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Search results 1601 to 1700 out of 1714 for Dnmt3a

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
HT Experiment
GSE202875 | Transcription Across the H19/Igf2 Imprinting Control Region Initiates Paternally Methylated Imprinting in Mouse Prospermatogonia (RNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-52261 | Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain (RNA-seq)
Series Id: GSE52261
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
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Strain
MGI:6286135 | B6.Cg-Gt(ROSA)26Sor<tm3(CAG-flpo/ERT2)Alj> Npm1<tm1Trow> Dnmt3a<tm1Trow> Tg(Mx1-cre)1Cgn
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Dnmt3a/Dnmt3a<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Npm1/Npm1<+> Tg(Mx1-cre)1Cgn/?
Background: B6.Cg-Gt(ROSA)26Sor Npm1 Dnmt3a Tg(Mx1-cre)1Cgn
Zygosity: cn
Has Mutant Allele: true
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Protein
D3YUQ4
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: false
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Publication
18541670 | J:137926
First Author: Bouska A
Year: 2008
Journal: Mol Cell Biol
Title: Mdm2 promotes genetic instability and transformation independent of p53.
Volume: 28
Issue: 15
Pages: 4862-74
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Publication
22733537 | -
First Author: Tang YA
Year: 2012
Journal: Clin Cancer Res
Title: MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer.
Volume: 18
Issue: 16
Pages: 4325-33
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Publication
8570197 | -
First Author: Dubs-Poterszman MC
Year: 1995
Journal: Oncogene
Title: MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest.
Volume: 11
Issue: 11
Pages: 2445-9
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Publication
20308078 | -
First Author: Xu H
Year: 2010
Journal: J Biol Chem
Title: MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.
Volume: 285
Issue: 24
Pages: 18407-14
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Publication
19321440 | -
First Author: Fu W
Year: 2009
Journal: J Biol Chem
Title: MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
Volume: 284
Issue: 21
Pages: 13987-4000
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Publication
19411066 | -
First Author: Gu L
Year: 2009
Journal: Cancer Cell
Title: Regulation of XIAP translation and induction by MDM2 following irradiation.
Volume: 15
Issue: 5
Pages: 363-75
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Publication
23885265 | -
First Author: Nag S
Year: 2013
Journal: J Biomed Res
Title: The MDM2-p53 pathway revisited.
Volume: 27
Issue: 4
Pages: 254-71
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Publication
23894490 | -
First Author: Gordon CA
Year: 2013
Journal: PLoS One
Title: Inactive DNMT3B splice variants modulate de novo DNA methylation.
Volume: 8
Issue: 7
Pages: e69486
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Publication
25198254 | -
First Author: Walton EL
Year: 2014
Journal: Biology (Basel)
Title: Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for Diseases.
Volume: 3
Issue: 3
Pages: 578-605
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Publication
16965791 | -
First Author: Kostic M
Year: 2006
Journal: J Mol Biol
Title: Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53.
Volume: 363
Issue: 2
Pages: 433-50
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Protein Domain
IPR028340 | Mdm2
Type: Family
Description: MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome []. p53 acts as an important defense mechanism against cancer, and is negatively regulated by interaction with the oncoprotein MDM2 []. MDM2 overexpression correlates with metastasis and advanced forms of several cancers and may be used as a cancer drug target []. In addition, MDM2 has important roles in the cell independent of p53. It interacts with several proteins such as Rb/E2F-1 complex [], the DNA methyltransferase DNMT3A [], p107 [], MTBP []and the cyclin kinase inhibitor p21 []. MDM2 also affects cell apoptosis [, ]. The core of MDM2 folds into an open bundle of four helices which is capped by two small 3-strandedβ-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 α-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain. In addition to its N-terminal p53 binding domain, MDM2 contains a central acidic domain, zinc finger domain and a C-terminal RING-finger domain.
