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Search results 1601 to 1700 out of 2033 for Epha4

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Type Details Score
Protein Domain
IPR035635 | Ephexin-1_SH3
Type: Domain
Description: Ephexin-1 is a RhoGEF (Rho-type guanine nucleotide exchange factor) that activates RhoA, Tac1, and Cdc42 by exchanging bound GDP for free GTP []. It is expressed mainly in the brain in a region associated with movement control. It regulates the stability of postsynaptic acetylcholine receptor (AChR) clusters and thus plays a critical role in the maturation and neurotransmission of neuromuscular junctions []. Ephexin-1 directly interacts with the ephrin receptor EphA4 and their coexpression enhances the ability of ephexin-1 to activate RhoA []. It is required for normal axon growth and EphA-induced growth cone collapse []. Ephexin-1 contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH) and SH3 domains. This entry represents the SH3 domain.
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Publication
20154726 | J:168266
First Author: Zhang W
Year: 2010
Journal: Oncogene
Title: A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
Volume: 29
Issue: 17
Pages: 2467-76
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Publication
21895656 | J:346501
First Author: Angibaud J
Year: 2011
Journal: J Neurochem
Title: The immune molecule CD3zeta and its downstream effectors ZAP-70/Syk mediate ephrin signaling in neurons to regulate early neuritogenesis.
Volume: 119
Issue: 4
Pages: 708-22
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Publication
22496572 | J:184449
First Author: Triplett JW
Year: 2012
Journal: J Neurosci
Title: Alignment of multimodal sensory input in the superior colliculus through a gradient-matching mechanism.
Volume: 32
Issue: 15
Pages: 5264-71
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Publication
35462405 | J:334513
First Author: Yan K
Year: 2023
Journal: Cereb Cortex
Title: TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.
Volume: 33
Issue: 5
Pages: 1752-1767
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Publication
23042409 | J:196350
First Author: Wallace MM
Year: 2013
Journal: J Comp Neurol
Title: Ephrin-B2 reverse signaling is required for topography but not pattern formation of lateral superior olivary inputs to the inferior colliculus.
Volume: 521
Issue: 7
Pages: 1585-97
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Publication
17942722 | J:126067
First Author: Bouzioukh F
Year: 2007
Journal: J Neurosci
Title: Tyrosine phosphorylation sites in ephrinB2 are required for hippocampal long-term potentiation but not long-term depression.
Volume: 27
Issue: 42
Pages: 11279-88
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Publication
23165658 | J:194685
First Author: Fang Y
Year: 2013
Journal: Stem Cells
Title: Ephrin-A3 suppresses Wnt signaling to control retinal stem cell potency.
Volume: 31
Issue: 2
Pages: 349-59
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Publication
36494892 | J:334412
First Author: Liang X
Year: 2023
Journal: Aging Cell
Title: Exosomal miR-532-5p induced by long-term exercise rescues blood-brain barrier function in 5XFAD mice via downregulation of EPHA4.
Volume: 22
Issue: 1
Pages: e13748
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Publication
23825607 | J:203741
First Author: Mulherkar S
Year: 2013
Journal: PLoS One
Title: The small GTPase RhoA is required for proper locomotor circuit assembly.
Volume: 8
Issue: 6
Pages: e67015
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Publication
11494128 | J:197520
First Author: Yu HH
Year: 2001
Journal: Oncogene
Title: Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor.
Volume: 20
Issue: 30
Pages: 3995-4006
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Publication
12775584 | J:177165
First Author: Ogita H
Year: 2003
Journal: Circ Res
Title: EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells.
Volume: 93
Issue: 1
Pages: 23-31
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Publication
11161563 | J:67303
First Author: Menzel P
Year: 2001
Journal: Dev Biol
Title: Ephrin-A6, a new ligand for EphA receptors in the developing visual system.
Volume: 230
Issue: 1
Pages: 74-88
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Publication
24081162 | J:215841
First Author: Rybak IA
Year: 2013
Journal: J Physiol
Title: Modelling genetic reorganization in the mouse spinal cord affecting left-right coordination during locomotion.
