|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1601 to 1700 out of 2795 for Egfr

0.034s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
First Author: Caldieri G
Year: 2017
Journal: Science
Title: Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.
Volume: 356
Issue: 6338
Pages: 617-624
Allele
Name: transgene insertion, Kwok-Kin Wong
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
Publication  
First Author: Wang S
Year: 2017
Journal: Cancer Lett
Title: EAI045: The fourth-generation EGFR inhibitor overcoming T790M and C797S resistance.
Volume: 385
Pages: 51-54
Publication
First Author: de Bruin EC
Year: 2014
Journal: Cancer Discov
Title: Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.
Volume: 4
Issue: 5
Pages: 606-19
Publication
First Author: Nakayama S
Year: 2014
Journal: Cancer Res
Title: β-catenin contributes to lung tumor development induced by EGFR mutations.
Volume: 74
Issue: 20
Pages: 5891-902
Publication
First Author: Ercan D
Year: 2012
Journal: Cancer Discov
Title: Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.
Volume: 2
Issue: 10
Pages: 934-47
Publication
First Author: Pascolutti R
Year: 2019
Journal: Cell Rep
Title: Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.
Volume: 27
Issue: 10
Pages: 3049-3061.e6
Publication
First Author: Gibbons DL
Year: 2014
Journal: Cancer Discov
Title: A HER 1-2 punch: dual EGFR targeting deals resistance a deadly blow.
Volume: 4
Issue: 9
Pages: 991-4
UniProt Feature
Begin: 604
Description: Phosphotyrosine; by CSK, EGFR and SRC
Type: modified residue
End: 604
UniProt Feature
Begin: 488
Description: Phosphotyrosine; by SRC, LCK, INSR and EGFR
Type: modified residue
End: 488
Transgene
Type: transgene
Organism: mouse, laboratory
Publication
First Author: Tomoshige K
Year: 2018
Journal: Oncogene
Title: An EGFR ligand promotes EGFR-mutant but not KRAS-mutant lung cancer in vivo.
Volume: 37
Issue: 28
Pages: 3894-3908
Publication
First Author: Qing X
Year: 2018
Journal: J Clin Invest
Title: iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling.
Volume: 128
Issue: 4
Pages: 1397-1412
Publication
First Author: Ho SR
Year: 2018
Journal: J Biol Chem
Title: RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation.
Volume: 293
Issue: 42
Pages: 16307-16323
Publication
First Author: Walter AO
Year: 2013
Journal: Cancer Discov
Title: Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC.
Volume: 3
Issue: 12
Pages: 1404-15
Pathway
Pathway
Publication  
First Author: Unni AM
Year: 2015
Journal: Elife
Title: Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma.
Volume: 4
Pages: e06907
ncRNA Gene
Type: ncRNA_gene
Organism: Mus caroli
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
lncRNA Gene
Type: lncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: Mus pahari
ncRNA Gene
Type: ncRNA_gene
Organism: Mus spretus
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2016-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5805541
Age: postnatal week 7.6-14.1
Image: 1D
Note: Expression was detected in layer VI cells lining the subcortical white matter.
Specimen Label: 1D
Detected: true
Specimen Num: 2
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2016-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284228
Pattern: Scattered
Stage: TS28
Assay Id: MGI:5805541
Age: postnatal week 7.6-14.1
Image: 1D
Note: Expression was scattered in the upper layers of the neocortex.
Specimen Label: 1D
Detected: true
Specimen Num: 2
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2016-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5805541
Age: embryonic day 14.5
Image: 1C
Note: Expression was detected in the ventral telencephalon.
Specimen Label: 1C
Detected: true
Specimen Num: 1
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2016-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5805541
Age: embryonic day 14.5
Image: 1C
Note: Expression was detected in the ventral telencephalon.
Specimen Label: 1C
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2016-10-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5805541
Age: postnatal week 7.6-14.1
Image: Dataset 2
Specimen Label: Dataset 2
Detected: true
Specimen Num: 3
Publication
First Author: Jun HJ
Year: 2012
Journal: Oncogene
Title: Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme.
Volume: 31
Issue: 25
Pages: 3039-50
Allele  
Name: Egfr long non-coding downstream RNA; gene trap OST60940, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: Egfr long non-coding downstream RNA; gene trap OST133326, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: Egfr long non-coding downstream RNA; gene trap OST324279, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: Egfr long non-coding downstream RNA; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: Egfr long non-coding downstream RNA; endonuclease-mediated mutation 1, Biocytogen
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Publication
First Author: Zhu H
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.