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Protein Domain
IPR044080 | MDM2_mRING-HC-C2H2C4
Type: Domain
Description: MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome []. p53 acts as an important defense mechanism against cancer, and is negatively regulated by interaction with the oncoprotein MDM2 []. MDM2 overexpression correlates with metastasis and advanced forms of several cancers and may be used as a cancer drug target []. In addition, MDM2 has important roles in the cell independent of p53. It interacts with several proteins such as Rb/E2F-1 complex [], the DNA methyltransferase DNMT3A [], p107 [], MTBP []and the cyclin kinase inhibitor p21 []. MDM2 also affects cell apoptosis [, ].MDM2 contains an N-terminal p53-binding domain, and a C-terminal modified C2H2C4-type RING-HC finger conferring E3 ligase activity that is required for ubiquitination and nuclear export of p53. It is also responsible for the hetero-oligomerization of MDM2, which is crucial for the suppression of P53 activity during embryonic development, and the recruitment of E2 ubiquitin-conjugating enzymes []. MDM2 also harbours a RanBP2-type zinc finger (Znf-RanBP2) domain, as well as a nuclear localisation signal (NLS) and a nuclear export signal (NES), near the central acidic region. The Znf-RanBP2 domain plays an important role in mediating MDM2 binding to ribosomal proteins and thus is involved in MDM2-mediated p53 suppression.This entry represents the C-terminal modified C2H2C4-type RING-HC finger.
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Protein Domain
IPR030488 | DNMT3B_ADD
Type: Domain
Description: This entry represents the ADD domain of DNMT3B. The ADD domain is composed of three clearly distinguishable modules that packtogether through extensive hydrophobic interactions to form a single globulardomain. Packed against this GATA-like finger is a second subdomain,which binds two zinc ions and closely resembles the structure reported forseveral PHD fingers. Finally, there is a long C-terminal α-helix that runsout from the PHD finger and makes extensive hydrophobic contacts with the N-terminal GATA finger, bringing the N- and C-termini of the ADD domain closetogether. This combination of fused GATA-like and PHD fingers within a singledomain is thus far unique [, ].In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. Many DNMT3B isoforms from alternative splicing have been described, among which DNMT3B3 stimulates the basal activity of DNMT3 enzymes, but partially inhibits the stimulatory effect of DNMT3L, whereas DNMT3B4 significantly impairs de novo methylation [, ]. DNMT3B is involved in development and is associated with several diseases, including cancers [].
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HT Experiment
GSE203226 | Mechanisms and function of de novo DNA methylation in placental development [snRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE203291 | Mechanisms and function of de novo DNA methylation in placental development [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
11836534 | J:74998
First Author: Qiu C
Year: 2002
Journal: Nat Struct Biol
Title: The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds.
Volume: 9
Issue: 3
Pages: 217-24
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Publication
21553025 | J:201510
First Author: Roberts AR
Year: 2011
Journal: Chromosoma
Title: Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo.
Volume: 120
Issue: 4
Pages: 377-85
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Publication
10857753 | J:62173
First Author: Aapola U
Year: 2000
Journal: Genomics
Title: Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.
Volume: 65
Issue: 3
Pages: 293-8
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Publication
29323282 | J:308602
First Author: Hanna CW
Year: 2018
Journal: Nat Struct Mol Biol
Title: MLL2 conveys transcription-independent H3K4 trimethylation in oocytes.
Volume: 25
Issue: 1
Pages: 73-82
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Publication
17643371 | J:201799
First Author: Zhu F
Year: 2007
Journal: Mol Cell
Title: IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing.
Volume: 27
Issue: 2
Pages: 214-27
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Publication
39236155 | J:353556
   