Volume: 591
Issue: 22
Pages: 5491-508
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Publication
30742094 | J:282883
First Author: Kraft K
Year: 2019
Journal: Nat Cell Biol
Title: Serial genomic inversions induce tissue-specific architectural stripes, gene misexpression and congenital malformations.
Volume: 21
Issue: 3
Pages: 305-310
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Publication
11684655 | J:72301
First Author: Stadler HS
Year: 2001
Journal: Development
Title: Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs.
Volume: 128
Issue: 21
Pages: 4177-88
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Publication
31300041 | J:295514
First Author: Rué L
Year: 2019
Journal: Acta Neuropathol Commun
Title: Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis.
Volume: 7
Issue: 1
Pages: 114
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Publication
11297511 | J:68814
First Author: Kullander K
Year: 2001
Journal: Genes Dev
Title: Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control.
Volume: 15
Issue: 7
Pages: 877-88
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Publication
22988240 | J:192472
First Author: Hitt B
Year: 2012
Journal: J Biol Chem
Title: β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.
Volume: 287
Issue: 46
Pages: 38408-25
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Publication
18721260 | J:151148
First Author: Kas MJ
Year: 2009
Journal: Genes Brain Behav
Title: High-resolution genetic mapping of mammalian motor activity levels in mice.
Volume: 8
Issue: 1
Pages: 13-22
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Publication
18055806 | J:132527
First Author: Du J
Year: 2007
Journal: Invest Ophthalmol Vis Sci
Title: Upregulation of EphB2 and ephrin-B2 at the optic nerve head of DBA/2J glaucomatous mice coincides with axon loss.
Volume: 48
Issue: 12
Pages: 5567-81
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Protein
A0A076N402
Organism: Mus musculus/domesticus
Length: 688  
Fragment?: true
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Protein
Q52KP9
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: true
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Protein
A0A076N9K6
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: true
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Protein
A0A076N8A1
Organism: Mus musculus/domesticus
Length: 718  
Fragment?: true
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Protein
A0A076NBC4
Organism: Mus musculus/domesticus
Length: 699  
Fragment?: true
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Protein
A0A076N1C3
Organism: Mus musculus/domesticus
Length: 661  
Fragment?: true
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Protein
A0A076N9K1
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: true
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Protein
D3YV54
Organism: Mus musculus/domesticus
Length: 34  
Fragment?: true
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Protein
A0A5F8MPI0
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
D3Z418
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
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Protein
A0A1Y7VJA6
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Publication
14704859 | -
First Author: Rothhammer T
Year: 2004
Journal: Cell Mol Life Sci
Title: The Ets-1 transcription factor is involved in the development and invasion of malignant melanoma.
Volume: 61
Issue: 1
Pages: 118-28
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Publication
9031109 | -
First Author: Wlodarska I
Year: 1996
Journal: Leuk Lymphoma
Title: ETV6 gene rearrangements in hematopoietic malignant disorders.
Volume: 23
Issue: 3-4
Pages: 287-95
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Publication
12389031 | -
First Author: Irie F
Year: 2002
Journal: Nat Neurosci
Title: EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP.
Volume: 5
Issue: 11
Pages: 1117-8
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Publication
14659698 | J:87527
First Author: Melino G
Year: 2003
Journal: Trends Biochem Sci
Title: Functional regulation of p73 and p63: development and cancer.
Volume: 28
Issue: 12
Pages: 663-70
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Publication
14499651 | -
First Author: Bloyer S
Year: 2003
Journal: Dev Biol
Title: Identification and characterization of polyhomeotic PREs and TREs.
