| Journal: |
Am J Respir Cell Mol Biol |
| Title: |
Phenotypic characterization of T lymphocytes emigrating into lung tissue and the airway lumen after antigen inhalation in sensitized mice. |
| Volume: |
12 |
| Issue: |
6 |
| Pages: |
613-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nagarkatti M |
| Year: |
1996 |
| Journal: |
J Toxicol Environ Health |
| Title: |
Effect of radon on the immune system: alterations in the cellularity and functions of T cells in lymphoid organs of mouse. |
| Volume: |
47 |
| Issue: |
6 |
| Pages: |
535-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oughton JA |
| Year: |
1999 |
| Journal: |
Clin Immunol |
| Title: |
Novel phenotype associated with in vivo activated CTL precursors. |
| Volume: |
90 |
| Issue: |
3 |
| Pages: |
323-33 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
167
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
145
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
354
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
157
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
228
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
381
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
174
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
459
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
273
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
278
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
300
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
131
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
99
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
226
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
47
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
98
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
533
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
418
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
537
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
326
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
143
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
140
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
400
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
214
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
421
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
103
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
132
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
122
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
246
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
307
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
268
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
174
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
337
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
361
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
320
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharon N |
| Year: |
2001 |
| Journal: |
Adv Exp Med Biol |
| Title: |
The structural basis for carbohydrate recognition by lectins. |
| Volume: |
491 |
|
| Pages: |
1-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kilpatrick DC |
| Year: |
2002 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Animal lectins: a historical introduction and overview. |
| Volume: |
1572 |
| Issue: |
2-3 |
| Pages: |
187-97 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
359
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
356
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
275
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
518
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
372
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
841
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
620
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
359
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
250
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
368
 |
| Fragment?: |
false |
|
•
•
•
•
•
|