First Author: Park MD
Year: 2024
Journal: Science
Title: Hematopoietic aging promotes cancer by fueling IL-1⍺-driven emergency myelopoiesis.
Pages: eadn0327
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Publication
32929285 | J:297731
First Author: Shirane K
Year: 2020
Journal: Nat Genet
Title: NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing.
Volume: 52
Issue: 10
Pages: 1088-1098
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Publication
29727682 | J:271528
First Author: Qian P
Year: 2018
Journal: Cell Stem Cell
Title: Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Volume: 22
Issue: 5
Pages: 740-754.e7
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Publication
33743191 | J:323037
First Author: Hormaechea-Agulla D
Year: 2021
Journal: Cell Stem Cell
Title: Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling.
Volume: 28
Issue: 8
Pages: 1428-1442.e6
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Publication
37098340 | J:350348
First Author: Hamagami N
Year: 2023
Journal: Mol Cell
Title: NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons.
Volume: 83
Issue: 9
Pages: 1412-1428.e7
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Publication
29861161 | J:263340
First Author: Dhar SS
Year: 2018
Journal: Mol Cell
Title: MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.
Volume: 70
Issue: 5
Pages: 825-841.e6
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Publication
37642942 | J:347913
 
First Author: Ralvenius WT
Year: 2023
Journal: J Exp Med
Title: A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.
Volume: 220
Issue: 11
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Publication
31923647 | J:306907
First Author: Kodani N
Year: 2020
Journal: iScience
Title: FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression.
Volume: 23
Issue: 1
Pages: 100798
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Publication
29320732 | J:270799
First Author: Xiu Y
Year: 2018
Journal: Cell Rep
Title: Stabilization of NF-κB-Inducing Kinase Suppresses MLL-AF9-Induced Acute Myeloid Leukemia.
Volume: 22
Issue: 2
Pages: 350-358
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Publication
33235221 | J:300821
First Author: Kim YC
Year: 2020
Journal: Nat Commun
Title: Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A.
Volume: 11
Issue: 1
Pages: 5969
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Publication
26729896 | J:232581
First Author: Schulze I
Year: 2016
Journal: Blood
Title: Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.
Volume: 127
Issue: 12
Pages: 1575-86
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Publication
27662091 | J:253610
First Author: Liu XS
Year: 2016
Journal: Cell
Title: Editing DNA Methylation in the Mammalian Genome.
Volume: 167
Issue: 1
Pages: 233-247.e17
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Publication
25613421 | J:219799
 
First Author: Xu X
Year: 2015
Journal: Nat Commun
Title: Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting.
Volume: 6
Pages: 6008
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Publication
14973270 | J:88571
First Author: Sado T
Year: 2004
Journal: Development
Title: De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation.
Volume: 131
Issue: 5
Pages: 975-82
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Publication
24757056 | J:211081
First Author: Leung D
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1.
Volume: 111
Issue: 18
Pages: 6690-5
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Publication
26147501 | J:238393
First Author: Kauffman L
Year: 2015
Journal: PLoS One
Title: Gradual Rarefaction of Hematopoietic Precursors and Atrophy in a Depleted microRNA 29a, b and c Environment.
Volume: 10
Issue: 7
Pages: e0131981
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Publication
31056481 | J:347888
First Author: Yagi M
Year: 2019
Journal: Stem Cell Reports
Title: De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency.
Volume: 12
Issue: 5
Pages: 1113-1128
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Publication
34518230 | J:310976
 
First Author: Kinoshita M
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory.
Volume: 118
Issue: 38
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Publication
35922445 | J:327089
First Author: Yano S
Year: 2022
Journal: Nat Commun
Title: Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes.
Volume: 13
Issue: 1
Pages: 4440
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Publication
36881554 | J:346277
First Author: Yin H
Year: 2023
Journal: PLoS Biol
Title: Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer's disease pathology in mice.
Volume: 21
Issue: 3
Pages: e3002017
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Publication
15632057 | -
First Author: Brady M
Year: 2005
Journal: Mol Cell Biol
Title: Regulation of p53 and MDM2 activity by MTBP.
Volume: 25
Issue: 2
Pages: 545-53
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Publication
14707283 | -
First Author: Moll UM
Year: 2003
Journal: Mol Cancer Res
Title: The MDM2-p53 interaction.
Volume: 1
Issue: 14
Pages: 1001-8
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Protein
Q9CWR8
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Protein
A3EWM2
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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HT Experiment
GSE124215 | Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE249659 | Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
18814855 | J:143379
First Author: Hirasawa R
Year: 2009
Journal: Gene Expr Patterns
Title: Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos.
Volume: 9
Issue: 1
Pages: 27-30
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Publication
19482874 | J:151340
First Author: Gopalakrishnan S
Year: 2009
Journal: Hum Mol Genet
Title: DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions.
Volume: 18
Issue: 17
Pages: 3178-93
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Publication
28792951 | J:247969
First Author: Lemaire K
Year: 2017
Journal: PLoS One
Title: How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?
Volume: 12
Issue: 8
Pages: e0181651
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Publication
27003684 | J:235874
First Author: Yan C
Year: 2016
Journal: Diabetologia
Title: A decrease in hepatic microRNA-9 expression impairs gluconeogenesis by targeting FOXO1 in obese mice.
Volume: 59
Issue: 7
Pages: 1524-1532
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Publication
25615794 | J:234530
First Author: Veeranki S
Year: 2015
Journal: Biochim Biophys Acta
Title: Hyperhomocysteinemia associated skeletal muscle weakness involves mitochondrial dysfunction and epigenetic modifications.
Volume: 1852
Issue: 5
Pages: 732-41
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Publication
24001767 | J:205419
First Author: Peters SL
Year: 2013
Journal: Mol Cell Biol
Title: Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas.
Volume: 33
Issue: 21
Pages: 4321-33
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Publication
33450231 | J:301988
   
First Author: Lopusna K
Year: 2021
Journal: J Biol Chem
Title: Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
Pages: 100285
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Publication
26098213 | J:224543
First Author: Dhawan S
Year: 2015
Journal: J Clin Invest
Title: DNA methylation directs functional maturation of pancreatic β cells.
Volume: 125
Issue: 7
Pages: 2851-60
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Publication
30553776 | J:277669
 