Volume: 106
Issue: 8
Pages: 2712-6
Publication
First Author: Li D
Year: 2007
Journal: Cancer Cell
Title: Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy.
Volume: 12
Issue: 1
Pages: 81-93
Publication
First Author: Kalinowski A
Year: 2014
Journal: Am J Physiol Lung Cell Mol Physiol
Title: EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production.
Volume: 307
Issue: 2
Pages: L186-96
Publication
First Author: de Graauw M
Year: 2014
Journal: Oncogene
Title: Annexin A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation.
Volume: 33
Issue: 20
Pages: 2610-9
Publication
First Author: Noma T
Year: 2007
Journal: J Clin Invest
Title: Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.
Volume: 117
Issue: 9
Pages: 2445-58
Publication
First Author: Lin SJ
Year: 2023
Journal: Nat Commun
Title: Endosomal Arl4A attenuates EGFR degradation by binding to the ESCRT-II component VPS36.
Volume: 14
Issue: 1
Pages: 7859
Publication
First Author: Yamaguchi T
Year: 2012
Journal: Cancer Cell
Title: NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
Volume: 21
Issue: 3
Pages: 348-61
Publication
First Author: George AJ
Year: 2013
Journal: FEBS J
Title: Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches.
Volume: 280
Issue: 21
Pages: 5258-68
Publication
First Author: Zhang H
Year: 2024
Journal: Cell Rep
Title: A MYC-STAMBPL1-TOE1 positive feedback loop mediates EGFR stability in hepatocellular carcinoma.
Volume: 43
Issue: 10
Pages: 114812
Publication
First Author: Gudiño V
Year: 2021
Journal: Nat Commun
Title: RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways.
Volume: 12
Issue: 1
Pages: 2335
Publication  
First Author: Zhang H
Year: 2017
Journal: Nat Commun
Title: Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis.
Volume: 8
Pages: 15016
Interaction Experiment
Description: UBPY-mediated epidermal growth factor receptor (EGFR) de-ubiquitination promotes EGFR degradation.
Publication
First Author: Jun HJ
Year: 2014
Journal: Stem Cells
Title: Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.
Volume: 32
Issue: 2
Pages: 338-48
Publication
First Author: Liu H
Year: 2020
Journal: Cancer Discov
Title: The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Volume: 10
Issue: 8
Pages: 1226-1239
Publication  
First Author: Kharbanda A
Year: 2020
Journal: Sci Signal
Title: Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis.
Volume: 13
Issue: 621
Publication
First Author: Hwang MK
Year: 2010
Journal: Cancer Res
Title: Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1.
Volume: 70
Issue: 17
Pages: 6859-69
Publication  
First Author: Le A
Year: 2020
Journal: Front Immunol
Title: JNK1 Signaling Downstream of the EGFR Pathway Contributes to Aldara®-Induced Skin Inflammation.
Volume: 11
Pages: 604785
Publication
First Author: Ryan MA
Year: 2010
Journal: Nat Med
Title: Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
Volume: 16
Issue: 10
Pages: 1141-6
Publication  
First Author: Keng VW
Year: 2012
Journal: Sarcoma
Title: Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.
Volume: 2012
Pages: 620834
Publication
First Author: Amato KR
Year: 2016
Journal: Cancer Res
Title: EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer.
Volume: 76
Issue: 2
Pages: 305-18
Publication
First Author: To C
Year: 2019
Journal: Cancer Discov
Title: Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor.
Volume: 9
Issue: 7
Pages: 926-943
Publication
First Author: Hsu TI
Year: 2016
Journal: Oncotarget
Title: Positive feedback regulation between IL10 and EGFR promotes lung cancer formation.
Volume: 7
Issue: 15
Pages: 20840-54
Publication
First Author: Regales L
Year: 2007
Journal: PLoS One
Title: Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors.
Volume: 2
Issue: 8
Pages: e810
Publication
First Author: Liccardi G
Year: 2011
Journal: Cancer Res
Title: EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment.
Volume: 71
Issue: 3
Pages: 1103-14
Publication
First Author: De S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal.
