| Type |
Details |
Score |
| Allele |
| Name: |
NEDD4 binding protein 3; gene trap IST13996D4, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 3; gene trap IST14108B9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 3; gene trap IST14161F8, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 2-like 2; gene trap IST14225D4, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 2-like 2; gene trap IST14315A2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 3; gene trap IST14330E1, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 3; gene trap IST14332C5, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 2; gene trap IST14420C2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 3; gene trap IST14517B4, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 2; gene trap IST14554A7, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 1; gene trap IST14556C12, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 2; gene trap IST14615H2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 2-like 2; gene trap IST14796D1, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 3; gene trap IST14825A7, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 3; gene trap IST14772A6, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 2; gene trap IST15089G3, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 2-like 2; gene trap IST15039G12, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 1; gene trap IST15055B9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 1; gene trap IST15088B2, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 1; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 2; targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 2; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 3; targeted mutation 1b, Mouse Biology Program, UC Davis |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 1; targeted mutation 1.1, Paula M Oliver |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 2; targeted mutation 1.1, Paula M Oliver |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 2-like 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 2-like 1; endonuclease-mediated mutation 5, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 2-like 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 2-like 2; endonuclease-mediated mutation 3, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 2; endonuclease-mediated mutation 5, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
NEDD4 binding protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 1; endonuclease-mediated mutation 1, Institute of Molecular Genetics |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Allele |
| Name: |
Nedd4 family interacting protein 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip1/Ndfip1 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip1/Ndfip1 |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip1/Ndfip1 |
| Background: |
involves: C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
N4bp1/N4bp1 |
| Background: |
C57BL/6N-N4bp1 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
N4bp1/N4bp1 |
| Background: |
involves: C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip1/Ndfip1 |
| Background: |
involves: C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip1/Ndfip1 |
| Background: |
involves: C57BL/6J * SJL |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip1/Ndfip1 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ramos-Hernández N |
| Year: |
2013 |
| Journal: |
J Immunol |
| Title: |
Ndfip1 enforces a requirement for CD28 costimulation by limiting IL-2 production. |
| Volume: |
191 |
| Issue: |
4 |
| Pages: |
1536-46 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
161
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
260
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yip KH |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation. |
| Volume: |
7 |
|
| Pages: |
13198 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lackovic J |
| Year: |
2012 |
| Journal: |
Exp Neurol |
| Title: |
Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke. |
| Volume: |
235 |
| Issue: |
1 |
| Pages: |
326-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vecchione A |
| Year: |
2003 |
| Journal: |
Mol Cell Biol |
| Title: |
The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. |
| Volume: |
23 |
| Issue: |
9 |
| Pages: |
3363-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Monami G |
| Year: |
2008 |
| Journal: |
J Cell Physiol |
| Title: |
Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization. |
| Volume: |
216 |
| Issue: |
2 |
| Pages: |
426-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Konstas AA |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. |
| Volume: |
277 |
| Issue: |
33 |
| Pages: |
29406-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gitlin AD |
| Year: |
2020 |
| Journal: |
Nature |
| Title: |
Integration of innate immune signalling by caspase-8 cleavage of N4BP1. |
| Volume: |
587 |
| Issue: |
7833 |
| Pages: |
275-280 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Watanabe N |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. |
| Volume: |
278 |
| Issue: |
28 |
| Pages: |
26102-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsuoka T |
| Year: |
2008 |
| Journal: |
J Reprod Dev |
| Title: |
Identification of ZAG1, a novel protein expressed in mouse preimplantation, and its putative roles in zygotic genome activation. |
| Volume: |
54 |
| Issue: |
3 |
| Pages: |
192-7 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Trimpert C |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation. |
| Volume: |
12 |
| Issue: |
9 |
| Pages: |
e0183774 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gitlin AD |
| Year: |
2024 |
| Journal: |
Immunity |
| Title: |
N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation. |
| Volume: |
57 |
| Issue: |
5 |
| Pages: |
973-986.e7 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, targeted mutation, coisogenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
targeted mutation, mutant strain, coisogenic |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip1/Ndfip1 Tg(Nes-cre)1Kln/? |
| Background: |
involves: C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Cd28/Cd28 Ndfip1/Ndfip1 |
| Background: |
involves: 129P2/OlaHsd * 129S2/SvPas |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip2/Ndfip2 |
| Background: |
C57BL/6N-Ndfip2 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip2/Ndfip2 |
| Background: |
C57BL/6N-Ndfip2/Ieg |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip1/Ndfip1 Tg(Nes-cre)1Kln/? |
| Background: |
involves: C57BL/6J * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
N4bp3/N4bp3 |
| Background: |
C57BL/6N-N4bp3/Ucd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
N4bp3/N4bp3 |
| Background: |
C57BL/6N-N4bp3/Ucd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Il4/Il4 Ndfip1/Ndfip1 |
| Background: |
involves: 129P2/OlaHsd |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip1/Ndfip1 Tg(Cd4-cre)1Cwi/? |
| Background: |
involves: C57BL/6 * DBA/2 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
N4bp3/N4bp3<+> |
| Background: |
C57BL/6N-N4bp3/Ucd |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
537
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
150
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
128
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
88
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schmeisser MJ |
| Year: |
2013 |
| Journal: |
Neural Dev |
| Title: |
The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons. |
| Volume: |
8 |
|
| Pages: |
18 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
N4BP3 was identified as a protein expressed during development that interacts with Nedd4 ubiquitin ligase. N4BP3 is not a ubiquitylation substrate of Nedd4, but it can alter Nedd4 subcellular location, indicating a functional interaction []. N4BP3 has been shown to be essential in neurite branching and circuit formation []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sharma P |
| Year: |
2010 |
| Journal: |
J Cell Sci |
| Title: |
N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies. |
| Volume: |
123 |
| Issue: |
Pt 8 |
| Pages: |
1227-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Glowacka WK |
| Year: |
2012 |
| Journal: |
J Biol Chem |
| Title: |
LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages. |
| Volume: |
287 |
| Issue: |
33 |
| Pages: |
27691-702 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Ndfip1/Ndfip1 Rag1/Rag1 Tg(TcraTcrb)425Cbn/? |
| Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6 |
| Zygosity: |
cx |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
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| Genotype |
| Symbol: |
Emx1/Emx1<+> Ndfip1/Ndfip1 |
| Background: |
involves: 129P2/OlaHsd * C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
313
 |
| Fragment?: |
true |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
241
 |
| Fragment?: |
false |
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| Publication |
| First Author: |
Mund T |
| Year: |
2009 |
| Journal: |
EMBO Rep |
| Title: |
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. |
| Volume: |
10 |
| Issue: |
5 |
| Pages: |
501-7 |
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