First Author: Wang T
Year: 2019
Journal: Exp Hematol
Title: Smc3 is required for mouse embryonic and adult hematopoiesis.
Volume: 70
Pages: 70-84.e6
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Publication
27760115 | J:239417
First Author: Dai HQ
Year: 2016
Journal: Nature
Title: TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling.
Volume: 538
Issue: 7626
Pages: 528-532
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Publication
27133822 | J:237877
First Author: Zheng Y
Year: 2016
Journal: Leukemia
Title: Loss of Dnmt3b accelerates MLL-AF9 leukemia progression.
Volume: 30
Issue: 12
Pages: 2373-2384
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Publication
22343140 | J:232470
First Author: Woods R
Year: 2012
Journal: Hum Mol Genet
Title: Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation.
Volume: 21
Issue: 11
Pages: 2399-411
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Publication
31371502 | J:278908
First Author: López-Moyado IF
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Paradoxical association of TET loss of function with genome-wide DNA hypomethylation.
Volume: 116
Issue: 34
Pages: 16933-16942
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Publication
19136628 | J:143477
First Author: Chotalia M
Year: 2009
Journal: Genes Dev
Title: Transcription is required for establishment of germline methylation marks at imprinted genes.
Volume: 23
Issue: 1
Pages: 105-17
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Publication
16403808 | J:106778
First Author: Arnaud P
Year: 2006
Journal: Hum Mol Genet
Title: Stochastic imprinting in the progeny of Dnmt3L-/- females.
Volume: 15
Issue: 4
Pages: 589-98
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Publication
16543361 | J:108227
First Author: Xie ZH
Year: 2006
Journal: Hum Mol Genet
Title: Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L.
Volume: 15
Issue: 9
Pages: 1375-85
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Publication
34773530 | J:347391
First Author: Long J
Year: 2023
Journal: Cell Biol Toxicol
Title: Uterine deficiency of Dnmt3b impairs decidualization and causes consequent embryo implantation defects.
Volume: 39
Issue: 3
Pages: 1077-1098
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Publication
25361568 | J:227805
First Author: Domingo-Gonzalez R
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation.
Volume: 308
Issue: 1
Pages: L86-95
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Publication
25995477 | J:247459
First Author: Chandra R
Year: 2015
Journal: J Neurosci
Title: Opposing role for Egr3 in nucleus accumbens cell subtypes in cocaine action.
Volume: 35
Issue: 20
Pages: 7927-37
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Publication
24291790 | J:207929
First Author: Yamaguchi S
Year: 2013
Journal: Nature
Title: Role of Tet1 in erasure of genomic imprinting.
Volume: 504
Issue: 7480
Pages: 460-4
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Publication
28596252 | J:252696
First Author: Cull AH
Year: 2017
Journal: J Leukoc Biol
Title: Success in bone marrow failure? Novel therapeutic directions based on the immune environment of myelodysplastic syndromes.
Volume: 102
Issue: 2
Pages: 209-219
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Publication
39098534 | J:355645
First Author: Khudaverdyan N
Year: 2024
Journal: J Biol Chem
Title: The structure of DNA methyltransferase DNMT3C reveals an activity-tuning mechanism for DNA methylation.
Volume: 300
Issue: 9
Pages: 107633
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Publication
12202768 | J:113944
First Author: Deplus R
Year: 2002
Journal: Nucleic Acids Res
Title: Dnmt3L is a transcriptional repressor that recruits histone deacetylase.
Volume: 30
Issue: 17
Pages: 3831-8
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Publication
10325416 | J:55369
First Author: Robertson KD
Year: 1999
Journal: Nucleic Acids Res
Title: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.
Volume: 27
Issue: 11
Pages: 2291-8
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Publication
10433969 | J:56959
First Author: Xie S
Year: 1999
Journal: Gene
Title: Cloning, expression and chromosome locations of the human DNMT3 gene family.
Volume: 236
Issue: 1
Pages: 87-95
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Publication
15203217 | J:90624
First Author: Lees-Murdock DJ
Year: 2004
Journal: Genomics
Title: Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci.
Volume: 84
Issue: 1
Pages: 193-204
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Publication
17380127 | J:122523
First Author: Yu Q
Year: 2007
Journal: EMBO J
Title: Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation.
Volume: 26
Issue: 8
Pages: 2052-60
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Publication
20018712 | J:156462
First Author: Hu JL
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The N-terminus of histone H3 is required for de novo DNA methylation in chromatin.
Volume: 106
Issue: 52
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