Volume: 261
Issue: 2
Pages: 426-42
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Protein Domain
IPR013761 | SAM/pointed_sf
Type: Homologous_superfamily
Description: Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions, associating with both SAM-containing and non-SAM-containing proteins pathway []. SAM domains exhibit a conserved structure, consisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function, being involved in interactions with proteins, DNA and RNA []. The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names, including SPM, PTN (pointed), SEP (yeast sterility, Ets-related, PcG proteins), NCR (N-terminal conserved region) and HLH (helix-loop-helix) domain, all of which are related and can be classified as SAM domains.SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains, including Ets-1 transcription factor, which plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases []; Etv6 transcription factor, gene rearrangements of which have been demonstrated in several malignancies []; EphA4 receptor tyrosine kinase, which is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord []; EphB2 receptor, which is involved in spine morphogenesis via intersectin, Cdc42 and N-Wasp []; p73, a p53 homologue involved in neuronal development []; and polyhomeotic, which is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes [].
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Publication
33416454 | J:304340
First Author: Dhagia V
Year: 2021
Journal: Am J Physiol Heart Circ Physiol
Title: G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.
Volume: 320
Issue: 3
Pages: H999-H1016
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Protein
Q8R3Y5
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
Q5SXE1
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
A0A087WPA4
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: true
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Protein
D2JZZ5
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
G5E8E3
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
A0A0R4J2B5
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
A0A087WRI8
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
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Protein
Q5SXE2
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Protein
Q6PAJ3
Organism: Mus musculus/domesticus
Length: 880  
Fragment?: false
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Protein
Q3UFT3
Organism: Mus musculus/domesticus
Length: 876  
Fragment?: false
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Protein
E9QAJ7
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
Q6TDG7
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
Q8CC79
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: true
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Protein
A7VK14
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
A0A3B2WCY8
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: true
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Protein
D3Z292
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
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Publication
12858164 | -
First Author: Aviv T
Year: 2003
Journal: Nat Struct Biol
Title: The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators.
Volume: 10
Issue: 8
Pages: 614-21
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Protein
Q03137
Organism: Mus musculus/domesticus
Length: 986  
Fragment?: false
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Protein
Q91V57
Organism: Mus musculus/domesticus
Length: 459  
Fragment?: false
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Protein
Q3V2R3
Organism: Mus musculus/domesticus
Length: 468  
Fragment?: false
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Protein
Q61127
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
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Protein
Q8K070
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
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Protein
F6XZJ7
Organism: Mus musculus/domesticus
Length: 620  
Fragment?: false
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Protein
D3YXK1
Organism: Mus musculus/domesticus
Length: 519  
Fragment?: false
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Protein
Q60710
Organism: Mus musculus/domesticus
Length: 658  
Fragment?: false
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Protein
Q8VCQ6
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
Q8C8Y5
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Protein
Q69Z37
Organism: Mus musculus/domesticus
Length: 1561  
Fragment?: false
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Protein
Q8C4H2
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: false
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Protein
Q9DA37
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
Q7TST3
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
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Protein
Q1RNF8
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
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Protein
Q0VE29
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
D3YUG0
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Protein
Q3V1H9
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
Q6NZC7
Organism: Mus musculus/domesticus
Length: 998  
Fragment?: false
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Protein
Q9ERA0
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
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Protein
Q3UNW5
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Protein
Q80VG1
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
Q811S7
Organism: Mus musculus/domesticus
Length: 540  
Fragment?: false
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Protein
Q3UH82
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q3U247
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Protein
Q8C5C0
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
E9Q3G4
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Protein
Q3TYF1
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
Q14AQ4
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
B9EKF8
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
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Protein
C4IXV3
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
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Protein
Q3UR41
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: false
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Protein
S4R2K2
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: false
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Protein
Q4G0C0
Organism: Mus musculus/domesticus
Length: 998  
Fragment?: false
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Protein
Q8CCF9
Organism: Mus musculus/domesticus
Length: 44  
Fragment?: true
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Protein
Q3TBN2
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
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Protein
E9PX59
Organism: Mus musculus/domesticus
Length: 1579  
Fragment?: false
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Protein
Q3UDX7
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: true
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Protein
A2BGK7
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Protein
Q3TCJ7
Organism: Mus musculus/domesticus
Length: 620  
Fragment?: false
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Protein
J3QN61
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
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Protein
Q8BY88
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: true
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Protein
V9GX63
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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Protein
A2BIB7
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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