Volume: 112
Issue: 31
Pages: 9680-5
Publication
First Author: Eberlein CA
Year: 2015
Journal: Cancer Res
Title: Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models.
Volume: 75
Issue: 12
Pages: 2489-500
Publication
First Author: Takezawa K
Year: 2012
Journal: Cancer Discov
Title: HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation.
Volume: 2
Issue: 10
Pages: 922-33
Publication
First Author: Abdi K
Year: 2019
Journal: Cell Rep
Title: EGFR Signaling Termination via Numb Trafficking in Ependymal Progenitors Controls Postnatal Neurogenic Niche Differentiation.
Volume: 28
Issue: 8
Pages: 2012-2022.e4
Publication
First Author: Fleming Martinez AK
Year: 2021
Journal: iScience
Title: Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells.
Volume: 24
Issue: 1
Pages: 102019
Publication
First Author: Xu N
Year: 2016
Journal: Oncotarget
Title: Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer.
Volume: 7
Issue: 4
Pages: 3884-96
Publication
First Author: Shen M
Year: 2019
Journal: Cancer Cell
Title: Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling.
Volume: 35
Issue: 1
Pages: 64-80.e7
Publication
First Author: Dahlhoff M
Year: 2013
Journal: Exp Cell Res
Title: Genetic deletion of the EGFR ligand epigen does not affect mouse embryonic development and tissue homeostasis.
Volume: 319
Issue: 4
Pages: 529-35
Publication
First Author: Fan JB
Year: 2014
Journal: Biochem Biophys Res Commun
Title: EGFR trans-activation mediates pleiotrophin-induced activation of Akt and Erk in cultured osteoblasts.
Volume: 447
Issue: 3
Pages: 425-30
Publication
First Author: Wang YN
Year: 2018
Journal: Cancer Cell
Title: Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer.
Volume: 33
Issue: 4
Pages: 752-769.e8
Publication
First Author: Becker JH
Year: 2019
Journal: Cancer Res
Title: CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC.
Volume: 79
Issue: 17
Pages: 4439-4452
Publication
First Author: Wei W
Year: 2023
Journal: Cell Rep
Title: NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer.
Volume: 42
Issue: 7
Pages: 112810
Publication
First Author: Gong K
Year: 2020
Journal: Nat Cancer
Title: EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer.
Volume: 1
Issue: 4
Pages: 394-409
Publication
First Author: Kusne Y
Year: 2014
Journal: Sci Signal
Title: Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.
Volume: 7
Issue: 338
Pages: ra75
Pathway
Pathway
Pathway
Publication
First Author: LaRusch GA
Year: 2010
Journal: Blood
Title: Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis.
Volume: 115
Issue: 24
Pages: 5111-20
Publication
First Author: Sahin U
Year: 2004
Journal: J Cell Biol
Title: Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.
Volume: 164
Issue: 5
Pages: 769-79
Publication  
First Author: Shoykhet M
Year: 2023
Journal: JCI Insight
Title: EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation.
Volume: 8
Issue: 6
Publication
First Author: Hewing NJ
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.
Volume: 54
Issue: 1
Pages: 864-70
Publication
First Author: Hosur V
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.
Volume: 111
Issue: 21
Pages: E2200-9
Publication
First Author: Lee JC
Year: 2014
Journal: PLoS One
Title: Amelioration of hypercholesterolemia by an EGFR tyrosine kinase inhibitor in mice with liver-specific knockout of Mig-6.
Volume: 9
Issue: 12
Pages: e114782
Publication
First Author: Astigarraga S
Year: 2007
Journal: EMBO J
Title: A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling.
Volume: 26
Issue: 3
Pages: 668-77
Publication
First Author: Li D
Year: 2007
Journal: J Clin Invest
Title: Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas.
Volume: 117
Issue: 2
Pages: 346-52
Publication
First Author: Ali S
Year: 2014
Journal: Cancer Lett
Title: Deregulation of miR-146a expression in a mouse model of pancreatic cancer affecting EGFR signaling.
Volume: 351
Issue: 1
Pages: 134-42
Publication    
First Author: Kuhlmann-Hogan A
Year: 2024
Journal: Cancer Discov
Title: EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth.
Pages: OF1-OF22
Publication
First Author: Wang J
Year: 2024
Journal: J Biol Chem
Title: Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment interactions that block developmental tissue closure.
Volume: 300
Issue: 7
Pages: 107486